Cited by 260Adipokines, Inflammation, and Metabolic DiseasesLipid metabolism and biosynthesisAdipose Tissue and Metabolism

The DOI matches its Crossref record; 183 of the 184 references it cites were found in a registry or an index.

What Is Lipotoxicity?

Engin, Ayse Basak·2017·Advances in experimental medicine and biology

DOI 10.1007/978-3-319-48382-5_8

Open this paper in CoChat — free account

Abstract

Enlarged fat cells in obese adipose tissue diminish capacity to store fat and are resistant to the anti-lipolytic effect of insulin. Insulin resistance (IR)-associated S-nitrosylation of insulin-signaling proteins increases in obesity. In accordance with the inhibition of insulin-mediated anti-lipolytic action, plasma free fatty acid (FFA) levels increase. Additionally, endoplasmic reticulum stress stimuli induce lipolysis by activating cyclic adenosine monophosphate/Protein kinase A (cAMP/PKA) and extracellular signal-regulated kinase ½ (ERK1/2) signaling in adipocytes. Failure of packaging of excess lipid into lipid droplets causes chronic elevation of circulating fatty acids, which can reach to toxic levels within non-adipose tissues. Deleterious effects of lipid accumulation in non-adipose tissues are known as lipotoxicity. In fact, triglycerides may also serve a storage function for long-chain non-esterified fatty acids and their products such as ceramides and diacylglycerols (DAGs). Thus, excess DAG, ceramide and saturated fatty acids in obesity can induce chronic inflammation and have harmful effect on multiple organs and systems. In this context, chronic adipose tissue inflammation, mitochondrial dysfunction and IR have been discussed within the scope of lipotoxicity.

Integrity signals

Registry

Crossref · 10.1007/978-3-319-48382-5_8

Cites

183 of 183 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The American Journal of Physiology
(1899) · The American Naturalist · doi:10.1086/277182 · Cited by 5,680
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Mitochondrial membrane permeabilization in cell death
Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598
Cellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714
The mitochondrial permeability transition pore and its role in cell death
CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630588100 · Cited by 2,075
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
Minokoshi, Y., Kim, Y.-B., Peroni, O. D., Fryer, L. G. D., Müller, C., Carling, D., & Kahn, B. B. (2002) · Nature · doi:10.1038/415339a · Cited by 2,053
Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance
Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990
Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes
Esser, N., Legrand-Poels, S., Piette, J., Scheen, A. J., & Paquot, N. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.04.006 · Cited by 1,981
Obesity-induced inflammatory changes in adipose tissue
Wellen, K. E., & Hotamisligil, G. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320514 · Cited by 1,823
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806
Diabetes and Vascular Disease
Creager, M. A., Lüscher, T. F., of, P. W. T. A., Cosentino, F., & Beckman, J. A. (2003) · Circulation · doi:10.1161/01.cir.0000091257.27563.32 · Cited by 1,675
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells
Inoguchi, T., Li, P., Umeda, F., Yu, H. Y., Kakimoto, M., Imamura, M., Aoki, T., Etoh, T., Hashimoto, T., Naruse, M., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1939 · Cited by 1,577
Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle
Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200958200 · Cited by 1,561
NAD + /NADH and NADP + /NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences
Ying, W. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1672 · Cited by 1,494
Banting Lecture 2001
McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435
Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity
Dresner, A., Laurent, D., Marcucci, M., Griffin, M. E., Dufour, S., Cline, G. W., Slezak, L. A., Andersen, D. K., Hundal, R. S., Rothman, D. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5001 · Cited by 1,311
Nrf2 signaling in coordinated activation of antioxidant gene expression
Jaiswal, A. K. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.02.074 · Cited by 1,263
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232
Inflammation and insulin resistance
de Luca, C., & Olefsky, J. M. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.11.057 · Cited by 1,161
Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway
Zhang, D. D. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600971974 · Cited by 1,105
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.
Copps, K. D., & White, M. F. (2012) · Diabetologia · doi:10.1007/s00125-012-2644-8 · Cited by 1,017
Thematic review series: Adipocyte Biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis
Brasaemle, D. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700014-jlr200 · Cited by 997
Lipotoxicity: when tissues overeat
Schaffer, J. E. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200306000-00008 · Cited by 933
Lipotoxic diseases
Unger, R. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104057 · Cited by 875
Ceramides in insulin resistance and lipotoxicity
Summers, S. A. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.11.002 · Cited by 866
Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice
Shimomura, I., Matsuda, M., Hammer, R. E., Bashmakov, Y. K., Brown, M. S., & Goldstein, J. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00010-9 · Cited by 860
Regulation of energy metabolism by long-chain fatty acids
Nakamura, M., Yudell, B. E., & Loor, J. J. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.12.001 · Cited by 858
Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction
Morino, K., Petersen, K. F., & Shulman, G. I. (2006) · Diabetes · doi:10.2337/db06-s002 · Cited by 853
Obesity and Free Fatty Acids
Boden, G. H. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.06.007 · Cited by 852
Fatty acid import into mitochondria
Kerner, J., & Hoppel, C. L. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00044-5 · Cited by 805
Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
Winder, W. W., & Hardie, D. G. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.2.e299 · Cited by 799
Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3
Brand, M. D., & Esteves, T. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.002 · Cited by 785
The randle cycle revisited: a new head for an old hat.
Hue, L., & Taegtmeyer, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00093.2009 · Cited by 743
A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
McGarry, J. D., Mannaerts, G. P., & Foster, D. W. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108764 · Cited by 736
Mechanisms of insulin resistance in obesity
Ye, J. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0262-6 · Cited by 699
Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms
Ueki, K., Kondo, T., & Kahn, C. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.12.5434-5446.2004 · Cited by 686
Influence of body fat distribution on free fatty acid metabolism in obesity.
Jensen, M. D., Haymond, M. W., Rizza, R. A., Cryer, P. E., & Miles, J. M. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113997 · Cited by 683
Minireview: Weapons of Lean Body Mass Destruction: The Role of Ectopic Lipids in the Metabolic Syndrome
Unger, R. H. (2003) · Endocrinology · doi:10.1210/en.2003-0870 · Cited by 678
Malonyl-CoA, fuel sensing, and insulin resistance
Ruderman, N. B., Saha, A. K., Vavvas, D. G., & Witters, L. A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e1 · Cited by 649
A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
Chavez, J. A., Knotts, T. A., Wang, L.-P., Li, G., Dobrowsky, R. T., Florant, G. L., & Summers, S. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212307200 · Cited by 617
Palmitate-induced Apoptosis Can Occur through a Ceramide-independent Pathway
Listenberger, L. L., Ory, D. S., & Schaffer, J. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010286200 · Cited by 594
Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
Borradaile, N. M., Han, X., Harp, J. D., Gale, S. E., Ory, D. S., & Schaffer, J. E. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600299-jlr200 · Cited by 564
A Molecular Basis for Insulin Resistance
Paz, K., Hemi, R., LeRoith, D., Karasik, A., Elhanany, E., Kanety, H., & Zick, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29911 · Cited by 556
Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor-κB Pathway in Rat Liver
Boden, G., She, P., Mozzoli, M., Cheung, P., Gumireddy, K., Reddy, P., Xiang, X., Luo, Z., & Ruderman, N. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3458 · Cited by 528
The Regulation and Physiology of Mitochondrial Proton Leak
Divakaruni, A. S., & Brand, M. D. (2011) · Physiology · doi:10.1152/physiol.00046.2010 · Cited by 514
Carnitine and Acylcarnitines
Reuter, S. E., & Evans, A. M. (2012) · Clinical Pharmacokinetics · doi:10.1007/bf03261931 · Cited by 507
Lipid accumulation in non-adipose tissue and lipotoxicity
van Herpen, N. A., & Schrauwen-Hinderling, V. B. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.049 · Cited by 500
Lipid signaling and lipotoxicity in metaflammation: indications for metabolic disease pathogenesis and treatment
Ertunc, M. E., & Hotamışlıgil, G. S. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r066514 · Cited by 500
Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria
Wang, H., Sreenivasan, U., Hu, H., Saladino, A. J., Polster, B. M., Lund, L. M., Gong, D., Stanley, W. C., & Sztalryd, C. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m017939 · Cited by 497
Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus.
Kelley, D. E., & Simoneau, J. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117600 · Cited by 487
Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide
Summers, S. A., Garza, L. A., Zhou, H., & Birnbaum, M. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5457 · Cited by 475
Fatty acids as modulators of the cellular production of reactive oxygen species
Schönfeld, P., & Wojtczak, L. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.029 · Cited by 452
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
An, J., Muoio, D. M., Shiota, M., Fujimoto, Y., Cline, G. W., Shulman, G. I., Koves, T. R., Stevens, R., Millington, D., & Newgard, C. B. (2004) · Nature Medicine · doi:10.1038/nm995 · Cited by 450
SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice
Emanuelli, B., Peraldi, P., Filloux, C., Carine Chavey, A., Freidinger, K., Hilton, D. J., Hotamışlıgil, G. S., & OBBERGHEN, E. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104602200 · Cited by 449
Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL
Brown, M. S., & Goldstein, J. L. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800054-jlr200 · Cited by 441
Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity
Unger, R. H., & Scherer, P. E. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.01.009 · Cited by 436
Tumor Necrosis Factor-α Stimulates Lipolysis in Differentiated Human Adipocytes Through Activation of Extracellular Signal-Related Kinase and Elevation of Intracellular cAMP
Zhang, H., Halbleib, M., Ahmad, F., Manganiello, V. C., & Greenberg, A. S. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2929 · Cited by 436
Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells
Londos, C., Brasaemle, D., Schultz, C. J., Segrest, J. P., & Kimmel, A. R. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1998.0275 · Cited by 435
Citrate as an Intermediary in the Inhibition of Phosphofructokinase in Rat Heart Muscle by Fatty Acids, Ketone Bodies, Pyruvate, Diabetes and Starvation
Garland, P. B., Randle, P. J., & Newsholme, E. A. (1963) · Nature · doi:10.1038/200169a0 · Cited by 429
Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus
Heilbronn, L. K., Smith, S. R., & Ravussin, É. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802853 · Cited by 416
Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
Szendroedi, J., Yoshimura, T., Phielix, E., Koliaki, C., Marcucci, M., Zhang, D., Jelenik, T., Müller, J., Herder, C., Nowotny, P., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409229111 · Cited by 415
Regulation of Insulin Action by Ceramide
Stratford, S., Hoehn, K. L., Liu, F., & Summers, S. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406499200 · Cited by 410
Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
Bonen, A., Parolin, M. L., Steinberg, G. R., Calles‐Escandon, J., Tandon, N. N., Glatz, J. F. C., Luiken, J. J. F. P., Heigenhauser, G. J. F., & Dyck, D. J. (2004) · The FASEB Journal · doi:10.1096/fj.03-1065fje · Cited by 410
Dose-Response Effect of Elevated Plasma Free Fatty Acid on Insulin Signaling
Belfort, R., Mandarino, L., Kashyap, S., Wirfel, K., Pratipanawatr, T., Berria, R., DeFronzo, R. A., & Cusi, K. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1640 · Cited by 404
Lipid overload and overflow: metabolic trauma and the metabolic syndrome
UNGER, R. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2003.09.008 · Cited by 399
Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease
Nielsen, T. S., Jessen, N., Jørgensen, J. O. L., Møller, N., & Lund, S. A. (2014) · Journal of Molecular Endocrinology · doi:10.1530/jme-13-0277 · Cited by 399
Acute Regulation of Fatty Acid Uptake Involves the Cellular Redistribution of Fatty Acid Translocase
Bonen, A., Luiken, J. J. F. P., Arumugam, Y., Glatz, J. F. C., & Tandon, N. N. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14501 · Cited by 380
Role of Endoplasmic Reticulum Stress and c-Jun NH2-Terminal Kinase Pathways in Inflammation and Origin of Obesity and Diabetes
Hotamisligil, G. S. (2005) · Diabetes · doi:10.2337/diabetes.54.suppl_2.s73 · Cited by 352
Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes.
Boden, G., & Chen, X. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118160 · Cited by 344
FABP4 Attenuates PPARγ and Adipogenesis and Is Inversely Correlated With PPARγ in Adipose Tissues
Garin-Shkolnik, T., Rudich, A., Hotamışlıgil, G. S., & Rubinstein, M. (2013) · Diabetes · doi:10.2337/db13-0436 · Cited by 344
Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle
Muoio, D. M., & Neufer, P. D. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.010 · Cited by 343
Perilipin Promotes Hormone-sensitive Lipase-mediated Adipocyte Lipolysis via Phosphorylation-dependent and -independent Mechanisms
Miyoshi, H., Souza, S. C., Zhang, H.-H., Strissel, K. J., Christoffolete, M. A., Kovsan, J., Rudich, A., Kraemer, F. B., Bianco, A. C., Obin, M. S., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601097200 · Cited by 330
Differential Roles of Unsaturated and Saturated Fatty Acids on Autophagy and Apoptosis in Hepatocytes
Mei, S., Ni, H., Manley, S., Bockus, A. B., Kassel, K. M., Luyendyk, J. P., Copple, B. L., & Ding, W. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.184341 · Cited by 325
The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals
Moon, Y.-A., Liang, G., Xie, X., Frank-Kamenetsky, M., Fitzgerald, K., Koteliansky, V., Brown, M. S., Goldstein, J. L., & Horton, J. D. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.017 · Cited by 320
Diabetes and apoptosis: lipotoxicity
Kusminski, C. M., Shetty, S., Orci, L., Unger, R. H., & Scherer, P. E. (2009) · Apoptosis · doi:10.1007/s10495-009-0352-8 · Cited by 302
Serine/Threonine Phosphorylation of IRS-1 Triggers Its Degradation
Pederson, T. M., Kramer, D. L., & Rondinone, C. M. (2001) · Diabetes · doi:10.2337/diabetes.50.1.24 · Cited by 298
Direct Effect of Glucocorticoids on Lipolysis in Adipocytes
Xu, C., He, J., Jiang, H., Zu, L., Zhai, W., Pu, S., & Xu, G. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0464 · Cited by 291
Electron Transport Chain-dependent and -independent Mechanisms of Mitochondrial H2O2 Emission during Long-chain Fatty Acid Oxidation
Seifert, E. L., Estey, C., Xuan, J. Y., & Harper, M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.026203 · Cited by 289
A role for lipid droplets in inter‐membrane lipid traffic
Zehmer, J. K., Huang, Y., Gong, P., Pu, J., Anderson, R. G. W., & Liu, P. (2009) · PROTEOMICS · doi:10.1002/pmic.200800584 · Cited by 282
Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress
Yuzefovych, L., Wilson, G., & Rachek, L. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00238.2010 · Cited by 280
As a Matter of Fat
Brookheart, R. T., Michel, C. I., & Schaffer, J. E. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.011 · Cited by 279
The Central Role of Perilipin A in Lipid Metabolism and Adipocyte Lipolysis
Tansey, J. T., Sztalryd, C., Hlavin, E. M., Kimmel, A. R., & Londos, C. (2004) · IUBMB Life · doi:10.1080/15216540400009968 · Cited by 275
Hepatic triacylglycerol accumulation and insulin resistance
Nagle, C. A., Klett, E. L., & Coleman, R. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800053-jlr200 · Cited by 272
Signalling aspects of insulin resistance in skeletal muscle
Schmitz‐Peiffer, C. (2000) · Cellular Signalling · doi:10.1016/s0898-6568(00)00110-8 · Cited by 269
A Role for Peroxisome Proliferator-activated Receptor α (PPARα) in the Control of Cardiac Malonyl-CoA Levels
Campbell, F., Kozak, R., Wagner, A. M., Altarejos, J. Y., Dyck, J. R. B., Belke, D. D., Severson, D. L., Kelly, D. P., & Lopaschuk, G. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106054200 · Cited by 265
A Novel Function for Fatty Acid Translocase (FAT)/CD36
Campbell, S. E., Tandon, N. N., Woldegiorgis, G., Luiken, J. J. F. P., Glatz, J. F. C., & Bonen, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400566200 · Cited by 259
The role of intramuscular lipid in insulin resistance
Hegarty, B. D., Furler, S. M., Ye, J.-M., Cooney, G. J., & Kraegen, E. W. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01162.x · Cited by 258
Mammalian Target of Rapamycin Pathway Regulates Insulin Signaling via Subcellular Redistribution of Insulin Receptor Substrate 1 and Integrates Nutritional Signals and Metabolic Signals of Insulin
Takano, A., Usui, I., Haruta, T., Kawahara, J., Uno, T., Iwata, M., & Kobayashi, M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5050-5062.2001 · Cited by 257
Mitochondrial and cellular mechanisms for managing lipid excess
Aon, M. A., Bhatt, N., & Cortassa, S. C. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00282 · Cited by 253
On the Control of Lipolysis in Adipocytes
Londos, C., Brasaemle, D., Schultz, C. J., Adler‐Wailes, D. C., LEVIN, D. M., Kimmel, A. R., & Rondinone, C. M. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07794.x · Cited by 251
Mapping of Early Signaling Events in Tumor Necrosis Factor-α-mediated Lipolysis in Human Fat Cells
Rydén, M., Dicker, A., van Harmelen, V., Hauner, H., Brunnberg, M., Perbeck, L. G., Lönnqvist, F., & Arner, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109498200 · Cited by 249
DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells
Montell, E., Turini, M., Marotta, M., Roberts, M., Noé, V., Ciudad, C. J., Macé, K., & Gómez-Foix, A. M. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.2.e229 · Cited by 245
Ceramide impairs the insulin-dependent membrane recruitment of Protein Kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells
Hajduch, É., Balendran, A., Batty, I. H., Litherland, G. J., Blair, A. S., Downes, C. P., & Hundal, H. S. (2001) · Diabetologia · doi:10.1007/s001250051596 · Cited by 244
Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation
Kuramoto, K., Okamura, T., Yamaguchi, T., Nakamura, T. Y., Wakabayashi, S., Morinaga, H., Nomura, M., Yanase, T., Otsu, K., Usuda, N., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.328708 · Cited by 243
Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle
Koonen, D. P. Y., Glatz, J. F. C., Bonen, A., & Luiken, J. J. F. P. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.08.018 · Cited by 243
Dysfunctional fat cells, lipotoxicity and type 2 diabetes
Defronzo, R. A. (2004) · International Journal of Clinical Practice · doi:10.1111/j.1368-504x.2004.00389.x · Cited by 236
A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet
Goglia, F., & Skulachev, V. P. (2003) · The FASEB Journal · doi:10.1096/fj.03-0159hyp · Cited by 233
Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state
van Loon, L. J. C., & Goodpaster, B. H. (2006) · Pflügers Archiv · doi:10.1007/s00424-005-1509-0 · Cited by 232
Free Fatty Acids Inhibit Insulin Signaling–Stimulated Endothelial Nitric Oxide Synthase Activation Through Upregulating PTEN or Inhibiting Akt Kinase
Wang, X. L., Zhang, L., Youker, K. A., Zhang, M., Wang, J., LeMaire, S. A., Coselli, J. S., & Shen, Y. H. (2006) · Diabetes · doi:10.2337/db05-1574 · Cited by 230
Obesity and Nonalcoholic Fatty Liver Disease
Angulo, P. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00329.x · Cited by 222
Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes.
Carpentier, A. C., Mittelman, S. D., Bergman, R. N., Giacca, A., & Lewis, G. F. (2000) · Diabetes · doi:10.2337/diabetes.49.3.399 · Cited by 222
Fatty Acids Suppress Autophagic Turnover in β-Cells
Las, G., Serada, S. B., Wikström, J. D., Twig, G., & Shirihai, O. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.242412 · Cited by 220
Lipotoxicity in the liver
Zámbó, V., Simon‐Szabó, L., Szelényi, P., Kereszturi, É., Bánhegyi, G., & Csala, M. (2013) · World Journal of Hepatology · doi:10.4254/wjh.v5.i10.550 · Cited by 217
Saturated fatty acid‐induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells
Hirabara, S. M., Curi, R., & Maechler, P. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.21936 · Cited by 215
Adipogenesis and lipotoxicity: role of peroxisome proliferator-activated receptor γ (PPARγ) and PPARγcoactivator-1 (PGC1)
Medina‐Gómez, G., Gray, S. L., & Vidal‐Puig, A. (2007) · Public Health Nutrition · doi:10.1017/s1368980007000614 · Cited by 204
Molecular Mechanism of Insulin-Induced Degradation of Insulin Receptor Substrate 1
Zhande, R., Mitchell, J. J., Wu, J., & Sun, X. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1016-1026.2002 · Cited by 202
Thematic review series: Patient-Oriented Research. Free fatty acid metabolism in human obesity
Koutsari, C., & Jensen, M. D. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r600011-jlr200 · Cited by 201
Very-long-chain Acyl-CoA Synthetases
Watkins, P. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.r700037200 · Cited by 199
Obesity and Nonalcoholic Fatty Liver Disease
Angulo, P. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.jun.s57-s63 · Cited by 198
A Role for Sphingolipids in Producing the Common Features of Type 2 Diabetes, Metabolic Syndrome X, and Cushing’s Syndrome
Summers, S. A., & Nelson, D. H. (2005) · Diabetes · doi:10.2337/diabetes.54.3.591 · Cited by 188
Fatty acids as natural uncouplers preventing generation of O⋅−2 and H2O2 by mitochondria in the resting state
Korshunov, S., Korkina, O. V., Ruuge, E. K., Skulachev, V. P., & Starkov, A. A. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01073-4 · Cited by 183
IV. Nonalcoholic fatty liver disease abnormalities in macrophage function and cytokines
Diehl, A. M. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00384.2001 · Cited by 178
Glutathionylation Acts as a Control Switch for Uncoupling Proteins UCP2 and UCP3
Mailloux, R. J., Seifert, E. L., Bouillaud, F., Aguer, C., Collins, S., & Harper, M.-E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.240242 · Cited by 174
High Dietary Fat Selectively Increases Catalase Expression within Cardiac Mitochondria
Rindler, P. M., Plafker, S. M., Szweda, L. I., & Kinter, M. T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.412890 · Cited by 173
cJun NH2-terminal kinase 1 (JNK1): Roles in metabolic regulation of insulin resistance
Sabio, G., & Davis, R. J. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.004 · Cited by 170
Evidence That IRS-2 Phosphorylation Is Required for Insulin Action in Hepatocytes
Rother, K. I., Imai, Y., Caruso, M., Bèguinot, F., Formisano, P., & Accili, D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17491 · Cited by 166
Muscular diacylglycerol metabolism and insulin resistance
Timmers, S., Schrauwen, P., & den Bosch, J. D. V. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.12.002 · Cited by 163
Palmitate-induced Activation of Mitochondrial Metabolism Promotes Oxidative Stress and Apoptosis in H4IIEC3 Rat Hepatocytes
Egnatchik, R. A., Leamy, A. K., Noguchi, Y., Shiota, M., & Young, J. D. (2014) · Metabolism · doi:10.1016/j.metabol.2013.10.009 · Cited by 161
PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation
Son, N.-H., Yu, S., Tuinei, J., Arai, K., Hamai, H., Homma, S., Shulman, G. I., Abel, E. D., & Goldberg, I. J. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40905 · Cited by 159
Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals
Holloway, G. P., Bonen, A., & Spriet, L. L. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26717b · Cited by 147
NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-Cells via JNK, p38 MAPK and p53 Pathways
Yuan, H., Zhang, X., Huang, X., Lu, Y., Tang, W., Man, Y., Wang, S., Xi, J., & Li, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015726 · Cited by 145
Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance
Abdul-Ghani, M. A., Muller, F. L., Liu, Y., Chavez, A. O., Balas, B., Zuo, P., Chang, Z., Tripathy, D., Jani, R., Molina-Carrion, M., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90287.2008 · Cited by 140
Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity
Jaishy, B. P., Zhang, Q., Chung, H. S., Riehle, C., Soto, J. E., Jenkins, S., Abel, P., Cowart, L. A., Eyk, J. E. V., & Abel, E. D. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m055152 · Cited by 132
Lipotoxicity: Why do saturated fatty acids cause and monounsaturates protect against it?
Nolan, C. J., & Larter, C. Z. (2009) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2009.05823.x · Cited by 132
Muscle Long‐Chain Acyl CoA Esters and Insulin Resistance
Cooney, G. J., Thompson, A. L., Furler, S. M., Ye, J.-M., & Kraegen, E. W. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04276.x · Cited by 131
Catecholamines and Obesity: Effects of Exercise and Training
Zouhal, H., Lemoine-Morel, S., Mathieu, M.-E., Casazza, G. A., & Jabbour, G. (2013) · Sports Medicine · doi:10.1007/s40279-013-0039-8 · Cited by 129
The role of uncoupling protein 3 in fatty acid metabolism: protection against lipotoxicity?
Schrauwen, P. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2003336 · Cited by 126
Mechanisms of Lipoapoptosis
Listenberger, L. L., & Schaffer, J. E. (2002) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(02)00152-4 · Cited by 123
Lipolysis Response to Endoplasmic Reticulum Stress in Adipose Cells
Deng, J., Liu, S., Zou, L., Xu, C. B., Geng, B., & Xu, G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.299115 · Cited by 122
An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart
Fang, X., Palanivel, R., Cresser, J., Schram, K., Ganguly, R., Thong, F. S. L., Tuinei, J., Xu, A., Abel, E. D., & Sweeney, G. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00086.2010 · Cited by 119
Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules
Ishii, M., Maeda, A., Tani, S., & Akagawa, M. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.12.009 · Cited by 118
Insulin stimulates fatty acid transport by regulating expression of FAT/CD36 but not FABPpm
Chabowski, A., Coort, S. L., Calles-Escandón, J., Tandon, N. N., Glatz, J. F. C., Luiken, J. J. F. P., & Bonen, A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00573.2003 · Cited by 112
Lipotoxicity contributes to endothelial dysfunction: A focus on the contribution from ceramide
Symons, J. D., & Abel, E. D. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-012-9235-3 · Cited by 112
Role of autophagy in diabetes and endoplasmic reticulum stress of pancreatic β-cells
Quan, W., Lim, Y.-M., & Lee, M. (2012) · Experimental & Molecular Medicine · doi:10.3858/emm.2012.44.2.030 · Cited by 109
Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity
Bosma, M., Dapito, D. H., Drosatos-Tampakaki, Z., Son, N. H., Huang, L., Kersten, S., Drosatos, K., & Goldberg, I. J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.012 · Cited by 109
Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids
Young, M. E., Goodwin, G. W., Ying, J., Guthrie, P. H., Wilson, C. R., Laws, F. A., & Taegtmeyer, H. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.3.e471 · Cited by 109
Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training
Schenk, S., & Horowitz, J. F. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00051.2006 · Cited by 108
Obesity and lipid stress inhibit carnitine acetyltransferase activity
Seiler, S. E., Martin, O. J., Noland, R. C., Slentz, D. H., DeBalsi, K. L., Ilkayeva, O., An, J., Newgard, C. B., Koves, T. R., & Muoio, D. M. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m043448 · Cited by 108
Acyl-CoA synthetases: fatty acid uptake and metabolic channeling
Digel, M., Ehehalt, R., Stremmel, W., & Füllekrug, J. (2008) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-0003-3 · Cited by 107
Evidence for concerted action of FAT/CD36 and FABPpm to increase fatty acid transport across the plasma membrane
Chabowski, A., Górski, J., Luiken, J. J. F. P., Glatz, J. F. C., & Bonen, A. (2007) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2007.10.017 · Cited by 106
Metabolic Adaptations in the Absence of Perilipin
Saha, P., Kojima, H., Martı́nez-Botas, J., Sunehag, A. L., & Chan, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405499200 · Cited by 105
Tissue-Specific Effects of Central Leptin on the Expression of Genes Involved in Lipid Metabolism in Liver and White Adipose Tissue
Gallardo, N., Bonzón‐Kulichenko, E., Fernández‐Agulló, T., Moltó, E., Gómez‐Alonso, S., Blanco, P., Carrascosa, J. M., Ros, M., & Andrés, A. (2007) · Endocrinology · doi:10.1210/en.2007-0933 · Cited by 105
Fatty acid-induced insulin resistance: role of insulin receptor substrate 1 serine phosphorylation in the retroregulation of insulin signalling
MARCHAND‐BRUSTEL, Y. L., Gual, P., Grémeaux, T., Gonzalez, T., Barrès, R., & Tanti, J. (2003) · Biochemical Society Transactions · doi:10.1042/bst0311152 · Cited by 102
NADPH Oxidase and Hydrogen Peroxide Mediate Insulin-induced Calcium Increase in Skeletal Muscle Cells
Espinosa, A., García, A., Härtel, S., Hidalgo, C., & Jaimovich, E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804249200 · Cited by 100
Overexpression of membrane-associated fatty acid binding protein (FABPpm) in vivo increases fatty acid sarcolemmal transport and metabolism
Clarke, D. C., Miskovic, D., Han, X.-X., Calles-Escandón, J., Glatz, J. F. C., Luiken, J. J. F. P., Heikkila, J. J., & Bonen, A. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00190.2003 · Cited by 100
Intracellular pH in adipocytes: effects of free fatty acid diffusion across the plasma membrane, lipolytic agonists, and insulin.
Civelek, V. N., Hamilton, J. A., Tornheim, K., Kelly, K. L., & Corkey, B. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10139 · Cited by 94
Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity
Carobbio, S., Hagen, R. M., Lelliott, C. J., Slawik, M., Medina‐Gómez, G., Tan, C.-Y., Sicard, A., Atherton, H. J., Barbarroja, N., Bjursell, M., et al. (2013) · Diabetes · doi:10.2337/db12-1748 · Cited by 92
Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis
Monsénégo, J., Mansouri, A., Akkaoui, M., Lenoir, V., Esnous, C., Fauveau, V., Tavernier, V., Girard, J., & Prip-Buus, C. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.10.008 · Cited by 91
Sterol Regulatory Element-binding Protein (SREBP) Cleavage Regulates Golgi-to-Endoplasmic Reticulum Recycling of SREBP Cleavage-activating Protein (SCAP)
Shao, W., & Espenshade, P. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.545699 · Cited by 88
Regulation of Adipocyte Lipolysis by Degradation of the Perilipin Protein
Kovsan, J., Ben-Romano, R., Souza, S. C., Greenberg, A. S., & Rudich, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702223200 · Cited by 82
Lipotoxicity, fatty acid uncoupling and mitochondrial carrier function
Rial, E., Rodríguez-Sánchez, L., Gallardo‐Vara, E., Zaragoza, P., Moyano, E., & González‐Barroso, M. M. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.04.001 · Cited by 80
Oxidative tissue: perilipin 5 links storage with the furnace
Wang, H., & Sztalryd, C. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.03.008 · Cited by 79
Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle
Holloway, G. P., Lally, J., Nickerson, J. G., Alkhateeb, H. H., Snook, L. A., Heigenhauser, G. J. F., Calles-Escandón, J., Glatz, J. F. C., Luiken, J. J. F. P., Spriet, L. L., et al. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135301 · Cited by 77
Effect of Anaplerotic Fluxes and Amino Acid Availability on Hepatic Lipoapoptosis
Noguchi, Y., Young, J. D., Alemán, J. O., Hansen, M. A. E., Kelleher, J. K., & Stephanopoulos, G. N. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.049478 · Cited by 71
Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase
Gao, X., Li, K., Hui, X., Kong, X., Sweeney, G., Wang, Y., Xu, A., Teng, M., Liu, P., & Wu, D. (2011) · Biochemical Journal · doi:10.1042/bj20101680 · Cited by 68
Fatty Acids Change the Conformation of Uncoupling Protein 1 (UCP1)
Divakaruni, A. S., Humphrey, D. M., & Brand, M. D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.381780 · Cited by 68
Reduction of non-esterified fatty acids improves insulin sensitivity and lowers oxidative stress, but fails to restore oxidative capacity in type 2 diabetes: a randomised clinical trial
Phielix, E., Jeleník, T., Nowotny, P., Szendroedi, J., & Roden, M. (2013) · Diabetologia · doi:10.1007/s00125-013-3127-2 · Cited by 66
Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes
Bellini, L., Campaña, M. B., Mahfouz, R., Carlier, A., Véret, J., Magnan, C., Hajduch, É., & Stunff, H. L. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1028359 · Cited by 66
The role of autophagy in β ‐cell lipotoxicity and type 2 diabetes
Las, G., & Shirihai, O. S. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01268.x · Cited by 63
ERRATA
(2009) · Journal of Lipid Research · doi:10.1194/jlr.volume50omission · Cited by 62
Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: The effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids
Lam, Y. Y., Hatzinikolas, G., Weir, J. M., Janovská, A., McAinch, A. J., Game, P. A., Meikle, P. J., & Wittert, G. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.04.011 · Cited by 60
Impaired mitochondrial activity and insulin-resistant offspring of patients with type 2 diabetes
(2004) · New England Journal of Medicine · doi:10.1056/nejm200406033502320 · Cited by 59
Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes
Valdecantos, M. P., Prieto-Hontoria, P. L., Pardo, V., Mòdol, T., Santamaría, B., Weber, M., Herrero, L., Serra, D., Muntané, J., Cuadrado, A., et al. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.019 · Cited by 58
Fatty Acid-Induced Apoptosis in Neonatal Cardiomyocytes: Redox Signaling
Sparagna, G. C., Hickson-Bick, D. L., Buja, L. M., & McMillin, J. B. (2001) · Antioxidants & Redox Signaling · doi:10.1089/152308601750100524 · Cited by 56
Redox regulation of insulin sensitivity due to enhanced fatty acid utilization in the mitochondria
Rindler, P. M., Crewe, C., Fernandes, J., Kinter, M. T., & Szweda, L. I. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00799.2012 · Cited by 54
Role of autophagy in the progression from obesity to diabetes and in the control of energy balance
Quan, W., Jung, H. S., & Lee, M. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0024-7 · Cited by 46
Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain
Senapedis, W. T., Kennedy, C. J., Boyle, P. M., & Silver, P. A. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-10-0854 · Cited by 35
Involvement of UCP3 in mild uncoupling and lipotoxicity
Hoeks, J., Hesselink, M. K. C., & Schrauwen, P. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.02.005 · Cited by 34
Emerging paradigms for understanding fatness and diabetes risk
Smith, S. R., & Ravussin, É. (2002) · Current Diabetes Reports · doi:10.1007/s11892-002-0087-1 · Cited by 34
Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity
Ratner, C., Madsen, A. N., Kristensen, L. V., Skov, L. J., Pedersen, K. S., Mortensen, O. H., Knudsen, G. M., Raun, K., & Holst, B. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00219.2014 · Cited by 31
Lipid droplet accumulation in the heart during fasting
Jacob, S. (1987) · Acta Histochemica · doi:10.1016/s0065-1281(87)80020-x · Cited by 30
Dysregulation of sterol regulatory element binding protein–1c in livers of morbidly obese women is associated with altered suppressor of cytokine signaling–3 and signal transducer and activator of transcription–1 signaling
Elam, M. B., Yellaturu, C. R., Howell, G., Deng, X., Cowan, G. S. M., Kumar, P., Park, E. A., Hiler, M. L., Wilcox, H. G., Hughes, T. A., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.09.001 · Cited by 29
Phospholipase C-Related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase
Okumura, T., Harada, K., Oue, K., Zhang, J., Asano, S., Hayashiuchi, M., Mizokami, A., Tanaka, H., Irifune, M., Kamata, N., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100559 · Cited by 26
Carnitine and Acylcarnitines
Reuter, S. E., & Evans, A. M. (2012) · Clinical Pharmacokinetics · doi:10.2165/11633940-000000000-00000 · Cited by 17
Neuropeptide Y potentiates beta-adrenergic stimulation of lipolysis in 3T3-L1 adipocytes
Li, R., Guan, H., & Yang, K. (2012) · Regulatory Peptides · doi:10.1016/j.regpep.2012.06.002 · Cited by 15

Sorted by citations

Role of Oxidative Stress in the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Implications for Prevention and Therapy
Arroyave-Ospina, J. C., Wu, Z., Geng, Y., & Moshage, H. J. (2021) · Antioxidants · doi:10.3390/antiox10020174 · Cited by 560
Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases
Demine, S., Renard, P., & Arnould, T. (2019) · Cells · doi:10.3390/cells8080795 · Cited by 476
Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice
Qi, J., Kim, J.-W., Zhou, Z., Lim, C.-W., & Kim, B. (2020) · The American Journal of Pathology · doi:10.1016/j.ajpath.2019.09.011 · Cited by 338
The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders
Zhang, S., Peng, X., Yang, S., Li, X., Huang, M., Wei, S., Liu, J., He, G., Zheng, H., Yang, L., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04593-3 · Cited by 335
Changes in Plasma Free Fatty Acids Associated with Type-2 Diabetes
Sobczak, A. I. S., Blindauer, C. A., & Stewart, A. J. (2019) · Nutrients · doi:10.3390/nu11092022 · Cited by 314

See all 260

Authors: Engin, A. B.
Venue: Advances in experimental medicine and biology
Publisher: Springer International Publishing
Published: 2017
Volume: 960
Pages: 197-220
ISSN: 0065-2598 (ISSN-L)
2214-8019
DOI: 10.1007/978-3-319-48382-5_8
OpenAlex: W2623539005
Cited by: 260
References: 184
Citations by year: 2026: 9 · 2025: 32 · 2024: 35 · 2023: 38 · 2022: 44 · 2021: 40 · 2020: 24 · 2019: 24 · 2018: 12 · 2017: 2
FWCI: 74.41
Type: book chapter
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Advances in experimental medicine and biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: lipotoxicity, obesity, insulin resistance, adipocytes, lipolysis, S-nitrosylation, free fatty acids, endoplasmic reticulum stress, cAMP/PKA signaling, ERK signaling, lipid droplets, diacylglycerol, ceramide, chronic inflammation, mitochondrial dysfunction
MeSH terms: Adipose Tissue, Animals, Humans, Inflammation, Insulin Resistance, Lipids, Mitochondria, Obesity, Adipocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

What Is Lipotoxicity?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks