What Is Lipotoxicity?

The American Journal of Physiology

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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TLR4 links innate immunity and fatty acid-induced insulin resistance

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Mitochondrial membrane permeabilization in cell death

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Cellular mechanisms of insulin resistance

Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714

The mitochondrial permeability transition pore and its role in cell death

CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245

Oleic acid-induced perilipin 5 expression and lipid droplets formation are regulated by the PI3K/PPARα pathway in HepG2 cells

Zhong, W., Fan, B., Cong, H., Wang, T., & Gu, J. (2019) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2018-0729 · Cited by 23

Circulating perturbation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) is associated to cardiac remodeling and NLRP3 inflammasome in cardiovascular patients with insulin resistance risk

Vianello, E., Ambrogi, F., Kalousová, M., Badalyan, J., Dozio, E., Tacchini, L., Schmitz, G., Zima, T., Tsongalis, G. J., & Romanelli, M. M. C. (2024) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2024.104895 · Cited by 24

The Anti-obesity Effect of Allium cepa L. leaves on High Fat Diet Induced Obesity in Male Wistar Rats

Momoh, B. J., Shekins, O. O., & Anyanwu, G. O. (2022) · Clinical Complementary Medicine and Pharmacology · doi:10.1016/j.ccmp.2022.100035 · Cited by 22

Platelet-Activating Factor Promotes the Development of Non-Alcoholic Fatty Liver Disease

Yin, H., Shi, A., & Wu, J. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s367483 · Cited by 22

Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities

Wang, R., Sun, Q., Wu, X., Zhang, Y., Xing, X., Lin, K., Feng, Y., Wang, M., Wang, M., & Wang, Y. (2022) · Cells · doi:10.3390/cells11233735 · Cited by 22

Hypertrophy and ER Stress Induced by Palmitate Are Counteracted by Mango Peel and Seed Extracts in 3T3-L1 Adipocytes

Pratelli, G., Liberto, D. D., Carlisi, D., Emanuele, S., Giuliano, M., Notaro, A., Blasio, A. D., Calvaruso, G., D’Anneo, A., & Lauricella, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065419 · Cited by 25

Sleep apnea: An overlooked cause of lipotoxicity?

Gu, C., Younas, H., & Jun, J. C. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.09.007 · Cited by 22

Comparison of HepaRG and HepG2 cell lines to model mitochondrial respiratory adaptations in non‑alcoholic fatty liver disease

Maseko, T., Elkalaf, M., Peterová, E., Lotková, H., Staňková, P., Melek, J., Dušek, J., Žádníková, P., Čížková, D., Bezrouk, A., et al. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5342 · Cited by 21

Role of selenium and 17 β oestradiol in modulating lipid accumulation in in vitro models of obesity and NAFLD

Walsh, S. K., Pettigrew, K., Mezzani, I., Alaswad, I., & Bermano, G. (2024) · Food & medicine homology. · doi:10.26599/fmh.2025.9420056 · Cited by 24

Mechanistic insights into impaired β-oxidation and its role in mitochondrial dysfunction: A comprehensive review

Aqeel, A., Akram, A., Ali, M., Iqbal, M., Aslam, M., Rukhma, & Shah, F. I. (2025) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112129 · Cited by 23

Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor

Personnaz, J., Piccolo, E. B., Dortignac, A., Iacovoni, J. S., Mariette, J., Rocher, V., Polizzi, A., Batut, A., Deleruyelle, S., Bourdens, L., et al. (2022) · Science Advances · doi:10.1126/sciadv.abg9055 · Cited by 22

Exercise regulation of hepatic lipid droplet metabolism

la Fuente, F. P.-D., Bórquez, J. C., Díaz‐Castro, F., Espinosa, A., Chiong, M., & Troncoso, R. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120522 · Cited by 20

Clostridium butyricum Inhibits Fat Deposition via Increasing the Frequency of Adipose Tissue‐Resident Regulatory T Cells

Li, H., Jia, Y., Weng, D., Ju, Z., Zhao, Y., Liu, S., Liu, Y., Song, M., Cui, L., Sun, S., et al. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100884 · Cited by 20

Therapeutic Effect of Curcumin on 5/6Nx Hypertriglyceridemia: Association with the Improvement of Renal Mitochondrial β-Oxidation and Lipid Metabolism in Kidney and Liver

Ceja-Galicia, Z. A., García‐Arroyo, F. E., Aparicio‐Trejo, O. E., El‐Hafidi, M., Gonzaga, G., León‐Contreras, J. C., Hernández‐Pando, R., Guevara‐Cruz, M., Tovar, A. R., Rojas‐Morales, P., et al. (2022) · Antioxidants · doi:10.3390/antiox11112195 · Cited by 19

Somatosensory innervation of adipose tissues

Wang, Y., & Li, Y. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114174 · Cited by 21

Lipotoxicity Induces Cardiomyocyte Ferroptosis via Activating the STING Pathway

Chen, Q., Wang, Y., Wang, J., Ouyang, X., Zheng, B., Huang, Y., Huang, Z., Zheng, B., Peng, L., Tang, X., et al. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0510 · Cited by 19

Nonalcoholic Fatty Liver Disease.

Ding, L.-L., Oligschlaeger, Y., Shiri-Sverdlov, R., & Houben, T. (2020) · Handbook of Experimental Pharmacology · doi:10.1007/164_2020_352 · Cited by 4

The Influence of Obesity and Associated Fatty Acids on Placental Inflammation

Eastman, A. J., Moore, R. E., Townsend, S. D., Gaddy, J. A., & Aronoff, D. M. (2021) · Clinical Therapeutics · doi:10.1016/j.clinthera.2020.12.018 · Cited by 24

Renal lipotoxicity in diabetic and obesity‐associated kidney diseases: Molecular mechanisms and therapeutic targeting

Liu, Q., Guo, S., Tong, Y., Li, Q., Baoxiang, Z., Wang, J., Wang, Y., Gao, W., & Zou, X. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70220 · Cited by 21

Calcium pyruvate attenuates fat deposition by augmenting fatty acid oxidation and inhibiting glucose oxidation in juvenile large yellow croaker (Larimichthys crocea) consuming a high-fat diet

Zhang, Y., Lai, W., Chen, Q., Fang, W. Y., Cui, K., He, Y., Li, X., Mai, K., & Ai, Q. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738778 · Cited by 18

Association of dietary antioxidant index with body mass index in adolescents

Kavkani, B. A., Roumi, Z., Ardekanizadeh, N. H., Vahid, F., Gholamalizadeh, M., Kalantari, N., Ataei, A., & Doaei, S. (2022) · Obesity Science & Practice · doi:10.1002/osp4.639 · Cited by 19

Nuciferine Ameliorates Nonesterified Fatty Acid-Induced Bovine Mammary Epithelial Cell Lipid Accumulation, Apoptosis, and Impaired Migration via Activating LKB1/AMPK Signaling Pathway

Li, J., Zhao, C., Liu, M., Chen, L., Zhu, Y., Gao, W., Du, X., Song, Y., Li, X., Liu, G., et al. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c06133 · Cited by 18

Changes of energy metabolism in failing heart and its regulation by SIRT3

Wang, X. Q., Huang, Y., Zhang, K., Chen, F., Nie, T., Zhao, Y., He, F., & Ni, J. (2023) · Heart Failure Reviews · doi:10.1007/s10741-023-10295-5 · Cited by 19

Pharmacokinetics and Biological Activities of Notoginsenoside R1: A Systematical Review

Wen, C., Liao, X., Ye, X., & Lai, W. (2025) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x25500090 · Cited by 17

Sterile inflammation in MASH: emerging role of extracellular RNA and therapeutic strategies

Raza, S., Mahamood, R., Medhe, P., Shahi, A., Yadav, A., Tewari, A., & Sinha, R. A. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00083-0 · Cited by 21

Simultaneous evaluation of metabolomic and inflammatory biomarkers in children with different body mass index (BMI) and waist-to-height ratio (WHtR)

Chavira-Suárez, E., Rosel-Pech, C., Polo‐Oteyza, E., Ancira‐Moreno, M., Ibarra‐González, I., Vela-Amieva, M. B., Meraz‐Cruz, N., Aguilar-Salinas, C. A., & Vadillo‐Ortega, F. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237917 · Cited by 17

Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies

Zhang, Z., Wu, H., Wang, T., Liu, Y., & Meng, C. (2022) · Medical Science Monitor · doi:10.12659/msm.937051 · Cited by 19

Vitamin D and Swimming Exercise Prevent Obesity in Rats under a High-Fat Diet via Targeting FATP4 and TLR4 in the Liver and Adipose Tissue

Kolieb, E., Maher, S. A., Shalaby, M. N., Alsuhaibani, A. M., Alharthi, A., Hassan, W. A., & El-Sayed, K. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192113740 · Cited by 17

The mTORC1–G9a–H3K9me2 axis negatively regulates autophagy in fatty acid–induced hepatocellular lipotoxicity

Mushtaq, A., Ashraf, N. U., & Altaf, M. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.102937 · Cited by 17

Lipolysis and gestational diabetes mellitus onset: a case-cohort genome-wide association study in Chinese

Zhang, M., Li, Q., Wang, K.-L., Dong, Y., Mu, Y., Cao, Y.-M., Liu, J., Li, Z., Cui, H.-L., Liu, H., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03902-4 · Cited by 17

Lipotoxicity and Oocyte Quality in Mammals: Pathogenesis, Consequences, and Reversibility

Meulders, B., Marei, W. F. A., Loier, L., & Leroy, J. (2024) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-111523-102249 · Cited by 16

Mitochondria to plasma membrane redox signaling is essential for fatty acid β-oxidation-driven insulin secretion

Jabůrek, M., Klöppel, E., Průchová, P., Mozheitová, O., Tauber, J. A., Engstová, H., & Ježek, P. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103283 · Cited by 16

Liver at crossroads: unraveling the links between obesity, chronic liver diseases, and the mysterious obesity paradox

Elsabaawy, M. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01493-y · Cited by 18

Do different lipid components accelerate the pathogenesis and severity of Diabetic Retinopathy?

Mondal, L. K., Pramanik, S., Chowdhury, S., Bose, C., Bera, D., Saha, A., & Bhattacharjee, K. (2022) · International Journal of Retina and Vitreous · doi:10.1186/s40942-022-00390-4 · Cited by 16

Circulating Short-Chain Fatty Acids in Preterm Birth: A Pilot Case-Control Study

Nickodem, C. A., Menon, R., McDonald, T. J., & Taylor, B. D. (2020) · Reproductive Sciences · doi:10.1007/s43032-019-00126-0 · Cited by 15

Effect and Signaling Pathways of Nelumbinis Folium in the Treatment of Hyperlipidemia Assessed by Network Pharmacology

Pan, Q., Zhang, Z., Tian, C.-Y., Yu, T., Yang, R., & Chai, X. (2021) · World Journal of Traditional Chinese Medicine · doi:10.4103/2311-8571.328619 · Cited by 14

DMF-Activated Nrf2 Ameliorates Palmitic Acid Toxicity While Potentiates Ferroptosis Mediated Cell Death: Protective Role of the NO-Donor S-Nitroso-N-Acetylcysteine

Abu-Halaka, D., Shpaizer, A., Zeigerman, H., Kanner, J., & Tirosh, O. (2023) · Antioxidants · doi:10.3390/antiox12020512 · Cited by 15

Hepatic protein Carbonylation profiles induced by lipid accumulation and oxidative stress for investigating cellular response to non-alcoholic fatty liver disease in vitro

Chienwichai, P., Reamtong, O., Boonyuen, U., Pisitkun, T., Somparn, P., Tharnpoophasiam, P., Worakhunpiset, S., & Topanurak, S. (2019) · Proteome Science · doi:10.1186/s12953-019-0149-9 · Cited by 16

Targeting Intramyocellular Lipids to Improve Aging Muscle Function

Russ, D. W., Manickam, R., & Tipparaju, S. M. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02622-6 · Cited by 15

Magnesium Isoglycyrrhizinate Reduces Hepatic Lipotoxicity through Regulating Metabolic Abnormalities

Lu, L., Hao, K., Hong, Y., Liu, J., Zhu, J., Jiang, W., Zhu, Z., Wang, G., & Peng, Y. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115884 · Cited by 14

Rapamycin suppresses inflammation and increases the interaction between p65 and IκBα in rapamycin-induced fatty livers

Ge, C., Ma, C., Cui, J., Dong, X., Sun, L., Li, Y., & Yu, A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281888 · Cited by 17

Palmitic Acid Inhibits Myogenic Activity and Expression of Myosin Heavy Chain MHC IIb in Muscle Cells through Phosphorylation-Dependent MyoD Inactivation

Matsuba, I., Fujita, R., & Iida, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065847 · Cited by 14

A Comprehensive Review on Non-Alcoholic Fatty Liver Disease

Sahu, P., Chhabra, P., & Mehendale, A. M. (2023) · Cureus · doi:10.7759/cureus.50159 · Cited by 22

Nifedipine Exacerbates Lipogenesis in the Kidney via KIM-1, CD36, and SREBP Upregulation: Implications from an Animal Model for Human Study

Lin, Y., Wang, J.-C., Wu, M.-S., Lin, Y., Chen, C.-R., Chen, C.-Y., Chen, K., & Peng, C.-C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124359 · Cited by 14

Cannabidiol improves glucose utilization and modulates glucose-induced dysmetabolic activities in isolated rats' peripheral adipose tissues

Erukainure, O. L., Matsabisa, M. G., Salau, V. F., Olofinsan, K. A., Oyedemi, S. O., Chukwuma, C. I., Nde, A. L., & Islam, M. S. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112863 · Cited by 14

Untargeted metabolomics based on ultra-high performance liquid chromatography-mass spectrometry/MS reveals the lipid-lowering mechanism of taurine in hyperlipidemia mice

Guo, X., Ou, T., Yang, X., Song, Q., Zhu, L., Mi, S., Zhang, J., Zhang, Y., Chen, W., & Guo, J. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1367589 · Cited by 13

Minor lipids profiling in subcutaneous and epicardial fat tissue using LC/MS with an optimized preanalytical phase

Tomášová, P., Cermakova, M., Pelantová, H., Vecka, M., Kratochvílová, H., Lipš, M., Lindner, J., Šedivá, B., Haluzı́k, M., & Kuzma, M. (2019) · Journal of Chromatography B · doi:10.1016/j.jchromb.2019.03.006 · Cited by 13

Catching Lipid Droplet Contacts by Proteomics

Krahmer, N., & Mann, M. (2019) · Contact · doi:10.1177/2515256419859186 · Cited by 14

Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions

Kim, J. T., Lim, M. A., Lee, S. E., Kim, H. J., Koh, H. Y., Lee, J. H., Jun, S. M., Kim, J., Kim, K. H., Shin, H. S., et al. (2022) · The Journal of Pathology · doi:10.1002/path.5997 · Cited by 11

Association between progranulin serum levels and dietary intake

Nicoletto, B. B., Sarmento, R. A., Pedrollo, E. F., Krolikowski, T. C., & Canani, L. H. S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202149 · Cited by 13

Juvenile high–fat diet–induced senescent glial cells in the medial prefrontal cortex drives neuropsychiatric behavioral abnormalities in mice

Yang, Y., Duan, C., Huang, L., Xia, X., Zhong, Z., Wang, B., Wang, Y., & Ding, W. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112838 · Cited by 13

Cutoff point of TyG index for metabolic syndrome in Brazilian farmers

Ferreira, J. R. S., Zandonade, E., Bezerra, O. M. D. P. A., & Salaroli, L. B. (2021) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000401 · Cited by 13

Mitochondrial Adaptive Responses to Hypertriglyceridemia and Bioactive Lipids

Alberici, L. C., & Oliveira, H. C. F. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0180 · Cited by 12

Tripterygium glycosides improve abnormal lipid deposition in nephrotic syndrome rat models

Zheng, B., Lu, D., Chen, X., Yin, Y.-H., Chen, W., Wang, X., Lin, H., Xu, P., Wu, A., & Liu, B. (2023) · Renal Failure · doi:10.1080/0886022x.2023.2182617 · Cited by 12

Z-Ligustilide restricts rabies virus replication by inducing ferroptosis through the ACSL4-LPCAT3-POR pathway

Zhao, J., Wang, Q., Liu, Z., Sun, M., Zhou, R., Fu, Z. F., Zhao, L., & Zhou, M. (2024) · Veterinary Microbiology · doi:10.1016/j.vetmic.2024.110260 · Cited by 12

Effects of Lifestyle Intervention in Tissue-Specific Lipidomic Profile of Formerly Obese Mice

Dahdah, N., González-Franquesa, A., Samino, S., Gama-Pérez, P., Herrero, L., Perales, J. C., Yanes, Ó., Malagón, M. M., & García-Rovés, P. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073694 · Cited by 13

The Lipid-Oxidative Stress Axis: Novel Therapeutic Targets for Podocytopathy

Liu, Y., Zou, M., & Wang, Y. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s530737 · Cited by 13

The Effects of a Meldonium Pre-Treatment on the Course of the Faecal-Induced Sepsis in Rats

Đurašević, S., Ružičić, A., Lakic, I. V., Tosti, T. B., Đurović, S. D., Glumac, S., Pavlović, S. Z., Borković-Mitić, S., Grigorov, I., Stankovic, S. D., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189698 · Cited by 11

Impact of renal tubular Cpt1a overexpression on the kidney metabolome in the folic acid-induced fibrosis mouse model

Cuevas-Delgado, P., Miguel, V., Rupérez, F. J., Lamas, S., & Barbas, C. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1161036 · Cited by 12

Progress in molecular mechanisms of coronary microvascular dysfunction

Li, H., Gao, Y., & Lin, Y. (2023) · Microcirculation · doi:10.1111/micc.12827 · Cited by 12

Linoleic acid, mitochondria, gut microbiome, and metabolic health: a mechanistic review

Mercola, J. M. (2025) · Advances in Redox Research · doi:10.1016/j.arres.2025.100128 · Cited by 11

Lipotoxicity suppresses the synthesis of growth hormone in pituitary somatotrophs via endoplasmic reticulum stress

Gong, Y., Yang, J., Wei, S., Yang, R., Gao, L., Shao, S., & Zhao, J. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16532 · Cited by 11

Quantification of Extramyocellular Lipids and Intramuscular Fat from Muscle Echo Intensity in Lower Limb Muscles: A Comparison of Four Ultrasound Devices against Magnetic Resonance Spectroscopy

Piponnier, E., Ishikawa, M., Kunimasa, Y., Sano, K., Jagot, K., Boisseau, N., Kurihara, T., & Martin, V. (2023) · Sensors · doi:10.3390/s23115282 · Cited by 13

Serum albumin saturation test based on non-esterified fatty acids imbalance for clinical employment

Gonçalves-de-Albuquerque, C. F., Barnese, M. R. C., Soares, M. A., Castro-Faria, M. V., Silva, A. R., Castro-Faria-Neto, H. C., Burth, P., & Younes-Ibrahim, M. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.05.003 · Cited by 11

Grease on—Perspectives in lipid droplet biology

Beller, M., Herker, E., & Füllekrug, J. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.06.017 · Cited by 12

Proteome of milk fat globule membrane and mammary gland tissue in goat fed different lipid supplementation

Marques, I. T. O., Vasconcelos, F. R., Alves, J. P. M., Montenegro, A. R., Fernandes, C. C. L., de Oliveira, F. B. B., Silva, C. P., Nagano, C. S., Figueiredo, F. C., Beserra, F. J., et al. (2021) · Small Ruminant Research · doi:10.1016/j.smallrumres.2021.106378 · Cited by 11

Fyn Phosphorylates Transglutaminase 2 (Tgm2) and Modulates Autophagy and p53 Expression in the Development of Diabetic Kidney Disease

Uehara, R., Yamada, E., Okada, S., Bastie, C. C., Maeshima, A., Ikeuchi, H., Horiguchi, K., & Yamada, M. (2023) · Cells · doi:10.3390/cells12081197 · Cited by 10

The beneficial impact of curcumin on cardiac lipotoxicity

Abolfazli, S., Butler, A. E., Kesharwani, P., & Sahebkar, A. (2024) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgae102 · Cited by 10

Non-invasive diagnosis of steatosis, inflammatory changes and liver fibrosis in patients with non-alcoholic fatty liver diseases. Pilot study

Ciećko-Michalska, I., Szczepanek, M., Wierzbicka-Tutka, I., Zahradnik-Bilska, J., & Mach, T. (2018) · Archives of Medical Science - Atherosclerotic Diseases · doi:10.5114/amsad.2018.81184 · Cited by 10

Fasting and refeeding cycles alter subcutaneous white depot growth dynamics and the morphology of brown adipose tissue in female rats

Fernández, M. A. R., Vilca, C. M. C., Batista, L. O., Figueiredo, L. S., Ribeiro, R. A., do Carmo, M. D. G. T., & de Albuquerque, K. T. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520004055 · Cited by 11

Body weight loss and glycemic control on the outcomes of patients with NAFLD. The role of new antidiabetic agents

García‐Compeán, D., Kumar, R., del Cueto-Aguilera, Á. N., Maldonado-Garza, H. J., & Villarreal‐Pérez, J. Z. (2022) · Annals of Hepatology · doi:10.1016/j.aohep.2022.100751 · Cited by 10

Lipid nanoparticle encapsulated oleic acid induced lipotoxicity to hepatocytes via ROS overload and the DDIT3/BCL2/BAX/Caspases signaling in vitro and in vivo

Liu, Y., Zhu, H., Li, T.-Y., Yang, X., Li, X.-J., & Zhang, W. K. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.06.024 · Cited by 9

Effect of Crocetin on Basal Lipolysis in 3T3-L1 Adipocytes

Cimas, F. J., de la Cruz-Morcillo, M. Á., Cifuentes, C., Moratalla‐López, N., Alonso, G. L., Nava, E., & Llorens, S. (2023) · Antioxidants · doi:10.3390/antiox12061254 · Cited by 9

Developmental programming: Prenatal testosterone excess disrupts pancreatic islet developmental trajectory in female sheep

Jackson, I. J., Puttabyatappa, M., Anderson, M. J., Muralidharan, M., Veiga‐Lopez, A., Gregg, B. E., Limesand, S. W., & Padmanabhan, V. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110950 · Cited by 9

Lipid Dyshomeostasis and Inherited Cerebellar Ataxia

Zhao, J., Zhang, H., Fan, X., Yu, X., & Huai, J. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02826-2 · Cited by 9

Paraoxonase 1 Ameliorates Renal Lipotoxicity by Activating Lipophagy and Inhibiting Pyroptosis

Liu, Q., Xiao, J., Wang, S., Li, Y., Yang, L.-J., Lu, Q., Wu, X., Cao, J., Hong, Y., & Zhang, B. (2022) · American Journal Of Pathology · doi:10.1016/j.ajpath.2022.07.011 · Cited by 8

Terminalia catappa Leaf Abrogates Diabetes-induced Dyslipidaemia in Type 2 Diabetic Rats by Upregulating Lipid Metabolic Genes

Iheagwam, F. N., Iheagwam, O. T., Ogunlana, O. O., & Chinedu, S. N. (2023) · Gene Expression · doi:10.14218/ge.2023.00053 · Cited by 8

Identifying early abdominal obesity risk in adolescents by telemedicine: A cross-sectional study in Greece

Bacopoulou, F., Landis, G., Pałasz, A., Τσίτσικα, Ά., Vlachakis, D., Tsarouhas, K., Tsitsimpikou, C., Stefanaki, C., Kouretas, D., & Efthymiou, V. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111532 · Cited by 8

Leptin modulates oocyte maturation by a central and a direct pathway in zebrafish

Lakshminarasimha, A. B., Puvvada, M., Hammerschmidt, M., & Michel, M. (2022) · Journal of Endocrinology · doi:10.1530/joe-22-0026 · Cited by 8

We are what we eat: The role of lipids in metabolic diseases

Berná, G., López-Bermudo, L., Escudero‐López, B., & Martı́n, F. (2023) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2022.11.004 · Cited by 8

Corticotropin‐releasing hormone and obesity: From fetal life to adulthood

Vasconcelos, I., von Hafe, M., Adão, R., Leite-Moreira, A. F., & Brás‐Silva, C. (2024) · Obesity Reviews · doi:10.1111/obr.13763 · Cited by 7

Serum albumin-fatty acid saturation test

Gonçalves-de-Albuquerque, C. F., Barnese, M. R. C., Soares, M. A., Faria, M. V. C., Silva, A. R., Neto, H. C. C. F., Burth, P., & Younes-Ibrahim, M. (2019) · MethodsX · doi:10.1016/j.mex.2019.08.004 · Cited by 7

Targeting Extracellular RNA Mitigates Hepatic Lipotoxicity and Liver Injury in NASH

Tewari, A., Rajak, S., Raza, S., Gupta, P., Chakravarti, B., Srivastava, J., Chaturvedi, C. P., & Sinha, R. A. (2023) · Cells · doi:10.3390/cells12141845 · Cited by 7

The impact of a maternal and offspring obesogenic diet on daughter’s oocyte mitochondrial ultrastructure and bioenergetic responses. Insights from an outbred mouse model

Xhonneux, I., Marei, W. F. A., Meulders, B., Andries, S., & Leroy, J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1288472 · Cited by 7

The relationship of oleic acid/albumin molar ratio and clinical outcomes in leptospirosis

Martins, C. D. A., dos Santos, M. C. B., Gonçalves-de-Albuquerque, C. F., Castro-Faria-Neto, H. C., Castro-Faria, M. V., Burth, P., & Younes-Ibrahim, M. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06420 · Cited by 7

Phaseolus vulgaris L. Leaves Increase Short-Chain Fatty Acid (SCFA) Production, Ameliorating Early Metabolic Alterations

Becerril-Campos, A. A., Ocampo-Anguiano, P. V., Mondragón-Jacobo, C., García, K. E., Camacho-Barrón, M., Anaya‐Loyola, M. A., Feregrino‐Pérez, A. A., García-Gasca, T., & Ahumada-Solórzano, S. M. (2022) · Plant Foods for Human Nutrition · doi:10.1007/s11130-022-00992-1 · Cited by 7

Circulating Extracellular Vesicles from Heart Failure Patients Inhibit Human Cardiomyocyte Activities

Ke, Z., Wei, X., Zhi, Z., Shang, S., Zhang, S., Xu, Y., Fu, X., Cheng, L., Yao, J., Li, Y., et al. (2024) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-024-10571-1 · Cited by 7

PPARγ—A Factor Linking Metabolically Unhealthy Obesity with Placental Pathologies

Kwiatkowski, S., Kajdy, A., Stefanska, K. A., Bednarek-Jędrzejek, M., Dzidek, S., Tousty, P., Sokołowska, M., & Kwiatkowska, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313167 · Cited by 8

Low-dose spironolactone abates cardio-renal disorder by reduction of BAX/inflammasome expression in experimentally induced polycystic ovarian syndrome rat model

Peter, M. U., Areloegbe, S. E. J., Akintayo, C. O., Oniyide, A. A., Aturamu, A., & Olaniyi, K. S. (2022) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2022-0176 · Cited by 6

Diagnostic performance of hypoechoic perinephric fat as a predictor of prediabetes and diabetes

Shen, L., Tse, J. R., Negrete, L. M., Shon, A., Yoon, L. S., Liang, T., & Kamaya, A. (2022) · Abdominal Radiology · doi:10.1007/s00261-022-03763-3 · Cited by 6

The aqueous fraction of Castanea crenata inner shell extract reduces obesity and intramuscular lipid accumulation via induction of mitochondrial respiration and fatty acid oxidation in muscle

Lee, S. R., Jo, S. L., Heo, J. H., Kim, T., Lee, K. P., & Hong, E. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153974 · Cited by 6

The role of high fat diet in the regulation of MAP kinases activity in left ventricular fibrosis

Czarzasta, K., Koperski, Ł., Segiet, A., Janiszewski, M., Kuch, M., Górnicka, B., & Cudnoch‐Jędrzejewska, A. (2019) · Acta Histochemica · doi:10.1016/j.acthis.2019.01.010 · Cited by 6

Plasma circulating microRNAs in patients with stable coronary artery disease – Impact of different cardiovascular risk profiles and glomerular filtration rates

Trušinskis, K., Lapsovs, M., Paeglīte, S., Knoka, E., Caunīte, L., Mazule, M., Briede, I., Jēgere, S., Kumsārs, I., Narbute, I., et al. (2021) · Journal of Clinical and Translational Research · doi:10.18053/jctres.07.202102.014 · Cited by 6

Dysfunctional glucose metabolism triggers oxidative stress to induce kidney injury in diabetes

Gao, M., Dai, M.-T., & Gong, G. (2025) · World Journal of Diabetes · doi:10.4239/wjd.v16.i4.102554 · Cited by 6

Growth, fusion and degradation of lipid droplets: advances in lipid droplet regulatory protein

Ge, Y., Cao, Y., Li, F., Wang, J., Liu, Y., Guo, W., Liu, J., & Fu, S. (2024) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2024.2388779 · Cited by 5

Distinct lipidomic profiles but similar improvements in aerobic capacity following sprint interval training versus moderate-intensity continuous training in male adolescents

Su, W., Liu, J., Wang, A., Zhang, H., Sun, Y., Yan, Z., Svensson, M., Yu, J., & Zhao, L. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1475391 · Cited by 5

Excessive dietary saturated fat or fructose and their combination (found in ultra-processed foods) impair mitochondrial dynamics markers and cause brown adipocyte whitening in adult mice

Glauser, J. S. D. O., Santana-Oliveira, D. A., Silva-Veiga, F. M., Fernandes‐da‐Silva, A., Águila, M. B., & Souza‐Mello, V. (2025) · Nutrition · doi:10.1016/j.nut.2025.112805 · Cited by 5

Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis.

Bourayou, E., Perchet, T., Meunier, S., Bouvier, H., Mailhe, M.-P., Melanitou, E., Cumano, A., & Golub, R. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113676 · Cited by 5

Effects of dietary chlorogenic acid supplementation on laying performance, egg quality, antioxidant capacity, and liver lipid metabolism in late-peak laying hens

Zhao, H., Guo, L., Yan, M. J., Sun, Y., Hong, Y., & Zhu, M. (2025) · Italian Journal of Animal Science · doi:10.1080/1828051x.2025.2462409 · Cited by 5

Caffeic Acid Phenethyl Ester Inhibits Basal Lipolysis by Activating PPAR-Gamma and Increasing Lipid Droplet-Associated Perilipin in Mature Rat Adipocytes

Trang, N. T. T., Chiu, W., Feng, Y., Hsieh, S.-L., Tung, D. D., Chang, J., & Fong, T.-H. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/6007233 · Cited by 5

Mechanism of Obesity-Related Lipotoxicity and Clinical Perspective

Engin, A. B. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_5 · Cited by 37

From chronic overnutrition to insulin resistance: The role of fat-storing capacity and inflammation

Lionetti, L., Mollica, M. P., Lombardi, A., Cavaliere, G., Gifuni, G., & Barletta, A. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2008.10.010 · Cited by 223

Insulin Resistance, Obesity and Lipotoxicity

Yazıcı, D., & Sezer, H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_12 · Cited by 525

Adipose tissue inflammation and ectopic lipid accumulation [Review]

Suganami, T., Tanaka, M., & Ogawa, Y. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0271 · Cited by 207

Adipose tissue and insulin resistance in obese

Ahmed, B., Sultana, R., & Greene, M. W. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111315 · Cited by 1,162