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Biopersistence of Synthetic Vitreous Fibers and Amosite Asbestos in the Rat Lung Following Inhalation
Abstract
Fiber biopersistence as a major mechanism of fiber-induced pathogenicity was investigated. The lung biopersistence of 5 synthetic vitreous fibers (SVFs) and amosite asbestos was evaluated using the rat inhalation model. In contrast to several previous studies, this study examined fibers that dissolve relatively slowly in vitro at pH 7.4. Fisher rats were exposed for 5 days by nose-only inhalation to refractory ceramic fiber (RCF1a), rock (stone) wool (MMVF21), 2 relatively durable special application fiber glasses (MMVF32 or MMVF33), HT stonewool (MMVF34), amosite asbestos, or filtered air. Lung burdens were analyzed during 1 year post-exposure. Fiber aerosols contained 150-230 fibers/cc longer than 20 micrometer (>20 micrometer). On post-exposure Day 1, long-fiber lung burdens for the 6 test fibers were similar (12-16 x 10(5) fibers/lung >20 micrometer). After 1 year, the percentage of fibers >20 micrometer remaining in the lung was 0.04-10% for SVFs but 27% for amosite. Lung clearance weighted half-times (WT1/2) for fibers >20 micrometer were 6 days for MMVF34, 50-80 days for the other 4 SVFs, and >400 days for amosite. This study and 3 previous studies demonstrate a broad range of biopersistences for 19 different SVFs and 2 asbestos types. Ten of these fibers also have been (or are being) tested in chronic inhalation studies; in these studies, the very biopersistent fibers were carcinogenic (amosite, crocidolite, RCF1, MMVF32, and MMVF33), while the more rapidly clearing f…
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“However, these samples consisted of short fibers (arithmetic mean length: 1.2 μm and 2.2 μm respectively [86,102]), and no fiber > 20 μm length [86,102,103] , then the fate of LAF versus SAF was not assessed.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [103]
In the citing paper
“However later, retention was the same for fibers > 5 μm, while the fibers > 20 μm had disappeared [103,115].”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [103]
In the citing paper
“Similarly, a greater retention of amosite fibers > 5 μm and > 20 μm in length compared to < 5 μm up to 60 days post-exposure was reported [103].”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [103]
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Research works printed but not linked: 25
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Metadata
- Authors
- Hesterberg, T. W., Chase, G., Axten, C., Miller, W. C., Musselman, R. P., Kamstrup, O., Hadley, J., Morscheidt, C., Bernstein, D. M., & Thevenaz, P.
- Venue
- Toxicology and Applied Pharmacology
- Publisher
- Elsevier BV
- Published
- 1998-08
- Volume
- 151
- Issue
- 2
- Pages
- 262-275
- ISSN
- 0041-008X
- Cited by
- 149
- References
- 0
- Language
- en
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