Cited by 260Adipokines, Inflammation, and Metabolic DiseasesLipid metabolism and biosynthesisAdipose Tissue and Metabolism

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What Is Lipotoxicity?

Engin, Ayse Basak·2017·Advances in experimental medicine and biology

DOI 10.1007/978-3-319-48382-5_8

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Abstract

Enlarged fat cells in obese adipose tissue diminish capacity to store fat and are resistant to the anti-lipolytic effect of insulin. Insulin resistance (IR)-associated S-nitrosylation of insulin-signaling proteins increases in obesity. In accordance with the inhibition of insulin-mediated anti-lipolytic action, plasma free fatty acid (FFA) levels increase. Additionally, endoplasmic reticulum stress stimuli induce lipolysis by activating cyclic adenosine monophosphate/Protein kinase A (cAMP/PKA) and extracellular signal-regulated kinase ½ (ERK1/2) signaling in adipocytes. Failure of packaging of excess lipid into lipid droplets causes chronic elevation of circulating fatty acids, which can reach to toxic levels within non-adipose tissues. Deleterious effects of lipid accumulation in non-adipose tissues are known as lipotoxicity. In fact, triglycerides may also serve a storage function for long-chain non-esterified fatty acids and their products such as ceramides and diacylglycerols (DAGs). Thus, excess DAG, ceramide and saturated fatty acids in obesity can induce chronic inflammation and have harmful effect on multiple organs and systems. In this context, chronic adipose tissue inflammation, mitochondrial dysfunction and IR have been discussed within the scope of lipotoxicity.

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Authors: Engin, A. B.
Venue: Advances in experimental medicine and biology
Publisher: Springer International Publishing
Published: 2017
Volume: 960
Pages: 197-220
ISSN: 0065-2598 (ISSN-L)
2214-8019
DOI: 10.1007/978-3-319-48382-5_8
OpenAlex: W2623539005
Cited by: 260
References: 184
Citations by year: 2026: 9 · 2025: 32 · 2024: 35 · 2023: 38 · 2022: 44 · 2021: 40 · 2020: 24 · 2019: 24 · 2018: 12 · 2017: 2
FWCI: 74.41
Type: book chapter
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Advances in experimental medicine and biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: lipotoxicity, obesity, insulin resistance, adipocytes, lipolysis, S-nitrosylation, free fatty acids, endoplasmic reticulum stress, cAMP/PKA signaling, ERK signaling, lipid droplets, diacylglycerol, ceramide, chronic inflammation, mitochondrial dysfunction
MeSH terms: Adipose Tissue, Animals, Humans, Inflammation, Insulin Resistance, Lipids, Mitochondria, Obesity, Adipocytes

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