Early diagnosis and targeted treatment strategy for improved therapeutic outcomes in Alzheimer’s disease
Abstract
There have been repeated failures of clinical studies in the development of new efficacious treatments for Alzheimer's disease. This may be due to the fact that Alzheimer's disease is a heterogeneous disorder caused by person-to-person differences in genetic background, epigenetic profiles, environmental triggers, or the presence of other diseases. Furthermore, most Alzheimer's disease patients are diagnosed in the middle to late stages of the illness, when irreversible damage to the brain has already occurred. With this in mind, a strategy is presented involving identification and implementation of biomarker tests for diagnosis during the prodromal or early stages of the disease. In addition, it is proposed that targeting specific components of the amyloid deposition, tau oligomerization and neuroinflammation pathways may lead to improved outcomes in clinical studies.
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5XFAD mice at 8 months of age, at which point significant neuronal loss occurs, were used.
“To investigate whether TN-PTBP1 could regenerate neurons in AD mice and improve their memory and cognitive skills, 5XFAD mice at 8 months of age, at which point significant neuronal loss occurs, were used.36,37”
From Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration (2026) · cites this paper as [37]
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Liu, H.-J., Wang, M., Wang, Y., Shi, S., Hu, X., Zhang, D.-B., Fan, D., Mintzer, J., & Xu, P. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100158 · Cited by 13 · see citing works
Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration
Wang, M., VanderVeen, B., Xu, Z. A., Xu, Y., Mintzer, J., Murphy, A., Zhang, Q., & Xu, P. (2026) · Cell Biomaterials · doi:10.1016/j.celbio.2026.100575
- Authors
- Guest, F. L., Rahmoune, H., & Guest, P. C.
- Affiliations
- Musgrove Park Hospital (GB)
- University of Cambridge (GB)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- ORCID
- Guest, Paul C.
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer International Publishing
- Published
- 2020
- Volume
- 1260
- Pages
- 175-191
- ISSN
- 0065-2598 (ISSN-L)
- 2214-8019
- OpenAlex
- W3017303762
- Cited by
- 34
- References
- 13
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 7 · 2020: 1
- FWCI
- 23.05
- Type
- book chapter
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, early diagnosis, prodromal Alzheimer's disease, biomarkers, amyloid deposition, tau oligomerization, neuroinflammation, targeted therapy, disease heterogeneity, treatment failure
- MeSH terms
- Alzheimer Disease, Brain, Humans, Biomarkers, Amyloid beta-Peptides, Treatment Outcome, Early Diagnosis
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