Regional Differences in the CBF and BOLD Responses to Hypercapnia: A Combined PET and fMRI Study
Abstract
Previous fMRI studies of the cerebrovascular response to hypercapnia have shown signal change in cerebral gray matter, but not in white matter. Therefore, the objective of the present study was to compare (15)O PET and T *(2)-weighted MRI during a hypercapnic challenge. The measurements were performed under similar conditions of hypercapnia, which were induced by inhalation of 5 or 7% CO(2). The baseline rCBF values were 65.1 ml hg(-1) min(-1) for temporal gray matter and 28.7 ml hg(-1) min(-1) for white matter. By linear regression, the increases in rCBF during hypercapnia were 23.0 and 7. 2 ml hg(-1) min(-1) kPa(-1) for gray and white matter. The signal changes were 6.9 and 1.9% for the FLASH sequence and were 3.8 and 1. 7% for the EPI sequence at comparable echo times. The regional differences in percentage signal change were significantly reduced when normalized by regional flow values. A deconvolution analysis is introduced to model the relation between fMRI signal and end-expiratory CO(2) level. Temporal parameters, such as mean transit time, were derived from this analysis and suggested a slower response in white matter than in gray matter regions. It was concluded that the differences in the magnitude of the fMRI response can largely be attributed to differences in flow and that there is a considerable difference in the time course of the response between gray and white matter.
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Cites
Brain magnetic resonance imaging with contrast dependent on blood oxygenation.
Ogawa, S., Lee, T. M., Kay, A. R., & Tank, D. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9868 · Cited by 6,483 · see citing works
Rapid Automated Algorithm for Aligning and Reslicing PET Images
Woods, R. P., Cherry, S. R., & Mazziotta, J. C. (1992) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199207000-00024 · Cited by 1,932 · see citing works
Deconvolution of impulse response in event-related BOLD fMRI.
Glover, G. (1999) · NeuroImage · doi:10.1006/nimg.1998.0419 · Cited by 1,532 · see citing works
Brain magnetic resonance imaging with contrast-dependent oxygenation
Ogawa, S. (1990) · Medical Entomology and Zoology · Cited by 1,367 · see citing works
The Effects of Changes in Pa CO 2 Cerebral Blood Volume, Blood Flow, and Vascular Mean Transit Time
Grubb, R. L., Raichle, M. E., Eichling, J. O., & Ter‐Pogossian, M. M. (1974) · Stroke · doi:10.1161/01.str.5.5.630 · Cited by 1,044 · see citing works
Olesen, J., Paulson, O. B., & Lassen, N. A. (1971) · Stroke · doi:10.1161/01.str.2.6.519 · Cited by 497 · see citing works
Self-citationMenon, R. S., Ogawa, S., Tank, D. W., & Uǧurbil, K. (1993) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910300317 · Cited by 412 · see citing works
MP RAGE: a three-dimensional, T1-weighted, gradient-echo sequence--initial experience in the brain.
Brant-Zawadzki, M. N., Gillan, G. D., & Nitz, W. R. (1992) · Radiology · doi:10.1148/radiology.182.3.1535892 · Cited by 345 · see citing works
Brain or veinoxygenation or flow? On signal physiology in functional MRI of human brain activation
Frahm, J., Merboldt, K., Hänicke, W., Kleinschmidt, A. K., & Boecker, H. (1994) · NMR in Biomedicine · doi:10.1002/nbm.1940070108 · Cited by 341 · see citing works
Kim, S., & Uǧurbil, K. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910380110 · Cited by 220 · see citing works
Meyer, E. (1989) · PubMed · Cited by 207 · see citing works
Performance Characteristics of an Eight-Ring Whole Body PET Scanner
Kops, E. R., Herzog, H. R., Schmid, A., Holte, S., & Feinendegen, L. E. (1990) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199005000-00022 · Cited by 194 · see citing works
Step Hypocapnia to Separate Arterial from Tissue Pco 2 in the Regulation of Cerebral Blood Flow
Severinghaus, J. W., & Lassen, N. A. (1967) · Circulation Research · doi:10.1161/01.res.20.2.272 · Cited by 177 · see citing works
Capillary circulation in the brain.
Kuschinsky, W., & Paulson, O. B. (1992) · PubMed · Cited by 167 · see citing works
Self-citationWang, Q., Paulson, O. B., & Lassen, N. A. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.131 · Cited by 161 · see citing works
Self-citationFunctional MRI of CO2 induced increase in cerebral perfusion
Rostrup, E., Larsson, H. B. W., Toft, P. B., Garde, K., Thomsen, C. E., Ring, P., Søndergaard, L., & Henriksen, O. B. (1994) · NMR in Biomedicine · doi:10.1002/nbm.1940070106 · Cited by 106 · see citing works
Self-citationWagerle, L. C., & Mishra, O. P. (1988) · Circulation Research · doi:10.1161/01.res.62.5.1019 · Cited by 97 · see citing works
Signal changes in gradient echo images of human brain induced by hypo‐ and hyperoxia
Rostrup, E., Larsson, H. B. W., Toft, P. B., Garde, K., & Henriksen, O. M. (1995) · NMR in Biomedicine · doi:10.1002/nbm.1940080109 · Cited by 83 · see citing works
Self-citationHypercapnia slightly raises blood volume and sizably elevates flow velocity in brain microvessels
Bereczki, D., Wei, L., Otsuka, T., Hans, F., Acuff, V., Patlak, C. S., & Fenstermacher, J. (1993) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1993.264.5.h1360 · Cited by 74 · see citing works
Ackerman, R. H., Zilkha, E., Bull, J. W. D., du Boulay, G. H., Marshall, J., Russell, R. W. R., & Symon, L. (1973) · Neurology · doi:10.1212/wnl.23.1.21 · Cited by 58 · see citing works
Keyeux, A., Ochrymowicz-Bemelmans, D., & Charlier, A. A. (1995) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1995.139 · Cited by 45 · see citing works
JENSEN, K. E., Thomsen, C., & Henriksen, O. M. (1988) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1988.tb08492.x · Cited by 40 · see citing works
Cerebral blood flow changes induced by CO2 in anxiety
Mathew, R. J., & Wilson, W. H. (1988) · Psychiatry Research · doi:10.1016/0165-1781(88)90019-4 · Cited by 38 · see citing works
Is central chemoreceptor sensitive to intracellular rather than extracellular pH?
Lassen, N. A. (1990) · Clinical Physiology · doi:10.1111/j.1475-097x.1990.tb00792.x · Cited by 37 · see citing works
Susceptibility Contrast Imaging of CO 2 -Induced Changes in the Blood Volume of the Human Brain
Rostrup, E., Larsson, H. B. W., Toft, P. B., Garde, K., Ring, P., & Henriksen, O. M. (1996) · Acta Radiologica · doi:10.1177/02841851960373p276 · Cited by 21 · see citing works
Self-citationSusceptibility Contrast Imaging of CO2-Induced Changes in the Blood Volume of the Human Brain
Rostrup, E., Larsson, H. B. W., Toft, P. B., et al. (1996) · Acta Radiologica · doi:10.3109/02841859609177722 · Cited by 10 · see citing works
Self-citationBrain pH Responses to Acetazolamide and Hypercapvnia in Cats
Kohshi, K., Kinoshita, Y., & Fukata, K. (1997) · Neurologia medico-chirurgica · doi:10.2176/nmc.37.313 · Cited by 7 · see citing works
Preserved CO2 response in cerebral and muscular blood vessels during cimetidine treatment
Saunier, C. G., Audibert, G., Hartemann, D., Sautegeau, A., AMEND, P., Bigard, O., & Alvernhe, C. (1991) · Clinical Physiology · doi:10.1111/j.1475-097x.1991.tb00665.x · Cited by 3 · see citing works
Biswal (1997) · doi:10.1002/(sici)1099-1492(199706/08)10:4/5
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Birn, R. M., Diamond, J. B., Smith, M. A., & Bandettini, P. A. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.048 · Cited by 1,342 · see citing works
Resting-state fMRI confounds and cleanup
Murphy, K., Birn, R. M., & Bandettini, P. A. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.001 · Cited by 666 · see citing works
Wise, R. G., Ide, K., Poulin, M. J., & Tracey, I. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.025 · Cited by 664 · see citing works
A method for removal of global effects from fMRI time series
Macey, P. M., Macey, K. E., Kumar, R., & Harper, R. M. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.12.042 · Cited by 407 · see citing works
The influence of carbon dioxide on brain activity and metabolism in conscious humans
Xu, F., Uh, J., Brier, M. R., Hart, J., Yezhuvath, U. S., Gu, H., Yang, Y., & Lu, H. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.153 · Cited by 304 · see citing works
Relationship between respiration, end-tidal CO2, and BOLD signals in resting-state fMRI
Chang, C. E., & Glover, G. H. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.04.048 · Cited by 292 · see citing works
Cerebrovascular reactivity (CVR) MRI with CO2 challenge: A technical review
Liu, P., Vis, J. B. D., & Lu, H. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.03.047 · Cited by 279 · see citing works
Gawryluk, J. R., Mazerolle, E. L., & D’Arcy, R. C. N. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00239 · Cited by 274 · see citing works
Compensation of susceptibility-induced bold sensitivity losses in echo-planar fMRI imaging
Deichmann, R., Josephs, O., Hutton, C., Corfield, D. R., & Turner, R. (2002) · NeuroImage · doi:10.1006/nimg.2001.0985 · Cited by 253 · see citing works
Detection of synchronous brain activity in white matter tracts at rest and under functional loading
Ding, Z., Huang, Y., Bailey, S., Gao, Y., Cutting, L. E., Rogers, B. P., Newton, A. T., & Gore, J. C. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711567115 · Cited by 255 · see citing works
Bianciardi, M., Fukunaga, M., van Gelderen, P., Horovitz, S. G., de Zwart, J. A., Shmueli, K., & Duyn, J. H. (2009) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2009.02.004 · Cited by 240 · see citing works
BOLD functional MRI in disease and pharmacological studies: room for improvement?
Iannetti, G. D., & Wise, R. G. (2007) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2007.03.018 · Cited by 211 · see citing works
Studying spontaneous EEG activity with fMRI
Salek‐Haddadi, A., Friston, K. J., Lemieux, L., & Fish, D. R. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00193-0 · Cited by 205 · see citing works
Cerebral Perfusion Response to Hyperoxia
Bulte, D. P., Chiarelli, P. A., Wise, R. G., & Jezzard, P. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600319 · Cited by 190 · see citing works
A calibration method for quantitative BOLD fMRI based on hyperoxia
Chiarelli, P. A., Bulte, D. P., Wise, R. G., Gallichan, D., & Jezzard, P. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.05.033 · Cited by 179 · see citing works
Zimmerman, B., Bart Rypma, A., Gratton, G., & Fabiani, M. (2021) · Psychophysiology · doi:10.1111/psyp.13796 · Cited by 173 · see citing works
Functional MRI and resting state connectivity in white matter - a mini-review
Gore, J. C., Li, M., Gao, Y., Wu, T., Schilling, K. G., Huang, Y., Mishra, A., Newton, A. T., Rogers, B. P., Chen, L. M., et al. (2019) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2019.07.017 · Cited by 172 · see citing works
Pattinson, K. T. S., Mitsis, G. D., HARVEY, A., Jbabdi, S., Dirckx, S. G., Mayhew, S. D., Rogers, R., Tracey, I., & Wise, R. G. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.09.007 · Cited by 164 · see citing works
Interhemispheric Transmission of Visuomotor Information in Humans: fMRI Evidence
Tettamanti, M., Paulesu, E., Scifo, P., Maravita, A., Fazio, F., Perani, D., & Marzi, C. A. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.2.1051 · Cited by 159 · see citing works
On the assessment of cerebrovascular reactivity using hypercapnia BOLD MRI
Yezhuvath, U. S., Lewis‐Amezcua, K., Varghese, R., Xiao, G., & Lu, H. (2009) · NMR in Biomedicine · doi:10.1002/nbm.1392 · Cited by 157 · see citing works
The relationship between cerebral blood flow and volume in humans
Rostrup, E., Knudsen, G. M., Law, I. G., Holm, S., Larsson, H. B. W., & Paulson, O. B. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.09.043 · Cited by 156 · see citing works
Self-citationMurphy, K., Harris, A. D., & Wise, R. G. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.07.059 · Cited by 137 · see citing works
Cerebral Microcirculation and Oxygen Tension in the Human Secondary Cortex
Linninger, A. A., Gould, I. G., Marinnan, T., Hsu, C., Chojecki, M., & Alaraj, A. M. (2013) · Annals of Biomedical Engineering · doi:10.1007/s10439-013-0828-0 · Cited by 134 · see citing works
Changes of Cerebral Blood Flow, Oxygenation, and Oxidative Metabolism during Graded Motor Activation
Kastrup, A., Krüger, G., Neumann‐Haefelin, T., Glover, G. H., & Moseley, M. E. (2002) · NeuroImage · doi:10.1006/nimg.2001.0916 · Cited by 134 · see citing works
Haller, S., & Bartsch, A. J. (2009) · European Radiology · doi:10.1007/s00330-009-1456-9 · Cited by 133 · see citing works
Separating vascular and neuronal effects of age on fMRI BOLD signals
Tsvetanov, K. A., Henson, R. N., & Rowe, J. B. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0631 · Cited by 127 · see citing works
Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's disease
Yezhuvath, U. S., Uh, J., Cheng, Y., Martin‐Cook, K., Weiner, M., Diaz-Arrastia, R. R., van Osch, M. J. P., & Lu, H. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.02.005 · Cited by 131 · see citing works
Rauscher, A., Sedlacik, J., Barth, M., Haacke, E. M., & Reichenbach, J. R. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20520 · Cited by 132 · see citing works
Thomas, B. P., Liu, P., Park, D. C., van Osch, M. J. P., & Lu, H. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.194 · Cited by 129 · see citing works
Wise, R. G., Pattinson, K. T. S., Bulte, D. P., Chiarelli, P. A., Mayhew, S. D., Balanos, G. M., O'Connor, D. F., Pragnell, T. R., Robbins, P. A., Tracey, I., et al. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600465 · Cited by 129 · see citing works
Scholkmann, F., Gerber, U. R., Wolf, M., & Wolf, U. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.10.025 · Cited by 122 · see citing works
Zeidan, F., Baumgartner, J. N., & Coghill, R. C. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000759 · Cited by 115 · see citing works
Lorthois, S., Cassot, F., & Lauwers, F. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.032 · Cited by 116 · see citing works
Piechnik, S. K., Chiarelli, P. A., & Jezzard, P. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.08.022 · Cited by 115 · see citing works
The role of the anterior insula in adolescent decision making
Smith, A. R., Steinberg, L., & Chein, J. (2014) · Developmental Neuroscience · doi:10.1159/000358918 · Cited by 110 · see citing works
Golestani, A., Chang, C. E., Kwinta, J. B., Khatamian, Y. B., & Chen, J. J. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.10.031 · Cited by 113 · see citing works
Exploring the functional connectome in white matter
Li, J., Biswal, B. B., Wang, P., Duan, X., Cui, Q., Chen, H., & Liao, W. (2019) · Human Brain Mapping · doi:10.1002/hbm.24705 · Cited by 104 · see citing works
The effect of global cerebral vasodilation on focal activation hemodynamics
Stefanovic, B., Warnking, J. M., Rylander, K., & Pike, G. B. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.10.038 · Cited by 103 · see citing works
Mapping white-matter functional organization at rest and during naturalistic visual perception
Lynch, L. K., Lu, K., Wen, H., & Liu, Z. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.10.005 · Cited by 102 · see citing works
Hypercapnic normalization of BOLD fMRI: comparison across field strengths and pulse sequences
Cohen, E. R., Rostrup, E., Sidaros, K., Lund, T. E., Paulson, O. B., Uǧurbil, K., & Kim, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.021 · Cited by 101 · see citing works
Self-citationChanges in oxygenation of intracranial tumors with carbogen: A BOLD MRI and EPR oximetry study
Dunn, J. F., O’Hara, J. A., Wadghiri, Y. Z., Lei, H. C., Meyerand, M. E., Grinberg, O. Y., Hou, H. G., Hoopes, P. J., Demidenko, E., & Swartz, H. M. (2002) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10192 · Cited by 100 · see citing works
An improved method for acquiring cerebrovascular reactivity maps
Blockley, N. P., Driver, I. D., Francis, S., Fisher, J. A., & Gowland, P. A. (2010) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22719 · Cited by 99 · see citing works
Altered cerebrovascular reactivity velocity in mild cognitive impairment and Alzheimer's disease
Richiardi, J., Monsch, A. U., Haas, T., Barkhof, F., Ville, D. V. D., Radue, E. W., Kressig, R. W., & Haller, S. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.020 · Cited by 96 · see citing works
Buckley, E. M., Hance, D. J., Lynch, J. M., Mesquita, R. C., Yodh, A. G., Licht, D. J., Pawlowski, T., Wilson, F. B., Fogel, M. A., Durduran, T., et al. (2012) · Journal of Biomedical Optics · doi:10.1117/1.jbo.17.3.037007 · Cited by 96 · see citing works
Donahue, M. J., Lu, H., Jones, C. K., Pekar, J. J., & van Zijl, P. C. M. (2006) · NMR in Biomedicine · doi:10.1002/nbm.1075 · Cited by 95 · see citing works
Calibrating BOLD fMRI Activations with Neurovascular and Anatomical Constraints
Di, X., Kannurpatti, S. S., Rypma, B., & Biswal, B. B. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs001 · Cited by 94 · see citing works
Yuan, R., Di, X., Kim, E. H., Barik, S., Rypma, B., & Biswal, B. B. (2013) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2013.07.005 · Cited by 92 · see citing works
Mazerolle, E. L., Beyea, S., Gawryluk, J. R., Brewer, K., Bowen, C. V., & D’Arcy, R. C. N. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.102 · Cited by 91 · see citing works
Lorthois, S., Cassot, F., & Lauwers, F. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.040 · Cited by 88 · see citing works
Mohtasib, R., Lumley, G., Goodwin, J., Emsley, H. C. A., Sluming, V., & Parkes, L. M. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.092 · Cited by 85 · see citing works
Cerebral and peripheral hemodynamics and oxygenation during maximal dry breath-holds
Palada, I., Obad, A., Baković, D., Valić, Z., Ivančev, V., & Dujić, Ž. (2007) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2007.02.002 · Cited by 85 · see citing works
Differential responses of the insular cortex gyri to autonomic challenges
Macey, P. M., Wu, P., Kumar, R., Ogren, J. A., Richardson, H. L., Woo, M. A., & Harper, R. M. (2012) · Autonomic Neuroscience · doi:10.1016/j.autneu.2012.01.009 · Cited by 84 · see citing works
Wang, P., Wang, J., Michael, A., Wang, Z., Klugah‐Brown, B., Meng, C., & Biswal, B. B. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab181 · Cited by 81 · see citing works
Stamatelos, S. K., Kim, E., Pathak, A. P., & Popel, A. S. (2013) · Microvascular Research · doi:10.1016/j.mvr.2013.12.003 · Cited by 84 · see citing works
Mark, C. I., Slessarev, M., Ito, S., Han, J. S., Fisher, J. A., & Pike, G. B. (2010) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22405 · Cited by 79 · see citing works
MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges
Lu, H., Liu, P., Yezhuvath, U. S., Cheng, Y., Marshall, O., & Ge, Y. (2014) · Journal of Visualized Experiments · doi:10.3791/52306 · Cited by 78 · see citing works
Reproducibility of BOLD signal change induced by breath holding
Magon, S., Basso, G., Farace, P., Ricciardi, G. K., Beltramello, A., & Sbarbati, A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.12.059 · Cited by 76 · see citing works
Ziyeh, S., Rick, J., Reinhard, M., Hetzel, A., Mader, I., & Speck, O. (2005) · Stroke · doi:10.1161/01.str.0000157593.03470.3d · Cited by 76 · see citing works
Improved fMRI calibration: Precisely controlled hyperoxic versus hypercapnic stimuli
Mark, C. I., Fisher, J. A., & Pike, G. B. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.070 · Cited by 75 · see citing works
Bhogal, A. A., Siero, J. C. W., Fisher, J. A., Froeling, M., Luijten, P. R., Philippens, M. E. P., & Hoogduin, H. M. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.05.006 · Cited by 75 · see citing works
Functional mapping in the corpus callosum: A 4T fMRI study of white matter
Gawryluk, J. R., D’Arcy, R. C. N., Mazerolle, E. L., Brewer, K., & Beyea, S. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.07.028 · Cited by 70 · see citing works
The dynamics of cerebrovascular reactivity shown with transfer function analysis
Duffin, J., Sobczyk, O., Crawley, A. P., Poublanc, J., Mikulis, D. J., & Fisher, J. A. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.04.029 · Cited by 70 · see citing works
Examining the regional and cerebral depth-dependent BOLD cerebrovascular reactivity response at 7 T
Bhogal, A. A., Philippens, M. E. P., Siero, J. C. W., Fisher, J. A., Petersen, E. T., Luijten, P. R., & Hoogduin, H. M. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.04.014 · Cited by 68 · see citing works
Bulte, D. P., Drescher, K., & Jezzard, P. (2009) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21862 · Cited by 67 · see citing works
A neuromarker of individual general fluid intelligence from the white-matter functional connectome
Li, J., Biswal, B. B., Meng, Y., Yang, S., Duan, X., Cui, Q., Chen, H., & Liao, W. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0829-3 · Cited by 68 · see citing works
Voxel-wise detection of functional networks in white matter
Huang, Y., Bailey, S., Wang, P., Cutting, L. E., Gore, J. C., & Ding, Z. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.08.049 · Cited by 66 · see citing works
The neural correlates of ideation in product design engineering practitioners
Hay, L., Duffy, A. H. B., Gilbert, S. J., Lyall, L. M., Campbell, G., Coyle, D., & Grealy, M. (2019) · Design Science · doi:10.1017/dsj.2019.27 · Cited by 65 · see citing works
Pharmacological FMRI: Measuring Opioid Effects on the BOLD Response to Hypercapnia
Pattinson, K. T. S., Rogers, R., Mayhew, S. D., Tracey, I., & Wise, R. G. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600347 · Cited by 60 · see citing works
Sedlacik, J., Kutschbach, C., Rauscher, A., Deistung, A., & Reichenbach, J. R. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.008 · Cited by 63 · see citing works
Cerebral Blood Flow Measurement Using fMRI and PET: A Cross‐Validation Study
Chen, J. J., Wieckowska, M., Meyer, E., & Pike, G. B. (2008) · International Journal of Biomedical Imaging · doi:10.1155/2008/516359 · Cited by 63 · see citing works
Mazerolle, E. L., D’Arcy, R. C. N., & Beyea, S. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-84 · Cited by 63 · see citing works
Wu, X., Yang, Z., Bailey, S., Zhou, J., Cutting, L. E., Gore, J. C., & Ding, Z. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.074 · Cited by 63 · see citing works
Investigation of fMRI activation in the internal capsule
Gawryluk, J. R., Mazerolle, E. L., Brewer, K., Beyea, S., & D’Arcy, R. C. N. (2011) · BMC Neuroscience · doi:10.1186/1471-2202-12-56 · Cited by 60 · see citing works
Detectability of blood oxygenation level-dependent signal changes during short breath hold duration
Liu, H. O.-L., Huang, J. U.-C., Wu, C., & Hsu, Y. Y. (2002) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(02)00595-7 · Cited by 61 · see citing works
Prilipko, O., Huynh, N. T., Thomason, M. E., Kushida, C. A., & Guilleminault, C. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.04.004 · Cited by 60 · see citing works
Controlled inspiration depth reduces variance in breath-holding-induced BOLD signal
Thomason, M. E., & Glover, G. H. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.08.014 · Cited by 60 · see citing works
Bolus Arrival Time and Cerebral Blood Flow Responses to Hypercarbia
Donahue, M. J., Faraco, C. C., Strother, M. K., Chappell, M. A., Levendovszky, S. R., Dethrage, L. M., Hendrikse, J., & Siero, J. C. W. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.81 · Cited by 59 · see citing works
Regional Cerebrovascular Reactivity and Cognitive Performance in Healthy Aging
Catchlove, S. J., Parrish, T. B., Chen, Y., Macpherson, H., Hughes, M. E., & Pipingas, A. (2018) · Journal of Experimental Neuroscience · doi:10.1177/1179069518785151 · Cited by 59 · see citing works
Vidyasagar, R., Greyling, A., Draijer, R., Corfield, D. R., & Parkes, L. M. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.40 · Cited by 58 · see citing works
Fraser, L. M., Stevens, M. T. R., Beyea, S., & D’Arcy, R. C. N. (2012) · BMC Neuroscience · doi:10.1186/1471-2202-13-91 · Cited by 57 · see citing works
Courtemanche, M., Sparrey, C. J., Song, X., MacKay, A. L., & D’Arcy, R. C. N. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.12.008 · Cited by 57 · see citing works
Wang, P., Wang, J., Tang, Q., Alvarez, T. L., Wang, Z., Kung, Y., Lin, C., Chen, H., Meng, C., & Biswal, B. B. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117642 · Cited by 56 · see citing works
“Brain over body”–A study on the willful regulation of autonomic function during cold exposure
Muzik, O., Reilly, K. T., & Diwadkar, V. A. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.01.067 · Cited by 59 · see citing works
Optimizing the detection of white matter fMRI using asymmetric spin echo spiral
Gawryluk, J. R., Brewer, K., Beyea, S., & D’Arcy, R. C. N. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.11.005 · Cited by 54 · see citing works
Respiratory challenge MRI: Practical aspects
Moreton, F. C., Dani, K., Goutcher, C. M., O'Hare, K., & Muir, K. W. (2016) · NeuroImage Clinical · doi:10.1016/j.nicl.2016.05.003 · Cited by 51 · see citing works
Schilling, K. G., Li, M., Rheault, F., Gao, Y., Cai, L. Y., Zhao, Y., Xu, L., Ding, Z., Anderson, A. W., Landman, B. A., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2219666120 · Cited by 50 · see citing works
Zhou, Y., Rodgers, Z. B., & Kuo, A. H. (2015) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2015.02.018 · Cited by 48 · see citing works
Iterative analysis of cerebrovascular reactivity dynamic response by temporal decomposition
van Niftrik, C. H. B., Piccirelli, M., Bozinov, O., Pangalu, A., Fisher, J. A., Valavanis, A., Luft, A. R., Weller, M., Regli, L., & Fierstra, J. (2017) · Brain and Behavior · doi:10.1002/brb3.705 · Cited by 47 · see citing works
Regional quantification of cerebral venous oxygenation from MRI susceptibility during hypercapnia
Fan, A. P., Evans, K. C., Stout, J. N., Rosen, B. R., & Elfar Adalsteinsson, A. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.09.068 · Cited by 45 · see citing works
MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges
Lu, H., Liu, P., Yezhuvath, U. S., Cheng, Y., Marshall, O., & Ge, Y. (2014) · Journal of Visualized Experiments · doi:10.3791/52306-v · Cited by 43 · see citing works
Leoni, R. F., Mazzetto‐Betti, K. C., Silva, A. C., dos Santos, A. C., de Araújo, D. B., Leite, J. P., & Pontes‐Neto, O. M. (2012) · Radiology Research and Practice · doi:10.1155/2012/268483 · Cited by 40 · see citing works
Functional MRI activation in white matter during the Symbol Digit Modalities Test
Gawryluk, J. R., Mazerolle, E. L., Beyea, S., & D’Arcy, R. C. N. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00589 · Cited by 40 · see citing works
Effects of Field-Map Distortion Correction on Resting State Functional Connectivity MRI
Togo, H., Rokicki, J., Yoshinaga, K., Hisatsune, T., Matsuda, H., Haga, N., & Hanakawa, T. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00656 · Cited by 38 · see citing works
Jiang, D., Lin, Z., Liu, P., Sur, S., Xu, C., Hazel, K., Pottanat, G., Yaşar, S., Rosenberg, P. B., Albert, M., et al. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19867154 · Cited by 39 · see citing works
Prokopiou, P. C., Pattinson, K. T. S., Wise, R. G., & Mitsis, G. D. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.10.084 · Cited by 37 · see citing works
Vascular Reactivity Maps in Patients with Gliomas Using Breath‐Holding BOLD fMRI
Iranmahboob, A. K., Peck, K. K., Brennan, N. M. P., Karimi, S., Fisicaro, R. A., Hou, B. L., & Holodny, A. I. (2015) · Journal of Neuroimaging · doi:10.1111/jon.12278 · Cited by 37 · see citing works
Hund‐Georgiadis, M., Zysset, S., Naganawa, S., Norris, D. G., & von Cramon, D. Y. (2003) · Cerebrovascular Diseases · doi:10.1159/000070596 · Cited by 37 · see citing works
Leoni, R. F., Mazzetto‐Betti, K. C., Andrade, K. C., & de Araújo, D. B. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.035 · Cited by 36 · see citing works
Lawrence, K. S., Ye, F. Q., Lewis, B. K., Weinberger, D. R., Frank, J. A., & McLaughlin, A. C. (2002) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10111 · Cited by 36 · see citing works
Tancredi, F. B., Lajoie, I., & Hoge, R. D. (2015) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24878 · Cited by 35 · see citing works
- Authors
- Rostrup, E., Law, I., Blinkenberg, M., Larsson, H. B. W., Born, A. P., Holm, S., & Paulson, O. B.
- Affiliations
- Hvidovre Hospital (DK)
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 11
- Issue
- 2
- Pages
- 87-97
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2075514568
- Cited by
- 216
- References
- 29
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 6 · 2023: 11 · 2022: 10 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 13 · 2017: 8 · 2016: 5 · 2015: 12 · 2014: 18 · 2013: 10 · 2012: 11
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- hypercapnia, cerebral blood flow, BOLD signal, cerebrovascular response, gray matter, white matter, regional variation, deconvolution, mean transit time, end-expiratory CO2, 15O PET, T2-weighted MRI, FLASH sequence
- MeSH terms
- Adult, Blood Flow Velocity, Brain, Brain Mapping, Carbon Dioxide, Female, Humans, Hypercapnia, Image Enhancement, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Reference Values, Regional Blood Flow, Tomography, Emission-Computed
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