The interface of stress and the HPA axis in behavioural phenotypes of mental illness
Abstract
Abnormalities of hypothalamic-pituitary-adrenal (HPA) axis function are one of the most consistent biological findings across several mental disorders, but many of the mechanisms underlying this abnormality as well as the potential contribution to behavioural phenotypes remain only partially understood. Interestingly, evidence suggests a U-curve, with dysregulation of the HPA axis towards both hyper- or hypoactivity manifesting as a risk to mental wellbeing. This review will elaborate on both the clinical and molecular role of the neuroendocrine stress system in depressive, psychotic and post-traumatic stress disorders and present some of the most recent findings that have shed light on the complex interface between environmental stressors, molecular mechanisms and clinical presentation. Crucially, plasticity of the HPA axis confers both vulnerability to adverse events, particularly so in early developmental stages, as well as hope for the treatment of mental disorder, as evidenced by changes in HPA functioning associated with remission of symptoms.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Our data are congruent with newer research developments that point towards shared underlying vulnerability factors, rather than direct HPA-depression links.
“Our data are congruent with newer research developments that point towards shared underlying vulnerability factors, rather than direct HPA-depression links (Baumeister et al., 2014).”
From Chronic Stress, Hair Cortisol and Depression: A Prospective and Longitudinal Study of Medical Internship (2018) · cites this paper as Baumeister et al., 2014
Some previously described HPA axis abnormalities in depression may reflect shared underlying vulnerability factors rather than direct HPA-depression links.
“Recent scientific developments suggest that some previously described HPA axis abnormalities in depression may reflect the impact of shared underlying vulnerability factors (e.g., genetic heritage interacting with developmental experiences) rather than direct HPA-depression links per se (Baumeister et al., 2014).”
From Chronic Stress, Hair Cortisol and Depression: A Prospective and Longitudinal Study of Medical Internship (2018) · cites this paper as Baumeister et al., 2014
Cites
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works
Miller, G. E., Chen, E., & Zhou, E. S. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.1.25 · Cited by 2,467 · see citing works
Varese, F., Smeets, F., Drukker, M., Lieverse, R., Lataster, T., Viechtbauer, W., Read, J., van Os, J., & Bentall, R. P. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs050 · Cited by 2,436 · see citing works
The HPA axis in major depression: classical theories and new developments
Pariante, C. M., & Lightman, S. L. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.006 · Cited by 2,009 · see citing works
Edwards, V. J., Holden, G. W., Felitti, V. J., & Anda, R. F. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1453 · Cited by 1,832 · see citing works
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447 · see citing works
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147 · see citing works
Stetler, C., & Miller, G. E. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820ad12b · Cited by 1,123 · see citing works
Major depressive disorder and hypothalamic-pituitary-adrenal axis activity
Vreeburg, S. A., Hoogendijk, W. J. G., van Pelt, J., DeRijk, R. H., Verhagen, J. C. M., van Dyck, R., Smit, J. H., Zitman, F. G., & Penninx, B. W. J. H. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.50 · Cited by 792 · cited 1× · see citing works
“Depression is also associated with an elevated cortisol response to awakening, a phenomenon that persists even after recovery (Bhagwagar et al. 2003, 2005; Vreeburg et al. 2009).”
BackgroundHair cortisol, stress exposure, and mental health in humans: A systematic review
Staufenbiel, S. M., Penninx, B. W. J. H., Spijker, A. T., Elzinga, B. M., & van Rossum, E. F. C. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.015 · Cited by 736 · see citing works
Work stress precipitates depression and anxiety in young, working women and men
MELCHIOR, M., CASPI, A., MILNE, B. J., DANESE, A., POULTON, R., & MOFFITT, T. E. (2007) · Psychological Medicine · doi:10.1017/s0033291707000414 · Cited by 691 · see citing works
Lamers, F., Vogelzangs, N., Merikangas, K. R., de Jonge, P., Beekman, A. T. F., & Penninx, B. W. J. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.144 · Cited by 691 · see citing works
Prenatal stress, glucocorticoids and the programming of adult disease
Cottrell, E. C. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.019.2009 · Cited by 640 · see citing works
Daskalakis, N. P., Bagot, R. C., Parker, K. J., Vinkers, C. H., & de Kloet, E. R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.008 · Cited by 579 · see citing works
HPA Axis Reactivity: A Mechanism Underlying the Associations Among 5-HTTLPR, Stress, and Depression
Gotlib, I. H., Joormann, J., Minor, K. L., & Hallmayer, J. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.008 · Cited by 558 · see citing works
de Kloet, C. S., Vermetten, E., Geuze, E., Kavelaars, A., Heijnen, C. J., & Westenberg, H. G. M. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.08.002 · Cited by 503 · see citing works
Tyrka, A. R., Price, L. H., Marsit, C., Walters, O. C., & Carpenter, L. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030148 · Cited by 486 · see citing works
(2005) · PubMed · Cited by 470 · see citing works
Morris, M. C., Compas, B. E., & Garber, J. (2012) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.02.002 · Cited by 466 · cited 2× · see citing works
“A recent meta-analysis comparing PTSD to PTSD comorbid with depression (PTSD + MDD) showed further interesting subtleties in differential HPA function: PTSD, PTSD + MDD and TE groups exhibited attenuated morning cortisol compared to NE groups, but whilst PTSD and TE groups showed similar patterns in afternoon cortisol…”
ResultEmotional reactivity to daily events in major and minor depression.
Bylsma, L. M., Taylor-Clift, A., & Rottenberg, J. (2011) · Journal of Abnormal Psychology · doi:10.1037/a0021662 · Cited by 388 · see citing works
Do Corticosteroids Damage the Brain?
Herbert, J., Goodyer, I. M., Grossman, A. B., Hastings, M. H., de Kloet, E. R., Lightman, S. L., LUPIEN, S. J., Roozendaal, B., & Seckl, J. R. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01429.x · Cited by 384 · see citing works
Heim, C., Mletzko, T., Purselle, D., Musselman, D. L., & Nemeroff, C. B. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.07.002 · Cited by 353 · see citing works
Ising, M., Depping, A., Siebertz, A., Lucae, S., Unschuld, P. G., Kloiber, S. M., Horstmann, S., Uhr, M., Müller‐Myhsok, B., & Holsboer, F. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06332.x · Cited by 312 · see citing works
Neurobiology of early life stress: Clinical studies
Heim, C., & Nemeroff, C. B. (2002) · Seminars in Clinical Neuropsychiatry · doi:10.1053/scnp.2002.33127 · Cited by 307 · see citing works
Behavioural sensitization to daily life stress in psychosis
MYIN-GERMEYS, I., DELESPAUL, P., & VAN OS, J. (2005) · Psychological Medicine · doi:10.1017/s0033291704004179 · Cited by 292 · cited 3× · see citing works
“Patients with psychosis also show a greater emotional reactivity to daily life stress (Myin-Germeys et al. 2005).”
BackgroundInfluentialIncreased salivary cortisol after waking in depression
Bhagwagar, Z., Hafizi, S., & Cowen, P. J. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0062-z · Cited by 281 · see citing works
Mondelli, V., Dazzan, P., Hepgul, N., Di Forti, M., Aas, M., D'Albenzio, A., Di Nicola, M., Fisher, H., Handley, R., Marques, T. R., et al. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2009.08.013 · Cited by 278 · see citing works
Life Events and Psychosis: Initial Results from the Camberwell Collaborative Psychosis Study
Bebbington, P., Wilkins, S., Jones, P., Foerster, A., Murray, R., Toone, B., & Lewis, S. (1993) · British Journal of Psychiatry · doi:10.1192/bjp.162.1.72 · Cited by 273 · see citing works
Hypothalamic-pituitary-adrenal axis and bipolar disorder
Daban, C., Vieta, E., Mackin, P., & Young, A. H. (2005) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2005.01.005 · Cited by 245 · see citing works
Ouellet-Morin, I., Wong, C. C. Y., Danese, A., Pariante, C. M., Papadopoulos, A. S., Mill, J., & Arseneault, L. (2013) · Psychological Medicine · doi:10.1017/s0033291712002784 · Cited by 207 · see citing works
Steudte, S., Kirschbaum, C., Gao, W., Alexander, N., Schönfeld, S., Hoyer, J., & Stalder, T. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.011 · Cited by 196 · see citing works
The glucocorticoid receptor: part of the solution or part of the problem?
Pariante, C. M. (2006) · Journal of Psychopharmacology · doi:10.1177/1359786806066063 · Cited by 192 · see citing works
Synergistic Childhood Adversities and Complex Adult Psychopathology
Putnam, K. T., Harris, W. W., & Putnam, F. W. (2013) · Journal of Traumatic Stress · doi:10.1002/jts.21833 · Cited by 191 · see citing works
The ACTH Response to Dexamethasone in PTSD
Yehuda, R., Golier, J. A., Halligan, S. L., Meaney, M. J., & Bierer, L. M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.8.1397 · Cited by 184 · see citing works
Increased cortisol concentrations in hair of severely traumatized Ugandan individuals with PTSD
Steudte‐Schmiedgen, S., Kolassa, I., Stalder, T., Pfeiffer, A., Kirschbaum, C., & Elbert, T. R. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.02.012 · Cited by 180 · see citing works
Adulthood trauma and HPA-axis functioning in healthy subjects and PTSD patients: A meta-analysis
Klaassens, E. R., Giltay, E. J., Cuijpers, P. J., van Veen, T., & Zitman, F. G. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.003 · Cited by 179 · see citing works
Increase in Concentration of Waking Salivary Cortisol in Recovered Patients With Depression
Bhagwagar, Z., Hafizi, S., & Cowen, P. J. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.10.1890 · Cited by 161 · see citing works
Borges, S., Gayer-Anderson, C., & Mondelli, V. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.12.025 · Cited by 153 · see citing works
Luo, H., Hu, X., Liu, X., Ma, X., Guo, W., Qiu, C., Wang, Y., Wang, Q., Zhang, X., Zhang, W., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.020 · Cited by 149 · see citing works
Cortisol secretion in depressed, and at-risk adults
Dienes, K. A., Hazel, N. A., & Hammen, C. L. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.09.019 · Cited by 128 · see citing works
Aas, M., Dazzan, P., Mondelli, V., Toulopoulou, T., Reichenberg, A., Di Forti, M., Fisher, H. L., Handley, R., Hepgul, N., Marques, T., et al. (2011) · Psychological Medicine · doi:10.1017/s0033291710001170 · Cited by 124 · see citing works
Stress and excitatory synapses: From health to disease
Timmermans, W., Xiong, H., Hoogenraad, C. C., & Krugers, H. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.05.043 · Cited by 118 · see citing works
Cortisol response to a psychosocial stressor in schizophrenia: Blunted, delayed, or normal?
Brenner, K., Liu, A., Laplante, D. P., LUPIEN, S. J., Pruessner, J. C., Ciampi, A., Joober, R., & King, S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.002 · Cited by 112 · see citing works
Pruessner, M., Béchard‐Evans, L., Boekestyn, L., Iyer, S. N., Pruessner, J. C., & MALLA, A. K. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.02.019 · Cited by 107 · see citing works
Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients
Wang, Q., Verweij, E. W. E., Krugers, H. J., Joëls, M., Swaab, D. F., & Lucassen, P. J. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0589-4 · Cited by 107 · see citing works
Morris, M. C., & Rao, U. (2012) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2012.07.012 · Cited by 102 · see citing works
Hinkelmann, K., Muhtz, C., Dettenborn, L., Agorastos, A., Wingenfeld, K., Spitzer, C., Gao, W., Kirschbaum, C., Wiedemann, K., & Otte, C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.021 · Cited by 96 · see citing works
Parental history of depression or anxiety and the cortisol awakening response
Vreeburg, S. A., Hartman, C. A., Hoogendijk, W. J. G., van Dyck, R., Zitman, F. G., Ormel, J., & Penninx, B. W. J. H. (2010) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.109.076869 · Cited by 94 · see citing works
Aardal-Eriksson, E., Eriksson, T. E., & Thorell, L. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01253-7 · Cited by 93 · see citing works
Hypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis
Belvederi Murri, M., Pariante, C. M., Dazzan, P., Hepgul, N., Papadopoulos, A. S., Zunszain, P., Di Forti, M., Murray, R. M., & Mondelli, V. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.08.013 · Cited by 93 · see citing works
Long-term cortisol in bipolar disorder: Associations with age of onset and psychiatric co-morbidity
Manenschijn, L., Spijker, A. T., Koper, J. W., Jetten, A. M., Giltay, E. J., Haffmans, J., Hoencamp, E., & van Rossum, E. F. C. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.04.010 · Cited by 76 · see citing works
Marin, T. J., Martin, T. M., Blackwell, E., Stetler, C., & Miller, G. E. (2007) · Health Psychology · doi:10.1037/0278-6133.26.4.447 · Cited by 76 · see citing works
Ellenbogen, M. A., Santo, J. B., Linnen, A., Walker, C., & Hodgins, S. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00770.x · Cited by 72 · see citing works
Pituitary volume in unaffected relatives of patients with schizophrenia and bipolar disorder
Mondelli, V., Dazzan, P., Gabilondo, A., Tournikioti, K., Walshe, M., Marshall, N., Schulze, K. K., Murray, R. M., McDonald, C., & Pariante, C. M. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.05.010 · Cited by 72 · see citing works
Dex/CRH test cortisol response in outpatients with major depression and matched healthy controls
Carpenter, L. L., Ross, N. S., Tyrka, A. R., Anderson, G. M., Kelly, M., & Price, L. H. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.03.009 · Cited by 70 · see citing works
Social Disadvantage: Cause or Consequence of Impending Psychosis?
Stilo, S. A., Forti, M. D., Mondelli, V., Falcone, A. M., Russo, M., O’Connor, J. A., Palmer-Cooper, E. C., Paparelli, A., Kolliakou, A., Sirianni, M., et al. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs112 · Cited by 69 · see citing works
Atkinson, H. C., Wood, S. A., Castrique, E. S., Kershaw, Y. M., Wiles, C. C. R., & Lightman, S. L. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00721.2007 · Cited by 68 · see citing works
Self-citationNordholm, D., Krogh, J., Mondelli, V., Dazzan, P., Pariante, C., & Nordentoft, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.030 · Cited by 67 · see citing works
THE IMPACT OF STRESSFUL LIFE EVENTS ON RELAPSE OF GENERALIZED ANXIETY DISORDER
Francis, J., Moitra, E., Dyck, I. R., & Keller, M. (2012) · Depression and Anxiety · doi:10.1002/da.20919 · Cited by 66 · see citing works
The Cortisol Awakening Response in Bipolar Illness: A Pilot Study
Deshauer, D., Duffy, A. C., Alda, M., Grof, E., Albuquerque, J., & Grof, P. (2003) · The Canadian Journal of Psychiatry · doi:10.1177/070674370304800706 · Cited by 65 · see citing works
Acculturation, childhood trauma and the cortisol awakening response in Mexican–American adults
Mangold, D. L., Wand, G. S., Javors, M. A., & Mintz, J. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.010 · Cited by 62 · see citing works
Lethbridge, R., & Allen, N. B. (2008) · Behaviour Research and Therapy · doi:10.1016/j.brat.2008.06.011 · Cited by 54 · see citing works
Duffy, A. C., Lewitzka, U., Doucette, S., Andreazza, A. C., & Grof, P. (2011) · Early Intervention in Psychiatry · doi:10.1111/j.1751-7893.2011.00323.x · Cited by 47 · see citing works
Lu, S., Gao, W., Wei, Z., Wu, W., Liao, M., Ding, Y., Zhang, Z., & Li, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069350 · Cited by 46 · see citing works
HPA-axis function, symptoms, and medication exposure in youths at clinical high risk for psychosis
Sugranyes, G., Thompson, J. L., & Corcoran, C. M. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.07.011 · Cited by 45 · see citing works
Subica, A. M. (2013) · Journal of Traumatic Stress · doi:10.1002/jts.21845 · Cited by 27 · see citing works
de Kloet, C. S., Vermetten, E. H. G. J. M., Rademaker, A. R., Geuze, E., & Westenberg, H. M. (2012) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v3i0.16206 · Cited by 21 · see citing works
The ACTH Response to Dexamethasone in Persian Gulf War Veterans
Golier, J. A., Legge, J., & Yehuda, R. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.040 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Baumeister, D., Akhtar, R., Ciufolini, S., Pariante, C. M., & Mondelli, V (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.67 · Cited by 1,084 · see citing works
Tafet, G. E., & Nemeroff, C. B. (2016) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.15030053 · Cited by 393 · see citing works
Traumatic Childhood Events and Autism Spectrum Disorder
Kerns, C. M., Newschaffer, C. J., & Berkowitz, S. J. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2392-y · Cited by 312 · see citing works
The future of rodent models in depression research
Gururajan, A., Reif, A., Cryan, J. F., & Slattery, D. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0221-6 · Cited by 269 · see citing works
Tractenberg, S. G., Levandowski, M. L., de Azeredo, L. A., Orso, R., Roithmann, L. G., Hoffmann, E. S., Brenhouse, H., & Grassi-Oliveira, R. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.021 · Cited by 267 · see citing works
Brain microglia in psychiatric disorders
Mondelli, V., Vernon, A. C., Turkheimer, F., Dazzan, P., & Pariante, C. M. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30101-3 · Cited by 262 · see citing works
Adverse childhood experiences and maternal anxiety and depression: a meta-analysis
Racine, N. M., Devereaux, C., Cooke, J. E., Eirich, R., Zhu, J., & Madigan, S. L. (2021) · BMC Psychiatry · doi:10.1186/s12888-020-03017-w · Cited by 197 · see citing works
Gene × Environment Interactions: From Molecular Mechanisms to Behavior
Halldorsdottir, T., & Binder, E. B. (2016) · Annual Review of Psychology · doi:10.1146/annurev-psych-010416-044053 · Cited by 211 · see citing works
Baumeister, D., Ciufolini, S., & Mondelli, V. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4044-5 · Cited by 183 · see citing works
Stress and depression: old questions, new approaches
Hammen, C. L. (2015) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2014.12.024 · Cited by 174 · see citing works
Legal highs: staying on top of the flood of novel psychoactive substances
Baumeister, D., Tojo, L. M., & Tracy, D. K. (2015) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125314559539 · Cited by 160 · see citing works
PTSD and autism spectrum disorder: Co-morbidity, gaps in research, and potential shared mechanisms.
Haruvi-Lamdan, N., Horesh, D., & Golan, O. (2017) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/tra0000298 · Cited by 151 · see citing works
Mayer, S. E., Lopez-Duran, N. L., Sen, S., & Abelson, J. L. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.03.020 · Cited by 135 · see citing works
Dinel, A., Joffre, C., Trifilieff, P., Aubert, A., Foury, A., Ruyet, P. L., & Layé, S. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0155-x · Cited by 134 · see citing works
Inflaming sex differences in mood disorders
Rainville, J. R., & Hodes, G. E. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0124-7 · Cited by 106 · see citing works
Hypothalamic-pituitary-adrenal axis functioning in borderline personality disorder: A meta-analysis
Drews, E., Fertuck, E. A., Koenig, J., Kaess, M., & Arntz, A. R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.008 · Cited by 93 · see citing works
Schweizer, S., Kievit, R., Emery, T., Cam-CAN, & Henson, R. N. (2017) · Psychological Medicine · doi:10.1017/s0033291717001519 · Cited by 83 · see citing works
Russell, G., Kalafatakis, K., & Lightman, S. (2015) · Journal of neuroendocrinology · doi:10.1111/jne.12247 · Cited by 64 · see citing works
Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease
Boero, G., Porcu, P., & Morrow, A. L. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100203 · Cited by 62 · see citing works
Associations between adverse childhood experiences and substance use: A meta-analysis
Zhu, J., Racine, N. M., Devereux, C., Hodgins, D. C., & Madigan, S. L. (2023) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2023.106431 · Cited by 63 · see citing works
Fibromyalgia and Chronic Fatigue: The Underlying Biology and Related Theoretical Issues
Romano, G. F., Tomassi, S., Russell, A., Mondelli, V., & Pariante, C. M. (2015) · Advances in psychosomatic medicine · doi:10.1159/000369085 · Cited by 59 · see citing works
Salokangas, R. K. R., Schultze‐Lutter, F., Patterson, P. H., von Reventlow, H. G., Heinimaa, M., From, T., Luutonen, S. H., Hankala, J., Kotimäki, M., & Tuominen, L. J. (2016) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v7.30062 · Cited by 57 · see citing works
García‐Rizo, C., & Bitanihirwe, B. K. Y. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109910 · Cited by 55 · see citing works
“Shanghuo” increases disease susceptibility: Modern significance of an old TCM theory
Pan, M., Zhu, S., Duan, W., Ma, X., Luo, X., Liu, B., Kurihara, H., Li, Y.-F., Chen, J., & He, R. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112491 · Cited by 54 · see citing works
A Rationale for Allopregnanolone Treatment of Alcohol Use Disorders: Basic and Clinical Studies
Morrow, A. L., Boero, G., & Porcu, P. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14253 · Cited by 51 · see citing works
Animal Models of Maternal Immune Activation in Depression Research
Ronovsky, M., Berger, S., Molz, B., Berger, A., & Pollak, D. D. (2015) · Current Neuropharmacology · doi:10.2174/1570159x14666151215095359 · Cited by 49 · see citing works
Murray, A. L., Kaiser, D. E., Valdebenito, S., Hughes, C. H., Băban, A., Fernando, A. D., Madrid, B. J., Ward, C. L., Osafo, J., Dunne, M. P., et al. (2018) · Trauma Violence & Abuse · doi:10.1177/1524838018813563 · Cited by 52 · see citing works
Jawad, M. Y., Meshkat, S., Tabassum, A., Mckenzie, A., Vincenzo, J. D. D., Guo, Z., Musavi, N. B., Phan, L., Ceban, F., Kwan, A. T. H., et al. (2022) · CNS Spectrums · doi:10.1017/s1092852922001043 · Cited by 48 · see citing works
Kuhlman, K. R., Chiang, J. J., Bower, J. E., Irwin, M. R., Seeman, T. E., McCreath, H. E., Almeida, D. M., Dahl, R. E., & Fuligni, A. J. (2019) · Development and Psychopathology · doi:10.1017/s0954579419000762 · Cited by 47 · see citing works
Interactions between FKBP5 variation and environmental stressors in adolescent Major Depression
Piechaczek, C., Greimel, E., Feldmann, L., Pehl, V., Allgaier, A., Frey, M., Freisleder, F. J., Halldorsdottir, T., Binder, E. B., Ising, M., et al. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.025 · Cited by 37 · see citing works
Pallier, P. N., Ferrara, M., Romagnolo, F., Ferretti, M. T., Soreq, H., & Cerase, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102353 · Cited by 35 · see citing works
Cramer, T., Kisliouk, T., Yeshurun, S., & Meiri, N. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22252 · Cited by 35 · see citing works
Balan, I. S., Boero, G., Chéry, S. L., McFarland, M. H., Lopez, A. G., & Morrow, A. L. (2024) · Life · doi:10.3390/life14050582 · Cited by 33 · see citing works
Behavioral Neurobiology of Stress-related Disorders
Bluhm, M. D. L., & Pariante, C. M. (2014) · Current topics in behavioral neurosciences · doi:10.1007/978-3-662-45126-7 · Cited by 34 · see citing works
Thomas, S. J., & Larkin, T. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00971 · Cited by 33 · see citing works
Li, C., Fu, P., Wang, M., Xia, Y., Hu, C., Liu, M., Zhang, H., Sheng, X., & Yang, Y. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04719-7 · Cited by 37 · see citing works
Johnson, S. B., Lingg, R. T., Skog, T. D., Hinz, D. C., Romig‐Martin, S. A., Viau, V., Narayanan, N. S., & Radley, J. J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210783119 · Cited by 32 · see citing works
A dual-pathway architecture for stress to disrupt agency and promote habit
Giovanniello, J. R., Paredes, N., Wiener, A., Ramírez-Armenta, K., Oragwam, C., Uwadia, H. O., Yu, A. L., Lim, K., Pimenta, J. S., Vilchez, G. E., et al. (2025) · Nature · doi:10.1038/s41586-024-08580-w · Cited by 30 · see citing works
Mayer, S. E., Peckins, M., Kuhlman, K. R., Rajaram, N., Lopez-Duran, N. L., Young, E. A., & Abelson, J. L. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104776 · Cited by 29 · see citing works
Mason, B. L. (2017) · Psychosomatics · doi:10.1016/j.psym.2017.06.002 · Cited by 28 · see citing works
Godara, M., Silveira, S., Matthaeus, H., & Singer, T. (2022) · Adversity and Resilience Science · doi:10.1007/s42844-022-00069-7 · Cited by 27 · see citing works
Taylor, K. S., Steptoe, A., & Iob, E. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01805-2 · Cited by 27 · see citing works
Rim, S. J., Kwak, K., & Park, S. (2023) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2023.102134 · Cited by 27 · see citing works
Prolactin variations during risperidone therapy in a sample of drug-naive children and adolescents
Margari, L., Matera, E., Petruzzelli, M. G., Simone, M., Lamanna, A. L., Pastore, A., Palmieri, V. O., & Margari, F. (2014) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000063 · Cited by 24 · see citing works
Brzozowska, A., & Grabowski, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115216 · Cited by 30 · see citing works
How hormonal contraceptives shape brain and behavior: A review of preclinical studies.
Concas, A., Serra, M., & Porcu, P. (2022) · Frontiers in neuroendocrinology (Print) · doi:10.1016/j.yfrne.2022.101017 · Cited by 21 · see citing works
He, Y., Lang, X.-Q., Lin, L., Ji, L., Yuan, X. ‐., Chen, Q., Ran, Y. ‐., Chen, H. ‐., Li, L., Wang, J. ‐., et al. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12976 · Cited by 21 · see citing works
Hoisington, A. J., Stearns‐Yoder, K. A., Kovacs, E. J., Postolache, T. T., & Brenner, L. A. (2024) · Current Environmental Health Reports · doi:10.1007/s40572-024-00437-8 · Cited by 20 · see citing works
The Allopregnanolone Response to Acute Stress in Females: Preclinical and Clinical Studies
Pisu, M., Concas, L., Siddi, C., Serra, M., & Porcu, P. (2022) · Biomolecules · doi:10.3390/biom12091262 · Cited by 22 · see citing works
Kumar, A., Kumar, P., Pareek, V., Faiq, M. A., Narayan, R., Raza, K., Prasoon, P., & Sharma, V. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2019.101688 · Cited by 16 · see citing works
Crick, D. C. P., Halligan, S. L., Howe, L. D., Lacey, R. E., Khandaker, G. M., Burgner, D. P., Herbert, A., Suderman, M. J., Anderson, E. L., & Fraser, A. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.11.001 · Cited by 15 · see citing works
Stress, mental disorder and ketamine as a novel, rapid acting treatment
Dutton, M., Can, A., Lagopoulos, J., & Hermens, D. F. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.09.006 · Cited by 15 · see citing works
Santos, M. T., & Shi, D. (2021) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2021.104501 · Cited by 15 · see citing works
Depressão materna e concentração de cortisol de recém-nascidos em uma amostra brasileira
Lucci, T. K., Otta, E., David, V. F., & Chelini, M. O. M. (2016) · Psico · doi:10.15448/1980-8623.2016.2.23655 · Cited by 14 · see citing works
Chalker, S. A., Parrish, E. M., Cano, M., Kelsven, S., Moore, R. C., Granholm, E. L., Pinkham, A. E., Harvey, P. D., & Depp, C. A. (2021) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000001462 · Cited by 13 · see citing works
Social desirability, stress and health in police officers: preliminary results
Habersaat, S., Abdellaoui, S., & Wolf, J. M. (2020) · Policing An International Journal · doi:10.1108/pijpsm-08-2020-0133 · Cited by 12 · see citing works
Childhood maltreatment and within-person associations between cortisol and affective experience
Kuhlman, K. R., Abelson, J. L., Mayer, S. E., Rajaram, N., Briggs, H., & Young, E. A. (2021) · Stress · doi:10.1080/10253890.2021.1928069 · Cited by 12 · see citing works
Tafet, G. E., & Alonso, T. O. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1600165 · Cited by 16 · see citing works
Decoding the impact of adverse childhood experiences on the progression of schizophrenia
Hirt, V., Schalinski, I., & Rockstroh, B. S. (2019) · Mental Health & Prevention · doi:10.1016/j.mhp.2019.01.002 · Cited by 11 · see citing works
Roby, Y. (2017) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000174 · Cited by 11 · see citing works
A review of the effects of parental PTSD: A focus on military children.
Banneyer, K. N., Koenig, S. A., Wang, L. A., & Stark, K. D. (2017) · Couple and Family Psychology Research and Practice · doi:10.1037/cfp0000093 · Cited by 10 · see citing works
Spitzer, C., Otte, C., Kuehl, L. K., May, A. E., Schultebraucks, K., Hellmann‐Regen, J., & Wingenfeld, K. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.10.016 · Cited by 10 · see citing works
Hogue, C. M., Fry, M. D., Fry, A. C., Wineinger, T. O., Chamberlin, J. M., Čabarkapa, D., & Eserhaut, D. A. (2025) · Psychology of sport and exercise · doi:10.1016/j.psychsport.2025.102849 · Cited by 9 · see citing works
Duplessis-Marcotte, F., Lapointe, R., LUPIEN, S. J., & Marin, M. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106051 · Cited by 9 · see citing works
Wu, Y., Li, S., Hu, K., & Yang, J. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.06.023 · Cited by 9 · see citing works
The researcher's guide to selecting biomarkers in mental health studies
Verhoeven, J. E., Wolkowitz, O. M., Satz, I. B., Conklin, Q. A., Lamers, F., Lavebratt, C., Lin, J., Lindqvist, D., Mayer, S. E., Melas, P. A., et al. (2024) · BioEssays · doi:10.1002/bies.202300246 · Cited by 9 · see citing works
Impact of Stress on Prefrontal Glutamatergic, Monoaminergic and Cannabinoid Systems
Bluhm, M. D. L. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_331 · Cited by 8 · see citing works
Zhang, X. G., Zhang, H., Liang, X. L., Liu, Q., Wang, H. Y., Cao, B., Cao, J., Liu, S., Long, Y. J., Xie, W., et al. (2016) · Genetics and Molecular Research · doi:10.4238/gmr.15039009 · Cited by 7 · see citing works
A dual-pathway architecture enables chronic stress to disrupt agency and promote habit formationPreprint
Giovanniello, J. R., Paredes, N., Wiener, A. J., Ramírez-Armenta, K., Oragwam, C., Uwadia, H. O., Yu, A. L., Lim, K. Y., Pimenta, J. S., Vilchez, G. E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.03.560731 · Cited by 7 · see citing works
He, Y., Houtenbos, S. P., & Wippert, P. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-07054-1 · Cited by 7 · see citing works
Risperidone and Cardiometabolic Risk in Children and Adolescents
Matera, E., Margari, L., Palmieri, V. O., Zagaria, G., Palumbi, R., & Margari, F. (2017) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000688 · Cited by 6 · see citing works
Association Between Autism and PTSD Among Adult Psychiatric Outpatients
Agebjörn, J., Gillberg, C., Eberhard, J., Billstedt, E., & Nyrenius, J. (2024) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-024-06439-7 · Cited by 7 · see citing works
Adverse Childhood Experiences and Socioemotional Outcomes of Children Born Very Preterm
Bishop, C. L., Lean, R. E., Smyser, T. A., Smyser, C. D., & Rogers, C. E. (2024) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2024.114377 · Cited by 5 · see citing works
Sim, K. (2019) · Korean Journal of Stress Research · doi:10.17547/kjsr.2019.27.3.259 · Cited by 5 · see citing works
Nowak, U., Wittkamp, M. F., Clamor, A., & Lincoln, T. M. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.626698 · Cited by 6 · see citing works
Binman, L., Ben‐Zeev, T., Harris, A., Levi, C., Weissman, I., Church, D. D., Ferrando, A. A., & Hoffman, J. R. (2025) · Nutrients · doi:10.3390/nu17182957 · Cited by 4 · see citing works
Kumar, A., Kumar, P., Faiq, M. A., Pareek, V., Raza, K., Mochan, S., Prasoon, P., & Sharma, V. (2017) · Preprints.org · doi:10.20944/preprints201710.0047.v2 · Cited by 3 · see citing works
Laufer, S., Bohn, J., Engel, S., Klusmann, H., Skoluda, N., Nater, U. M., Knaevelsrud, C., & Schumacher, S. (2025) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2025.100314 · Cited by 3 · see citing works
Neurobiological Approach to Stress
Tafet, G. E. (2022) · Springer eBooks · doi:10.1007/978-3-031-00864-1_2 · Cited by 3 · see citing works
Yuan, J., Zhong, Y., Li, Y., Liao, Y., & Tang, H. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1519492 · Cited by 3 · see citing works
Murata, S., Murphy, M. L. M., Khanna, R., Hoppensteadt, D., Fareed, J., & Halaris, A. E. (2021) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2021.100117 · Cited by 3 · see citing works
Mayer, S. E. (2017) · Deep Blue (University of Michigan) · Cited by 4 · see citing works
Kumar, A., Kumar, P., Pareek, V., Faiq, M. A., Raza, K., Prasoon, P., Mochan, S., & Sharma, V. (2017) · Preprints.org · doi:10.20944/preprints201710.0047.v1 · Cited by 3 · see citing works
Colangelo, J., Smith, A. J., Keay, N., Buadze, A., & Liebrenz, M. (2024) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2024.1480574 · Cited by 2 · see citing works
Racialized Police Use of Force and Maternal Health
Muchomba, F. M., Teitler, J. O., Fox, C., & Reichman, N. E. (2024) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2024.11.017 · Cited by 2 · see citing works
Zivlak-Radulović, N., Banjac, V., & Miskovic, M. (2018) · Psychiatria Danubina · doi:10.24869/psyd.2018.99 · Cited by 2 · see citing works
Galtrey, C. M., & Cock, H. R. (2015) · Neuropsychiatric symptoms of neurological disease · doi:10.1007/978-3-319-22159-5_15 · Cited by 1 · see citing works
Tafet, G. E. (2022) · Springer eBooks · doi:10.1007/978-3-031-00864-1_4 · Cited by 1 · see citing works
Characterization, treatment, and prevention of stress-induced psychopathology
Brachman, R. A. (2014) · doi:10.7916/d84b2zwq
Glucocorticoids and Programming of the Fetal Brain
Reynolds, R. M., & Seckl, J. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00074-2
MoodSwings: an online self-guided intervention for bipolar disorder
Lauder, S. D. (2016) · Minerva Access (University of Melbourne)
De effecten van PTSS op de kinderen van militairen: een review
Banneyer, K. N., Koenig, S. A., Wang, L. A., & Stark, K. D. (2019) · Gezinstherapie Wereldwijd · doi:10.1007/s12440-019-00097-3
Neurobiología de la depresión.
Piedimonte, L., Helguero, D. F., Mato, A. L., & Tafet, G. (2019) · NeuroTarget · doi:10.47924/neurotarget201950
Neurobiologischer Ansatz zum Stress
Tafet, G. E. (2024) · Springer eBooks · doi:10.1007/978-3-031-58285-1_2
Tafet, G. E. (2024) · Springer eBooks · doi:10.1007/978-3-031-58285-1_4
Belonio, K. C., Fyke, Z., Haile, E. S., Nadeem, T., & Zak, J. D. (2026) · eNeuro · doi:10.1523/eneuro.0330-25.2026
Racine, N., Devereaux, C., Cooke, J. E., Eirich, R., Zhu, J., & Madigan, S. L. (2021) · Figshare · doi:10.6084/m9.figshare.13558716
Li, C., Fu, P., Wang, M., Xia, Y., Hu, C., Liu, M., Zhang, H., Sheng, X., & Yang, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26581649
- Authors
- Baumeister, D., Lightman, S. L., & Pariante, C. M.
- Affiliations
- King's College London (GB)
- University of Bristol (GB)
- Corresponding author
- Pariante, Carmine M.
- Venue
- Current topics in behavioral neurosciences
- Publisher
- Springer Berlin Heidelberg
- Published
- 2014
- Volume
- 18
- Pages
- 13-24
- ISSN
- 1866-3370 (ISSN-L)
- 1866-3389
- OpenAlex
- W142506613
- Cited by
- 104
- References
- 69
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 10 · 2023: 5 · 2022: 10 · 2021: 9 · 2020: 5 · 2019: 11 · 2018: 6 · 2017: 11 · 2016: 8 · 2015: 9 · 2014: 8
- FWCI
- 15.13
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- Locations
- Current topics in behavioral neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Explore Bristol Research (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Funders
- Medical Research Council (MR/J002739/1)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- hypothalamic-pituitary-adrenal axis, stress, depression, psychosis, post-traumatic stress disorder, environmental stressors, developmental adversity, symptom remission
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review