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Stimulation of the Human Cytomegalovirus IE Enhancer/Promoter in HL-60 Cells by TNFα Is Mediated via Induction of NF-κB
Open accessAbstract
TNFalpha enhances the basal activity of the major Immediate Early (IE) enhancer/promoter of human cytomegalovirus (HCMV) in the immature premonocytic HL-60 cell line. The stimulatory effect of TNFalpha is mediated by induction of the transcription factor NF-kappaB, which specifically binds to the 18-bp repetitive sequence motif of the enhancer region. Complex formation could be competed by oligonucleotides representing the 18-bp sequence motif or the prototype NF-kappaB sequence of the immunoglobulin kappa gene. In gel mobility shift assays antisera specific to NF-kappaB p50 and p65 subunits were shown to react with the DNA-protein complex. Addition of the antioxidant PDTC blocked TNFalpha-mediated stimulation in a dose dependent manner. Electrophoretic mobility shift assays indicated that PDTC prevents NF-kappaB induction. Furthermore, it is suggested that protein kinases like PK-C are involved in the TNFalpha signal transduction pathway which leads to the activation of NF-kappaB and its binding to the HCMV IE enhancer in HL-60 cells. Our data are consistent with a role of TNFalpha in reactivation of latent HCMV infection in premonocytic cells.
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“Finally, if antioxidant molecules are depleted in T cells, then cytokine production, can become uncontrolled (Michalek et al. 2012), potentially resulting in an inflammatory environment that is also known to reactivate CMV (Docke et al. 1994; Prosch et al. 1995; Stein et al. 1993).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Prosch et al. 1995
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BackgroundSelf-citationMolecular basis of persistence and latency
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Hancock, M. H., Caposio, P., Collins-McMillen, D. K., Diggins, N. L., Lee, B.-J., Medica, S., Streblow, D. N., White, T., Yurochko, A. D., & Goodrum, F. D. (2025) · Journal of Virology · doi:10.1128/jvi.00664-25 · Cited by 6
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“We believe that these stimulatory effects are due to the up-regulation of UL122/123 genes transcription, as it occurs in other cell types after treatment with TNF-α, IL-1β, IL-6, and PGE2 (Stein et al., 1993; Prösch et al., 1995; Kline et al., 1998; Zhu et al., 2002).”
BackgroundPromoting Gene Therapy: Expression Systems for Iransgenes and Post-transcriptional Gene Silencing
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“Severe in fl ammation is known to induce CMV reactivation (20 – 22).”
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Metadata
- Authors
- Prösch, S., Staak, K., Stein, J., Liebenthal, C., Stamminger, T., Volk, H.-D., & Krüger, D. H.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Venue
- Virology
- Publisher
- Elsevier BV
- Published
- 1995-04
- Volume
- 208
- Issue
- 1
- Pages
- 197-206
- ISSN
- 0042-6822 (ISSN-L)
- OpenAlex
- W2046219854
- Cited by
- 188
- References
- 0
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Virology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
- Keywords
- human cytomegalovirus, TNF-α, NF-κB, HL-60 cells, latent viral reactivation, pyrrolidine dithiocarbamate, protein kinase C, signal transduction, transcriptional activation
- MeSH terms
- Antigens, Viral, Cytomegalovirus Infections, Cytomegalovirus, Dose-Response Relationship, Drug, Humans, Tumor Necrosis Factor-alpha, Virus Replication, Signal Transduction, NF-kappa B, Immediate-Early Proteins, HL-60 Cells
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