The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effects of Subchronic Exposure of Monochloramine in Drinking Water on Male Rats
Abstract
A subchronic rat study with paired-water control was conducted to resolve the question of whether monochloramine at 200 ppm in drinking water can cause reduced body weight gain and other changes observed in earlier investigations. Male Sprague-Dawley rats (93 +/- 5 g) were divided into three groups of 10 rats each: the treatment group was fed drinking water containing 200 ppm monochloramine, the control group was fed bicarbonate-buffered water ad libitum, and the paired-water control rats were given a daily volume of bicarbonate-buffered water equal to that consumed by the monochloramine treatment group. Compared to the control group, rats in the treatment group consumed an average of 42% less fluid and 16% less food over the 13-week treatment period and had 15-20% lower final body weight gain. Similar degrees of reduction in food consumption and body weight gain were observed in the paired-water rats. A decreased liver to body weight ratio occurred in the treatment and paired-water groups. Increased inorganic phosphate, albumin, total protein, and urea nitrogen were detected in sera from both the treatment group and the paired-water groups. The paired-water animals had lower levels of white blood cells and lymphocytes, while the paired-water and monochloramine-treated groups had reduced monocyte counts. Except for a slightly increased response to Con A observed in splenic lymphocytes of the monochloramine-treated rats (versus the paired-water), no significant changes were fo…
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“The authors concluded that reduced body weight gain and the minor biochemical, hematological, immunological and histopathological changes in exposed rats were largely related to reduced water and food consumption and not a direct effect of monochloramine (Poon et al. 1997).”
From Inorganic chloramines: a critical review of the toxicological and epidemiological evidence as a basis for occupational exposure limit setting (2020) · cites this paper as Poon et al. 1997
In the citing paper
“Reduced body weight gain and minor biochemical, hematological, immunological and histopathological changes were observed in rats exposed to 21.6 mg/kg bw/day of monochloramine for 13 weeks in drinking water.”
From Inorganic chloramines: a critical review of the toxicological and epidemiological evidence as a basis for occupational exposure limit setting (2020) · cites this paper as Poon et al. 1997
In the citing paper
“The effects were largely related to reduced water and food consumption (Poon et al. 1997).”
From Inorganic chloramines: a critical review of the toxicological and epidemiological evidence as a basis for occupational exposure limit setting (2020) · cites this paper as Poon et al. 1997
In the citing paper
“In long-term drinking water studies, reduced body weight gain and minor biochemical, hematological, immunological and histopathological changes were observed in rats exposed to 21.6 mg/kg/day for 13 weeks.The effects were largely related to reduced water and food consumption (Poon et al. 1997).”
From Inorganic chloramines: a critical review of the toxicological and epidemiological evidence as a basis for occupational exposure limit setting (2020) · cites this paper as Poon et al. 1997
Citations
Cites
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Cited by
Sorted by citations
Wastensson, G., & Eriksson, K. (2020) · Critical Reviews in Toxicology · doi:10.1080/10408444.2020.1744514 · Cited by 30
Metadata
- Authors
- Poon, R., Lecavalier, P., Tryphonas, H., Bondy, G., Chen, M., Chu, I., Yagminas, A., Valli, V. E., D'amour, M., & Thomas, B.
- Venue
- Regulatory Toxicology and Pharmacology
- Publisher
- Elsevier BV
- Published
- 1997-04
- Volume
- 25
- Issue
- 2
- Pages
- 166-175
- ISSN
- 0273-2300
- Cited by
- 7
- References
- 1
- Language
- en
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