Cited by 188Cytomegalovirus and herpesvirus researchNF-κB Signaling PathwaysHerpesvirus Infections and Treatments

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Stimulation of the Human Cytomegalovirus IE Enhancer/Promoter in HL-60 Cells by TNFα Is Mediated via Induction of NF-κB

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Prösch, Susanna, Staak, Kerstin, Stein, Joachim, Liebenthal, Christa, Stamminger, Thomas, Volk, Hans-Dieter, Krüger, Detlev H.·1995·Virology

DOI 10.1006/viro.1995.1143

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Abstract

TNFalpha enhances the basal activity of the major Immediate Early (IE) enhancer/promoter of human cytomegalovirus (HCMV) in the immature premonocytic HL-60 cell line. The stimulatory effect of TNFalpha is mediated by induction of the transcription factor NF-kappaB, which specifically binds to the 18-bp repetitive sequence motif of the enhancer region. Complex formation could be competed by oligonucleotides representing the 18-bp sequence motif or the prototype NF-kappaB sequence of the immunoglobulin kappa gene. In gel mobility shift assays antisera specific to NF-kappaB p50 and p65 subunits were shown to react with the DNA-protein complex. Addition of the antioxidant PDTC blocked TNFalpha-mediated stimulation in a dose dependent manner. Electrophoretic mobility shift assays indicated that PDTC prevents NF-kappaB induction. Furthermore, it is suggested that protein kinases like PK-C are involved in the TNFalpha signal transduction pathway which leads to the activation of NF-kappaB and its binding to the HCMV IE enhancer in HL-60 cells. Our data are consistent with a role of TNFalpha in reactivation of latent HCMV infection in premonocytic cells.

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Self-citation
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“This immediate enhancement of NFκB activation appears to be pro-viral, as HCMV’s MIEP possesses NFκB binding motifs [93] that facilitate the expression of IE genes, an effect that can be enhanced by TNFα stimulation [94].”
Background
The multi-targeted kinase inhibitor sorafenib inhibits human cytomegalovirus replication
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“For example, NF-jB inhibitors interfere with HCMV replication in fibroblasts [ 23 , 24] but not in RPE cells [31].”
Background
IMPACT OF OXIDATIVE STRESS ON HUMAN CYTOMEGALOVIRUS REPLICATION AND ON CYTOKINE-MEDIATED STIMULATION OF ENDOTHELIAL CELLS1
Scholz, M., Cínatl, J., Gross, V., Vogel, J.-U., Blaheta, R. A., Freisleben, H., Markus, B. H., & Doerr, H. W. (1996) · Transplantation · doi:10.1097/00007890-199606270-00017 · Cited by 39
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“It is well known that the major HCMV IE promoter (MIEP) contains four NF- B consensus binding sites (41) that are important for efficient transcription (48, 49).”
Background
Human Cytomegalovirus Blocks Tumor Necrosis Factor Alpha- and Interleukin-1β-Mediated NF-κB Signaling
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Self-citation
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“In a first approach we could demonstrate that the antioxidant PDTC is able to block TNFα stimulation of the IE1/2 enhancer/promoter in HL-60 cells (Prösch et al., 1995).”
BackgroundMethodInfluentialSelf-citation
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The Human Cytomegalovirus Virion Possesses an Activated Casein Kinase II That Allows for the Rapid Phosphorylation of the Inhibitor of NF-κB, IκBα
Nogalski, M. T., Podduturi, J. P., DeMeritt, I. B., Milford, L. E., & Yurochko, A. D. (2007) · Journal of Virology · doi:10.1128/jvi.02382-06 · Cited by 31
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Neuroinflammatory processes are augmented in mice overexpressing human heat-shock protein B1 following ethanol-induced brain injury
Dukay, B., Walter, F. R., Vigh, J. P., Barabási, B., Hajdu, P., Balassa, T., Migh, E., Kincses, A., Hoyk, Z., Szögi, T., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02070-2 · Cited by 30
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Authors: Prösch, S., Staak, K., Stein, J., Liebenthal, C., Stamminger, T., Volk, H.-D., & Krüger, D. H.
Affiliations: Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
ORCID: Stamminger, Thomas
Volk, Hans-Dieter
Krüger, Detlev H.
Venue: Virology
Publisher: Elsevier BV
Published: 1995-04
Volume: 208
Issue: 1
Pages: 197-206
ISSN: 0042-6822 (ISSN-L)
DOI: 10.1006/viro.1995.1143
OpenAlex: W2046219854
Cited by: 188
References: 0
Citations by year: 2026: 4 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 7 · 2014: 2 · 2013: 3 · 2012: 1
FWCI: 2.69
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6682 d)
Locations: Virology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Keywords: human cytomegalovirus, TNF-α, NF-κB, HL-60 cells, latent viral reactivation, pyrrolidine dithiocarbamate, protein kinase C, signal transduction, transcriptional activation
MeSH terms: Antigens, Viral, Cytomegalovirus Infections, Cytomegalovirus, Dose-Response Relationship, Drug, Humans, Tumor Necrosis Factor-alpha, Virus Replication, Signal Transduction, NF-kappa B, Immediate-Early Proteins, HL-60 Cells

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Stimulation of the Human Cytomegalovirus IE Enhancer/Promoter in HL-60 Cells by TNFα Is Mediated via Induction of NF-κB

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