Cited by 123Neuropeptides and Animal PhysiologyNeuroendocrine regulation and behaviorChemical Synthesis and Analysis

Neuropeptides from concept to online database www.neuropeptides.nl

Burbach, J. Peter H.·2010·European Journal of Pharmacology

Abstract

In the early 1970's the term "neuropeptide" was used for the first time by David de Wied for peptides related to peptide hormones but with non-endocrine biological activity in the brain. This early notion appreciated neuropeptides as a specific class of chemical signals produced by neurons, released in a regulated fashion and acting on other neural cells. As we define them today, neuropeptides are encoded by over 70 genes in mammalian genomes. Neuropeptides can be clustered in at least 10 subfamilies according to structural features, for which often shared or related receptors exist. A complete overview is provided through hyperlinks to bioinformatic databases on genome and transcripts, protein structure and brain expression. Other proteineous signaling molecules in the nervous system which originally were discovered in other biological systems, particularly chemokines, growth factors and peptide hormones, share the hallmarks of classical neuropeptides and may be considered as neuropeptides as well.

Integrity signals

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Crossref · 10.1016/j.ejphar.2009.10.015

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31 of 31 references verified0 citation errors · 0 not checkable

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  • The study relied on the reasonably exhaustive list of 96 classical and candidate human and mouse NPP genes from Burbach 2010.

    “For the purposes of the present work, we have relied therefore on the reasonably exhaustive list of 96 classical and candidate human and mouse NPP genes put forth in a widely cited publication (Burbach, 2010) and related website (http://neuropeptides.nl/, last accessed 10 October 2019).”

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Authors
Burbach, J. P. H.
Affiliations
University Medical Center Utrecht (NL)
Corresponding author
Burbach, J. Peter H.
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
2010-01
Volume
626
Issue
1
Pages
27-48
ISSN
0014-2999 (ISSN-L)
OpenAlex
W2140412940
Cited by
123
References
31
Citations by year
2026: 7 · 2025: 12 · 2024: 7 · 2023: 9 · 2022: 13 · 2021: 7 · 2020: 14 · 2019: 7 · 2018: 10 · 2017: 2 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 5
FWCI
0.37
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
Keywords
neuropeptides, neuropeptide genes, neuropeptide receptors, neuropeptide signaling, chemokines, growth factors, peptide hormones, brain expression
MeSH terms
Animals, Gene Expression Regulation, Humans, Neurons, Neuropeptides, Terminology as Topic, Internet, Databases, Protein

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