The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Comparative Subchronic Toxicity of Chlorine and Monochloramine in the B6C3F1 Mouse
Abstract
Separate groups of male and female B6C3F1 mice were administered chlorine and monochloramine in drinking water for 90 consecutive days. Both disinfectants were supplied at 12.5, 25, 50, 100, and 200 mg/L. Criteria evaluated included mortality, clinical signs, body weight, food consumption, hematology, clinical chemistry, organ weights, gross pathology, and histopathology. Overall, the correlation of the biochemical, hematological, and organ weight data, in the absence of histopathology and observable clinical signs of toxicity, suggests that the chlorine and monochloramine induced effects via an indirect mechanism, e.g., nutritional deficiencies, rather than a direct toxicological effect on specific organs or tissues.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In B6C3F1 mice, 90-day monochloramine in drinking water caused decreased final body weight at >=100 mg/l, body weight gain at >=50 mg/l in males and >=100 mg/l in females, dose-related decreases in water and food consumption, and organ weight reductions; no exposure-related histopathology was observed.
“Final body weight was significantly decreased at doses !100 mg/l in both sexes and body weight gain at doses !50 mg/l in males and !100 mg/l in females.In parallel, dose-related decreases in water and food consumption were observed in both sexes.”
From Inorganic chloramines: a critical review of the toxicological and epidemiological evidence as a basis for occupational exposure limit setting (2020) · cites this paper as Daniel et al. 1991
The 50 mg/l concentration (8.6-9.2 mg/kg bw/day) was considered a NOAEL in mice.
“The 50 mg/l concentration (8.6-9.2 mg/kg bw/ day) was considered to be the NOAEL (Daniel et al. 1991).”
From Inorganic chloramines: a critical review of the toxicological and epidemiological evidence as a basis for occupational exposure limit setting (2020) · cites this paper as Daniel et al. 1991
Similar effects were reported also in other long-term studies in rats and mice at daily doses of 5-17 mg/kg bw/day.
“Similar effects were reported also in other long-term studies in rats and mice at daily doses of 5-17 mg/kg bw/day (Abdel-Rahman et al. 1984;Daniel et al. 1990;Daniel et al. 1991;NTP 1992).”
From Inorganic chloramines: a critical review of the toxicological and epidemiological evidence as a basis for occupational exposure limit setting (2020) · cites this paper as Daniel et al. 1991
Citations
Cites
Exon, J. H., Koller, L. D., O'Reilly, C. A., & Peter Bercz, J. (1987) · Toxicology · doi:10.1016/0300-483x(87)90028-x · Cited by 29
Flagged first, then by citations
Research works printed but not linked: 30
- White G.C., 1978, Water Chlorination: Environmental Impact and Health Effects,
- Larson T.V., 1978, Environmental Stress Proceedings
- Isaac R.A., 1980, Water Chlorination: Environmental Impact and Health Effects,
- Trussel R., 1984, Proc. of AWWA Seminar on Chloramines
- Jolley R.L., 1983, Water Chlorination: Environmental Impact and Health Effects,
- 10.1002/j.1551-8833.1990.tb07038.x · DOI · Paper page
- 10.1002/jat.2550040205 · DOI
- Cunningham H.M., 1980, Effect of Sodium Hypochlorite on the Growth of Rats and Guinea Pigs., Amer. Jour. Vet. Res., 41, 295, 10.2460/ajvr.1980.41.02.295 · DOI
- 10.1002/j.1551-8833.1956.tb16701.x · DOI
- 10.1016/0278-6915(86)90061-X · DOI
- 10.1080/15287398409530543 · DOI
- 10.1002/j.1551-8833.1980.tb04515.x · DOI · Paper page
- 10.1289/ehp.824647 · DOI
- Moore G.S., 1980, Health Effects of Monochloramines in Drinking Water., Jour. Envir. Sci. Health, 15, 239
- Gulf South Research Institute, 1981, A Subchronic Study of Monochloramine Generated In‐Situ in the Drinking Water of F344 Rats and B6C3F1 Mice. Draft rept.
- 1989, Standard Methods for the Examination of Water and Wastewater
- Palin A.T., 1967, Methods for the Determination, in Water, of Free and Combined Available Chlorine, Chlorine Dioxide and Chlorite, Bromine, Iodine, and Ozone Using DPD., Jour. Inst. Water Engrs., 21, 537
- Dixon W.J., 1969, Introduction to Statistical Analysis
- Hollander M., 1973, Nonparametric Statistical Methods
- 10.1289/ehp.8669221 · DOI
- 10.1126/science.181.4098.463 · DOI
- 10.1073/pnas.83.5.1485 · DOI
- 10.1289/ehp.824647 · DOI
- 10.1128/jb.125.3.934-945.1976 · DOI
- Shih K.L., 1976, Chloramine Mutagenesis in, Bacillus subtilis. Science, 192, 1141
- 10.1016/0165-1218(87)90112-1 · DOI · Paper page
- 10.1289/ehp.866959 · DOI
- 10.1002/em.2860070208 · DOI
- Abdel‐Rahman M.S., 1982, Effect of Chlorine and Monochloramine in Drinking Water on the Developing Rat Fetus., Jour. Appl. Toxicol., 2, 256
- 10.1289/ehp.8669281 · DOI
Cited by
Sorted by citations
Wastensson, G., & Eriksson, K. (2020) · Critical Reviews in Toxicology · doi:10.1080/10408444.2020.1744514 · Cited by 30
Metadata
- Authors
- Daniel, F. B., Ringhand, H. P., Robinson, M., Stober, J. A., Olson, G. R., & Page, N. P.
- Venue
- Journal AWWA
- Publisher
- Wiley
- Published
- 1991-11
- Volume
- 83
- Issue
- 11
- Pages
- 68-75
- ISSN
- 0003-150X (ISSN-L)
- 1551-8833
- OpenAlex
- W1532445469
- Cited by
- 10
- References
- 1
- Citations by year
- 2024: 1 · 2020: 1 · 2019: 1
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Water Works Association (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Water Treatment and Disinfection
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- chlorine, monochloramine, subchronic toxicity, B6C3F1 mice, hematological effects, clinical chemistry, organ weight, histopathology, nutritional deficiency
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
