Store-Operated Calcium Entry Channels in Pulmonary Endothelium: The Emerging Story of TRPCS and Orai1

Cioffi, Donna L.; Barry, Christina; Stevens, Troy

doi:10.1007/978-1-60761-500-2_9

Cited by 41Ion Channels and ReceptorsCalcium signaling and nucleotide metabolismIon channel regulation and function

Store-Operated Calcium Entry Channels in Pulmonary Endothelium: The Emerging Story of TRPCS and Orai1

Cioffi, Donna L., Barry, Christina, Stevens, Troy·2010·Advances in Experimental Medicine and Biology

DOI 10.1007/978-1-60761-500-2_9

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Abstract

Cells of diverse origin utilize shifts in cytosolic calcium concentrations as intracellular signals to elicit physiological responses. In endothelium, inflammatory first messengers increase cytosolic calcium as a signal to disrupt cell-cell borders and produce inter-cellular gaps. Calcium influx across the plasma membrane is required to initiate barrier disruption, although the calcium entry mechanism responsible for this effect remains poorly understood. This chapter highlights recent efforts to define the molecular anatomy of the ion channel responsible for triggering endothelial cell gap formation. Resolving the identity and function of this calcium channel will pave the way for new anti-inflammatory therapeutic targets.

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TRP channels are non-voltage-gated Ca2+ channels involved in Ca2+ entry.
“TRP channels are non-voltage-gated Ca2+ channels involved in Ca2+ entry [42].”
From G-protein-coupled receptor participates in 20-hydroxyecdysone signaling on the plasma membrane (2014) · cites this paper as [42]

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Authors: Cioffi, D. L., Barry, C., & Stevens, T.
Affiliations: University of South Alabama (US)
Corresponding author: Stevens, Troy
ORCID: Cioffi, Donna L.
Stevens, Troy
Venue: Advances in Experimental Medicine and Biology
Publisher: Humana Press
Published: 2009-12-26
Volume: 661
Pages: 137-154
ISSN: 0065-2598 (ISSN-L)
DOI: 10.1007/978-1-60761-500-2_9
OpenAlex: W78485540
Cited by: 41
References: 92
Citations by year: 2025: 1 · 2024: 1 · 2023: 1 · 2021: 2 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 1 · 2012: 8
FWCI: 10.25
Type: book chapter
Language: en
Open access: closed
Locations: Advances in experimental medicine and biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords: store-operated calcium entry, TRPC channels, Orai1, pulmonary endothelium, endothelial barrier disruption, cytosolic calcium signaling, inflammatory signaling
MeSH terms: Amino Acid Sequence, Animals, Calcium, Cell Membrane Permeability, Endothelium, Vascular, Enzyme Inhibitors, Lung, Models, Molecular, Molecular Sequence Data, Calcium Channels, Signal Transduction, Protein Structure, Secondary, Thapsigargin, TRPC Cation Channels

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Store-Operated Calcium Entry Channels in Pulmonary Endothelium: The Emerging Story of TRPCS and Orai1

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