The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways
Open accessAbstract
The neuropsychological effects of naturally occurring psychoactive chemicals have been recognized for millennia. Hallucinogens, which include naturally occurring chemicals such as mescaline and psilocybin, as well as synthetic compounds, such as lysergic acid diethylamide (LSD), induce profound alterations of human consciousness, emotion, and cognition. The discovery of the hallucinogenic effects of LSD and the observations that LSD and the endogenous ligand serotonin share chemical and pharmacological profiles led to the suggestion that biogenic amines like serotonin were involved in the psychosis of mental disorders such as schizophrenia. Although they bind other G protein-coupled receptor (GPCR) subtypes, studies indicate that several effects of hallucinogens involve agonist activity at the serotonin 5-HT2A receptor. In this chapter, we review recent advances in understanding hallucinogen drug action through characterization of structure, neuroanatomical location, and function of the 5-HT2A receptor.
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Cited by
Towards an understanding of psychedelic-induced neuroplasticity
Calder, A. E., & Hasler, G. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01389-z · Cited by 313
Jefsen, O. H., Elfving, B., Wegener, G., & Müller, H. K. (2021) · Journal of Psychopharmacology · doi:10.1177/0269881120959614 · Cited by 127
Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression
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Dark Classics in Chemical Neuroscience: Mescaline
Cassels, B. K., & Sáez-Briones, P. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00215 · Cited by 85
Metadata
- Authors
- López-Giménez, J. F., & González-Maeso, J.
- Venue
- Current Topics in Behavioral Neurosciences
- Publisher
- Springer Berlin Heidelberg
- Published
- 2017
- Volume
- 36
- Pages
- 45-73
- ISSN
- 1866-3370 (ISSN-L)
- 1866-3389
- OpenAlex
- W2725596576
- Cited by
- 299
- References
- 151
- FWCI
- 43.54
- Type
- book chapter
- Language
- en
- Open access
- green
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