O verview of N europeptides: A wakening the S enses?
Open accessAbstract
Humans have a diverse collection of neuropeptides that can influence a multitude of activities. There are now over 100 known neuropeptides and probably many more yet to be identified from the over 1000 predicted peptides encoded in the genome. While diverse, peptides generally share three common characteristics: (1) post-translational processing and release from vesicles, (2) activation of cell-surface receptors over a relatively large distance, and (3) modulation of target cells that are often in the brain and periphery. Within the brain, neuropeptides can modulate the activity of co-released neurotransmitters to either increase or decrease the strength of synaptic signaling. Within the periphery, neuropeptides can function similar to peptide hormones and modulate nearly all bodily functions. Given the clear involvement of the neuropeptide CGRP in migraine and the emerging evidence for other peptides, it seems likely that neuropeptides may help "awaken" the senses and contribute to the heightened sensory state of migraine.
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Secreted neuropeptides are thought to persist long enough (e.g., minutes) in brain interstitial spaces for diffusion to very-high-affinity NP-GPCRs hundreds of micrometers distant from release sites.
“secreted neuropeptides are thought to persist long enough (e.g., minutes) in brain interstitial spaces for diffusion to very-high-affinity NP-GPCRs hundreds of micrometers distant from release sites”
From Single-cell transcriptomic evidence for dense intracortical neuropeptide networks (2019) · cites this paper as Russo, 2017
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Single-cell transcriptomic evidence for dense intracortical neuropeptide networks
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- Authors
- Russo, A. F.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Russo, Andrew F.
- ORCID
- Russo, Andrew F.
- Venue
- Headache The Journal of Head and Face Pain
- Publisher
- Wiley
- Published
- 2017-05
- Volume
- 57
- Issue
- S2
- Pages
- 37-46
- ISSN
- 0017-8748 (ISSN-L)
- 1526-4610
- PMC
- PMC5424629
- OpenAlex
- W2613276313
- Cited by
- 229
- References
- 33
- Citations by year
- 2026: 18 · 2025: 47 · 2024: 27 · 2023: 22 · 2022: 35 · 2021: 26 · 2020: 30 · 2019: 12 · 2018: 10 · 2017: 2
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Headache The Journal of Head and Face Pain (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NS075599)
- Center for Integrated Healthcare, U.S. Department of Veterans Affairs (1IO1RX002101)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- neuropeptides, migraine, sensory sensitization, calcitonin gene-related peptide, post-translational processing, neuropeptide receptors, neurotransmitter co-release, synaptic modulation, peptide hormones
- MeSH terms
- Animals, Humans, Neuropeptides, Sensation
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