Genes associated with Alzheimer's disease: an overview and current status
Open accessAbstract
Alzheimer's disease (AD) is a progressive, neurodegenerative disease and the most common form of dementia in elderly people. It is an emerging public health problem that poses a huge societal burden. Linkage analysis was the first milestone in unraveling the mutations in APP, PSEN1, and PSEN2 that cause early-onset AD, followed by the discovery of apolipoprotein E-ε4 allele as the only one genetic risk factor for late-onset AD. Genome-wide association studies have revolutionized genetic research and have identified over 20 genetic loci associated with late-onset AD. Recently, next-generation sequencing technologies have enabled the identification of rare disease variants, including unmasking small mutations with intermediate risk of AD in PLD3, TREM2, UNC5C, AKAP9, and ADAM10. This review provides an overview of the genetic basis of AD and the relationship between these risk genes and the neuropathologic features of AD. An understanding of genetic mechanisms underlying AD pathogenesis and the potentially implicated pathways will lead to the development of novel treatment for this devastating disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
It takes 10-20 years for AD to manifest itself.
“It takes 10–20 years for AD to manifest itself (e.g., [5, 69]).”
From Current therapeutics for Alzheimer’s disease and clinical trials (2024) · cites this paper as [5]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659 · see citing works
Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336 · see citing works
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786 · see citing works
Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326 · see citing works
Blennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134 · see citing works
<i>TREM2</i> Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020 · see citing works
Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease
Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558 · see citing works
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
the European Alzheimer's Disease Initiative Investigators, Lambert, J.-C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., Combarros, O., Zelenika, D., Bullido, M. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.439 · Cited by 2,234 · see citing works
Initiative, T. A. D. N., Hollingworth, P., CHARGE consortium, EADI1 consortium, Harold, D., Sims, R., Gerrish, A., Lambert, J.-C., Carrasquillo, M. M., Abraham, R., et al. (2011) · Nature Genetics · doi:10.1038/ng.803 · Cited by 1,997 · see citing works
Naj, A. C., Jun, G., Beecham, G. W., Wang, L.-S., Vardarajan, B. N., Buros, J., Gallins, P. J., Buxbaum, J. D., Jarvik, G. P., Crane, P. K., et al. (2011) · Nature Genetics · doi:10.1038/ng.801 · Cited by 1,901 · see citing works
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
Tanzi, R. E., & Bertram, L. (2005) · Cell · doi:10.1016/j.cell.2005.02.008 · Cited by 1,849 · see citing works
Role of Genes and Environments for Explaining Alzheimer Disease
Gatz, M., Reynolds, C. A., Fratiglioni, L., Johansson, B., Mortimer, J. A., Berg, S., Fiske, A., & Pedersen, N. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.2.168 · Cited by 1,798 · see citing works
Alzheimer Mechanisms and Therapeutic Strategies
Huang, Y., & Mucke, L. (2012) · Cell · doi:10.1016/j.cell.2012.02.040 · Cited by 1,758 · see citing works
A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
Jonsson, T., Atwal, J. K., Steinberg, S., Snaedal, J., Jonsson, P. V., Bjornsson, S., Stefansson, H., Sulem, P., Gudbjartsson, D., Maloney, J., et al. (2012) · Nature · doi:10.1038/nature11283 · Cited by 1,738 · see citing works
The role of apolipoprotein E in Alzheimer's disease
Kim, J., Basak, J. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.026 · Cited by 1,661 · see citing works
Mullan, M., Crawford, F., Axelman, K., Houlden, H., Lilius, L., Winblad, B., & Lannfelt, L. (1992) · Nature Genetics · doi:10.1038/ng0892-345 · Cited by 1,513 · see citing works
Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance
Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,227 · see citing works
Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease
Seshadri, S. (2010) · JAMA · doi:10.1001/jama.2010.574 · Cited by 1,219 · see citing works
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
Nilsberth, C., Westlind-Danielsson, A., Eckman, C. B., Condron, M. M., Axelman, K., Forsell, C., Stenh, C., Luthman, J., Teplow, D. B., Younkin, S. G., et al. (2001) · Nature Neuroscience · doi:10.1038/nn0901-887 · Cited by 1,209 · see citing works
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
Bu, G. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2620 · Cited by 1,168 · see citing works
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Rogaeva, E., Meng, Y., Lee, J. H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C. T., Cheng, R., Hasegawa, H., et al. (2007) · Nature Genetics · doi:10.1038/ng1943 · Cited by 1,167 · see citing works
Amyloid Precursor Protein Trafficking, Processing, and Function
Thinakaran, G., & Koo, E. H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800019200 · Cited by 1,141 · see citing works
Review Article: Genetics of Alzheimer Disease
Bekris, L. M., Yu, C.-E., Bird, T. D., & Tsuang, D. W. (2010) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988710383571 · Cited by 1,029 · see citing works
Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
Griciuc, A., Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. H., Hyman, B. T., & Tanzi, R. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.014 · Cited by 1,004 · see citing works
Apolipoprotein E in Alzheimer’s disease and other neurological disorders
Verghese, P. B., Castellano, J. M., & Holtzman, D. M. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70325-2 · Cited by 857 · see citing works
Hamza, T. H., Zabetian, C. P., Tenesa, A., Laederach, A., Montimurro, J. S., Yearout, D., Kay, D. M., Doheny, K. F., Paschall, J. E., Pugh, E., et al. (2010) · Nature Genetics · doi:10.1038/ng.642 · Cited by 779 · see citing works
Hendriks, L., van Duijn, C. M., Cras, P. P., Cruts, M., Hul, W. V., van Harskamp, F., Warren, A., McInnis, M. G., Antonarakis, S. E., Martin, J., et al. (1992) · Nature Genetics · doi:10.1038/ng0692-218 · Cited by 735 · see citing works
The genetics of Alzheimer disease
Tanzi, R. E. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006296 · Cited by 727 · see citing works
APOLIPOPROTEIN E ALLELES AS RISK FACTORS IN ALZHEIMER'S DISEASE
Roses, M. D. (1996) · Annual Review of Medicine · doi:10.1146/annurev.med.47.1.387 · Cited by 707 · see citing works
Paloneva, J., Manninen, T., Christman, G., Hovanes, K., Mandelin, J., Adolfsson, R., Bianchin, M., Bird, T., Miranda, R., Salmaggi, A., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342259 · Cited by 683 · see citing works
Andersen, O. M., Reiche, J., Schmidt, V., Gotthardt, M., Spoelgen, R., Behlke, J., von Arnim, C. A. F., Breiderhoff, T., Jansen, P., Wu, X., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503689102 · Cited by 655 · see citing works
Proteolytic processing and cell biological functions of the amyloid precursor protein
Strooper, B. D., & Annaert, W. G. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.11.1857 · Cited by 628 · see citing works
A functional and structural basis for TCR cross-reactivity in multiple sclerosis
Lang, H., Jacobsen, H. J., Ikemizu, S., Andersson, C., Harlos, K., Madsen, L. S., Hjorth, P., Søndergaard, L., Svejgaard, A., Wucherpfennig, K. W., et al. (2002) · Nature Immunology · doi:10.1038/ni835 · Cited by 592 · see citing works
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800069-jlr200 · Cited by 580 · see citing works
CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
Initiative, T. A. D. N., Bradshaw, E. M., Chibnik, L. B., Keenan, B. T., Ottoboni, L., Raj, T., Tang, A., Rosenkrantz, L. L., Imboywa, S., Lee, M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3435 · Cited by 570 · see citing works
Solomon, A., Kivipelto, M., Wolozin, B., Zhou, J., & Whitmer, R. A. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000231980 · Cited by 557 · see citing works
Isoform-specific binding of apolipoprotein E to beta-amyloid.
LaDu, M. J., Falduto, M. T., Manelli, A. M., Reardon, C. A., Getz, G. S., & Frail, D. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31529-6 · Cited by 540 · see citing works
Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease
Morris, G. P., Clark, I. A., & Vissel, B. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0135-5 · Cited by 522 · see citing works
Bertram, L., Lange, C., Mullin, K., Parkinson, M., Hsiao, M., Hogan, M. F., Schjeide, B. M. M., Hooli, B., DiVito, J., Ionita, I., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.10.008 · Cited by 511 · see citing works
Han, J., Kraft, P., Nan, H., Guo, Q., Chen, C., Qureshi, A., Hankinson, S. E., Hu, F. B., Duffy, D. L., Zhao, Z. Z., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000074 · Cited by 499 · see citing works
A Portrait of Alzheimer Secretases--New Features and Familiar Faces
Esler, W. P., & Wolfe, M. S. (2001) · Science · doi:10.1126/science.1064638 · Cited by 493 · see citing works
Apolipoprotein E, Dementia, and Cortical Deposition of β-Amyloid Protein
Polvikoski, T., Sulkava, R., Haltia, M., Kainulainen, K., Vuorio, A., Verkkoniemi, A., Niinistö, L., Halonen, P., & Kontula, K. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511093331902 · Cited by 493 · see citing works
Jones, S. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00155-8 · Cited by 488 · see citing works
Alzheimer’s Disease Genetics: From the Bench to the Clinic
Karch, C. M., Cruchaga, C., & Goate, A. M. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.041 · Cited by 473 · see citing works
What makes a good genetic association study?
Hattersley, A. T., & McCarthy, M. I. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67531-9 · Cited by 465 · see citing works
Locus‐specific mutation databases for neurodegenerative brain diseases
Cruts, M., Theuns, J., & Broeckhoven, C. V. (2012) · Human Mutation · doi:10.1002/humu.22117 · Cited by 462 · see citing works
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease
Cruchaga, C., Karch, C. M., Jin, S. C., Benitez, B. A., Cai, Y., Guerreiro, R., Harari, O., Norton, J., Budde, J., Bertelsen, S., et al. (2014) · Nature · doi:10.1038/nature12825 · Cited by 461 · see citing works
Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts
Paloneva, J., Kestilä, M., Wu, J., Salminen, A., Böhling, T., Ruotsalainen, V., Hakola, P., Bakker, A. B. H., Phillips, J. H., Pekkarinen, P., et al. (2000) · Nature Genetics · doi:10.1038/77153 · Cited by 460 · see citing works
Kuyumcu-Martinez, N. M., Wang, G., & Cooper, T. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.027 · Cited by 445 · see citing works
Reitz, C., Jun, G., Naj, A., Rajbhandary, R., Vardarajan, B. N., Wang, L.-S., Valladares, O., Lin, C.-F., Larson, E. B., Graff-Radford, N. R., et al. (2013) · JAMA · doi:10.1001/jama.2013.2973 · Cited by 431 · see citing works
Clusterin: Physiologic and pathophysiologic considerations
Rosenberg, M. E., & Silkensen, J. R. (1995) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/1357-2725(95)00027-m · Cited by 427 · see citing works
Molecular mapping of alzheimer‐type dementia in Down's syndrome
Prasher, V. P., Farrer, M. J., Kessling, A. M., Fisher, E. M. C., West, R. J., Barber, P. C., & Butler, A. C. (1998) · Annals of Neurology · doi:10.1002/ana.410430316 · Cited by 414 · see citing works
Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms
Bentahir, M., Nyabi, O., Verhamme, J., Tolia, A., Horré, K., Wiltfang, J., Esselmann, H., & Strooper, B. D. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03578.x · Cited by 412 · see citing works
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
Zhao, Z., Sagare, A. P., Ma, Q., Halliday, M. R., Kong, P., Kisler, K., Winkler, E. A., Ramanathan, A., Kanekiyo, T., Bu, G., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4025 · Cited by 410 · see citing works
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
GERAD consortium, Chapuis, J., Hansmannel, F., Gistelinck, M., Mounier, A., Van Cauwenberghe, C., Kolen, K. V., Geller, F., Sottejeau, Y., Harold, D., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.1 · Cited by 407 · see citing works
Rayaprolu, S., Mullen, B., Baker, M., Lynch, T., Finger, E., Seeley, W. W., Hatanpaa, K. J., Lomen-Hoerth, C., Kertesz, A., Bigio, E. H., et al. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-19 · Cited by 404 · see citing works
GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease
Cruchaga, C., Kauwe, J. S. K., Harari, O., Jin, S. C., Cai, Y., Karch, C. M., Benitez, B. A., Jeng, A. T., Skorupa, T., Carrell, D., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.026 · Cited by 383 · see citing works
Treusch, S., Hamamichi, S., Goodman, J. L., Matlack, K. E. S., Chung, C. Y., Baru, V., Shulman, J. M., Parrado, A., Bevis, B. J., Valastyan, J. S., et al. (2011) · Science · doi:10.1126/science.1213210 · Cited by 379 · see citing works
Potkin, S. G., Guffanti, G., Lakatos, A., Turner, J. A., Kruggel, F., Fallon, J. H., Saykin, A. J., Orro, A., Lupoli, S., Salvi, E., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006501 · Cited by 376 · see citing works
Guerreiro, R. J., Lohmann, E., Brás, J. M., Gibbs, J. R., Rohrer, J. D., Gurunlian, N., Dursun, B., Bilgic, B., Hanagasi, H., Gurvit, H., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.579 · Cited by 374 · see citing works
Beecham, G. W., Hamilton, K., Naj, A. C., Martin, E. R., Huentelman, M., Myers, A. J., Corneveaux, J. J., Hardy, J., Vonsattel, J.-P., Younkin, S. G., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004606 · Cited by 343 · see citing works
Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains
Karch, C. M., Jeng, A. T., Nowotny, P., Cady, J., Cruchaga, C., & Goate, A. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050976 · Cited by 328 · see citing works
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease
DemGene, Steinberg, S., Stefansson, H., Jonsson, T., Johannsdottir, H., Ingason, A., Helgason, H., Sulem, P., Magnusson, O. T., Gudjonsson, S. A., et al. (2015) · Nature Genetics · doi:10.1038/ng.3246 · Cited by 324 · see citing works
<scp>F</scp>yn inhibition rescues established memory and synapse loss in <scp>A</scp>lzheimer mice
Kaufman, A. C., Salazar, S. V., Haas, L. T., Yang, J., Kostylev, M. A., Jeng, A. T., Robinson, S. A., Gunther, E. C., van Dyck, C. H., Nygaard, H. B., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24394 · Cited by 314 · see citing works
Coding variants in TREM2 increase risk for Alzheimer's disease
Jin, S. C., Benitez, B. A., Karch, C. M., Cooper, B., Skorupa, T., Carrell, D., Norton, J. B., Hsu, S., Harari, O., Cai, Y., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu277 · Cited by 314 · see citing works
Role of complement in neurodegeneration and neuroinflammation
Bonifati, D. M., & Kishore, U. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.03.007 · Cited by 310 · see citing works
Alzheimer's Presenilin 1 Mutations Impair Kinesin-Based Axonal Transport
Pigino, G. F., Morfini, G. A., Pelsman, A., Mattson, M. P., Brady, S. T., & Busciglio, J. A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04499.2003 · Cited by 300 · see citing works
Apolipoprotein E–dependent accumulation of Alzheimer disease–related lesions begins in middle age
Kok, E., Haikonen, S., Luoto, T., Huhtala, H., Goebeler, S., Haapasalo, H., & Karhunen, P. J. (2009) · Annals of Neurology · doi:10.1002/ana.21696 · Cited by 299 · see citing works
Yu, L., Chibnik, L. B., Srivastava, G. P., Pochet, N., Yang, J., Xu, J., Kozubek, J., Obholzer, N., Leurgans, S. E., Schneider, J. A., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2014.3049 · Cited by 290 · see citing works
The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE
Guerreiro, R. J., Gustafson, D. R., & Hardy, J. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.025 · Cited by 285 · see citing works
PICALM modulates autophagy activity and tau accumulation
Moreau, K., Fleming, A., Imarisio, S., Lopez Ramirez, A., Mercer, J. L., Jimenez-Sanchez, M., Bento, C. F., Puri, C., Zavodszky, E., Siddiqi, F., et al. (2014) · Nature Communications · doi:10.1038/ncomms5998 · Cited by 281 · see citing works
Offe, K., Dodson, S. E., Shoemaker, J. T., Fritz, J. J., Gearing, M., Levey, A. I., & Lah, J. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4946-05.2006 · Cited by 279 · see citing works
Human<i>APOE</i>Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice
Bales, K. R., Liu, F., Wu, S., Lin, S., Koger, D., DeLong, C., Hansen, J. C., Sullivan, P. M., & Paul, S. M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0887-09.2009 · Cited by 274 · see citing works
Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region.
Kamino, K., Orr, H. T., Payami, H., Wijsman, E. M., Alonso, M. E., Pulst, S. M., Anderson, L., O'dahl, S., Nemens, E. J., & White, J. A. (1992) · PubMed · Cited by 268 · see citing works
Clusterin: A forgotten player in Alzheimer's disease
Nuutinen, T., Suuronen, T., Kauppinen, A., & Salminen, A. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.05.007 · Cited by 267 · see citing works
<i>TREM2</i>Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis
Cady, J., Koval, E. D., Benitez, B. A., Zaidman, C., Jockel-Balsarotti, J., Allred, P., Baloh, R. H., Ravits, J., Simpson, E., Appel, S. H., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.6237 · Cited by 262 · see citing works
Genomic organization of the human amyloid beta-protein precursor gene
Yoshikai, S.-I., Sasaki, H., Doh‐ura, K., Furuya, H., & Sakaki, Y. (1990) · Gene · doi:10.1016/0378-1119(90)90310-n · Cited by 259 · see citing works
TREM2and Neurodegenerative Disease
Reitz, C., & Mayeux, R. P. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1306509 · Cited by 254 · see citing works
Fjorback, A. W., Seaman, M. N. J., Gustafsen, C., Mehmedbašić, A., Gokool, S., Wu, C., Militz, D., Schmidt, V., Madsen, P., Nyengaard, J. R., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2272-11.2012 · Cited by 253 · see citing works
Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2
Jayadev, S., Leverenz, J. B., Steinbart, E. J., Stahl, J. H., Klunk, W. E., Yu, C.-E., & Bird, T. D. (2010) · Brain · doi:10.1093/brain/awq033 · Cited by 246 · see citing works
Genome-wide association study of Alzheimer's disease
Kamboh, M. I., Demirci, F. Y., Wang, X., Minster, R. L., Carrasquillo, M. M., Pankratz, V. S., Younkin, S. G., Saykin, A. J., Initiative, A. D. N., Jun, G., et al. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.45 · Cited by 242 · see citing works
Kim, M., Suh, J., Romano, D., Truong, M. H., Mullin, K., Hooli, B., Norton, D., Tesco, G., Elliott, K., Wagner, S. L., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp323 · Cited by 234 · see citing works
Brouwers, N., Van Cauwenberghe, C., Engelborghs, S., Lambert, J.-C., Bettens, K., Le Bastard, N., Pasquier, F., Montoya, A. G., Peeters, K., Mattheijssens, M., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.24 · Cited by 227 · see citing works
De Jonghe, C. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.16.1665 · Cited by 223 · see citing works
Genetic Variation and Neuroimaging Measures in Alzheimer Disease
Biffi, A. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.108 · Cited by 222 · see citing works
Plasma clusterin and the risk of Alzheimer disease
Schrijvers, E. M. C. (2011) · JAMA · doi:10.1001/jama.2011.381 · Cited by 220 · see citing works
AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling
Pant, S., Sharma, M., Patel, K., Caplan, S., Carr, C. M., & Grant, B. D. (2009) · Nature Cell Biology · doi:10.1038/ncb1986 · Cited by 218 · see citing works
Suh, J., Choi, S. H., Romano, D. M., Gannon, M. A., Lesinski, A. N., Kim, D. Y., & Tanzi, R. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.035 · Cited by 217 · see citing works
Complement Receptor 1: Disease associations and therapeutic implications
Khera, R., & Das, N. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.09.026 · Cited by 213 · see citing works
Mullane, K., & Williams, M. J. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.11.014 · Cited by 212 · see citing works
Kim, W. S., Li, H., Ruberu, K. R., Chan, S. L., Elliott, D. A., Low, J. K., Cheng, D., Karl, T., & Garner, B. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4165-12.2013 · Cited by 209 · see citing works
Ramanan, V. K., Risacher, S. L., Nho, K. T., Kim, S., Swaminathan, S., Shen, L., Foroud, T., Hakonarson, H. H., Huentelman, M. J., Aisen, P. S. S., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.19 · Cited by 202 · see citing works
Maloney, J. A., Bainbridge, T. W., Gustafson, A. E., Zhang, S., Kyauk, R. V., Steiner, P., van der Brug, M., Liu, Y., Ernst, J. A., Watts, R. J., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.589069 · Cited by 199 · see citing works
Duriez, B., Duquesnoy, P., Escudier, E. F., Bridoux, A.-M., Escalier, D., Rayet, I., Marcos, É., Vojtek, A.-M., Bercher, J., & Amselem, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611405104 · Cited by 198 · see citing works
Apolipoprotein Eε4 modifies Alzheimer's disease onset in an E280A PS1 kindred
Pastor, P., Roe, C. M., Villegas, A., Bedoya, G., Chakraverty, S., García, G., Tirado, V., Norton, J., Ríos, S., Martínez, M., et al. (2003) · Annals of Neurology · doi:10.1002/ana.10636 · Cited by 194 · see citing works
RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway
Kajiho, H., Saito, K., Tsujita, K., Kontani, K., Araki, Y., Kurosu, H., & Katada, T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00718 · Cited by 191 · see citing works
Synapse development and plasticity: roles of ephrin/Eph receptor signaling
Lai, K., & Ip, N. Y. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.04.009 · Cited by 191 · see citing works
Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease
Tan, M., Yu, J., & Tan, L. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.06.004 · Cited by 187 · see citing works
Variant <i>TREM2</i> as Risk Factor for Alzheimer's Disease
Neumann, H., & Daly, M. J. (2013) · New England Journal of Medicine · doi:10.1056/nejme1213157 · Cited by 177 · see citing works
Apolipoprotein E and Alzheimer's Disease A Role in Amyloid Catabolism
Poirier, J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05564.x · Cited by 171 · see citing works
Shulman, J. M., Imboywa, S., Giagtzoglou, N., Powers, M. P., Hu, Y., Devenport, D., Chipendo, P., Chibnik, L. B., Diamond, A., Perrimon, N., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddt478 · Cited by 167 · see citing works
Xiao, Q., Gil, S.-C., Yan, P., Wang, Y., Han, S., Gonzales, E., Perez, R., Cirrito, J. R., & Lee, J.-M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.338376 · Cited by 166 · see citing works
Lidström, A.-M., Bogdanović, N., Hesse, C., Volkmann, I., Davidsson, P., & Blennow, K. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6892 · Cited by 163 · see citing works
MEF2 Is an In Vivo Immune-Metabolic Switch
Clark, R. I., Tan, S. W. S., Péan, C. B., Roostalu, U., Vivancos, V., Bronda, K., Pilátová, M., Fu, J., Walker, D. W., Berdeaux, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.007 · Cited by 163 · see citing works
Meta-analysis of the Association Between Variants in SORL1 and Alzheimer Disease
Reitz, C. (2011) · Archives of Neurology · doi:10.1001/archneurol.2010.346 · Cited by 162 · see citing works
Kim, W., Guillemin, G., Glaros, E., Lim, C. K., & Garner, B. (2006) · NeuroReport · doi:10.1097/01.wnr.0000221833.41340.cd · Cited by 158 · see citing works
Genetic Susceptibility for Alzheimer Disease Neuritic Plaque Pathology
Shulman, J. M., Chen, K., Keenan, B. T., Chibnik, L. B., Fleisher, A., Thiyyagura, P., Roontiva, A., Aubin, C., Patsopoulos, N. A., Corneveaux, J. J., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.2815 · Cited by 156 · see citing works
Alzheimer's Disease Genetics Consortium, Wetzel-Smith, M. K., Hunkapiller, J., Bhangale, T. R., Srinivasan, K., Maloney, J. A., Atwal, J. K., Sa, S. M., B Yaylaoglu, M., Foreman, O., et al. (2014) · Nature Medicine · doi:10.1038/nm.3736 · Cited by 153 · see citing works
LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche
Gajera, C. R., Emich, H., Lioubinski, O., Christ, A., Beckervordersandforth, R., Yoshikawa, K., Bachmann, S., Christensen, E., Götz, M., Kempermann, G., et al. (2010) · Journal of Cell Science · doi:10.1242/jcs.065912 · Cited by 153 · see citing works
Incidence of cerebral microbleeds in preclinical Alzheimer disease
Yates, P. A., Desmond, P. M., Phal, P. M., Steward, C., Szoeke, C., Salvado, O., Ellis, K. A., Martins, R. N., Masters, C. L., Ames, D., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000285 · Cited by 150 · see citing works
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia
Chen, Z., Shojaee, S., Buchner, M., Geng, H., Lee, J. W., Klemm, L., Titz, B., Graeber, T. G., Park, E., Tan, Y. X., et al. (2015) · Nature · doi:10.1038/nature14231 · Cited by 149 · see citing works
Apolipoprotein E and Alzheimer Disease: An Update on Genetic and Functional Analyses
Saunders, A. M. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.9.751 · Cited by 148 · see citing works
Two rare <i>AKAP9</i> variants are associated with Alzheimer's disease in African Americans
Logue, M. W., Schu, M., Vardarajan, B. N., Farrell, J., Bennett, D. A., Buxbaum, J. D., Byrd, G. S., Ertekin‐Taner, N., Evans, D., Foroud, T., et al. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.06.010 · Cited by 136 · see citing works
ATP‐binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro
Chan, S. L., Kim, W. S., Kwok, J. B., Hill, A. F., Cappai, R., Rye, K., & Garner, B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05433.x · Cited by 133 · see citing works
Presenilins: Members of the γ-Secretase Quartets, But Part-Time Soloists Too
Wakabayashi, T., & Strooper, B. D. (2008) · Physiology · doi:10.1152/physiol.00009.2008 · Cited by 124 · see citing works
Tateno, H., Li, H., Schur, M. J., Bovin, N. V., Crocker, P. R., Wakarchuk, W. W., & Paulson, J. C. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00383-07 · Cited by 123 · see citing works
Structural Insight into the Zinc Finger CW Domain as a Histone Modification Reader
He, F., Umehara, T., Saito, K., Harada, T., Watanabe, S., Yabuki, T., Kigawa, T., Takahashi, M., Kuwasako, K., Tsuda, K., et al. (2010) · Structure · doi:10.1016/j.str.2010.06.012 · Cited by 121 · see citing works
Distribution and Expression of Picalm in Alzheimer Disease
Baig, S., Joseph, S. A., Tayler, H., Abraham, R., Owen, M. J., Williams, J., Kehoe, P. G., & Love, S. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181f52e01 · Cited by 115 · see citing works
SnapShot: genetics of Alzheimer's disease.
Guerreiro, R., Bras, J., & Hardy, J. (2013) · Cell · doi:10.1016/j.cell.2013.10.037 · Cited by 114 · see citing works
APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer’s disease
Vélez, J. I., Lopera, F., Sepulveda-Falla, D., Patel, H. R., Johar, A. S., Chuah, A., Tobón, C., Rivera, D., Villegas, A., Cai, Y., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.177 · Cited by 111 · see citing works
EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility
Yamazaki, T., Masuda, J., Omori, T., Usui, R., Akiyama, H., & Maru, Y. (2008) · Journal of Cell Science · doi:10.1242/jcs.036467 · Cited by 107 · see citing works
Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein
Gustafsen, C., Glerup, S., Pallesen, L. T., Olsen, D., Andersen, O. M., Nykjær, A., Madsen, P., & Petersen, C. M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2371-12.2013 · Cited by 106 · see citing works
Genomic organization of the human-amyloid beta-protein precursor gene
Yoshikai, S.-I., Sasaki, H., Doh‐ura, K., Furuya, H., & Sakaki, Y. (1991) · Gene · doi:10.1016/0378-1119(91)90093-q · Cited by 105 · see citing works
Expression of desmosomal proteins in squamous cell carcinomas of the skin
Kurzen, H., Münzing, I., & Hartschuh, W. (2003) · Journal of Cutaneous Pathology · doi:10.1034/j.1600-0560.2003.00122.x · Cited by 101 · see citing works
Schjeide, B. M., Schnack, C., Lambert, J., Lill, C. M., Kirchheiner, J., Tumani, H., Otto, M., Tanzi, R. E., Lehrach, H. R., Amouyel, P., et al. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.196 · Cited by 100 · see citing works
Antúnez, C., Boada, M., González‐Pérez, A., Gayán, J., Ramírez‐Lorca, R., Marín, J., Hernández, I., Moreno‐Rey, C., Morón, F. J., López‐Arrieta, J., et al. (2011) · Genome Medicine · doi:10.1186/gm249 · Cited by 99 · see citing works
Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer’s disease
Dorey, E., Chang, N., Liu, Q. Y., Yang, Z., & Zhang, W. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1422-z · Cited by 99 · see citing works
Severe mental retardation, seizures, and hypotonia due to deletions of MEF2C
Nowakowska, B., Obersztyn, E., Szymańska, K., Bekiesińska‐Figatowska, M., Xia, Z., Ricks, C. B., Bocian, E., Stockton, D. W., Szczałuba, K., Nawara, M., et al. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31071 · Cited by 97 · see citing works
Genetic variation at CR1 increases risk of cerebral amyloid angiopathy
Biffi, A., Shulman, J. M., Jagiella, J. M., Cortellini, L., Ayres, A. M., Schwab, K. M., Brown, D. L., Silliman, S. L., Selim, M. H., Worrall, B. B., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e3182452b40 · Cited by 97 · see citing works
Ruiz, A., Heilmann, S., Becker, T., Hernández, I., Wagner, H., Thelen, M., Mauleón, A., Rosende-Roca, M., Bellenguez, C., Bis, J. C., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.2 · Cited by 97 · see citing works
Hippocampal atrophy rates and CSF biomarkers in elderly <i>APOE</i> 2 normal subjects
Chiang, G. C., Insel, P. S., Tosun, D., Schuff, N., Truran-Sacrey, D., Raptentsetsang, S. T., Jack, C. R., Aisen, P. S., Petersen, R. C., Weiner, M. W., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181ffe4d1 · Cited by 94 · see citing works
Han, M.-R., Schellenberg, G. D., Wang, L.-S., & Initiative, T. A. D. N. (2010) · BMC Neurology · doi:10.1186/1471-2377-10-90 · Cited by 93 · see citing works
Kindlin-2 is required for myocyte elongation and is essential for myogenesis
Dowling, J. J., Vreede, A. P., Kim, S., Golden, J. A., & Feldman, E. L. (2008) · BMC Cell Biology · doi:10.1186/1471-2121-9-36 · Cited by 92 · see citing works
Targeting Siglecs—A novel pharmacological strategy for immuno- and glycotherapy
Jandus, C., Simon, H., & von Gunten, S. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.05.018 · Cited by 88 · see citing works
APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy
Breyhan, H., Wirths, O., Duan, K., Marcello, A., Rettig, J., & Bayer, T. A. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0539-7 · Cited by 87 · see citing works
Steiner, H., Révész, T., Neumann, M., Romig, H., Grim, M. G., Pesold, B., Kretzschmar, H. A., Hardy, J., Holton, J. L., Baumeister, R., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007183200 · Cited by 86 · see citing works
Variant Alzheimer Disease With Spastic paraparesis: Neuropathological phenotype
Verkkoniemi, A., Kalimo, H., Paetau, A. E., Somer, M., Iwatsubo, T., Hardy, J., & Haltia, M. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.5.483 · Cited by 85 · see citing works
Polygenic Analysis of Late-Onset Alzheimer’s Disease from Mainland China
Jiao, B., Liu, X., Zhou, L., Wang, M. H., Zhou, Y., Xiao, T., Zhang, W., Sun, R., Waye, M. M. Y., Tang, B., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144898 · Cited by 82 · see citing works
Takao, M., Ghetti, B. F., Hayakawa, I., Ikeda, E., Fukuuchi, Y., Miravalle, L., Piccardo, P., Murrell, J. R., Glazier, B. S., & Koto, A. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0536-6 · Cited by 81 · see citing works
The integrin coactivator Kindlin-2 plays a critical role in angiogenesis in mice and zebrafish
Pluskota, E., Dowling, J. J., Gordon, N., Golden, J. A., Szpak, D., West, X. Z., Nestor, C., Ma, Y., Białkowska, K., Byzova, T. V., et al. (2011) · Blood · doi:10.1182/blood-2010-11-321182 · Cited by 81 · see citing works
Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family
Yu, Y., Wu, J., Guan, L., Qi, L., Tang, Y., Ma, B., Zhan, J., Wang, Y., Fang, W., & Zhang, H. (2013) · International Journal of Cancer · doi:10.1002/ijc.28151 · Cited by 81 · see citing works
Clues to CD2-associated Protein Involvement in Cytokinesis
Monzo, P., Gauthier, N. C., Keslair, F., Loubat, A., Field, C. M., MARCHAND‐BRUSTEL, Y. L., & Cormont, M. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-09-0773 · Cited by 80 · see citing works
Desmoglein 2 is a substrate of kallikrein 7 in pancreatic cancer
Ramani, V. C., Hennings, L. J., & Haun, R. S. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-373 · Cited by 76 · see citing works
Expanding functions of lipoprotein receptors
Herz, J., Chen, Y., Masiulis, I., & Zhou, L. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800077-jlr200 · Cited by 75 · see citing works
A novel Cas family member, HEPL, regulates FAK and cell spreading
Singh, M. K., Dadke, D., Nicolas, E., Serebriiskii, I. G., Apostolou, S., Canutescu, A., Egleston, B. L., & Golemis, E. A. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-09-0953 · Cited by 74 · see citing works
Late-onset Alzheimer disease risk variants mark brain regulatory loci
Allen, M., Kachadoorian, M., Carrasquillo, M. M., Karhade, A., Manly, L., Burgess, J. D., Wang, C., Serie, D., Wang, X., Siuda, J., et al. (2015) · Neurology Genetics · doi:10.1212/nxg.0000000000000012 · Cited by 73 · see citing works
Lu, P. H., Thompson, P. M., Leow, A., Lee, G. J., Lee, A., Yanovsky, I., Parikshak, N., Khoo, T., Wu, S., Geschwind, D. H., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101398 · Cited by 70 · see citing works
Larsson, M., Duffy, D. L., Zhu, G., Liu, J. Z., MacGregor, S., McRae, A. F., Wright, M. J., Sturm, R. A., Mackey, D. A., Montgomery, G. W., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.07.011 · Cited by 69 · see citing works
AKAP9 Is a Genetic Modifier of Congenital Long-QT Syndrome Type 1
de Villiers, C. P., van der Merwe, L., Crotti, L., Goosen, A., George, A. L., Schwartz, P. J., Brink, P. A., Moolman‐Smook, J. C., & Corfield, V. A. (2014) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.113.000580 · Cited by 67 · see citing works
Multiple loci influencing hippocampal degeneration identified by genome scan
Melville, S. A., Buros, J. L., Parrado, A., Vardarajan, B. N., Logue, M. W., Shen, L., Risacher, S. L., Kim, S., Jun, G., DeCarli, C. S., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23644 · Cited by 67 · see citing works
A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin
Deming, Y., Xia, J., Cai, Y., Lord, J., Holmans, P., Bertelsen, S., Holtzman, D., Morris, J. C., Bales, K., Pickering, E. H., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.09.009 · Cited by 66 · see citing works
Chen, H., Wu, G., Jiang, Y., Feng, R., Liao, M., Zhang, L., Ma, G., Chen, Z., Zhao, B., Li, K., et al. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8834-2 · Cited by 66 · see citing works
Jiao, B., Liu, X., Tang, B., Hou, L., Zhou, L., Zhang, F., Zhou, Y., Guo, J., Yan, X., & Shen, L. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.04.025 · Cited by 66 · see citing works
Cuenco, K. T. (2008) · Archives of Neurology · doi:10.1001/archneur.65.12.1640 · Cited by 61 · see citing works
Morgen, K., Ramı́rez, A., Frölich, L., Tost, H., Plichta, M. M., Kölsch, H., Rakebrandt, F., Rienhoff, O., Jessen, F., Peters, O., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.11.001 · Cited by 59 · see citing works
Discovery and Development of Small Molecule SHIP Phosphatase Modulators
Viernes, D. R., Choi, L. B., Kerr, W. G., & Chisholm, J. D. (2013) · Medicinal Research Reviews · doi:10.1002/med.21305 · Cited by 57 · see citing works
Kindlins, Integrin Activation and the Regulation of Talin Recruitment to αIIbβ3
Kahner, B. N., Kato, H., Banno, A., Ginsberg, M. H., Shattil, S. J., & Ye, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034056 · Cited by 57 · see citing works
Kim, S. H., Fountoulakis, M., Cairns, N. J., & Lübec, G. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02035-1 · Cited by 56 · see citing works
The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer’s disease
Lee, J. H., Barral, S., & Reitz, C. (2008) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-008-0060-8 · Cited by 56 · see citing works
Liao, F., Jiang, H., Srivatsan, S., Xiao, Q., Lefton, K. B., Yamada, K., Mahan, T. E., Lee, J.-M., Shaw, A. S., & Holtzman, D. M. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0006-y · Cited by 53 · see citing works
Shen, Z., Ye, Y., Kauttu, T., Seppänen, H. E., Vainionpää, S., Wang, S., Mustonen, H. K., & Puolakkainen, P. A. (2013) · Journal of Surgical Oncology · doi:10.1002/jso.23353 · Cited by 50 · see citing works
Opposite Role of Kindlin-1 and Kindlin-2 in Lung Cancers
Zhan, J., Zhu, X., Guo, Y., Wang, Y., Wang, Y., Qiang, G., Niu, M., Hu, J., Du, J., Li, Z., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050313 · Cited by 50 · see citing works
A Role for Phospholipase D3 in Myotube Formation
Osisami, M., Ali, W. H., & Frohman, M. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033341 · Cited by 50 · see citing works
PLD3 is accumulated on neuritic plaques in Alzheimer’s disease brains
Satoh, J., Kino, Y., Yamamoto, Y., Kawana, N., Ishida, T., Saito, Y., & Arima, K. (2014) · Alzheimer s Research & Therapy · doi:10.1186/s13195-014-0070-5 · Cited by 50 · see citing works
Beck, T. N., Nicolas, E., Kopp, M. C., & Golemis, E. A. (2014) · Oncoscience · doi:10.18632/oncoscience.64 · Cited by 50 · see citing works
Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1
Wang, Z., Lei, H., Zheng, M., Li, Y., Cui, Y., & Hao, F. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9546-y · Cited by 49 · see citing works
Initial Assessment of the Pathogenic Mechanisms of the Recently Identified Alzheimer Risk Loci
Holton, P., Ryten, M., Nalls, M., Trabzuni, D., Weale, M. E., Hernandez, D., Crehan, H., Gibbs, J. R., Mayeux, R., Haines, J. L., et al. (2013) · Annals of Human Genetics · doi:10.1111/ahg.12000 · Cited by 48 · see citing works
Expression of MS4A and TMEM176 Genes in Human B Lymphocytes
Zuccolo, J., Deng, L., Unruh, T. L., Sanyal, R., Bau, J. A., Storek, J., Demetrick, D. J., Luider, J. M., Auer-Grzesiak, I. A., Mansoor, A., et al. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00195 · Cited by 48 · see citing works
Rosenthal, S. L., Barmada, M. M., Wang, X., Demirci, F. Y., & Kamboh, M. I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095152 · Cited by 45 · see citing works
Steiner, H. (2004) · Current Alzheimer Research · doi:10.2174/1567205043332081 · Cited by 45 · see citing works
Genetic Analysis of 16 NMR‐Lipoprotein Fractions in Humans, the GOLDN Study
Kraja, A. T., Borecki, I. B., Tsai, M. Y., Ordovás, J. M., Hopkins, P. N., Lai, C., Wood, A. C., Straka, R. J., Hixson, J. E., Province, M. A., et al. (2012) · Lipids · doi:10.1007/s11745-012-3740-8 · Cited by 42 · see citing works
Liu, Y., Yu, J., Wang, H.-F., Hao, X., Yang, Y.-F., Jiang, T., Zhu, X., Cao, L., Zhang, D., & Tan, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114777 · Cited by 39 · see citing works
CR1 genotype is associated with entorhinal cortex volume in young healthy adults
Bralten, J., Franke, B., Vásquez, A. A., Heister, A. J. G. A. M., Brunner, H. G., Fernández, G., & Rijpkema, M. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.05.017 · Cited by 39 · see citing works
CLU, CR1 and PICALM genes associate with Alzheimer's-related senile plaques
Kok, E., Luoto, T. M., Haikonen, S., Goebeler, S., Haapasalo, H. K., & Karhunen, P. J. (2011) · Alzheimer s Research & Therapy · doi:10.1186/alzrt71 · Cited by 35 · see citing works
House, R. P., Talwar, S., Hazard, E. S., Hill, E. G., & Palanisamy, V. (2015) · Oncotarget · doi:10.18632/oncotarget.6204 · Cited by 35 · see citing works
Potkin, S. G., Guffanti, G., Lakatos, A., Ja, T., Kruggel, F., Jh, F., Saykin, A. J., Orro, A., Lupoli, S., Salvi, E., et al. (2009) · UNICA IRIS Institutional Research Information System (University of Cagliari) · Cited by 34 · see citing works
Evidence against a role for rare ADAM10 mutations in sporadic Alzheimer Disease
Cai, G., Atzmon, G., Naj, A. C., Beecham, G. W., Barzilai, N., Haines, J. L., Sano, M., Pericak‐Vance, M. A., & Buxbaum, J. D. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.03.003 · Cited by 30 · see citing works
Alternative polyadenylation regulates CELF1/CUGBP1 target transcripts following T cell activation
Beisang, D. J., Reilly, C., & Bohjanen, P. R. (2014) · Gene · doi:10.1016/j.gene.2014.08.021 · Cited by 30 · see citing works
Wang, H.-F., Initiative, A. D. N., Tan, L., Hao, X., Jiang, T., Tan, M., Liu, Y., Zhang, D., & Yu, J. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141488 · Cited by 29 · see citing works
AKAP9, a Regulator of Microtubule Dynamics, Contributes to Blood-Testis Barrier Function
Venkatesh, D., Mruk, D. D., Herter, J. M., Culleré, X., Chojnacka, K., Cheng, C. Y., & Mayadas, T. N. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.10.007 · Cited by 29 · see citing works
CELF1 is Up-Regulated in Glioma and Promotes Glioma Cell Proliferation by Suppression of CDKN1B
Xia, L., Sun, C., Li, Q., Fěng, F., Qiao, E., Jiang, L., Wu, B., & Ge, M. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.11344 · Cited by 29 · see citing works
Ting, S. K. S., Chong, M.-S., Kandiah, N., Hameed, S., Tan, L., Au, W.-L., Prakash, K. M., Pavanni, R., Lee, T.-S., Foo, J.-N., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.04.012 · Cited by 26 · see citing works
Park, M. H., Choi, D. Y., Jin, H. W., Yoo, H. S., Han, J., Oh, K., Han, S., Hwang, D. Y., & Hong, J. T. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3182432967 · Cited by 26 · see citing works
CR1 and the cell membrane proteins that bind C3 and C4
Wilson, J. G., Andriopoulos, N. A., & Fearon, D. T. (1987) · Immunologic Research · doi:10.1007/bf02918091 · Cited by 26 · see citing works
Tsolakidou, A. F., Alexopoulos, P., Guo, L., Grimmer, T., Westerteicher, C., Kratzer, M., Jiang, M., Bujo, H., Roselli, F., Leante, M. R., et al. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.01.015 · Cited by 19 · see citing works
Shi, D., Nakamura, T., Nakajima, M., Dai, J. M., Qin, J., Ni, H., Xu, Y., Chen, Y., Wei, J., Liu, B., et al. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2423 · Cited by 18 · see citing works
Next Generation Sequencing in Alzheimer’s Disease
Bertram, L. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2627-5_17 · Cited by 17 · see citing works
Capsoni, S., Carlo, A.-S., Vignone, D., Amato, G., Criscuolo, C., Willnow, T. E., & Cattaneo, A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121399 · Cited by 17 · see citing works
Zhang, M., Xue, A., Shen, Y., Oliveira, J. B., Li, L., Zhao, Z., & BURKE, A. P. (2015) · Forensic Science International · doi:10.1016/j.forsciint.2015.07.052 · Cited by 14 · see citing works
Self-citationDivergent regulation of Pyk2/CAKβ phosphorylation by Ca2+ and cAMP in the hippocampus
Alier, K. A., & MORRIS, B. J. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.04.003 · Cited by 14 · see citing works
The APP A673T frequency differs between Nordic countries
Mengel‐From, J., Jeune, B., Pentti, T., McGue, M. K., Christensen, K., & Christiansen, L. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.07.011 · Cited by 13 · see citing works
LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche
Gajera, C. R., Emich, H., Lioubinski, O., Christ, A., Beckervordersandforth, R., Yoshikawa, K., Bachmann, S., Christensen, E., Götz, M., Kempermann, G., et al. (2010) · Development · doi:10.1242/dev.054361 · Cited by 8 · see citing works
F2–01–01: A rare variant alters UNC5C function and predisposes to Alzheimer's disease
Graham, R. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.04.125 · Cited by 5 · see citing works
A question of standards: What makes a good genetic association study?
Hattersley, A. T., & McCarthy, M. I. (2011) · Cited by 3 · see citing works
Flagged first, then by citations
6 of the 201 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [113]Rajagopalan P Hibar DP Thompson PM TREM2 and neurodegenerative disease N Engl J Med 2013 369 16 1565 1567 24131186 PMC4024453
Cited by
Sorted by citations
Alzheimer’s disease: risk factors and potentially protective measures
Silva, M. V. F., Loures, C. D. M. G., Alves, L. C. V., de Souza, L. C., Borges, K. B. G., & Ferriani, M. D. G. C. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0524-y · Cited by 962 · see citing works
Role of gut-brain axis, gut microbial composition, and probiotic intervention in Alzheimer's disease
Kesika, P., Suganthy, N., Sivamaruthi, B. S., & Chaiyasut, C. (2021) · Life Sciences · doi:10.1016/j.lfs.2020.118627 · Cited by 479 · see citing works
Lipids and Alzheimer’s Disease
Kao, Y.-C., Ho, P.-C., Tu, Y.-K., Jou, I.-M., & Tsai, K.-J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041505 · Cited by 485 · see citing works
New Insights Into the Pathogenesis of Alzheimer's Disease
Fan, L., Mao, C.-Y., Hu, X., Zhang, S., Yang, Z.-H., Hu, Z., Sun, H.-F., Fan, Y., Dong, Y., Yang, J., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2019.01312 · Cited by 294 · see citing works
Cellular Specificity of NF-κB Function in the Nervous System
Dresselhaus, E. C., & Meffert, M. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01043 · Cited by 345 · see citing works
Kwart, D., Gregg, A., Scheckel, C., Murphy, E. A., Paquet, D., Duffield, M. D., Fak, J. J., Olsen, O., Darnell, R. B., & Tessier‐Lavigne, M. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.010 · Cited by 317 · see citing works
In vitro Models of Neurodegenerative Diseases
Slanzi, A., Iannoto, G., Rossi, B., Zenaro, E., & Constantin, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00328 · Cited by 293 · see citing works
Clearance of cerebral Aβ in Alzheimer’s disease: reassessing the role of microglia and monocytes
Zuroff, L. R., Daley, D. A., Black, K. L., & Koronyo‐Hamaoui, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2463-7 · Cited by 275 · see citing works
Alzheimer’s Amyloid-β is an Antimicrobial Peptide: A Review of the Evidence
Gosztyla, M. L., Brothers, H. M., & Robinson, S. R. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-171133 · Cited by 238 · see citing works
Rossini, P. M., Iorio, R. D., Vecchio, F., Anfossi, M., Babiloni, C., Bozzali, M., Bruni, A. C., Cappa, S. F., Escudero, J., Fraga, F. J., et al. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2020.03.003 · Cited by 239 · see citing works
Morris, G. P., Clark, I. A., & Vissel, B. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1918-8 · Cited by 212 · see citing works
Safiri, S., Jolfayi, A. G., Fazlollahi, A., Morsali, S., Sarkesh, A., Sorkhabi, A. D., Golabi, B., Aletaha, R., Asghari, K. M., Hamidi, S., et al. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1474043 · Cited by 242 · see citing works
Neuroinflammation: A Potential Risk for Dementia
Ahmad, M. A., Kareem, O., Khushtar, M., Akbar, M., Haque, M. R., Iqubal, A., Haider, M. F., Pottoo, F. H., Abdulla, F. S., Al-Haidar, M. B., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020616 · Cited by 163 · see citing works
Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease
Pennisi, M., Crupi, R., Di Paola, R., Ontario, M. L., Bella, R., Calabrese, E. J., Crea, R., Cuzzocrea, S., & Calabrese, V. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23986 · Cited by 157 · see citing works
Melatonin: A review of its potential functions and effects on neurological diseases
Günata, M., Parlakpınar, H., & Acet, A. (2019) · Revue Neurologique · doi:10.1016/j.neurol.2019.07.025 · Cited by 154 · see citing works
Neurodegeneration and the Circadian Clock
Hood, S., & Amir, S. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00170 · Cited by 150 · see citing works
Tewari, D., Stankiewicz, A. M., Mocan, A., Sah, A. N., Tzvetkov, N. T., Huminiecki, Ł., Horbańczuk, J. O., & Atanasov, A. G. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00003 · Cited by 136 · see citing works
β-Amyloid and the Pathomechanisms of Alzheimer’s Disease: A Comprehensive View
Penke, B., Bogár, F., & Fülöp, L. (2017) · Molecules · doi:10.3390/molecules22101692 · Cited by 135 · see citing works
Cholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation
Gamage, R. V., Wagnon, I. M., Rossetti, I., Childs, R., Niedermayer, G., Chesworth, R., & Gyengési, E. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.577912 · Cited by 133 · see citing works
Alzheimer's disease in the omics era
Sancesario, G. M., & Bernardini, S. (2018) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2018.06.011 · Cited by 111 · see citing works
Robert, J., Button, E. B., Yuen, B., Gilmour, M., Kang, K., Bahrabadi, A., Stukas, S. K., Zhao, W., Kulić, I., & Wellington, C. L. (2017) · eLife · doi:10.7554/elife.29595 · Cited by 113 · see citing works
Role of miRNAs in Alzheimer’s Disease and Possible Fields of Application
Silvestro, S., Bramanti, P., & Mazzon, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163979 · Cited by 112 · see citing works
Kumar, A., Su, Y., Sharma, M., Singh, S., Kim, S., Peavey, J. J., Suerken, C. K., Lockhart, S. N., Whitlow, C. T., Craft, S., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13055 · Cited by 110 · see citing works
Hoogmartens, J., Cacace, R., & Broeckhoven, C. V. (2021) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12155 · Cited by 101 · see citing works
López‐Ortiz, S., Pinto-Fraga, J., Valenzuela, P. L., Martín-Hernández, J., Seisdedos, M. M., Garcı́a, Ó., Toschi, N., Giuliano, F. D., Garaci, F. G., Mercuri, N. B., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062897 · Cited by 101 · see citing works
Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause?
Martínez‐Menárguez, J. A., Tomás, M., Martínez-Martínez, N., & Martínez‐Alonso, E. (2019) · Cells · doi:10.3390/cells8070748 · Cited by 95 · see citing works
Taylor, X., Cisternas, P., You, Y., You, Y., Xiang, S., Marambio, Y. G., Zhang, J., Vidal, R., & Lasagna‐Reeves, C. A. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01900-7 · Cited by 91 · see citing works
Vecchio, F., Miraglia, F., Iberite, F., Lacidogna, G., Guglielmi, V., Marra, C., Pasqualetti, P., Tiziano, F. D., & Rossini, P. M. (2018) · Annals of Neurology · doi:10.1002/ana.25289 · Cited by 89 · see citing works
Essential Oils as Treatment Strategy for Alzheimerʼs Disease: Current and Future Perspectives
Benny, A., & Thomas, J. (2018) · Planta Medica · doi:10.1055/a-0758-0188 · Cited by 89 · see citing works
Kim, D. K., Han, D., Park, J., Choi, H., Park, J., Cha, M.-Y., Woo, J. J., Byun, M. S., Lee, D. Y., Kim, Y., et al. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0326-z · Cited by 86 · see citing works
Bioavailability and Pharmaco-therapeutic Potential of Luteolin in Overcoming Alzheimer’s Disease
Ali, F. R., & Siddique, Y. H. (2019) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527318666190319141835 · Cited by 82 · see citing works
Ratan, Y., Rajput, A., Maleysm, S., Pareek, A., Jain, V. K., Pareek, A., Kaur, R., & Singh, G. (2023) · Biomedicines · doi:10.3390/biomedicines11051398 · Cited by 87 · see citing works
Alzheimer’s Disease: Pathogenesis and Therapeutic Interventions
Ogbodo, J. O., Agbo, C. P., Njoku, U. O., Ogugofor, M. O., Egba, S. I., Ihim, S. A., Echezona, A. C., Brendan, K. C., Upaganlawar, A. B., & Upasani, C. D. (2021) · Current Aging Science · doi:10.2174/1874609814666210302085232 · Cited by 81 · see citing works
Fan, J., Tao, W., Li, X., Li, H., Zhang, J., Wei, D., Chen, Y., & Zhang, Z. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051177 · Cited by 83 · see citing works
An overview of the genes and biomarkers in Alzheimer’s disease
Krishnamurthy, H. K., Jayaraman, V., Krishna, K., Wang, T., Bei, K., Changalath, C., & Rajasekaran, J. J. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102599 · Cited by 85 · see citing works
Friedberg, J. S., Aytan, N., Cherry, J. D., Xia, W., Standring, O. J., Alvarez, V. E., Nicks, R., Svirsky, S. E., Meng, G., Jun, G., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59869-5 · Cited by 78 · see citing works
Kasza, Á., Penke, B., Frank, Z., Bozsó, Z., Szegedi, V., Hunya, Á. G., Németh, K., Kozma, G., & Fülöp, L. (2017) · Molecules · doi:10.3390/molecules22112007 · Cited by 75 · see citing works
Transcriptomics in Alzheimer’s Disease: Aspects and Challenges
Bagyinszky, E., Giau, V. V., & An, S. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103517 · Cited by 75 · see citing works
The Role of Genetics in Advancing Precision Medicine for Alzheimer’s Disease—A Narrative Review
Freudenberg‐Hua, Y., Li, W., & Davies, P. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00108 · Cited by 74 · see citing works
Treatment strategies in Alzheimer’s disease: a review with focus on selenium supplementation
Aaseth, J., Alexander, J., Bjørklund, G., Hestad, K. A., Dušek, P., Roos, P. M., & Alehagen, U. (2016) · BioMetals · doi:10.1007/s10534-016-9959-8 · Cited by 73 · see citing works
Vassileff, N., Cheng, L., & Hill, A. F. (2020) · Journal of Cell Science · doi:10.1242/jcs.243139 · Cited by 73 · see citing works
Chachaj, A., Gąsiorowski, K., Szuba, A., Sieradzki, A., & Leszek, J. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220411091332 · Cited by 71 · see citing works
Epigenetic Modifications in Alzheimer’s Neuropathology and Therapeutics
Esposito, M. M., & Sherr, G. L. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00476 · Cited by 67 · see citing works
Quantile regression for functional partially linear model in ultra-high dimensions
Ma, H., Li, T., Hongtu Zhu, B., & Zhu, Z. (2018) · Computational Statistics & Data Analysis · doi:10.1016/j.csda.2018.06.005 · Cited by 63 · see citing works
Effects of Anserine/Carnosine Supplementation on Mild Cognitive Impairment with APOE4
Masuoka, N., Yoshimine, C., Hori, M., Tanaka, M., Asada, T., Abe, K., & Hisatsune, T. (2019) · Nutrients · doi:10.3390/nu11071626 · Cited by 63 · see citing works
Sialometabolism in Brain Health and Alzheimer’s Disease
Rawal, P., & Zhao, L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.648617 · Cited by 62 · see citing works
Recent Progress in the Pharmacotherapy of Alzheimer’s Disease
Khoury, R., Patel, K., Gold, J., Hinds, S., & Grossberg, G. T. (2017) · Drugs & Aging · doi:10.1007/s40266-017-0499-x · Cited by 62 · see citing works
AbuelEzz, N. Z., Nasr, F. E., Abdulkader, M. A., Bassiouny, A. R., & Zaky, A. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.743573 · Cited by 60 · see citing works
Gao, H., Zhang, A., Yu, J., Sun, H. J., Kong, L. D., Wang, X., Yan, G., Liu, L., & Wang, X. (2018) · Journal of Chromatography B · doi:10.1016/j.jchromb.2018.06.032 · Cited by 56 · see citing works
<i>INPP5D</i> deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease
Lin, P. B., Tsai, A. P., Soni, D., Lee‐Gosselin, A., Moutinho, M., Puntambekar, S. S., Landreth, G. E., Lamb, B. T., & Oblak, A. L. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.12849 · Cited by 54 · see citing works
Alzheimer’s Disease: A Molecular View of β-Amyloid Induced Morbific Events
Asik, R. M., Suganthy, N., Aarifa, M. A., Kumar, A., Szigeti, K., Máthé, D., Gulyás, B. Z., Archunan, G., & Padmanabhan, P. (2021) · Biomedicines · doi:10.3390/biomedicines9091126 · Cited by 53 · see citing works
Mirabnahrazam, G., Initiative, T. A. D. N., Ma, D., Lee, S., Popuri, K., Lee, H., Cao, J., Wang, L., Galvin, J. E., & Beg, M. F. (2022) · Journal of Alzheimer's Disease · doi:10.3233/jad-220021 · Cited by 50 · see citing works
Rossini, P. M., Miraglia, F., Alù, F., Cotelli, M., Ferreri, F., Iorio, R. D., Iodice, F., & Vecchio, F. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10020034 · Cited by 49 · see citing works
Genetic Data: Potential Uses and Misuses in Marketing
Daviet, R., Nave, G., & Wind, J. Y. (2020) · Journal of Marketing · doi:10.1177/0022242920980767 · Cited by 52 · see citing works
Diabetes: Risk factor and translational therapeutic implications for Alzheimer's disease
Cummings, J. L., Ortiz, A. A., Castellino, J., & Kinney, J. W. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15619 · Cited by 50 · see citing works
Pontifex, M. G., Martinsen, A., Saleh, R. N. M., Harden, G., Tejera, N., Müller, M. M., Fox, C., Vauzour, D., & Minihane, A. M. (2021) · The FASEB Journal · doi:10.1096/fj.202002621rr · Cited by 48 · see citing works
Bavarsad, N. H., Bagheri, S., Kourosh‐Arami, M., & Komaki, A. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18492 · Cited by 48 · see citing works
Padhy, B., Hayat, B., Nanda, G. G., Mohanty, P. P., & Alone, D. P. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx329 · Cited by 48 · see citing works
Cerasuolo, M., Di Meo, I., Auriemma, M. C., Paolisso, G., Papa, M., & Rizzo, M. R. (2024) · Biomolecules · doi:10.3390/biom14111362 · Cited by 47 · see citing works
Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer's disease
Chaudhury, S., Patel, T., Barber, I., Guetta‐Baranes, T., Brookes, K. J., Chappell, S., Turton, J. C., Guerreiro, R. J., Brás, J., Hernandez, D. G., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.035 · Cited by 47 · see citing works
Sen, T., & Thummer, R. P. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00564-w · Cited by 50 · see citing works
Flavonoid-Based Nanomedicines in Alzheimer’s Disease Therapeutics: Promises Made, a Long Way To Go
Prasanna, P., & Upadhyay, A. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00224 · Cited by 46 · see citing works
Systems healthcare: a holistic paradigm for tomorrow
Fiandaca, M. S., Mapstone, M. E., Connors, E. E., Jacobson, M., Monuki, E. S., Malik, S., Macciardi, F. M., & Federoff, H. J. (2017) · BMC Systems Biology · doi:10.1186/s12918-017-0521-2 · Cited by 45 · see citing works
Pons, V., Lévesque, P., Plante, M.-M., & Rivest, S. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00747-7 · Cited by 43 · see citing works
Pathogenesis of Neurodegenerative Diseases and the Protective Role of Natural Bioactive Components
Samanta, S., Chakraborty, S., & Bagchi, D. (2023) · Journal of the American Nutrition Association · doi:10.1080/27697061.2023.2203235 · Cited by 43 · see citing works
siRNA drug delivery across the blood–brain barrier in Alzheimer's disease
Sajid, M. I., Sheikh, F. S., Anis, F., Nasim, N., Sumbria, R. K., Nauli, S. M., & Tiwari, R. K. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114968 · Cited by 45 · see citing works
Ding, Q., Tanigawa, K., Kaneko, J., Totsuka, M., Katakura, Y., Imabayashi, E., Matsuda, H., & Hisatsune, T. (2018) · Aging and Disease · doi:10.14336/ad.2017.0809 · Cited by 43 · see citing works
Alzobaidi, N., Quasimi, H., Emad, N. A., Alhalmi, A., & Naqvi, M. (2021) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s299589 · Cited by 43 · see citing works
Regulation of the Late Onset alzheimer’s Disease Associated HLA-DQA1/DRB1 Expression
Zhang, X., Zou, M., Wu, Y., Jiang, D., Wu, T., Zhao, Y., Wu, D., Cui, J., & Li, G. (2022) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175221085066 · Cited by 45 · see citing works
Fairless, R., Bading, H., & Diem, R. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.741280 · Cited by 42 · see citing works
The Amyloid-Tau-Neuroinflammation Axis in the Context of Cerebral Amyloid Angiopathy
Cisternas, P., Taylor, X., & Lasagna‐Reeves, C. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246319 · Cited by 41 · see citing works
Firdaus, Z., & Li, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042320 · Cited by 43 · see citing works
Vlontzou, M. E., Αθανασίου, Μ., Dalakleidi, K. V., Skampardoni, I., Davatzikos, C. A., & Nikita, K. S. (2025) · Scientific Reports · doi:10.1038/s41598-025-92577-6 · Cited by 42 · see citing works
Prasanth, M. I., Malar, D. S., Tencomnao, T., & Brimson, J. M. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1939681 · Cited by 40 · see citing works
Factors Associated with Alzheimer's Disease: An Overview of Reviews
Rochoy, M., Rivas, V., Chazard, E., Decarpentry, E., Saudemont, G., Hazard, P.-A., Puisieux, F. L., Gautier, S., & Bordet, R. (2019) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2019.7 · Cited by 37 · see citing works
Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice
Sos, K. E., Mayer, M. I., Takács, V. T., Major, A., Bardóczi, Z., Beres, B. M., Szeles, T., Saito, T., Saido, T. C., Mody, I., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0233700 · Cited by 37 · see citing works
The dialog between neurons and microglia in Alzheimer's disease: The neurotransmitters view
Stolero, N., & Frenkel, D. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15262 · Cited by 37 · see citing works
Tau Abnormalities and the Potential Therapy in Alzheimer’s Disease
Almansoub, H. A. M. M., Tang, H. R., Wu, Y., Wang, D., Mahaman, Y. A. R., Wei, N., Almansob, Y. A. M., He, W., & Liu, D. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180868 · Cited by 37 · see citing works
Aducanumab and Its Effects on Tau Pathology: Is This the Turning Point of Amyloid Hypothesis?
Silvestro, S., Valeri, A., & Mazzon, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042011 · Cited by 35 · see citing works
Qin, X., Xiang, Y., Liu, Y., Chen, Y., He, Q., Chen, T., Tang, L., He, B., & Li, J. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1468561 · Cited by 35 · see citing works
Bridging Genomics to Phenomics at Atomic Resolution through Variation Spatial Profiling
Wang, C., & Balch, W. E. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.059 · Cited by 35 · see citing works
The vexing complexity of the amyloidogenic pathway
Castro, M., Hadziselimovic, A., & Sanders, C. R. (2019) · Protein Science · doi:10.1002/pro.3606 · Cited by 36 · see citing works
Schweickart, A., Batra, R., Neth, B. J., Martino, C., Shenhav, L., Zhang, A. R., Shi, P., Karu, N., Huynh, K., Meikle, P. J., et al. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00016-3 · Cited by 36 · see citing works
Alterations of Golgi organization in Alzheimer’s disease: A cause or a consequence?
Ayala, I., & Colanzi, A. (2016) · Tissue and Cell · doi:10.1016/j.tice.2016.11.007 · Cited by 34 · see citing works
Genetic Variants and Oxidative Stress in Alzheimer’s Disease
Kowalska, M., Wize, K., Prendecki, M., Lianeri, M., Kozubski, W. P., & Dorszewska, J. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666200224121447 · Cited by 34 · see citing works
γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor
Restrepo, L. J., DePew, A. T., Moese, E. R., Tymanskyj, S. R., Parisi, M. J., Aimino, M. A., Duhart, J. C., Fei, H., & Mosca, T. J. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.05.006 · Cited by 26 · see citing works
Mullane, K., & Williams, M. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.09.027 · Cited by 32 · see citing works
Guest, F. L., Rahmoune, H., & Guest, P. C. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-42667-5_8 · Cited by 34 · see citing works
Kezhu, W., Xu, P., Lü, C., Liming, D., Beiyue, Z., Jingwei, L., Yanyan, Y., & Liu, X. (2016) · Phytotherapy Research · doi:10.1002/ptr.5733 · Cited by 32 · see citing works
Tafoya, M., Madi, S., & Sillerud, L. O. (2016) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25563 · Cited by 31 · see citing works
Reale, M., Gonzales-Portillo, I., & Borlongan, C. V. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146535 · Cited by 31 · see citing works
A concise review of human brain methylome during aging and neurodegenerative diseases
Prasad G, R., & Jho, E.-H. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.10.215 · Cited by 31 · see citing works
Pregnancy as a model for aging
Giller, A., Andrawus, M., Gutman, D., & Atzmon, G. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101093 · Cited by 30 · see citing works
Olsen, I., & Singhrao, S. K. (2020) · Journal of Oral Microbiology · doi:10.1080/20002297.2020.1820834 · Cited by 32 · see citing works
Molecular Pathogenesis and Interventional Strategies for Alzheimer’s Disease: Promises and Pitfalls
Bhute, S., Sarmah, D., Datta, A., Rane, P., Shard, A., Goswami, A., Borah, A., Kalia, K., Dave, K. R., & Bhattacharya, P. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00104 · Cited by 30 · see citing works
Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis)
Wanionok, N. E., Morel, G. R., & Fernández, J. M. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102408 · Cited by 30 · see citing works
Khan, M. S., Qureshi, N., Khan, R., Son, Y., & Maqbool, T. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1578138 · Cited by 33 · see citing works
Hsieh, P., Wang, C., Tsai, C., Yeh, Y., Lee, Y. S., & Wu, Y. (2019) · Brain and Behavior · doi:10.1002/brb3.1281 · Cited by 29 · see citing works
Rao, C. V., Farooqui, M., Madhavaram, A., Zhang, Y., Asch, A. S., & Yamada, H. Y. (2020) · Aging Cell · doi:10.1111/acel.13221 · Cited by 29 · see citing works
Pierouli, K., Papakonstantinou, E., Papageorgiou, L., Diakou, I., Mitsis, Τ., Dragoumani, K., Spandidos, D. A., Bacopoulou, F., Chrousos, G. P., Goulielmos, G. N., et al. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5208 · Cited by 29 · see citing works
- Authors
- Giri, M., Lü, Y., & Zhang, M.
- Affiliations
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Venue
- Clinical Interventions in Aging
- Publisher
- Informa UK Limited
- Published
- 2016-05
- Volume
- 11
- Pages
- 665
- ISSN
- 1176-9092 (ISSN-L)
- 1178-1998
- PMC
- PMC4876682
- OpenAlex
- W2405825843
- Cited by
- 311
- References
- 201
- Citations by year
- 2026: 10 · 2025: 24 · 2024: 33 · 2023: 33 · 2022: 41 · 2021: 36 · 2020: 41 · 2019: 35 · 2018: 29 · 2017: 21 · 2016: 7 · 2015: 1
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Clinical Interventions in Aging (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, genetic risk factors, APP, presenilin 1, presenilin 2, APOE ε4, late-onset Alzheimer's disease, early-onset Alzheimer's disease, genome-wide association study, rare variants, PLD3, TREM2, UNC5C, AKAP9, ADAM10, neuropathology, pathogenesis
- MeSH terms
- Alzheimer Disease, Humans, Mutation, Risk Factors, Amyloid beta-Protein Precursor, Genetic Predisposition to Disease, Apolipoprotein E4, Presenilin-1, Presenilin-2, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review