The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies
Open accessAbstract
Alzheimer's disease constitutes a growing cause of cognitive impairment in aging population. Given that current treatments do not produce the desired therapeutic effects, the need for finding alternative biological and pharmacological approaches is critical. Accumulating evidence suggests inflammatory and oxidative stress responses as potential causal factors of cognitive impairments in Alzheimer's disease and healthy aging. Curcumin has received increased interest due to its unique molecular structure that targets inflammatory and antioxidant pathways as well as (directly) amyloid aggregation; one of the major hallmarks of Alzheimer's disease. Therefore, this review summarizes preclinical and clinical findings on curcumin as a potential cognitive enhancer in Alzheimer's disease and normal aging. Databases used for literature searches include PubMed, EMBASE and Web of Science; in addition, clinicaltrials.gov was used to search for clinical studies. Overall, animal research has shown very promising results in potentiating cognition, both physiologically and behaviourally. However, human studies are limited and results are less consistent, complicating their interpretation. These inconsistencies may be related to differences in methodology and the included population. Taking into account measurements of important inflammatory and antioxidant biomarkers, optimal dosages of curcumin, food interactions, and duration of treatment would increase our understanding on curcumin's promising effects on cognition. In addition, increasing curcumin's bioavailability could benefit future research.
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Curcumin in combination with vitamin C, B vitamins, piperine, and other dietary supplements has neuroprotective and synergistic effects.
“Although research has demonstrated that curcumin in combination with vitamin C, B vitamins, piperine, and other dietary supplements has neuroprotective and synergistic effects, further research is necessary to conclusively state curcumin’s ability at ameliorating cognitive function in humans [146,162,169].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [162]
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- Authors
- Voulgaropoulou, S. D., van Amelsvoort, T. A. M. J., Prickaerts, J., & Vingerhoets, C.
- Affiliations
- Maastricht University (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Voulgaropoulou, S.D.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 1725
- Pages
- 146476
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2976713729
- Cited by
- 243
- References
- 89
- Citations by year
- 2026: 20 · 2025: 42 · 2024: 53 · 2023: 36 · 2022: 35 · 2021: 39 · 2020: 16 · 2019: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, cc-by)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- curcumin, Alzheimer's disease, healthy aging, cognitive impairment, neuroinflammation, oxidative stress, amyloid fibril formation, cognitive enhancement, curcumin bioavailability, dietary interactions, clinical trials
- MeSH terms
- Healthy Aging, Aging, Alzheimer Disease, Animals, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Cognition, Curcumin, Humans, Treatment Outcome, Oxidative Stress
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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