Prediction and Pathogenesis in Type 1 Diabetes

Ziegler, Anette-G.; Nepom, Gerald T.

doi:10.1016/j.immuni.2010.03.018

Cited by 346Diabetes and associated disordersT-cell and B-cell ImmunologyDiabetes Management and Research

Prediction and Pathogenesis in Type 1 Diabetes

Open access

Ziegler, Anette-G., Nepom, Gerald T.·2010·Immunity

DOI 10.1016/j.immuni.2010.03.018PMC PMC2861716

Open this paper in CoChat — free account Open PDF

Abstract

A combination of genetic and immunological features is useful for prediction of autoimmune diabetes. Patterns of immune response correspond to the progression from a preclinical phase of disease to end-stage islet damage, with biomarkers indicating transition from susceptibility to active autoimmunity, and to a final loss of immune regulation. Here, we review the markers that provide evidence for immunological checkpoint failure and that also provide tools for assessment of individualized disease risk. When viewed in the context of genetic variation that influences immune response thresholds, progression from susceptibility to overt disease displays predictable modalities of clinical presentation resulting from a sequential series of failed homeostatic checkpoints for selection and activation of immunity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2010.03.018

Cites

101 of 101 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

More than 90% of individuals with newly diagnosed type 1 diabetes have one or more of the following autoantibodies at disease onset: IAA, GADA, IA2A, and ZnT8A.
“More than 90% of individuals with newly diagnosed type 1 diabetes have one or more of the following autoantibodies at disease onset:53 those reactive to insulin (IAA), glutamic acid decarboxylase (GADA), insulinoma-associated autoantigen 2 (IA2A), and zinc transporter 8 (ZnT8A).65”
From Type 1 diabetes (2014) · cites this paper as [65]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
Baekkeskov, S., Aanstoot, H.-J., Christgai, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F., Richter-Olesen, H., & Camilli, P.-D. (1990) · Nature · doi:10.1038/347151a0 · Cited by 1,964 · see citing works
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
Wildin, R. S., Ramsdell, F., Peake, J., Faravelli, F., Casanova, J., Buist, N. R. M., Levy‐Lahad, E., Mazzella, M., Goulet, O., Perroni, L., et al. (2001) · Nature Genetics · doi:10.1038/83707 · Cited by 1,916 · see citing works
A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis
Begovich, A. B., Carlton, V. E. H., Honigberg, L. A., Schrodi, S. J., Chokkalingam, A. P., Alexander, H. C., Ardlie, K., Huang, Q., Smith, A. M., Spoerke, J. M., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/422827 · Cited by 1,501 · see citing works
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
Bottini, N., Musumeci, L., Alonso, A., Rahmouni, S., Nika, K., Rostamkhani, M., MacMurray, J. P., Meloni, T., Lucarelli, P., Pellecchia, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1323 · Cited by 1,419 · see citing works
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
The International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), Harley, J. B., Alarcón-Riquelme, M. E., Criswell, L. A., Jacob, C. O., Kimberly, R. P., Moser, K. L., Tsao, B. P., Vyse, T. J., & Langefeld, C. D. (2008) · Nature Genetics · doi:10.1038/ng.81 · Cited by 1,309 · see citing works
Insulin antibodies in insulin-dependent diabetics before insulin treatment
Palmer, J. P., Asplin, C. M., Clemons, P., Lyen, K., Tatpati, O., Raghu, P. K., & Paquette, T. L. (1983) · Science · doi:10.1126/science.6362005 · Cited by 1,078 · see citing works
The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
Wenzlau, J. M., Juhl, K., Yu, L., Moua, O., Sarkar, S. A., Gottlieb, P., Rewers, M., Eisenbarth, G. S., Jensen, J., Davidson, H. W., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705894104 · Cited by 1,014 · see citing works
Incidence of diabetes in youth in the United States
SEARCH for Diabetes in Youth Study Group*, T. W. G. F. T. (2007) · JAMA · doi:10.1001/jama.297.24.2716 · Cited by 991 · see citing works
The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
Pugliese, A., Zeller, M., Fernandez, A., Zalcberg, L. J., Bartlett, R. J., Ricordi, C., Pietropaolo, M., Eisenbarth, G. S., Bennett, S. T., & Patel, D. D. (1997) · Nature Genetics · doi:10.1038/ng0397-293 · Cited by 945 · see citing works
Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes
Sm, L., Dayan, C. M., Bishop, A. J., Roep, B. O., Peakman, M., & Tree, T. I. M. (2005) · Diabetes · doi:10.2337/diabetes.54.1.92 · Cited by 858 · see citing works
Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies
Verge, C. F., Gianani, R., Kawasaki, E., Yu, L., Pietropaolo, M., Chase, H. P., Eisenbarth, G. S., & Jackson, R. A. (1996) · Diabetes · doi:10.2337/diab.45.7.926 · Cited by 827 · see citing works
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
Vafiadis, P., Bennett, S. T., Todd, J. A., Nadeau, J., Grabs, R., Goodyer, C. G., Wickramasinghe, S., Colle, E., & Polychronakos, C. (1997) · Nature Genetics · doi:10.1038/ng0397-289 · Cited by 809 · see citing works
Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus
Bennett, S. T., Lucassen, A. M., Gough, S. C. L., Powell, E. E., Undlien, D. E., Pritchard, L. E., Merriman, M. E., Kawaguchi, Y., Dronsfield, M. J., Pociot, F., et al. (1995) · Nature Genetics · doi:10.1038/ng0395-284 · Cited by 746 · see citing works
Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients
Battaglia, M., Stabilini, A., Migliavacca, B., Horejs‐Hoeck, J., Kaupper, T., & Roncarolo, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8338 · Cited by 731 · see citing works
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
Vang, T., Congia, M., Macis, M. D., Musumeci, L., Orrù, V., Zavattari, P., Nika, K., Tautz, L., Taskén, K., Cucca, F., et al. (2005) · Nature Genetics · doi:10.1038/ng1673 · Cited by 724 · see citing works
Genetic Association of the R620W Polymorphism of Protein Tyrosine Phosphatase PTPN22 with Human SLE
Kyogoku, C., Ortmann, W. A., Lee, A., Selby, S. A., Carlton, V. E. H., Chang, M., Ramos, P. S., Baechler, E. C., Batliwalla, F., Novitzke, J. M., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/423790 · Cited by 671 · see citing works
A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus
Chaussabel, D., Quinn, C., Shen, J., Patel, P., Glaser, C., Baldwin, N., Stichweh, D., Blankenship, D., Li, L., Munagala, I., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.012 · Cited by 649 · see citing works
Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study.
Ziegler, A., Hummel, M., Schenker, M., & Bonifacio, E. E. (1999) · Diabetes · doi:10.2337/diabetes.48.3.460 · Cited by 640 · see citing works
Self-citation
Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases
Beeton, C., Wulff, H., Standifer, N. E., Azam, P., Mullen, K. M., Pennington, M. W., Kolski‐Andreaco, A., Wei, E. K., Grino, A., Counts, D., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605136103 · Cited by 540 · see citing works
Self-citation
Genetics of type 1A diabetes
Concannon, P., Rich, S. S., & Nepom, G. T. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0808284 · Cited by 510 · see citing works
Self-citation
Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus
Smyth, D. J., Cooper, J. D., Collins, J. E., Heward, J. M., Franklyn, J. A., Howson, J. M. M., Vella, A. V., Nutland, S. L., Rance, H. E., Maier, L. M., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.11.3020 · Cited by 504 · see citing works
The Codon 620 Tryptophan Allele of the Lymphoid Tyrosine Phosphatase (LYP) Gene Is a Major Determinant of Graves’ Disease
Velaga, M., Wilson, V., Jennings, C., Owen, C. J., Herington, S. D., Donaldson, P. T., Ball, S. G., James, R. A., Quinton, R., Perros, P., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1108 · Cited by 464 · see citing works
Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
Orešič, M., Simell, S., Sysi-Aho, M., Näntö-Salonen, K., Seppänen-Laakso, T., Parikka, V., Katajamaa, M., Hekkala, A., Mattila, I., Keskinen, P., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081800 · Cited by 449 · see citing works
Combined Analysis of Autoantibodies Improves Prediction of IDDM in Islet Cell Antibody-Positive Relatives
Bingley, P. J., Christie, M. R., Bonifacio, E. E., Bonfanti, R., Shattock, M., Fonte, M.-T., Bottazzo, G.-F., & Gale, E. A. (1994) · Diabetes · doi:10.2337/diab.43.11.1304 · Cited by 384 · see citing works
Diabetes Antibody Standardization Program: first assay proficiency evaluation
Bingley, P. J., Bonifacio, E., Mueller, P. W., & Laboratories, P. (2003) · Diabetes · doi:10.2337/diabetes.52.5.1128 · Cited by 362 · see citing works
Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes
Putnam, A. L., Brusko, T. M., Lee, M. R., Liu, W., Szot, G. L., Ghosh, T., Atkinson, M. A., & Bluestone, J. A. (2008) · Diabetes · doi:10.2337/db08-1168 · Cited by 357 · see citing works
Genetic Variation in PTPN22 Corresponds to Altered Function of T and B Lymphocytes
Rieck, M., Arechiga, A. F., Önengüt-Gümüşcü, S., Greenbaum, C. J., CONCANNON, P. J., & Buckner, J. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.7.4704 · Cited by 355 · see citing works
Concordance for islet autoimmunity among monozygotic twins
Redondo, M. J., Jeffrey, J., Fain, P. R., Eisenbarth, G. S., & Orban, T. (2008) · New England Journal of Medicine · doi:10.1056/nejmc0805398 · Cited by 353 · see citing works
TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs
Bisikirska, B. C., Colgan, J. D., Luban, J., Bluestone, J. A., & Herold, K. C. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23961 · Cited by 340 · see citing works
Analysis of HLA-DQ Genotypes and Susceptibility in Insulin-Dependent Diabetes Mellitus
Baisch, J. M., Weeks, T., Giles, R. C., Hoover, M. L., Šťastný, P., & Capra, J. D. (1990) · New England Journal of Medicine · doi:10.1056/nejm199006283222602 · Cited by 332 · see citing works
Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases.
Rabin, D. U., Pleasic, S. M., Shapiro, J., Yoo-Warren, H., Oles, J., Hicks, J. M., Goldstein, D. E., & Rae, P. M. M. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.6.3183 · Cited by 305 · see citing works
The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells
Schneider, A., Rieck, M., Sanda, S., Pihoker, C., Greenbaum, C. J., & Buckner, J. H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7350 · Cited by 303 · see citing works
Prediction of insulin-dependent diabetes mellitus in siblings of children with diabetes. A population-based study. The Childhood Diabetes in Finland Study Group.
Kulmala, P., Savola, K., Petersen, J. S., Vähäsalo, P., Karjalainen, J., Löppönen, T., Dyrberg, T., Åkerblom, H. K., & Knip, M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci119879 · Cited by 284 · see citing works
Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects
Long, S. A., Cerosaletti, K. M., Bollyky, P. L., Tatum, M., Shilling, H. G., Zhang, S., Zhang, Z., Pihoker, C., Sanda, S., Greenbaum, C. J., et al. (2009) · Diabetes · doi:10.2337/db09-0694 · Cited by 284 · see citing works
Stratification of Type 1 Diabetes Risk on the Basis of Islet Autoantibody Characteristics
Achenbach, P., Warncke, K., Reiter, J., Naserke, H. E., Williams, A. J. K., Bingley, P. J., Bonifacio, E. E., & Ziegler, A. (2004) · Diabetes · doi:10.2337/diabetes.53.2.384 · Cited by 276 · see citing works
Self-citation
Extreme genetic risk for type 1A diabetes
Aly, T. A., Ide, A., Jahromi, M. M., Barker, J. M., Fernando, M. S., Babu, S. R., Yu, L., Miao, D., Erlich, H. A., Fain, P. R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606349103 · Cited by 256 · see citing works
No Alterations in the Frequency of FOXP3+ Regulatory T-Cells in Type 1 Diabetes
Brusko, T. M., Wasserfall, C. H., MCGRAIL, K. M., Schatz, R., Viener, H. L., Schatz, D., Haller, M. J., Rockell, J., Gottlieb, P. A., Clare-Salzler, M. J., et al. (2007) · Diabetes · doi:10.2337/db06-1248 · Cited by 253 · see citing works
Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4+ T Cells in Multiple Sclerosis
Bielekova, B., Sung, M., Kadom, N., Simon, R. M., McFarland, H. F., & Martinꝉ, R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3893 · Cited by 241 · see citing works
Absolute Risk of Childhood-Onset Type 1 Diabetes Defined by Human Leukocyte Antigen Class II Genotype: A Population-Based Study in the United Kingdom
Lambert, A. P., Gillespie, K. M., Thomson, G. J., Cordell, H. J., Todd, J. A., Gale, E. A., & Bingley, P. J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032084 · Cited by 240 · see citing works
Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes
Achenbach, P., Koczwara, K., Knopff, A., Naserke, H. E., Ziegler, A., & Bonifacio, E. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21307 · Cited by 238 · see citing works
Self-citation
Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes
Graham, J., Hagopian, W. A., Kockum, I., Li, L. S., Sanjeevi, C. B., Lowe, R. M., Schaefer, J. B., Zarghami, M., Day, H. L., Landin-Olsson, M., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1346 · Cited by 230 · see citing works
Insulin resistance is a risk factor for progression to Type 1 diabetes
Fourlanos, S., Narendran, P., Byrnes, G. B., Colman, P. G., & Harrison, L. C. (2004) · Diabetologia · doi:10.1007/s00125-004-1507-3 · Cited by 228 · see citing works
Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade
Allantaz, F., Chaussabel, D., Stichweh, D., Bennett, L. B., Allman, W., Mejías, A., Ardura, M. I., Chung, W. K., Smith, E. J., Wise, C. A., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070070 · Cited by 228 · see citing works
First-Degree Relatives of Patients with Type I Diabetes Mellitus
Srikanta, S., Ganda, O. P., Rabizadeh, A., Soeldner, J. S., & Eisenbarth, G. S. (1985) · New England Journal of Medicine · doi:10.1056/nejm198508223130801 · Cited by 221 · see citing works
Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.
Lu, J., Li, Q., Xie, H., Chen, Z., Borovitskaya, A., Maclaren, N. K., Notkins, A. L., & Lan, M. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2307 · Cited by 209 · see citing works
HLA-DQB1*0602 Is Associated With Dominant Protection From Diabetes Even Among Islet Cell Antibody–Positive First-Degree Relatives of Patients with IDDM
Pugliese, A., Gianani, R., Moromisato, R., Awdeh, Z., Alper, C. A., Erlich, H. A., Jackson, R. A., & Eisenbarth, G. S. (1995) · Diabetes · doi:10.2337/diab.44.6.608 · Cited by 207 · see citing works
CD4+CD25high regulatory T cells in human autoimmune diabetes
Putnam, A. L., Vendrame, F., Dotta, F., & Gottlieb, P. A. (2005) · Journal of Autoimmunity · doi:10.1016/j.jaut.2004.11.004 · Cited by 206 · see citing works
Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk
Achenbach, P., Lampasona, V., Landherr, U., Koczwara, K., Krause, S. W., Grallert, H., Winkler, C., Pflüger, M., Illig, T., Bonifacio, E. E., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1438-0 · Cited by 197 · see citing works
Self-citation
Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling
Arechiga, A. F., Habib, T., He, Y., Zhang, X., Zhang, Z., Funk, A., & Buckner, J. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0713370 · Cited by 196 · see citing works
Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes
Lawson, J. M., Tremble, J. M., Dayan, C. M., Beyan, H., Leslie, R. D., Peakman, M., & Tree, T. I. M. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03810.x · Cited by 170 · see citing works
Successful Prospective Prediction of Type 1 Diabetes in Schoolchildren Through Multiple Defined Autoantibodies
LaGasse, J. M., Brantley, M. S., Leech, N., Rowe, R. E., Monks, S. A., Palmer, J. P., Nepom, G. T., McCulloch, D. K., & Hagopian, W. (2002) · Diabetes Care · doi:10.2337/diacare.25.3.505 · Cited by 170 · see citing works
Self-citation
Zinc Transporter 8 Antibodies Complement GAD and IA-2 Antibodies in the Identification and Characterization of Adult-Onset Autoimmune Diabetes
Lampasona, V., Petrone, A., Tiberti, C., Capizzi, M., Spoletini, M., di Pietro, S., Songini, M., Bonicchio, S., Giorgino, F., Bonifacio, E. E., et al. (2009) · Diabetes Care · doi:10.2337/dc08-2305 · Cited by 159 · see citing works
Brief Communication: Early Appearance of Islet Autoantibodies Predicts Childhood Type 1 Diabetes in Offspring of Diabetic Parents
Hummel, M., Bonifacio, E. E., Schmid, S., Walter, M., Knopff, A., & Ziegler, A. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-11-200406010-00009 · Cited by 151 · see citing works
Self-citation
Familial association between type 1 diabetes and other autoimmune and related diseases
Hemminki, K., Li, X., Sundquist, J., & Sundquist, K. (2009) · Diabetologia · doi:10.1007/s00125-009-1427-3 · Cited by 147 · see citing works
Rapamycin Monotherapy in Patients With Type 1 Diabetes Modifies CD4+CD25+FOXP3+ Regulatory T-Cells
Monti, P., Scirpoli, M., Maffi, P., Piemonti, L., Secchi, A., Bonifacio, E. E., Roncarolo, M., & Battaglia, M. (2008) · Diabetes · doi:10.2337/db08-0138 · Cited by 138 · see citing works
A functional polymorphism (1858C/T) in the PTPN22 gene is linked and associated with type I diabetes in multiplex families
Önengüt-Gümüşcü, S., Ewens, K. G., Spielman, R. S., & CONCANNON, P. J. (2004) · Genes and Immunity · doi:10.1038/sj.gene.6364138 · Cited by 138 · see citing works
Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes
Ladner, M. B., Bottini, N., Valdes, A. M., & Noble, J. A. (2004) · Human Immunology · doi:10.1016/j.humimm.2004.09.016 · Cited by 128 · see citing works
Interactions of Age, Islet Cell Antibodies, Insulin Autoantibodies, and First-Phase Insulin Response in Predicting Risk of Progression to IDDM in ICA+ Relatives: The ICARUS Data Set
Bingley, P. J. (1996) · Diabetes · doi:10.2337/diab.45.12.1720 · Cited by 126 · see citing works
TEDDY–The Environmental Determinants of Diabetes in the Young: An Observational Clinical Trial
HAGOPIAN, W. A., LERNMARK, Å., REWERS, M. J., SIMELL, O. G., SHE, J., ZIEGLER, A. G., KRISCHER, J. P., & AKOLKAR, B. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1375.049 · Cited by 125 · see citing works
Self-citation
Early Autoantibody Responses in Prediabetes Are IgG1 Dominated and Suggest Antigen-Specific Regulation
Bonifacio, E. E., Scirpoli, M., Kredel, K., Füchtenbusch, M., & Ziegler, A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.1.525 · Cited by 124 · see citing works
Self-citation
Evidence for In Vivo Primed and Expanded Autoreactive T Cells as a Specific Feature of Patients with Type 1 Diabetes
Monti, P., Scirpoli, M., Rigamonti, A., Mayr, A., Jaeger, A., Bonfanti, R., Chiumello, G., Ziegler, A. G., & Bonifacio, E. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.9.5785 · Cited by 123 · see citing works
Self-citation
Clinical Heterogeneity in Patients With FOXP3 Mutations Presenting With Permanent Neonatal Diabetes
Rubio-Cabezas, Ó., Minton, J., Caswell, R., Shield, J., Deiss, D., Šumník, Z., Cayssials, A., Herr, M., Loew, A., Lewis, V. E., et al. (2009) · Diabetes Care · doi:10.2337/dc08-1188 · Cited by 122 · see citing works
Identification of a Molecular Signature in Human Type 1 Diabetes Mellitus Using Serum and Functional Genomics
Wang, X., Jia, S., Geoffrey, R., Alemzadeh, R., Ghosh, S., & Hessner, M. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1929 · Cited by 110 · see citing works
IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71)
Bottazzo, G. F., Bosi, E., Cull, C. A., Bonifacio, E. E., Locatelli, M., Zimmet, P., Mackay, I. R., & Holman, R. R. (2005) · Diabetologia · doi:10.1007/s00125-005-1691-9 · Cited by 101 · see citing works
Early expression and high prevalence of islet autoantibodies for DR3/4 heterozygous and DR4/4 homozygous offspring of parents with Type I diabetes: The German BABYDIAB study
Schenker, M., Hummel, M., Ferber, K. M., Walter, M., Keller, E., Albert, E. D., Janka, H.-U., Kastendiek, C., Sorger, M., Louwen, F., et al. (1999) · Diabetologia · doi:10.1007/s001250051214 · Cited by 97 · see citing works
Self-citation
Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects
Danke, N. A., Yang, J., Greenbaum, C. J., & Kwok, W. W. (2005) · Journal of Autoimmunity · doi:10.1016/j.jaut.2005.08.007 · Cited by 91 · see citing works
Insulin gene VNTR genotype associates with frequency and phenotype of the autoimmune response to proinsulin
Durinovic‐Belló, I., Wu, R. P., Gersuk, V. H., Sanda, S., Shilling, H. G., & Nepom, G. T. (2010) · Genes and Immunity · doi:10.1038/gene.2009.108 · Cited by 90 · see citing works
Self-citation
GAD Autoantibody Affinity and Epitope Specificity Identify Distinct Immunization Profiles in Children at Risk for Type 1 Diabetes
Mayr, A., Schlosser, M., Grober, N., Kenk, H., Ziegler, A. G., Bonifacio, E. E., & Achenbach, P. (2007) · Diabetes · doi:10.2337/db06-1715 · Cited by 89 · see citing works
Self-citation
Characterization of Insulin Autoantibodies in Relatives of Patients With Type I Diabetes
Castaño, L. A., Ziegler, A. G., Ziegler, R., Shoelson, S. E., & Eisenbarth, G. S. (1993) · Diabetes · doi:10.2337/diab.42.8.1202 · Cited by 79 · see citing works
Self-citation
How the study of children with rheumatic diseases identified interferon‐α and interleukin‐1 as novel therapeutic targets
Pascual, V., Allantaz, F., Patel, P., Palucka, K., Chaussabel, D., & Banchereau, J. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00643.x · Cited by 78 · see citing works
A Mini Meta‐Analysis of Studies on CD4+CD25+ T cells in Human Type 1 Diabetes
Tree, T. I. M., Roep, B. O., & Peakman, M. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1375.002 · Cited by 77 · see citing works
IDDM1 and Multiple Family History of Type 1 Diabetes Combine to Identify Neonates at High Risk for Type 1 Diabetes
Bonifacio, E. E., Hummel, M., Walter, M., Schmid, S., & Ziegler, A. (2004) · Diabetes Care · doi:10.2337/diacare.27.11.2695 · Cited by 76 · see citing works
Self-citation
Proposed Guidelines on Screening for Risk of Type 1 Diabetes
Bingley, P. J., Bonifacio, E. E., Ziegler, A., Schatz, D., Atkinson, M. A., Eisenbarth, G. S., & the Immunology of Diabetes Society (2001) · Diabetes Care · doi:10.2337/diacare.24.2.398 · Cited by 72 · see citing works
Self-citation
Human Autoreactive CD4+ T Cells from Naive CD45RA+ and Memory CD45RO+ Subsets Differ with Respect to Epitope Specificity and Functional Antigen Avidity
Muraro, P. A., Pette, M., Bielekova, B., McFarland, H. F., & Martinꝉ, R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.10.5474 · Cited by 62 · see citing works
Transient Antiislet Autoantibodies: Infrequent Occurrence and Lack of Association with “Genetic” Risk Factors1
Yu, J., Yu, L., Bugawan, T. L., Erlich, H. A., Barriga, K., Hoffman, M., Rewers, M., & Eisenbarth, G. S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6670 · Cited by 59 · see citing works
HLA-Associated Insulin Autoantibody Formation in Newly Diagnosed Type I Diabetic Patients
Ziegler, A. G., Standl, E., Albert, E. D., & Mehnert, H. (1991) · Diabetes · doi:10.2337/diab.40.9.1146 · Cited by 58 · see citing works
Self-citation
CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope
Yang, J., Danke, N. A., Roti, M., Huston, L., Greenbaum, C. J., Pihoker, C., James, E. A., & Kwok, W. W. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.02.001 · Cited by 56 · see citing works
Combined testing of antibody titer and affinity improves insulin autoantibody measurement: Diabetes Antibody Standardization Program
Achenbach, P., Schlosser, M., Williams, A. J. K., Yu, L., Mueller, P. W., Bingley, P. J., & Bonifacio, E. E. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.09.004 · Cited by 53 · see citing works
Effects of the second HLA‐DQ haplotype on the association with childhood insulin‐dependent diabetes mellitus
Sanjeevi, C. B., Landin‐Olsson, M., Kockum, I. S., Dahlquist, G. G., & Lernmark, Å. (1995) · Tissue Antigens · doi:10.1111/j.1399-0039.1995.tb02434.x · Cited by 50 · see citing works
Functional islet‐specific Treg can be generated from CD4+CD25− T cells of healthy and type 1 diabetic subjects
Long, S. A., Walker, M., Rieck, M., James, E. A., Kwok, W. W., Sanda, S., Pihoker, C., Greenbaum, C. J., Nepom, G. T., & Buckner, J. H. (2009) · European Journal of Immunology · doi:10.1002/eji.200838819 · Cited by 47 · see citing works
Self-citation
Prevalence, Characteristics and Diabetes Risk Associated with Transient Maternally Acquired Islet Antibodies and Persistent Islet Antibodies in Offspring of Parents with Type 1 Diabetes
Naserke, H. E., Bonifacio, E. E., & Ziegler, A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7931 · Cited by 47 · see citing works
Self-citation
Predominantly Recognized ProInsulin T Helper Cell Epitopes in Individuals With and Without Islet Cell Autoimmunity
Durinovic‐Belló, I., Boehm, B. O., & Ziegler, A. (2002) · Journal of Autoimmunity · doi:10.1006/jaut.2001.0566 · Cited by 47 · see citing works
Self-citation
Type 1 diabetes risk assessment: improvement by follow-up measurements in young islet autoantibody-positive relatives
Achenbach, P., Warncke, K., Reiter, J., Williams, A. J. K., Ziegler, A., Bingley, P. J., & Bonifacio, E. E. (2006) · Diabetologia · doi:10.1007/s00125-006-0451-9 · Cited by 46 · see citing works
Self-citation
Newborn HLA-DR,DQ genotype screening: age- and ethnicity-specific type 1 diabetes risk estimates
Emery, L. M., Babu, S. R., Bugawan, T. L., Norris, J. M., Erlich, H. A., Eisenbarth, G. S., & Rewers, M. (2005) · Pediatric Diabetes · doi:10.1111/j.1399-543x.2005.00117.x · Cited by 45 · see citing works
Immunoglobulin G Insulin Autoantibodies in BABYDIAB Offspring Appear Postnatally: Sensitive Early Detection Using a Protein A/G-Based Radiobinding Assay 1
Naserke, H. E., Bonifacio, E. E., & Ziegler, A. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.4.5597 · Cited by 45 · see citing works
Self-citation
Maternal type 1 diabetes reduces the risk of islet autoantibodies: relationships with birthweight and maternal HbA1c
Bonifacio, E. E., Pflüger, M., Marienfeld, S., Winkler, C., Hummel, M., & Ziegler, A. (2008) · Diabetologia · doi:10.1007/s00125-008-1022-z · Cited by 44 · see citing works
Self-citation
Transient Antiislet Autoantibodies: Infrequent Occurrence and Lack of Association with "Genetic" Risk Factors
Yu, J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.7.2421 · Cited by 43 · see citing works
Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients
Turunen, J. A., Wessman, M., Forsblom, C. M., Kilpikari, R., Parkkonen, M., Pöntynen, N., Ilmarinen, T., Ulmanen, I., Peltonen, L., & Groop, P. (2006) · Immunogenetics · doi:10.1007/s00251-006-0088-3 · Cited by 43 · see citing works
The CD4+ regulatory T-cells is decreased in adults with latent autoimmune diabetes
Yang, Z., Zhou, Z., Huang, G., He, L., Yan, X., Peng, J., & Li, X. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.08.013 · Cited by 41 · see citing works
Validated protocol for FoxP3 reveals increased expression in type 1 diabetes patients
Grant, J., Bourcier, K., Wallace, S., Pan, D., Conway, A. N., Seyfert‐Margolis, V., & Wallace, P. K. (2008) · Cytometry Part B Clinical Cytometry · doi:10.1002/cyto.b.20446 · Cited by 36 · see citing works
Switch from a dominant Th1‐associated immune profile during the pre‐diabetic phase in favour of a temporary increase of a Th3‐associated and inflammatory immune profile at the onset of type 1 diabetes
Ryden, A., Štechová, K., Durilová, M., & Faresjö, M. (2009) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.958 · Cited by 30 · see citing works
Immunoglobulin G Insulin Autoantibodies in BABYDIAB Offspring Appear Postnatally: Sensitive Early Detection Using a Protein A/G-Based Radiobinding Assay
Naserke, H. E. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.4.1239 · Cited by 30 · see citing works
APC dysfunction is correlated with defective suppression of T cell proliferation in human type 1 diabetes
Jin, Y., Chen, X., Podolsky, R. H., Hopkins, D., Makala, L., Muir, A., & She, J. (2008) · Clinical Immunology · doi:10.1016/j.clim.2008.10.005 · Cited by 27 · see citing works
Changes in autoreactive T cell avidity during type 1 diabetes development
Standifer, N. E., Burwell, E. A., Gersuk, V. H., Greenbaum, C. J., & Nepom, G. T. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.04.013 · Cited by 27 · see citing works
Self-citation
CD 127 − and FoxP3 + Expression on CD25 + CD4 + T Regulatory Cells upon Specific Diabetogeneic Stimulation in High‐risk Relatives of Type 1 Diabetes Mellitus Patients
Vrabelová, Z., Hroteková, Z., Hladíková, Z., Böhmová, K., Štechová, K., & Michálek, J. (2008) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2008.02074.x · Cited by 25 · see citing works
Lower percentages of T regulatory cells in children with type 1 diabetes - preliminary report.
Łuczyński, W., Stasiak‐Barmuta, A., Urban, R., Urban, M., Florys, B., & Hryszko, M. (2009) · PubMed · Cited by 25 · see citing works
Circulating CD4+CD25high Regulatory T Cells and Natural Killer T Cells in Children with Newly Diagnosed Type 1 Diabetes or with Diabetes‐Associated Autoantibodies
Öling, V., Marttila, J., Knip, M., Simell, O., & Ilonen, J. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1381.038 · Cited by 20 · see citing works
Gene expression profiling of human pancreatic islets undergoing a simulated process of instant blood-mediated inflammatory reaction.
Jackson, A., McWilliams, C., Kaizer, E., Chaussabel, D., Glaser, C., Noguchi, H., Matsumoto, S., Levy, M., & Naziruddin, B. (2008) · Transplantation Proceedings · doi:10.1016/j.transproceed.2008.01.021 · Cited by 15 · see citing works
Expression Profiling of Human Genetic and Protein Interaction Networks in Type 1 Diabetes
Bergholdt, R., Brorsson, C., Lage, K., Nielsen, J. H., Brunak, S., & Pociot, F. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006250 · Cited by 14 · see citing works
Higher FoxP3 mRNA expression in peripheral blood mononuclear cells of GAD65 or IA‐2 autoantibody‐positive compared with autoantibody‐negative persons
Link, M., Salur, L., Kisand, K. E., Tillmann, V., & Uibo, R. (2008) · Apmis · doi:10.1111/j.1600-0463.2008.00889.x · Cited by 8 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Long SA Walker MR Rieck M James E Kwok WW Sanda S Pihoker C Greenbaum C Nepom GT Buckner JH Functional islet-specific Treg can be generated from CD4+ Eur. J. Immunol 2009b 39 612 620 19180473 PMC2743096

Sorted by citations

Type 1 diabetes
Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,713 · see citing works
Diabetes mellitus: The epidemic of the century
Kharroubi, A. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i6.850 · Cited by 1,270 · see citing works
Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective
Zaccardi, F., Webb, D. R., Yates, T. E., & Davies, M. J. (2015) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2015-133281 · Cited by 571 · see citing works
Gut microbiota, obesity and diabetes
Patterson, E., Ryan, P. M., Cryan, J. F., Dinan, T. G., Ross, R. P., Fitzgerald, G. F., & Stanton, C. (2016) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2015-133285 · Cited by 552 · see citing works
Is autoimmunity the Achilles' heel of cancer immunotherapy?
June, C. H., Warshauer, J. T., & Bluestone, J. A. (2017) · Nature Medicine · doi:10.1038/nm.4321 · Cited by 445 · see citing works
Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology
Rossin, E. J., Lage, K., Raychaudhuri, S., Xavier, R. J., Tatar, D., Benita, Y., Constortium, I. I. B. D. G., Cotsapas, C., & Daly, M. J. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001273 · Cited by 438 · see citing works
Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial
Wherrett, D. K., Bundy, B., Becker, D. J., DiMeglio, L. A., Gitelman, S. E., Goland, R., Gottlieb, P. A., Greenbaum, C. J., Herold, K. C., Marks, J. B., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60895-7 · Cited by 371 · see citing works
Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes
Battaglia, M., Ahmed, S., Anderson, M. S., Atkinson, M. A., Becker, D., Bingley, P. J., Bosi, E., Brusko, T. M., DiMeglio, L. A., Evans-Molina, C., et al. (2020) · Diabetes Care · doi:10.2337/dc19-0880 · Cited by 351 · see citing works
Restoration of the Unfolded Protein Response in Pancreatic β Cells Protects Mice Against Type 1 Diabetes
Engin, F., Yermalovich, A. V., Nguyen, T., Hummasti, S., Fu, W., Eizirik, D. L., Mathis, D. J., & Hotamışlıgil, G. S. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006534 · Cited by 321 · see citing works
The Pathogenesis and Natural History of Type 1 DiabetesPreprint
Atkinson, M. A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007641 · Cited by 318 · see citing works
Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders
Song, Y., Li, J., & Wu, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01952-8 · Cited by 301 · see citing works
Inflammasomes and autoimmunity
Shaw, P. J., McDermott, M., & Kanneganti, T. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.11.001 · Cited by 233 · see citing works
Gut microbiome in type 1 diabetes: A comprehensive review
Zheng, P., Li, Z., & Zhou, Z. (2018) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3043 · Cited by 229 · see citing works
Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer
von Boehmer, H., & Daniel, C. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3683 · Cited by 221 · see citing works
Primary Dietary Intervention Study to Reduce the Risk of Islet Autoimmunity in Children at Increased Risk for Type 1 Diabetes
Hummel, S., Pflüger, M., Hummel, M., Bonifacio, E. E., & Ziegler, A. (2011) · Diabetes Care · doi:10.2337/dc10-2456 · Cited by 217 · see citing works
Self-citation
Patterns of β-Cell Autoantibody Appearance and Genetic Associations During the First Years of Life
Ilonen, J., Hammais, A., Laine, A., Lempainen, J., Vaarala, O., Veijola, R., Simell, O., & Knip, M. (2013) · Diabetes · doi:10.2337/db13-0300 · Cited by 206 · see citing works
Effects of High-Dose Oral Insulin on Immune Responses in Children at High Risk for Type 1 Diabetes
Bonifacio, E. E., Ziegler, A., KLINGENSMITH, G. J., Schober, E., Bingley, P. J., Rottenkolber, M., Theil, A., Eugster, A., Puff, R., Peplow, C., et al. (2015) · JAMA · doi:10.1001/jama.2015.2928 · Cited by 198 · see citing works
Self-citation
Predicting Type 1 Diabetes Using Biomarkers
Bonifacio, E. E. (2015) · Diabetes Care · doi:10.2337/dc15-0101 · Cited by 191 · see citing works
Circulating miR-375 as a Biomarker of β-Cell Death and Diabetes in Mice
Erener, S., Mojibian, M., Fox, J. K., Denroche, H. C., & Kieffer, T. J. (2013) · Endocrinology · doi:10.1210/en.2012-1744 · Cited by 180 · see citing works
Compromised Gut Microbiota Networks in Children With Anti-Islet Cell Autoimmunity
Endesfelder, D., zu Castell, W., Ardissone, A. N., Davis‐Richardson, A. G., Achenbach, P., Hagen, M., Pflueger, M., Gano, K. A., Fagen, J. R., Drew, J. C., et al. (2014) · Diabetes · doi:10.2337/db13-1676 · Cited by 174 · see citing works
Self-citation
Gene-environment interactions in chronic inflammatory disease
Renz, H., von Mutius, E., Brandtzaeg, P., Cookson, W., Autenrieth, I., & Haller, D. (2011) · Nature Immunology · doi:10.1038/ni0411-273 · Cited by 170 · see citing works
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression
Wiedeman, A. E., Muir, V. S., Rosasco, M. G., DeBerg, H. A., Presnell, S., Haas, B., Dufort, M. J., Speake, C., Greenbaum, C. J., Serti, E., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126595 · Cited by 168 · see citing works
Self-citation
Latent autoimmune diabetes of the adult: current knowledge and uncertainty
Laugesen, E., Østergaard, J. A., & Leslie, R. D. (2015) · Diabetic Medicine · doi:10.1111/dme.12700 · Cited by 168 · see citing works
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
Ramos-Rodríguez, M., Raurell‐Vila, H., Colli, M. L., Alvelos, M. I., Subirana-Granés, M., Juan‐Mateu, J., Norris, R., Turatsinze, J., Nakayasu, E. S., Webb‐Robertson, B., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0524-6 · Cited by 155 · see citing works
Neurological Syndromes Associated with Anti-GAD Antibodies
Dade, M., Berzero, G., Izquierdo, C., Giry, M., Benazra, M., Delattre, J., Psimaras, D., & Alentorn, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103701 · Cited by 158 · see citing works
Feature ranking of type 1 diabetes susceptibility genes improves prediction of type 1 diabetes
Winkler, C., Krumsiek, J., Buettner, F., Angermueller, C., Giannopoulou, E. Z., Theis, F. J., Ziegler, A., & Bonifacio, E. E. (2014) · Diabetologia · doi:10.1007/s00125-014-3362-1 · Cited by 136 · see citing works
Self-citation
The Influence of the Microbiome on Type 1 Diabetes
Paun, A., Yau, C., & Danska, J. S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601519 · Cited by 125 · see citing works
Type 2 diabetes mellitus—an autoimmune disease?
Velloso, L. A., Eizirik, D. L., & Cnop, M. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.131 · Cited by 124 · see citing works
Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
Serr, I., Fürst, R. W., Achenbach, P., Scherm, M. G., Gökmen, F., Haupt, F., Sedlmeier, E., Knopff, A., Shultz, L. D., Willis, R. A., et al. (2016) · Nature Communications · doi:10.1038/ncomms10991 · Cited by 124 · see citing works
Self-citation
Effect of Associated Autoimmune Diseases on Type 1 Diabetes Mellitus Incidence and Metabolic Control in Children and Adolescents
Krzewska, A., & Beń‐Skowronek, I. (2016) · BioMed Research International · doi:10.1155/2016/6219730 · Cited by 124 · see citing works
Markedly reduced rate of diabetic ketoacidosis at onset of type 1 diabetes in relatives screened for islet autoantibodies
Winkler, C., Schober, E., Ziegler, A., & Holl, R. W. (2011) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2011.00829.x · Cited by 122 · see citing works
Self-citation
Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading
Prasad, S., Kohm, A. P., McMahon, J. S., Luo, X., & Miller, S. D. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.04.005 · Cited by 113 · see citing works
Prediction and Prevention of Type 1 Diabetes
Primavera, M., Giannini, C., & Chiarelli, F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00248 · Cited by 117 · see citing works
Age- and Islet Autoimmunity–Associated Differences in Amino Acid and Lipid Metabolites in Children at Risk for Type 1 Diabetes
Pflueger, M., Seppänen-Laakso, T., Suortti, T., Hyötyläinen, T., Achenbach, P., Bonifacio, E., Orešič, M., & Ziegler, A.-G. (2011) · Diabetes · doi:10.2337/db10-1652 · Cited by 112 · see citing works
Self-citation
Stopping Type 1 Diabetes: Attempts to Prevent or Cure Type 1 Diabetes in Man
Skyler, J., & Ricordi, C. (2011) · Diabetes · doi:10.2337/db10-1114 · Cited by 112 · see citing works
Genetic risk analysis of a patient with fulminant autoimmune type 1 diabetes mellitus secondary to combination ipilimumab and nivolumab immunotherapy
Lowe, J. R., Perry, D. J., Salama, A. K. S., Mathews, C. E., Moss, L. G., & Hanks, B. A. (2016) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-016-0196-z · Cited by 110 · see citing works
Glycemic Control, Cardiac Autoimmunity, and Long-Term Risk of Cardiovascular Disease in Type 1 Diabetes Mellitus: A DCCT/EDIC Cohort–Based Study
Sousa, G. R., Pober, D., Galderisi, A., Lv, H., Yu, L., Pereira, A. C., Doria, A., Kosiborod, M., & Lipes, M. A. (2019) · Circulation · doi:10.1161/circulationaha.118.036068 · Cited by 117 · see citing works
Cesarean Section and Interferon-Induced Helicase Gene Polymorphisms Combine to Increase Childhood Type 1 Diabetes Risk
Bonifacio, E. E., Warncke, K., Winkler, C., Wallner, M., & Ziegler, A. (2011) · Diabetes · doi:10.2337/db11-0729 · Cited by 100 · see citing works
Self-citation
Role of immune system in type 1 diabetes mellitus pathogenesis
Szablewski, L. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.06.033 · Cited by 98 · see citing works
Hyaluronan in immune dysregulation and autoimmune diseases
Nagy, N., Kuipers, H. F., Marshall, P. L., Wang, E., Kaber, G., & Bollyky, P. L. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.022 · Cited by 91 · see citing works
Oral insulin therapy for primary prevention of type 1 diabetes in infants with high genetic risk: the GPPAD-POInT (global platform for the prevention of autoimmune diabetes primary oral insulin trial) study protocol
Ziegler, A., Achenbach, P., Berner, R., Casteels, K., Danne, T., Gündert, M., Hasford, J., Hoffmann, V. S., Kordonouri, O., Lange, K., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-028578 · Cited by 90 · see citing works
Self-citation
The Immunogenetic Architecture of Autoimmune DiseasePreprint
Goris, A., & Liston, A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007260 · Cited by 90 · see citing works
Islet autoantibody phenotypes and incidence in children at increased risk for type 1 diabetes
Giannopoulou, E. Z., Winkler, C., Chmiel, R., Matzke, C., Scholz, M., Beyerlein, A., Achenbach, P., Bonifacio, E. E., & Ziegler, A. (2015) · Diabetologia · doi:10.1007/s00125-015-3672-y · Cited by 87 · see citing works
Self-citation
Nutrigenetics and Nutrigenomics Insights into Diabetes Etiopathogenesis
Berná, G., Oliveras‐López, M., Jurado‐Ruiz, E., Tejedo, J. R., Bedoya, F. J., Soria, B., & Martı́n, F. (2014) · Nutrients · doi:10.3390/nu6115338 · Cited by 91 · see citing works
Targeting type II diabetes with plant terpenes: the new and promising antidiabetic therapeutics
Panigrahy, S. K., Bhatt, R., & Kumar, A. (2020) · Biologia · doi:10.2478/s11756-020-00575-y · Cited by 86 · see citing works
The Long and Winding Road to Understanding and Conquering Type 1 Diabetes
Santamaría, P. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.003 · Cited by 86 · see citing works
Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis
Nagy, N., Kaber, G., Johnson, P. Y., Gebe, J. A., Preisinger, A., Falk, B. A., Sunkari, V. G., Gooden, M. D., Vernon, R. B., Bogdani, M., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79271 · Cited by 83 · see citing works
Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children
Ziegler, A., Pflueger, M., Winkler, C., Achenbach, P., Akolkar, B., Krischer, J. P., & Bonifacio, E. E. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.02.004 · Cited by 81 · see citing works
Self-citation
Beyond genetics. Influence of dietary factors and gut microbiota on type 1 diabetes
Nielsen, D. S., Krych, Ł., Buschard, K., Hansen, C. H. F., & Hansen, A. K. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.04.010 · Cited by 76 · see citing works
T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives
Mallone, R., Brezar, V., & Boîtard, C. (2011) · Clinical and Developmental Immunology · doi:10.1155/2011/513210 · Cited by 76 · see citing works
Serum biomarkers for diagnosis and prediction of type 1 diabetes
Yi, L., Swensen, A., & Qian, W. (2018) · Translational research · doi:10.1016/j.trsl.2018.07.009 · Cited by 74 · see citing works
Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells
Marroquí, L., Lopes, M., dos Santos, R. S., Grieco, F. A., Roivainen, M., Richardson, S. J., Morgan, N. G., Beeck, A. O. D., & Eizirik, D. L. (2015) · eLife · doi:10.7554/elife.06990 · Cited by 70 · see citing works
Harmonization of immunoassays for biomarkers in diabetes mellitus
Hörber, S., Achenbach, P., Schleicher, E. D., & Peter, A. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.02.015 · Cited by 71 · see citing works
Efficacy of GAD-alum immunotherapy associated with HLA-DR3-DQ2 in recently diagnosed type 1 diabetes
Hannelius, U., Beam, C. A., & Ludvigsson, J. (2020) · Diabetologia · doi:10.1007/s00125-020-05227-z · Cited by 68 · see citing works
Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetes
Levy, H., Wang, X., Kaldunski, M. L., Jia, S., Kramer, J., Pavletich, S. J., Reske, M., Gessel, T., Yassai, M. B., Quasney, M. W., et al. (2012) · Genes and Immunity · doi:10.1038/gene.2012.41 · Cited by 69 · see citing works
An Interferon-Induced Helicase (<i>IFIH1</i>) Gene Polymorphism Associates With Different Rates of Progression From Autoimmunity to Type 1 Diabetes
Winkler, C., Lauber, C., Adler, K., Grallert, H., Illig, T., Ziegler, A.-G., & Bonifacio, E. (2011) · Diabetes · doi:10.2337/db10-1269 · Cited by 68 · see citing works
Self-citation
Primary prevention of beta-cell autoimmunity and type 1 diabetes – The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) perspectives
Ziegler, A., Danne, T., Dunger, D. B., Berner, R., Puff, R., Kiess, W., Agiostratidou, G., Todd, J. A., & Bonifacio, E. E. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.02.003 · Cited by 67 · see citing works
Self-citation
Autoimmune responses and inflammation in type 2 diabetes
Prasad, M., Chen, E. W., Toh, S.-A. E. S., & Gascoigne, N. R. J. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0220-243r · Cited by 65 · see citing works
Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease
Paramel, G. V., Sirsjö, A., & Fransén, K. (2015) · Mediators of Inflammation · doi:10.1155/2015/846782 · Cited by 66 · see citing works
A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes
Serr, I., Scherm, M. G., Zahm, A. M., Schug, J., Flynn, V. K., Hippich, M., Kälin, S., Becker, M., Achenbach, P., Nikolaev, A., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aag1782 · Cited by 63 · see citing works
Self-citation
Rising incidence of type 1 diabetes is associated with altered immunophenotype at diagnosis
Long, A. E., Gillespie, K. M., Rokni, S., Bingley, P. J., & Williams, A. J. K. (2012) · Diabetes · doi:10.2337/db11-0962 · Cited by 60 · see citing works
Identification of infants with increased type 1 diabetes genetic risk for enrollment into Primary Prevention Trials—GPPAD‐02 study design and first results
Winkler, C., Haupt, F., Heigermoser, M., Zapardiel‐Gonzalo, J., Ohli, J., Faure, T., Kalideri, E., Hommel, A., Delivani, P., Berner, R., et al. (2019) · Pediatric Diabetes · doi:10.1111/pedi.12870 · Cited by 63 · see citing works
Self-citation
Hyaluronan content governs tissue stiffness in pancreatic islet inflammation
Nagy, N., de la Zerda, A., Kaber, G., Johnson, P. Y., Hu, K. H., Kratochvil, M. J., Yadava, K., Zhao, W., Cui, Y., Navarro, G., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000148 · Cited by 60 · see citing works
MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research
Juan‐Mateu, J., Villate, O., & Eizirik, D. L. (2016) · European Journal of Endocrinology · doi:10.1530/eje-15-0916 · Cited by 58 · see citing works
Glycotoxin and Autoantibodies Are Additive Environmentally Determined Predictors of Type 1 Diabetes
Beyan, H., Riese, H., Hawa, M. I., Beretta, G., Davidson, H. W., Hutton, J. C., Burger, H., Schlosser, M., Snieder, H., Boehm, B. O., et al. (2012) · Diabetes · doi:10.2337/db11-0971 · Cited by 60 · see citing works
miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity
Serr, I., Fürst, R. W., Ott, V. B., Scherm, M. G., Nikolaev, A., Gökmen, F., Kälin, S., Zillmer, S., Bunk, M., Weigmann, B., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606646113 · Cited by 58 · see citing works
Self-citation
Birth and coming of age of islet autoantibodies
Bonifacio, E. E., & Achenbach, P. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13360 · Cited by 58 · see citing works
Potential viral pathogenic mechanism in human type 1 diabetes
Schneider, D., & von Herrath, M. G. (2014) · Diabetologia · doi:10.1007/s00125-014-3340-7 · Cited by 57 · see citing works
Infection as a cause of type 1 diabetes?
Christen, U., Bender, C., & von Herrath, M. G. (2012) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e3283533719 · Cited by 56 · see citing works
The Non-Obese Diabetic (NOD) Mouse as a Model of Human Type 1 Diabetes
Kachapati, K., Adams, D., Bednar, K., & Ridgway, W. M. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-62703-068-7_1 · Cited by 54 · see citing works
It’s Time to Bring Dendritic Cell Therapy to Type 1 Diabetes
Creusot, R. J., Giannoukakis, N., Trucco, M., Clare-Salzler, M. J., & Fathman, C. G. (2013) · Diabetes · doi:10.2337/db13-0886 · Cited by 51 · see citing works
Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes
Bagge, S. L., Fotheringham, A. K., Leung, S. S., & Forbes, J. M. (2020) · Medicinal Research Reviews · doi:10.1002/med.21654 · Cited by 51 · see citing works
Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance
Miani, M., Barthson, J., Colli, M. L., Brozzi, F., Cnop, M., & Eizirik, D. L. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.236 · Cited by 50 · see citing works
Predicting progression to type 1 diabetes from ages 3 to 6 in islet autoantibody positive TEDDY children
Jacobsen, L. M., Larsson, H. E., Tamura, R. N., Vehik, K., Clasen, J., Sosenko, J., Hagopian, W. A., She, J., Steck, A. K., Rewers, M., et al. (2019) · Pediatric Diabetes · doi:10.1111/pedi.12812 · Cited by 48 · see citing works
Self-citation
The case for an autoimmune aetiology of type 1 diabetes
Mannering, S. I., Pathiraja, V., & Kay, T. W. H. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12699 · Cited by 49 · see citing works
Discovery of Molecular Pathways Mediating 1,25-Dihydroxyvitamin D3 Protection Against Cytokine-Induced Inflammation and Damage of Human and Male Mouse Islets of Langerhans
Wolden-Kirk, H., Rondas, D., Bugliani, M., Korf, H., Lommel, L. V., Brusgaard, K., Christesen, H. T., Schuit, F. C., Proost, P., Masini, M., et al. (2014) · Endocrinology · doi:10.1210/en.2013-1409 · Cited by 48 · see citing works
Transcriptional networks in at-risk individuals identify signatures of type 1 diabetes progression
Xhonneux, L.-P., Knight, O., Lernmark, Å., Bonifacio, E. E., Hagopian, W., Rewers, M., She, J., Toppari, J., Parikh, H. M., Smith, K. G. C., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd5666 · Cited by 47 · see citing works
Self-citation
Protection against or triggering of Type 1 diabetes? Different roles for viral infections
Boettler, T., & von Herrath, M. (2010) · Expert Review of Clinical Immunology · doi:10.1586/eci.10.91 · Cited by 48 · see citing works
Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families
Hippich, M., Beyerlein, A., Hagopian, W., Krischer, J. P., Vehik, K., Knoop, J., Winker, C., Toppari, J., Lernmark, Å., Rewers, M., et al. (2019) · Diabetes · doi:10.2337/db18-0882 · Cited by 48 · see citing works
Self-citation
Can 14-3-3 proteins serve as therapeutic targets for the treatment of metabolic diseases?
Diallo, K., Oppong, A. K., & Lim, G. E. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.021 · Cited by 46 · see citing works
Deletion of 12/15-Lipoxygenase Alters Macrophage and Islet Function in NOD-Alox15null Mice, Leading to Protection against Type 1 Diabetes Development
Green-Mitchell, S. M., Tersey, S. A., Cole, B. K., Ma, K., Kuhn, N. S., Cunningham, T. D., Maybee, N. A., Chakrabarti, S. K., MCDUFFIE, M. J., Taylor, D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056763 · Cited by 44 · see citing works
Pancreatic islet autoimmunity
Boîtard, C. (2012) · La Presse Médicale · doi:10.1016/j.lpm.2012.10.003 · Cited by 44 · see citing works
Differential effect of DJ-1/PARK7 on development of natural and induced regulatory T cells
Singh, Y., Chen, H., Zhou, Y., Föller, M., Mak, T. W., Salker, M. S., & Lang, F. J. W. (2015) · Scientific Reports · doi:10.1038/srep17723 · Cited by 44 · see citing works
Incomplete immune response to coxsackie B viruses associates with early autoimmunity against insulin
Ashton, M. P., Eugster, A., Walther, D., Daehling, N., Riethausen, S., Kuehn, D., Klingel, K., Beyerlein, A., Zillmer, S., Ziegler, A., et al. (2016) · Scientific Reports · doi:10.1038/srep32899 · Cited by 43 · see citing works
Self-citation
Challenges in diagnosis and management of diabetes in the young
Unnikrishnan, R., Shah, V. N., & Mohan, V. (2016) · Clinical Diabetes and Endocrinology · doi:10.1186/s40842-016-0036-6 · Cited by 47 · see citing works
Immunology of β-Cell Destruction
Torre, D. L., & Lernmark, Å. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-90-481-3271-3_24 · Cited by 42 · see citing works
Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes
the TEDDY study group, Lee, H.-S., Briese, T., Winkler, C., Rewers, M., Bonifacio, E. E., Hyöty, H., Pflueger, M., Simell, O., She, J., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2924-y · Cited by 42 · see citing works
Self-citation
A novel approach for the analysis of longitudinal profiles reveals delayed progression to type 1 diabetes in a subgroup of multiple-islet-autoantibody-positive children
Endesfelder, D., Hagen, M., Winkler, C., Haupt, F., Zillmer, S., Knopff, A., Bonifacio, E., Ziegler, A., zu Castell, W., & Achenbach, P. (2016) · Diabetologia · doi:10.1007/s00125-016-4050-0 · Cited by 34 · see citing works
Self-citation
Prevention or acceleration of type 1 diabetes by viruses
Ghazarian, L., Diana, J., Simoni, Y., Beaudoin, L., & Lehuen, A. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1042-1 · Cited by 40 · see citing works
Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study
Beyerlein, A., Bonifacio, E. E., Vehik, K., Hippich, M., Winkler, C., Frohnert, B. I., Steck, A. K., Hagopian, W., Krischer, J. P., Lernmark, Å., et al. (2018) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2018-105532 · Cited by 40 · see citing works
Self-citation
Reversal of Diabetes in Mice with a Bioengineered Islet Implant Incorporating a Type I Collagen Hydrogel and Sustained Release of Vascular Endothelial Growth Factor
Vernon, R. B., Preisinger, A., Gooden, M. D., D’Amico, L., Yue, B. B., Bollyky, P. L., Kuhr, C. S., Hefty, T. R., Nepom, G. T., & Gebe, J. A. (2012) · Cell Transplantation · doi:10.3727/096368912x636786 · Cited by 38 · see citing works
Self-citation
Use of the Electronic Medical Record to Assess Pancreas Size in Type 1 Diabetes
Virostko, J. M., Hilmes, M. A., Eitel, K. B., Moore, D. J., & Powers, A. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158825 · Cited by 38 · see citing works
Type 1 Diabetes Mellitus
Eisenbarth, G. S., & Buse, J. B. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00032-8 · Cited by 39 · see citing works
SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood
Lugar, M., Eugster, A., Achenbach, P., Berge, T. V. D., Berner, R., Besser, R. E. J., Casteels, K., Larsson, H. E., Gemulla, G., Kordonouri, O., et al. (2023) · JAMA · doi:10.1001/jama.2023.16348 · Cited by 38 · see citing works
Self-citation
Metabolomics in childhood diabetes
Frohnert, B. I., & Rewers, M. (2015) · Pediatric Diabetes · doi:10.1111/pedi.12323 · Cited by 37 · see citing works
Prospective evaluation of risk factors for the development of islet autoimmunity and type 1 diabetes during puberty - TEENDIAB: study design
Ziegler, A., Meier-Stiegen, F., Winkler, C., Bonifacio, E. E., & the TEENDIAB Study Group (2011) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2011.00763.x · Cited by 36 · see citing works
Self-citation
Gene-environment interaction in chronic disease: A European Science Foundation Forward Look
Renz, H., Autenrieth, I. B., Brandtzæg, P., Cookson, W., Holgate, S. T., von Mutius, E., Valenta, R., & Haller, D. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.09.039 · Cited by 35 · see citing works
Harnessing CXCL12 signaling to protect and preserve functional β-cell mass and for cell replacement in type 1 diabetes
Alagpulinsa, D. A., Cao, J. J. L., Sobell, D., & Poznansky, M. C. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.08.011 · Cited by 33 · see citing works
The Emerging Jamboree of Transformative Therapies for Autoimmune Diseases
Carballido, J. M., Regairaz, C., Rauld, C., Raad, L., Picard, D., & Kammuller, M. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00472 · Cited by 34 · see citing works
Challenges in the diagnosis of diabetes type in pediatrics
Siller, A. F., Tosur, M., Relan, S., Astudillo, M., McKay, S. V., Dabelea, D., & REDONDO, M. J. (2020) · Pediatric Diabetes · doi:10.1111/pedi.13070 · Cited by 33 · see citing works

Advances in the Prediction and Natural History of Type 1 Diabetes
Bonifacio, E., & Ziegler, A. G. (2010) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2010.05.007 · Cited by 61 · see citing works
Self-citation
Prediction of Autoimmune Disease
Eisenbarth, G. S., Barker, J. M., & Gianani, R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-384929-8.00078-2 · Cited by 4 · see citing works
How Do We Screen for and Predict Autoimmune Diabetes?
Achenbach, P., Bonifacio, E. E., & Bingley, P. J. (2008) · CRC Press eBooks · doi:10.3109/9781420047363-8
Predicting type 1 diabetes
Achenbach, P., Bonifacio, E. E., & Ziegler, A. (2005) · Current Diabetes Reports · doi:10.1007/s11892-005-0035-y · Cited by 60 · see citing works
Self-citation
Established and emerging biomarkers for the prediction of type 1 diabetes: a systematic review
Watkins, R. A., Evans‐Molina, C., Blum, J. S., & DiMeglio, L. A. (2014) · Translational research · doi:10.1016/j.trsl.2014.02.004 · Cited by 85 · see citing works

Authors: Ziegler, A.-G., & Nepom, G. T.
Affiliations: TUM Klinikum (DE)
Benaroya Research Institute (US)
Corresponding author: Ziegler, Anette-G.
Nepom, Gerald T.
ORCID: Ziegler, Anette-G.
Nepom, Gerald T.
Venue: Immunity
Publisher: Elsevier BV
Published: 2010-04
Volume: 32
Issue: 4
Pages: 468-478
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2010.03.018
PMC: PMC2861716
OpenAlex: W2047768051
Cited by: 346
References: 101
Citations by year: 2026: 5 · 2025: 21 · 2024: 20 · 2023: 12 · 2022: 15 · 2021: 25 · 2020: 18 · 2019: 19 · 2018: 26 · 2017: 10 · 2016: 26 · 2015: 30 · 2014: 28 · 2013: 29 · 2012: 25
FWCI: 3.08
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1239 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Site cant be reached (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Bundesministerium für Bildung und Forschung
National Institutes of Health
Juvenile Diabetes Research Foundation International
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: type 1 diabetes, autoimmune diabetes, disease prediction, pathogenesis, genetic susceptibility, immune response, biomarkers, immune checkpoint, immune regulation, islet autoimmunity, disease risk assessment, preclinical stage, immune homeostasis
MeSH terms: Animals, Diabetes Mellitus, Type 1, Humans, Risk Factors, Genetic Variation, Biomarkers, Genetic Predisposition to Disease

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Prediction and Pathogenesis in Type 1 Diabetes

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks