Cited by 93Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis Research

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Biomarkers in Neurodegenerative Diseases

Jeromin, Andreas, Bowser, Robert·2017·Advances in Neurobiology

DOI 10.1007/978-3-319-57193-5_20

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Abstract

The past decade has seen tremendous efforts in biomarker discovery and validation for neurodegenerative diseases. The source and type of biomarkers has continued to grow for central nervous system diseases, from biofluid-based biomarkers (blood or cerebrospinal fluid (CSF)), to nucleic acids, tissue, and imaging. While DNA remains a predominant biomarker used to identify familial forms of neurodegenerative diseases, various types of RNA have more recently been linked to familial and sporadic forms of neurodegenerative diseases during the past few years. Imaging approaches continue to evolve and are making major contributions to target engagement and early diagnostic biomarkers. Incorporation of biomarkers into drug development and clinical trials for neurodegenerative diseases promises to aid in the development and demonstration of target engagement and drug efficacy for neurologic disorders. This review will focus on recent advancements in developing biomarkers for clinical utility in Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS).

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BindingDB Entry 50004319: The medicinal chemistry of mitochondrial dysfunction: a critical overview of efforts to modulate mitochondrial health.
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Authors: Jeromin, A., & Bowser, R.
Affiliations: Barrow Neurological Institute (US)
Corresponding author: Bowser, Robert
ORCID: Bowser, Robert
Venue: Advances in Neurobiology
Publisher: Springer International Publishing
Published: 2017
Volume: 15
Pages: 491-528
ISSN: 2190-5215 (ISSN-L)
2190-5223
DOI: 10.1007/978-3-319-57193-5_20
OpenAlex: W2733688271
Cited by: 92
References: 260
Citations by year: 2026: 3 · 2025: 9 · 2024: 11 · 2023: 20 · 2022: 16 · 2021: 13 · 2020: 5 · 2019: 7 · 2018: 8
FWCI: 17.51
Type: book chapter
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Advances in neurobiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (RC1NS068179, NS068179, NS061867)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: biomarkers, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, cerebrospinal fluid biomarkers, blood biomarkers, RNA biomarkers, DNA biomarkers, neuroimaging biomarkers, familial neurodegenerative disease, drug development, clinical trials, target engagement
MeSH terms: Alzheimer Disease, Amyotrophic Lateral Sclerosis, Brain, DNA, Humans, Parkinson Disease, Prognosis, RNA, Biomarkers, Neurodegenerative Diseases

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