Cited by 104Stress Responses and CortisolNeuroendocrine regulation and behaviorPosttraumatic Stress Disorder Research

The interface of stress and the HPA axis in behavioural phenotypes of mental illness

Baumeister, David, Lightman, Stafford L., Pariante, Carmine M.·2014·Current topics in behavioral neurosciences

Abstract

Abnormalities of hypothalamic-pituitary-adrenal (HPA) axis function are one of the most consistent biological findings across several mental disorders, but many of the mechanisms underlying this abnormality as well as the potential contribution to behavioural phenotypes remain only partially understood. Interestingly, evidence suggests a U-curve, with dysregulation of the HPA axis towards both hyper- or hypoactivity manifesting as a risk to mental wellbeing. This review will elaborate on both the clinical and molecular role of the neuroendocrine stress system in depressive, psychotic and post-traumatic stress disorders and present some of the most recent findings that have shed light on the complex interface between environmental stressors, molecular mechanisms and clinical presentation. Crucially, plasticity of the HPA axis confers both vulnerability to adverse events, particularly so in early developmental stages, as well as hope for the treatment of mental disorder, as evidenced by changes in HPA functioning associated with remission of symptoms.

Integrity signals

Registry

Crossref · 10.1007/7854_2014_304

Cites

69 of 69 references verified0 citation errors · 0 not checkable

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  • Our data are congruent with newer research developments that point towards shared underlying vulnerability factors, rather than direct HPA-depression links.

    “Our data are congruent with newer research developments that point towards shared underlying vulnerability factors, rather than direct HPA-depression links (Baumeister et al., 2014).”
  • Some previously described HPA axis abnormalities in depression may reflect shared underlying vulnerability factors rather than direct HPA-depression links.

    “Recent scientific developments suggest that some previously described HPA axis abnormalities in depression may reflect the impact of shared underlying vulnerability factors (e.g., genetic heritage interacting with developmental experiences) rather than direct HPA-depression links per se (Baumeister et al., 2014).”

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Authors
Baumeister, D., Lightman, S. L., & Pariante, C. M.
Affiliations
  • King's College London (GB)
  • University of Bristol (GB)
Corresponding author
Pariante, Carmine M.
Venue
Current topics in behavioral neurosciences
Published
2014
Volume
18
Pages
13-24
ISSN
  • 1866-3370 (ISSN-L)
  • 1866-3389
OpenAlex
W142506613
Cited by
104
References
69
Citations by year
2026: 3 · 2025: 9 · 2024: 10 · 2023: 5 · 2022: 10 · 2021: 9 · 2020: 5 · 2019: 11 · 2018: 6 · 2017: 11 · 2016: 8 · 2015: 9 · 2014: 8
FWCI
15.13
Type
book chapter
Language
en
Open access
closed
Locations
  • Current topics in behavioral neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
  • Explore Bristol Research (submittedVersion)
  • Bristol Research (University of Bristol) (submittedVersion)
Funders
Medical Research Council (MR/J002739/1)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords
hypothalamic-pituitary-adrenal axis, stress, depression, psychosis, post-traumatic stress disorder, environmental stressors, developmental adversity, symptom remission

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