Cited by 146T-cell and B-cell ImmunologySystemic Lupus Erythematosus Researchvaccines and immunoinformatics approaches

Molecular Mimicry, Microbial Infection, and Autoimmune Disease: Evolution of the Concept

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Oldstone, M. B. A.·2005·Current Topics in Microbiology and Immunology

Abstract

Molecular mimicry is defined as similar structures shared by molecules from dissimilar genes or by their protein products. Either several linear amino acids or their conformational fit may be shared, even though their origins are separate. Hence, during a viral or microbe infection, if that organism shares cross-reactive epitopes for B or T cells with the host, then the response to the infecting agent will also attack the host, causing autoimmune disease. A variation on this theme is when a second, third, or repeated infection(s) shares cross-reactive B or T cell epitopes with the first (initiating) virus but not necessarily the host. In this instance, the secondary infectious agents increase the number of antiviral/antihost effector antibodies or T cells that potentiate or precipitate the autoimmune assault. The formation of this concept initially via study of monoclonal antibody or clone T cell cross-recognition in vitro through its evolution to in vivo animal models and to selected human diseases is explored in this mini-review.

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  • Evolution of molecular mimicry between gut bacteria and the host can affect host eating behavior.

    “These ground-breaking findings posit that evolution of molecular mimicry between gut bacteria and the host (Oldstone, 2005) can affect host eating behavior.”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Oldstone, 2005

    The paper’s introductory passage describes molecular mimicry between microbes and hosts, and its References list examples involving bacteria. It does not say that mimicry evolved between gut bacteria and hosts or that it affects eating behavior; the title’s “evolution” refers to the development of the concept. (LLM, conf=0.82)

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Authors
Oldstone, M. B. A.
Affiliations
Scripps Research Institute (US)
Corresponding author
Oldstone, M. B. A.
Venue
Current Topics in Microbiology and Immunology
Published
2005
Volume
296
Pages
1-17
ISSN
0070-217X (ISSN-L)
OpenAlex
W96814828
Cited by
146
References
53
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 5 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 13 · 2013: 17 · 2012: 6
FWCI
8.50
Type
book chapter
Language
en
Open access
Locations
  • Current topics in microbiology and immunology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (AI045927, R01AI045927, AI036222, R01AI036222, AI-009484)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058541, DK-058541)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Keywords
molecular mimicry, autoimmune disease, microbial infection, cross-reactive epitopes, B-cell epitopes, T cell epitopes, viral infection, secondary infection, autoimmunity, monoclonal antibodies, animal models of autoimmunity
MeSH terms
Amino Acid Sequence, Animals, Epitopes, Autoantibodies, Autoantigens, Autoimmune Diseases, Disease Models, Animal, Humans, Infections, Molecular Sequence Data, T-Lymphocytes, Models, Immunological, Molecular Mimicry

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