Neuropeptides from concept to online database www.neuropeptides.nl
Abstract
In the early 1970's the term "neuropeptide" was used for the first time by David de Wied for peptides related to peptide hormones but with non-endocrine biological activity in the brain. This early notion appreciated neuropeptides as a specific class of chemical signals produced by neurons, released in a regulated fashion and acting on other neural cells. As we define them today, neuropeptides are encoded by over 70 genes in mammalian genomes. Neuropeptides can be clustered in at least 10 subfamilies according to structural features, for which often shared or related receptors exist. A complete overview is provided through hyperlinks to bioinformatic databases on genome and transcripts, protein structure and brain expression. Other proteineous signaling molecules in the nervous system which originally were discovered in other biological systems, particularly chemokines, growth factors and peptide hormones, share the hallmarks of classical neuropeptides and may be considered as neuropeptides as well.
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The study relied on the reasonably exhaustive list of 96 classical and candidate human and mouse NPP genes from Burbach 2010.
“For the purposes of the present work, we have relied therefore on the reasonably exhaustive list of 96 classical and candidate human and mouse NPP genes put forth in a widely cited publication (Burbach, 2010) and related website (http://neuropeptides.nl/, last accessed 10 October 2019).”
From Single-cell transcriptomic evidence for dense intracortical neuropeptide networks (2019) · cites this paper as Burbach, 2010
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Using synthetic biology to understand the gut-brain axis
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Selected neuropeptide genes show genetic differentiation between Africans and non-Africans
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Expression of substance P, NPY and their Receptors Is Altered in Major DepressionPreprint
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The molecular basis of memory. Part 3: tagging with “emotive” neurotransmitters
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Classical Neurotransmitters and Neuropeptides
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cNPDB: A comprehensive empirical crustacean neuropeptide databasePreprint
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Neuroprotective Effects of Vapreotide on Tau Transfection–Induced Neurodegeneration
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The Molecular Basis of Neural Memory. Part 6: Chemical Coding of Logical and Emotive Modes
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Review of Fish Neuropeptides: A Novel Perspective on Animal Welfare
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Pituitary neuropeptides and B lymphocyte function
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Natural Plant Materials as a Source of Neuroprotective Peptides
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The alternative proteome in neurobiology
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Neuropeptidergic systems in psychiatric disorders
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Neuropeptide Systems— Some Basic Concepts
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Bioinformatics for Prohormone and Neuropeptide Discovery
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Identification of a neuropeptide in suppressing food intake in zebrafish
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Anxiety-Like Behaviors and Neuropeptide Y, Tachykinins and Beyond
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Focal ischemic reperfusion stroke model in rats and the role of galanin
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Neurotransmission—Evolving Systems
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- Authors
- Burbach, J. P. H.
- Affiliations
- University Medical Center Utrecht (NL)
- Corresponding author
- Burbach, J. Peter H.
- ORCID
- Burbach, J. Peter H.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 626
- Issue
- 1
- Pages
- 27-48
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2140412940
- Cited by
- 123
- References
- 31
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 7 · 2023: 9 · 2022: 13 · 2021: 7 · 2020: 14 · 2019: 7 · 2018: 10 · 2017: 2 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 4 · 2012: 5
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Keywords
- neuropeptides, neuropeptide genes, neuropeptide receptors, neuropeptide signaling, chemokines, growth factors, peptide hormones, brain expression
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Neurons, Neuropeptides, Terminology as Topic, Internet, Databases, Protein
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