Cited by 167Neuropeptides and Animal PhysiologyNeuroendocrine regulation and behaviorChemical Synthesis and Analysis

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

What Are Neuropeptides?

Burbach, J. Peter H.·2011·Methods in molecular biology

Open this paper in CoChat — free account

Abstract

We know neuropeptides now for over 40 years as chemical signals in the brain. The discovery of neuropeptides is founded on groundbreaking research in physiology, endocrinology, and biochemistry during the last century and has been built on three seminal notions: (1) peptide hormones are chemical signals in the endocrine system; (2) neurosecretion of peptides is a general principle in the nervous system; and (3) the nervous system is responsive to peptide signals. These historical lines have contributed to how neuropeptides can be defined today: "Neuropeptides are small proteinaceous substances produced and released by neurons through the regulated secretory route and acting on neural substrates." Thus, neuropeptides are the most diverse class of signaling molecules in the brain engaged in many physiological functions. According to this definition almost 70 genes can be distinguished in the mammalian genome, encoding neuropeptide precursors and a multitude of bioactive neuropeptides. In addition, among cytokines, peptide hormones, and growth factors there are several subfamilies of peptides displaying most of the hallmarks of neuropeptides, for example neural chemokines, cerebellins, neurexophilins, and granins. All classical neuropeptides as well as putative neuropeptides from the latter families are presented as a resource.

Integrity signals

Registry

Crossref · 10.1007/978-1-61779-310-3_1

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Neurotrophins: Roles in Neuronal Development and Function
Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
Amara, S. G., Jonas, V., Rosenfeld, M. G., Ong, E. S., & Evans, R. M. (1982) · Nature · doi:10.1038/298240a0 · Cited by 2,105
An unidentified depressor substance in certain tissue extracts
von Euler, U. S., & Gaddum, J. H. (1931) · The Journal of Physiology · doi:10.1113/jphysiol.1931.sp002763 · Cited by 1,584
Peptidergic neurones
Hökfelt, T. G. M., Johansson, O., Ljungdahl, Å., Lundberg, J. M., & Schultzberg, M. (1980) · Nature · doi:10.1038/284515a0 · Cited by 1,548
The mechanism of pancreatic secretion
Bayliss, W. M., & Starling, E. H. (1902) · The Journal of Physiology · doi:10.1113/jphysiol.1902.sp000920 · Cited by 1,274
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTRand Sortilin
Teng, H. K., Teng, K. K., Lee, R., Wright, S., Tevar, S., Almeida, R. D., Kermani, P., Torkin, R., Chen, Z.-Y., Lee, F. S., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5123-04.2005 · Cited by 1,013
Synthesis, transport, and release of posterior pituitary hormones
Brownstein, M. J., Russell, J. T., & Gainer, H. (1980) · Science · doi:10.1126/science.6153132 · Cited by 838
Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides
Tatemoto, K., & Mutt, V. (1980) · Nature · doi:10.1038/285417a0 · Cited by 663
Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing
Nawa, H., Kotani, H., & Nakanishi, S. (1984) · Nature · doi:10.1038/312729a0 · Cited by 572

Show all 42 references

Research works printed but not linked: 6

Von den Velden, R. (1913) Die Nierenwirkung von Hypophysenextrakten beim Menschen. Klin. Wochschr. (Berlin) 50, 2083–2086.
Starling, E.H. (1904) The chemical regulation of the secretory process (Croonian Lecture to the Royal Society). Proc. Royal Soc. 73B, 310–322.
Starling, E.H. (1905) Croonian Lecture: On the chemical correlation of the functions of the body II. Lancet 2, 423–425.
Starling, E.H. (1905) Croonian Lecture: On the chemical correlation of the functions of the body III. Lancet 2, 501–503.
Starling, E.H. (1905) Croonian Lecture: On the chemical correlation of the functions of the body IV. Lancet 2, 579–583.
Speidel, C.C. (1919) Gland-cells of internal secretion in the spinal cord of the skaes. Carengie Institute Washington Publications 13, 1–31

Sorted by citations

Evolution of neuropeptide signalling systems
Elphick, M. R., Mirabeau, O., & Larhammar, D. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.151092 · Cited by 264
Overview of Neuropeptides: Awakening the Senses?
Russo, A. F. (2017) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13084 · Cited by 229
Coreleased Orexin and Glutamate Evoke Nonredundant Spike Outputs and Computations in Histamine Neurons
Schöne, C., Apergis‐Schoute, J., Sakurai, T., Adamantidis, A., & Burdakov, D. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.055 · Cited by 195
Peptide-based drug discovery through artificial intelligence: towards an autonomous design of therapeutic peptides
Goles, M., Sanchez–Daza, A., Cabas-Mora, G., Varón, L. S., Sepúlveda-Yáñez, J., Anvari-Kazemabad, H., Davari, M. D., Uribe-Paredes, R., Olivera‐Nappa, Á., Navarrete, M. A., et al. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae275 · Cited by 188
Single-cell transcriptomic evidence for dense intracortical neuropeptide networks
Smith, S. J., Sümbül, U., Graybuck, L. T., Collman, F., Seshamani, S., Gala, R., Gliko, O., Elabbady, L., Miller, J. A., Bakken, T. E., et al. (2019) · eLife · doi:10.7554/elife.47889 · Cited by 156
Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour
Mills, E., Izzi‐Engbeaya, C. N., Abbara, A., Comninos, A. N., & Dhillo, W. S. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00438-1 · Cited by 122
C. elegans Stress-Induced Sleep Emerges from the Collective Action of Multiple Neuropeptides
Nath, R. D., Chow, E. S. H., Wang, H., Schwarz, E. M., & Sternberg, P. W. (2016) · Current Biology · doi:10.1016/j.cub.2016.07.048 · Cited by 109
No pain, no gain? The effects of pain-promoting neuropeptides and neurotrophins on fracture healing
Sun, S., Diggins, N. H., Gunderson, Z. J., Fehrenbacher, J. C., White, F. A., & Kacena, M. A. (2019) · Bone · doi:10.1016/j.bone.2019.115109 · Cited by 106
Biological Markers in Anxiety Disorders
Łoś, K., & Waszkiewicz, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081744 · Cited by 105
Neuropeptides encoded by the genomes of the Akoya pearl oyster Pinctata fucata and Pacific oyster Crassostrea gigas: a bioinformatic and peptidomic survey
Stewart, M. J., Favrel, P., Rotgans, B. A., Wang, T., Zhao, M., Sohail, M., O’Connor, W. A., Elizur, A., Henry, J., & Cummins, S. F. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-840 · Cited by 96
The Neuroimmune Axis in Skin Sensation, Inflammation, and Immunity
Trier, A. M., Mack, M. R., & Kim, B. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801473 · Cited by 98
Cellular Mechanisms for the Biogenesis and Transport of Synaptic and Dense-Core Vesicles
Gondré‐Lewis, M. C., Park, J. J., & Loh, Y. P. (2012) · International review of cytology · doi:10.1016/b978-0-12-394310-1.00002-3 · Cited by 96
Neuropeptidergic control of sleep and wakefulness
Richter, C., Woods, I. G., & Schier, A. F. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150447 · Cited by 75
The Role of Hypothalamic Neuropeptides in Neurogenesis and Neuritogenesis
Bakoš, J., Zatkova, M., Bačová, Z., & Ostatníková, D. (2016) · Neural Plasticity · doi:10.1155/2016/3276383 · Cited by 63
Neuropeptides in asthma, chronic obstructive pulmonary disease and cystic fibrosis
Atanasova, K. R., & Reznikov, L. R. (2018) · Respiratory Research · doi:10.1186/s12931-018-0846-4 · Cited by 61
Neuropeptides: Potential neuroprotective agents in ischemic injury
Saklani, P., Khan, H., Gupta, S., Kaur, A., & Singh, T. G. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120186 · Cited by 57
Organ-On-A-Chip Technology: An In-depth Review of Recent Advancements and Future of Whole Body-on-chip
Driver, R., & Mishra, S. (2022) · BioChip Journal · doi:10.1007/s13206-022-00087-8 · Cited by 61
Roles of Neuropeptides in Sleep–Wake Regulation
Shen, Y.-C., Sun, X., Li, L., Zhang, H.-Y.-L., Huang, Z., & Wang, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094599 · Cited by 56
Quantitative Neuropeptidome Analysis Reveals Neuropeptides Are Correlated with Social Behavior Regulation of the Honeybee Workers
Han, B., Fang, Y., Mao, F., Hu, H., Qi, Y., Huo, X., Meng, L., Wu, B., & Li, J. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00632 · Cited by 55
Neuropeptides: Roles and Activities as Metal Chelators in Neurodegenerative Diseases
Ben-Shushan, S., & Miller, Y. (2021) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.0c11151 · Cited by 53
Reproductive neuropeptides that stimulate spawning in the Sydney Rock Oyster (Saccostrea glomerata)
In, V. V., Ntalamagka, N., O’Connor, W. A., Wang, T., Powell, D., Cummins, S. F., & Elizur, A. (2016) · Peptides · doi:10.1016/j.peptides.2016.06.007 · Cited by 50
The evolution of neuropeptide signalling: insights from echinoderms
Semmens, D. C., & Elphick, M. R. (2017) · Briefings in Functional Genomics · doi:10.1093/bfgp/elx005 · Cited by 49
Substance P: A neuropeptide involved in the psychopathology of anxiety disorders
Iftikhar, K., Siddiq, A., Baig, S. G., & Zehra, S. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.101993 · Cited by 48
Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders
Casello, S. M., Flores, R. J., Yarur, H. E., Wang, H., Awanyai, M., Arenivar, M. A., Jaime-Lara, R. B., Bravo-Rivera, H., & Tejeda, H. A. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.796443 · Cited by 49
The Neuropeptide System and Colorectal Cancer Liver Metastases: Mechanisms and Management
Kasprzak, A., & Adamek, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103494 · Cited by 47
Peripheral Biomarkers in DSM-5 Anxiety Disorders: An Updated Overview
Vismara, M. E. M., Girone, N., Cirnigliaro, G., Fasciana, F., Vanzetto, S., Ferrara, L., Priori, A., D’Addario, C., Viganò, C. A., & Dell’Osso, B. M. (2020) · Brain Sciences · doi:10.3390/brainsci10080564 · Cited by 48
Neuropeptides as Primary Mediators of Brain Circuit Connectivity
Guillaumin, M. C. C., & Burdakov, D. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.644313 · Cited by 46
NeuroPred-PLM: an interpretable and robust model for neuropeptide prediction by protein language model
Wang, L., Huang, C., Wang, M., Xue, Z., & Wang, Y. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad077 · Cited by 41
Gonadotropin-releasing hormone and adipokinetic hormone/corazonin-related peptide in the female prawn
Suwansa‐ard, S., Zhao, M., Thongbuakaew, T., Chansela, P., Ventura, T., Cummins, S. F., & Sobhon, P. (2016) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2016.07.008 · Cited by 42
Neuropeptide signalling systems – An underexplored target for venom drug discovery
Mendel, H. C., Kaas, Q., & Muttenthaler, M. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114129 · Cited by 44
Microfluidic Device for the Selective Chemical Stimulation of Neurons and Characterization of Peptide Release with Mass Spectrometry
Croushore, C. A., Supharoek, S.-A., Lee, C. Y., Jakmunee, J., & Sweedler, J. V. (2012) · Analytical Chemistry · doi:10.1021/ac302283u · Cited by 39
Crosstalk Between Epithelial Cells, Neurons and Immune Mediators in HSV-1 Skin Infection
Duarte, L. F., Reyes, A., Farías, M. A., Riedel, C. A., Bueno, S. M., Kalergis, A. M., & González, P. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.662234 · Cited by 39
Neuropeptides in Obesity and Metabolic Disease
van der Klaauw, A. A. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2017.281568 · Cited by 42
Cell-type–specific neuromodulation guides synaptic credit assignment in a spiking neural network
Liu, Y. H., Smith, S. J., Mihalaş, Ş., Shea‐Brown, E., & Sümbül, U. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111821118 · Cited by 44
What a pain in the back: etiology, diagnosis and future treatment directions for discogenic low back pain
Kaneda, G., Zila, L., Wechsler, J. T., Shafi, K. A., Cheema, K., Bae, H. W., Kim, S. D., Tuchman, A., Li, D., & Sheyn, D. (2025) · Bone Research · doi:10.1038/s41413-025-00472-7 · Cited by 39
Neuropeptides in Rhipicephalus microplus and other hard ticks
Waldman, J., Xavier, M. A., Vieira, L. R., Logullo, R., Braz, G. R. C., Tirloni, L., Ribeiro, J. M. C., Veenstra, J. A., & Vaz, I. D. S. (2022) · Ticks and Tick-borne Diseases · doi:10.1016/j.ttbdis.2022.101910 · Cited by 33
Nicotinic Cholinergic System in the Hypothalamus Modulates the Activity of the Hypothalamic Neuropeptides During the Stress Response
Balkan, B., & Pöğün, Ş. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170720092442 · Cited by 32
Lessons from lonely flies: Molecular and neuronal mechanisms underlying social isolation
Yadav, R. S. P., Ansari, F., Bera, N., Kent, C. F., & Agrawal, P. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105504 · Cited by 38
NeuroPep 2.0: An Updated Database Dedicated to Neuropeptide and Its Receptor Annotations
Wang, M., Wang, L., Xu, W., Chu, Z., Wang, H., Lu, J., Xue, Z., & Wang, Y. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.168416 · Cited by 33
Neuropeptides in Cancer: Friend and Foe?
Wu, Y., Berisha, A., & Borniger, J. C. (2022) · Advanced Biology · doi:10.1002/adbi.202200111 · Cited by 30
Tear film and ocular surface neuropeptides: Characteristics, synthesis, signaling and implications for ocular surface and systemic diseases
Asiedu, K., Markoulli, M. P., Bonini, S., Bron, A. J., Doğru, M., Kwai, N. C. G., Poynten, A. M., Willcox, M. D. P., & Krishnan, A. V. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.108973 · Cited by 29
Identification and quantification of neuropeptides in naïve mouse spinal cord using mass spectrometry reveals [des‐Ser1]‐cerebellin as a novel modulator of nociception
Su, J., Sándor, K., Sköld, K., Hökfelt, T. G. M., Svensson, C. I., & Kultima, K. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12730 · Cited by 29
New light on cortical neuropeptides and synaptic network plasticity
Smith, S. J., Hawrylycz, M., Rossier, J., & Sümbül, U. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.04.002 · Cited by 26
Mass spectrometric analysis of spatio-temporal dynamics of crustacean neuropeptides
OuYang, C., Liang, Z., & Li, L. (2014) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2014.10.023 · Cited by 26
Platform for micro-invasive membrane-free biochemical sampling of brain interstitial fluid
Raman, R., Rousseau, E. B., Wade, M., Tong, A., Cotler, M. J., Kuang, J., Aponte, A., Zhang, E., Graybiel, A. M., White, F. M., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb0657 · Cited by 26
Optogenetic activation of short neuropeptide F (sNPF) neurons induces sleep in Drosophila melanogaster
Juneau, Z., Stonemetz, J. M., Toma, R., Possidente, D. R., Heins, R. C., & Vecsey, C. G. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.03.027 · Cited by 25
Neuropeptidomics: Improvements in Mass Spectrometry Imaging Analysis and Recent Advancements
Vu, N. Q., DeLaney, K., & Li, L. (2020) · Current Protein and Peptide Science · doi:10.2174/1389203721666201116115708 · Cited by 24
Cerebrospinal Fluid and Brain Proteoforms of the Granin Neuropeptide Family in Alzheimer’s Disease
Quinn, J. P., Ethier, E. C., Novielli, A., Malone, A., Ramirez, C. E., Salloum, L., Trombetta, B. A., Kivisäkk, P., Bremang, M., Selzer, S., et al. (2023) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.2c00341 · Cited by 24
Characterization of NGFFYamide Signaling in Starfish Reveals Roles in Regulation of Feeding Behavior and Locomotory Systems
Tinoco, A. B., Semmens, D. C., Patching, E. C., Gunner, E. F., Egertová, M., & Elphick, M. R. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00507 · Cited by 24
Neuropeptide receptors as potential pharmacological targets for obesity
Meneguetti, B. T., Cardoso, M. H. E. S., Ribeiro, C. F. A., Felício, M. R., Pinto, I. B., Santos, N. C., Carvalho, C. M. E., & Franco, O. L. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.11.002 · Cited by 23
Brain Tissue Sample Stabilization and Extraction Strategies for Neuropeptidomics
Fridjonsdottir, E., Nilsson, A., Wadensten, H., & Andrén, P. E. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7537-2_2 · Cited by 21
From Synapse to Function: A Perspective on the Role of Neuroproteomics in Elucidating Mechanisms of Drug Addiction
Natividad, L. A., Buczynski, M. W., McClatchy, D. B., & Yates, J. R. (2018) · Proteomes · doi:10.3390/proteomes6040050 · Cited by 21
The Roles of Chemical Cues in the Life Cycle of Bivalves: Spawning, Settlement, and Metamorphosis
Rato, A., Joaquim, S., Matias, D. D. C. C., & Hubbard, P. C. (2025) · Reviews in Aquaculture · doi:10.1111/raq.13007 · Cited by 21
Sleep Disturbance and Alzheimer’s Disease: The Glial Connection
Sunkaria, A., & Bhardwaj, S. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03578-0 · Cited by 19
Protective Role and Functional Engineering of Neuropeptides in Depression and Anxiety: An Overview
Okdeh, N., Mahfouz, G., Harb, J., Sabatier, J., Roufayel, R., Gazo-Hanna, E., Kovacic, H., & Fajloun, Z. (2023) · Bioengineering · doi:10.3390/bioengineering10020258 · Cited by 19
Tachykinin signaling inhibits task-specific behavioral responsiveness in honeybee workers
Han, B., Wei, Q., Wu, F., Hu, H., Ma, C., Meng, L., Zhang, X., Feng, M., Fang, Y., Rueppell, O., et al. (2021) · eLife · doi:10.7554/elife.64830 · Cited by 20
Regulation of appetite-related neuropeptides by Panax ginseng: A novel approach for obesity treatment
Phung, H. M., Jang, D., Trinh, T. A., Lee, D., Nguyen, Q. N., Kim, C.-E., & Kang, K. S. (2022) · Journal of Ginseng Research · doi:10.1016/j.jgr.2022.03.007 · Cited by 18
Dynamic Measurement of Extracellular Opioid Activity: Status Quo, Challenges, and Significance in Rewarded Behaviors
Murphy, N. P. (2015) · ACS Chemical Neuroscience · doi:10.1021/cn500295q · Cited by 18
Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation
Mack, S. M., Gomes, I., & Devi, L. A. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00559 · Cited by 18
The Role of Neuropeptide-Stimulated cAMP-EPACs Signalling in Cancer Cells
Gao, Z., Lei, W. I., & Lee, L. T. O. (2022) · Molecules · doi:10.3390/molecules27010311 · Cited by 18
Challenges for TheIn VivoQuantification of Brain Neuropeptides Using Microdialysis Sampling and LC–MS
Wanseele, Y. V., Prins, A. D., Bundel, D. D., Smolders, I. J., & Eeckhaut, A. V. (2016) · Bioanalysis · doi:10.4155/bio-2016-0119 · Cited by 18
Neuropeptides and Neurotransmission
Gantait, A. M., Bataineh, Y. A., Surchi, H. S., Gantait, A., Rani, G. T., Paul, P., Kokaz, S. F., Al-Jaidi, B. A., Kumar, P., Karan, S., et al. (2020) · Springer eBooks · doi:10.1007/978-981-15-3556-7_16 · Cited by 18
DeepNeuropePred: A robust and universal tool to predict cleavage sites from neuropeptide precursors by protein language model
Wang, L., Zeng, Z., Xue, Z., & Wang, Y. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.12.004 · Cited by 18
Identification of neuropeptides in the sea cucumber Holothuria leucospilota
Chieu, H. D., Suwansa‐ard, S., Wang, T., Elizur, A., & Cummins, S. F. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.113229 · Cited by 17
Effects of maternal immune activation in porcine transcript isoforms of neuropeptide and receptor genes
Southey, B. R., Zhang, P., Keever-Keigher, M. R., Rymut, H. E., Johnson, R. W., Sweedler, J. V., & Rodriguez‐Zas, S. L. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2021.01.332 · Cited by 18
FlyXCDB—A Resource for Drosophila Cell Surface and Secreted Proteins and Their Extracellular Domains
Pei, J., Kinch, L. N., & Grishin, N. V. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.06.002 · Cited by 14
Putative target sites in synganglion for novel ixodid tick control strategies
Waldman, J., Klafke, G., Tirloni, L., Logullo, C., & Vaz, I. D. S. (2023) · Ticks and Tick-borne Diseases · doi:10.1016/j.ttbdis.2023.102123 · Cited by 19
Comparison between Substance P and Calcitonin Gene-Related Peptide and Their Receptors in Colorectal Adenocarcinoma
Șerban, R.-E., Boldeanu, M. V., Florescu, D. N., Ionescu, M., Şerbănescu, M.-S., Boldeanu, L., Florescu, M. M., Stepan, M. D., Obleagă, C. V., Constantin, C., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13185616 · Cited by 15
Decoding Neuropeptide Complexity: Advancing Neurobiological Insights from Invertebrates to Vertebrates through Evolutionary Perspectives
Fields, L. G., Dang, T. C., Tran, V. N. H., Ibarra, A. E., & Li, L. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00053 · Cited by 17
Molecular characterization of nervous system organization in the hemichordate acorn worm Saccoglossus kowalevskii
López, J. M. A., Pani, A. M., Wu, M., Gerhart, J. C., & Lowe, C. J. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002242 · Cited by 14
Brain-derived neurotrophic factor – a key player in the gastrointestinal system
Singh, A. (2023) · Gastroenterology Review · doi:10.5114/pg.2023.132957 · Cited by 15
When the society dictates food search – Neural signalling underlying appetitive motivation in honey bees
da Silva, R. C., Bestea, L., Sanchez, M. G. D. B., & Giurfa, M. (2024) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2024.102930 · Cited by 16
Parkinson disease: Protective role and function of neuropeptides
Tabikh, M., Chahla, C., Okdeh, N., Kovacic, H., Sabatier, J., & Fajloun, Z. (2021) · Peptides · doi:10.1016/j.peptides.2021.170713 · Cited by 15
Mass Spectrometry Measurements of Neuropeptides: From Identification to Quantitation
Toba, E. A. D. L., Bell, S. E., Romanova, E. V., & Sweedler, J. V. (2022) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-061020-022048 · Cited by 15
Differential expression of the FMRF gene in adult and hatchling stellate ganglia of the squid Loligo pealei
Burbach, J. P. H., Grant, P. G., Hellemons, A. J. C. G. M., DeGiorgis, J. A., Li, K. W., & Pant, H. C. (2013) · Biology Open · doi:10.1242/bio.20136890 · Cited by 14
Transcriptomic evidence for dense peptidergic networks within forebrains of four widely divergent tetrapods
Smith, S. J. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.09.011 · Cited by 12
Molecular and functional characterization of the luqin-type neuropeptide signaling system in the sea cucumber Apostichopus japonicus
Li, C., Zheng, Y., Cong, X., Liu, H., Storey, K. B., & Chen, M. (2022) · Peptides · doi:10.1016/j.peptides.2022.170839 · Cited by 13
Mass spectrometric characterization of the crustacean neuropeptidome
Yu, Q., OuYang, C., Liang, Z., & Li, L. (2014) · EuPA Open Proteomics · doi:10.1016/j.euprot.2014.02.015 · Cited by 12
The Neuropeptide Vasoactive Intestinal Peptide Levels in Serum are Inversely Related to Disease Severity of Postmenopausal Osteoporosis: A Cross-Sectional Study
Wang, W., Wang, Z.-P., Huang, C., Chen, Y., Yao, W., & Shi, B. (2019) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2019.0041 · Cited by 12
Neuropeptide Y – Its role in human performance and extreme environments
Kienast, C., Gunga, H., & Steinach, M. (2019) · REACH · doi:10.1016/j.reach.2019.100032 · Cited by 12
RNAi-based screens uncover a potential new role for the orphan neuropeptide receptor Moody in Drosophila female germline stem cell maintenance
Ma, T., Matsuoka, S., & Drummond‐Barbosa, D. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243756 · Cited by 12
Molecular heterogeneity of C. elegans glia across sexesPreprint
Purice, M. D., Quitevis, E. J. A., Manning, R. S., Severs, L. J., Tran, N., Sorrentino, V., Setty, M. N., & Singhvi, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.21.533668 · Cited by 13
Anxiety and the brain: Neuropeptides as emerging factors
Satao, K. S., & Doshi, G. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173878 · Cited by 12
Peptide discovery across the spectrum of neuroinflammation; microglia and astrocyte phenotypical targeting, mediation, and mechanistic understanding
Benita, B. A., & Koss, K. M. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1443985 · Cited by 12
A Mini-Review on Potential of Neuropeptides as Future Therapeutics
Sharma, D., Kumar, K., & Bisht, G. S. (2022) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-021-10309-6 · Cited by 11
Single‐cell sequencing of entorhinal cortex reveals widespread disruption of neuropeptide networks in Alzheimer's disease
Li, M., & Larsen, P. A. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.12979 · Cited by 10
Enrichment and fragmentation approaches for enhanced detection and characterization of endogenous glycosylated neuropeptides
Phetsanthad, A., Roycroft, C., & Li, L. (2022) · PROTEOMICS · doi:10.1002/pmic.202100375 · Cited by 11
HyPep: An Open-Source Software for Identification and Discovery of Neuropeptides Using Sequence Homology Search
Vu, N. Q., Yen, H.-C., Fields, L. G., Cao, W., & Li, L. (2023) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00597 · Cited by 10
Natriuretic peptides modulate monocyte-derived Langerhans cell differentiation and promote a migratory phenotype
Horváth, D., Pénzes, Z., Molnár, P., Rebenku, I., Vereb, G., Szántó, M., Muzsai, S., Szegedi, A., Dajnoki, Z., Pázmándi, K., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1593141 · Cited by 7
MotifQuest: An Automated Pipeline for Motif Database Creation to Improve Peptidomics Database Searching Programs
Dang, T. C., Fields, L. G., & Li, L. (2024) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.4c00192 · Cited by 8
Peptibodies: Bridging the gap between peptides and antibodies
Khezri, H., Mostafavi, M., Dabirmanesh, B., & Khajeh, K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134718 · Cited by 9
Molecular profiling of adult C. elegans glia across sexes by single-nuclear RNA-seq
Purice, M. D., Quitevis, E. J. A., Manning, R. S., Severs, L. J., Tran, N., Sorrentino, V., Finkbeiner, C., Wu, F., Zager, M. A., Setty, M. N., et al. (2025) · Developmental Cell · doi:10.1016/j.devcel.2025.05.013 · Cited by 10
Exploring the roles of neuropeptides in trigeminal neuropathic pain: A systematic review and narrative synthesis of animal studies
Chuinsiri, N., Edwards, D., Telezhkin, V., Nile, C. J., der Cruyssen, F. V., & Durham, J. (2021) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2021.105247 · Cited by 8
Advancements in neuroactive peptides in seizures
Јаnkovic, S., & Đešević, M. (2022) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2022.2031983 · Cited by 8
Members of the neuropeptide transcriptional network in Helicoverpa armigera and their expression in response to light stress
Wang, L., Liu, X., Liu, Z., Wang, X., Lei, C., & Zhu, F. (2018) · Gene · doi:10.1016/j.gene.2018.05.070 · Cited by 8
Organization of neuropeptide systems in the human brain
Ceballos, E. G., Farahani, A., Liu, Z.-Q., Milisav, F., Hansen, J. Y., Dagher, A., & Mišić, B. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02236-w · Cited by 14
Deciphering the role of neuropeptides as biomarkers for early diagnosis of Parkinson's disease
Thakur, J., & Godad, A. P. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123376 · Cited by 7
Chronic unpredictable stress (CUS) reduced phoenixin expression, induced abnormal sperm and testis morphology in male rats
Isnaini, M. Z., Sivalingam, M., Radhakrishnan, A. K., Jaafar, F., & Abidin, S. A. Z. (2024) · Neuropeptides · doi:10.1016/j.npep.2024.102447 · Cited by 6
Functional characterization of CCHamides and deorphanization of their receptors in the yellow fever mosquito, Aedes aegypti
Tan, J., Neupert, S., & Paluzzi, J.-P. V. (2024) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2024.114618 · Cited by 6
Selected neuropeptide genes show genetic differentiation between Africans and non-Africans
Tai, K. Y., Wong, K., Aghakhanian, F. F., Parhar, I. S., Dhaliwal, J., & Ayub, Q. (2020) · BMC Genetics · doi:10.1186/s12863-020-0835-8 · Cited by 6

Authors: Burbach, J. P. H.
Affiliations: University Medical Center Utrecht (NL)
Corresponding author: Burbach, J. Peter H.
ORCID: Burbach, J. Peter H.
Venue: Methods in molecular biology
Publisher: Humana Press
Published: 2011
Volume: 789
Pages: 1-36
ISSN: 1064-3745 (ISSN-L)
1940-6029
DOI: 10.1007/978-1-61779-310-3_1
OpenAlex: W8789689
Cited by: 167
References: 42
Citations by year: 2026: 9 · 2025: 13 · 2024: 16 · 2023: 20 · 2022: 18 · 2021: 13 · 2020: 25 · 2019: 10 · 2018: 10 · 2017: 9 · 2016: 7 · 2015: 5 · 2014: 6 · 2013: 1 · 2012: 4
FWCI: 3.59
Type: book chapter
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Methods in molecular biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
Keywords: neuropeptides, neuropeptide precursors, regulated secretory pathway, neurosecretion, peptide hormones, neuronal signaling, neuropeptide families, cerebellin, granins
MeSH terms: Animals, Chromogranins, Humans, Models, Biological, Nerve Tissue Proteins, Neuropeptides, Chemokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

What Are Neuropeptides?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks