The Non-Obese Diabetic (NOD) Mouse as a Model of Human Type 1 Diabetes

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

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TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES

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Genetics, pathogenesis and clinical interventions in type 1 diabetes

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Development of a self-inactivating lentivirus vector

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Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide–based retroviral vector

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Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

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Foxp3 occupancy and regulation of key target genes during T-cell stimulation

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The NOD mouse model of type 1 diabetes: As good as it gets?

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Genetic Control of Autoimmune Diabetes in the Nod Mouse

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Genetic analysis of autoimmune type 1 diabetes mellitus in mice

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IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

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Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice

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Inducible T cell antigen 4-1BB. Analysis of expression and function

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Initiation of Autoimmune Diabetes by Developmentally Regulated Presentation of Islet Cell Antigens in the Pancreatic Lymph Nodes

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

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4-1BB Promotes the Survival of CD8+ T Lymphocytes by Increasing Expression of Bcl-xL and Bfl-1

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A Multicolor Panel of Novel Lentiviral “Gene Ontology” (LeGO) Vectors for Functional Gene Analysis

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Prediction and Pathogenesis in Type 1 Diabetes

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Dendritic cell–expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice

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A Comprehensive Review of Interventions in the NOD Mouse and Implications for Translation

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Role of 4-1BB in immune responses

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Where CD4 + CD25 + T reg cells impinge on autoimmune diabetes

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Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

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Temporal Segregation of 4-1BB Versus CD28-Mediated Costimulation: 4-1BB Ligand Influences T Cell Numbers Late in the Primary Response and Regulates the Size of the T Cell Memory Response Following Influenza Infection

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Costimulation of T cells by OX40, 4-1BB, and CD27

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Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse.

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An Autoimmune Disease-Associated CTLA-4 Splice Variant Lacking the B7 Binding Domain Signals Negatively in T Cells

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Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice

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Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes

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Administration of Agonistic Anti-4-1BB Monoclonal Antibody Leads to the Amelioration of Experimental Autoimmune Encephalomyelitis

Sun, Y., Lin, X., Chen, H. M., Wu, Q., Subudhi, S. K., Chen, L., & Fu, Y. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1457 · Cited by 188 · see citing works

Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice

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Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease

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The Countervailing Actions of Myeloid and Plasmacytoid Dendritic Cells Control Autoimmune Diabetes in the Nonobese Diabetic Mouse

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The NOD Idd9 Genetic Interval Influences the Pathogenicity of Insulitis and Contains Molecular Variants of Cd30, Tnfr2, and Cd137

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Curative and β cell regenerative effects of α1-antitrypsin treatment in autoimmune diabetic NOD mice

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Type 1 diabetes genes and pathways shared by humans and NOD mice

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Congenic Mesenchymal Stem Cell Therapy Reverses Hyperglycemia in Experimental Type 1 Diabetes

Jurewicz, M. M., Yang, S., Augello, A., Godwin, J. G., Moore, R. F., Azzi, J. R., Fiorina, P., Atkinson, M. A., Sayegh, M. H., & Abdi, R. (2010) · Diabetes · doi:10.2337/db10-0542 · Cited by 149 · see citing works

Targeting CD22 Reprograms B-Cells and Reverses Autoimmune Diabetes

Fiorina, P., Vergani, A., Dada, S., Jurewicz, M., Wong, M., Law, K., Wu, E., Tian, Z., Abdi, R., Guleria, I., et al. (2008) · Diabetes · doi:10.2337/db08-0420 · Cited by 149 · see citing works

T Cell Islet Accumulation in Type 1 Diabetes Is a Tightly Regulated, Cell-Autonomous Event

Lennon, G. P., Bettini, M., Burton, A. R., Vincent, E., Arnold, P. Y., Santamaría, P., & Vignali, D. A. A. (2009) · Immunity · doi:10.1016/j.immuni.2009.07.008 · Cited by 137 · see citing works

Reversal of New-Onset Diabetes through Modulating Inflammation and Stimulating β-Cell Replication in Nonobese Diabetic Mice by a Dipeptidyl Peptidase IV Inhibitor

Tian, L., Gao, J., Hao, J., Zhang, Y., Yi, H., O'Brien, T. D., Sorenson, R., Luo, J., & Guo, Z. (2010) · Endocrinology · doi:10.1210/en.2010-0068 · Cited by 120 · see citing works

Fine Mapping, Gene Content, Comparative Sequencing, and Expression Analyses Support Ctla4 and Nramp1 as Candidates for Idd5.1 and Idd5.2 in the Nonobese Diabetic Mouse

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ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival

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Immune responses to lentiviral vectors.

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Mixed Hematopoietic Chimerism Allows Cure of Autoimmune Diabetes Through Allogeneic Tolerance and Reversal of Autoimmunity

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The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function

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The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation

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Use of Nonobese Diabetic Mice to Understand Human Type 1 Diabetes

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T1DBase: update 2011, organization and presentation of large-scale data sets for type 1 diabetes research

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Immune Depletion With Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice

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Chapter 6 Gene–Gene Interactions in the NOD Mouse Model of Type 1 Diabetes

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DIFFERENTIAL GLYCOSYLATION OF INTERLEUKIN 2, THE MOLECULAR BASIS FOR THE NOD Idd3 TYPE 1 DIABETES GENE?

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EXPRESSION OF SOLUBLE CD137 CORRELATES WITH ACTIVATION-INDUCED CELL DEATH OF LYMPHOCYTES

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Engagement of 4-1BB Inhibits the Development of Experimental Allergic Conjunctivitis in Mice

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Modulating Protective and Pathogenic CD4+ Subsets via CD137 in Type 1 Diabetes

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Genetic and functional association of the immune signaling molecule 4-1BB (CD137/TNFRSF9) with type 1 diabetes

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A mRNA variant encoding a soluble form of 4-1BB, a member of the murine NGF/TNF receptor family

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The role of CD4 and CD8 T cells in type I diabetes in the NOD mouse

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Polyclonal Adaptive Regulatory CD4 Cells That Can Reverse Type I Diabetes Become Oligoclonal Long-Term Protective Memory Cells

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Characterisation of soluble murine CD137 and its association with systemic lupus

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Mice deficient for CD137 ligand are predisposed to develop germinal center–derived B-cell lymphoma

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Genetic-induced Variations in the GAD65 T-cell Repertoire Governs Efficacy of Anti-CD3/GAD65 Combination Therapy in New-onset Type 1 Diabetes

Bresson, D., Fradkin, M., Manenkova, Y., Rottembourg, D., & von Herrath, M. (2009) · Molecular Therapy · doi:10.1038/mt.2009.197 · Cited by 38 · see citing works

Antigen-Based Immune Therapeutics for Type 1 Diabetes: Magic Bullets or Ordinary Blanks?

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Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species

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CD137‐Mediated T Cell Co‐Stimulation Terminates Existing Autoimmune Disease in SLE‐Prone NZB/NZW F1 Mice

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New tools for defining the 'genetic background' of inbred mouse strains

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Tuning the immune system: competing positive and negative feedback loops

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Dendritic Cells in the Autoimmune Insulitis in NOD Mouse Models of Diabetes

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Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

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Constitutive expression of 4-1BB on T cells enhances CD4+ T cell responses

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Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse

Kamanaka, M., Rainbow, D. B., Schuster-Gossler, K., Eynon, E. E., Chervonsky, A. V., Wicker, L. S., & Flavell, R. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904780106 · Cited by 13 · see citing works

CXC chemokine ligand 10 DNA vaccination plus Complete Freund's Adjuvant reverses hyperglycemia in non-obese diabetic mice.

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Gut Microbiota Regulation of T Cells During Inflammation and Autoimmunity

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Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes

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Vitamin D and Immunity in Infants and Children

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Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype

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LncRNA MALAT1 induces the dysfunction of β cells via reducing the histone acetylation of the PDX-1 promoter in type 1 diabetes

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Genetic Epidemiology of Type 1 Diabetes in the 22 Arab Countries

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Fatty acid binding protein 4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages

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Islet–immune interactions in type 1 diabetes: the nexus of beta cell destruction

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Recombinant soluble CD137 prevents type one diabetes in nonobese diabetic mice

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Tolerance Strategies Employing Antigen-Coupled Apoptotic Cells and Carboxylated PLG Nanoparticles for the Treatment of Type 1 Diabetes

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Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes

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Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes

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Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice

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Vitamin D supplementation induces CatG-mediated CD4+ T cell inactivation and restores pancreatic β-cell function in mice with type 1 diabetes

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Thymic B Cell-Mediated Attack of Thymic Stroma Precedes Type 1 Diabetes Development

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The Non-Obese Diabetic Mouse Strain as a Model to Study CD8+ T Cell Function in Relapsing and Progressive Multiple Sclerosis

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Vitamin D-independent benefits of safe sunlight exposure

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Animal Models and Renal Biomarkers of Diabetic Nephropathy

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Unveiling the Therapeutic Potential of the Second-Generation Incretin Analogs Semaglutide and Tirzepatide in Type 1 Diabetes and Latent Autoimmune Diabetes in Adults

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Spatiotemporal Dynamics of Insulitis in Human Type 1 Diabetes

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Type 1 Diabetes Mellitus and Vitamin D

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Designing a Bioelectronic Treatment for Type 1 Diabetes: Targeted Parasympathetic Modulation of Insulin Secretion

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Discovery of 5-(3,4-Difluorophenyl)-3-(pyrazol-4-yl)-7-azaindole (GNF3809) for β-Cell Survival in Type 1 Diabetes

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Structure modeling and antidiabetic activity of a seed protein of Momordica charantia in non-obese diabetic (NOD) mice

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Gut Microbiota and Metabolites: Biomarkers and Therapeutic Targets for Diabetes Mellitus and Its Complications

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Helminth therapy for organic diseases?

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ESRRA modulation by empagliflozin mitigates diabetic tubular injury via mitochondrial restoration

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Immunotherapies and immune biomarkers in Type 1 diabetes: A partnership for success

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Interactions Between the Neuroendocrine System and T Lymphocytes in Diabetes

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Major Topics in Type 1 Diabetes

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Thymic B Cells as a New Player in the Type 1 Diabetes Response

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A Distinctive γδ T Cell Repertoire in NOD Mice Weakens Immune Regulation and Favors Diabetic Disease

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Effect of Oral Infections on Serum Creatinine Levels in Diabetic Rats

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Interleukin-1 Antagonism: A Sturdy Companion for Immune Tolerance Induction in Type 1 Diabetes?

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The Innate Immune System via Toll-Like Receptors (TLRs) in Type 1 Diabetes - Mechanistic Insights

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NOD mice have distinct metabolic and immunologic profiles when compared with genetically similar MHC-matched ICR mice

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NOD Mice Recapitulate the Cardiac Disturbances Observed in Type 1 Diabetes

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Combined Use of Vitamin D and DPP-4 Inhibitors as a Potential Adjuvant Treatment Strategy to Enhance the Efficacy of Novel Beta-Cell Replacement Therapies for Type 1 Diabetes

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γδ T cells in diabetes mellitus: dual roles and therapeutic implications

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Effect of antioxidant treatment with n-acetylcysteine and swimming on lipid expression of sebaceous glands in diabetic mice

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Diabetes-related impairment in bone strength is established early in the life course

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Diabetes Mellitus’ta Mikrobiyotanın Rolü ve Hedeflenmesi

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Animal Models Used for Studying the Benefits of Probiotics in Metabolic Disorders

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The Genetic Landscape of Diabetes Mellitus: Lessons from Monogenic and Polygenic Forms

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Antigen Deimination in Human Type 1 Diabetes and Nonobese Diabetic Mice

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Az 1-es típusú diabetes prevenciójának jelenlegi állása

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Fluoride effect on parameters related to glucose homeostasis in NOD mice: using proteomic analysis of liver and gastrocnemius muscle to unravel the underlying mechanisms

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Hybrid computational modeling demonstrates the utility of simulating complex cellular networks in type 1 diabetes

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Animal models of disease states

Blass, B. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817214-8.00007-5

NOD alleles at Idd1 and Idd2 loci drive exocrine pancreatic inflammation

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The Role and Targeting of Microbiota in Diabetes Mellitus

Aksoyalp, Z. Ş., & Nacıtarhan, C. (2020) · DergiPark (Istanbul University)

De l’importance des médiateurs du stress dans le contrôle de l’immunité

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Hyperglycemia associated brain dysfunction: rodent models for studying diabetic cognitive deficits

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Thinking bedside at the bench: the NOD mouse model of T1DM

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Comparative Genetics: Synergizing Human and NOD Mouse Studies for Identifying Genetic Causation of Type 1 Diabetes

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The NOD mouse

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REVIEW www.The-RDS.org 169 DOI 10.1900/RDS.2012.9.169 DIABETIC STUDIES The Review of Chapter I.3 Comparative Genetics: Synergizing Human and NOD Mouse Studies for Identifying Genetic Causation of Type 1 Diabetes

Driver, J. P., Chen, Y.-G., & Mathews, C. E. (2012)

Mouse models for Type 1 Diabetes

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