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Study protocol on the safety and feasibility of a normocaloric ketogenic diet in people with amyotrophic lateral sclerosis

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Two Cases of Sporadic Amyotrophic Lateral Sclerosis With Contrasting Clinical Phenotypes: Genetic Insights

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Gastrointestinal Status and Microbiota Shaping in Amyotrophic Lateral Sclerosis: A New Frontier for Targeting?

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Distinct Plasma Immune Profile in ALS Implicates sTNFR-II in pAMPK/Leptin Homeostasis

Picher‐Martel, V., Boutej, H., Vézina, A., Cordeau, P., Kaneb, H., Julien, J., Genge, A. L., Dupré, N., & Križ, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065065 · Cited by 10 · see citing works

The multifaceted role of the CXC chemokines and receptors signaling axes in ALS pathophysiology

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Recent therapeutic advances in the treatment and management of amyotrophic lateral sclerosis: the era of regenerative medicine

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Immunosenescence and Inflammaging as Drivers of Neurodegeneration: Cellular Mechanisms, Neuroimmune Crosstalk, and Therapeutic Implications

Bertoni, G., Ristori, S., & Monti, D. (2026) · Cells · doi:10.3390/cells15080657 · Cited by 9 · see citing works

Causal ALS genes impact the MHC class II antigen presentation pathway

Chi, B., Öztürk, M. M., Paraggio, C. L., Leonard, C. E., Sanita, M. E., Dastpak, M., O’Connell, J. D., Coady, J. A., Zhang, J., Gygi, S. P., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2305756120 · Cited by 9 · see citing works

Imaging immunological processes from blood to brain in amyotrophic lateral sclerosis

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Astaxanthin relieves HT22 cells from LPS-induced inflammation and apoptosis by inhibiting oxygen species and regulating the TLR4/MyD88/NFκB signaling pathway

Wang, T., Li, R., Niu, P., Wei, Z., Xie, D., Huang, H., Pan, J., & Rong, C. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106676 · Cited by 8 · see citing works

Passive Transfer of Blood Sera from ALS Patients with Identified Mutations Results in Elevated Motoneuronal Calcium Level and Loss of Motor Neurons in the Spinal Cord of Mice

Polgár, T. F., Meszlényi, V., Nógrádi, B., Körmöczy, L., Spisák, K., Tripolszki, K., Széll, M., Obál, I., Engelhardt, J. I., Siklós, L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189994 · Cited by 8 · see citing works

The Neonatal Microbiome: Implications for Amyotrophic Lateral Sclerosis and Other Neurodegenerations

Eisen, A., & Kiernan, M. C. (2025) · Brain Sciences · doi:10.3390/brainsci15020195 · Cited by 7 · see citing works

Glutathione oxidation in cerebrospinal fluid as a biomarker of oxidative stress in amyotrophic lateral sclerosis

Pham, T. K., Verber, N. S., Turner, M. R., Malaspina, A., Collins, M. O., Mead, R. J., & Shaw, P. J. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00496-3 · Cited by 7 · see citing works

The dual role of microglia in neurodegenerative diseases: A review

Zhang, N., Xiong, N., He, Y., & Zhou, L. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.111887 · Cited by 8 · see citing works

Therapeutic Approaches to Amyotrophic Lateral Sclerosis from the Lab to the Clinic

Chavda, V. P., Patel, C. A., Modh, D. H., Ertaş, Y. N., Sonak, S. S., Munshi, N. K., Anand, K., Soni, A., & Pande, S. V. (2022) · Current Drug Metabolism · doi:10.2174/1389200223666220310113110 · Cited by 8 · see citing works

Ageing-Induced Decline in Primary Myeloid Cell Phagocytosis Is Unaffected by Optineurin Insufficiency

Peradinović, J., Mohovic, N., Bulic, K., Markovinović, A., Cimbro, R., & Munitić, I. (2023) · Biology · doi:10.3390/biology12020240 · Cited by 6 · see citing works

Genome-wide study of DNA methylation in Amyotrophic Lateral Sclerosis identifies differentially methylated loci and implicates metabolic, inflammatory and cholesterol pathwaysPreprint

Hop, P. J., Zwamborn, R., Hannon, E., Shireby, G., Nabais, M. F., Walker, E., van Rheenen, W., van Vugt, J. V., Dekker, A. M., Westeneng, H., et al. (2021) · medRxiv · doi:10.1101/2021.03.12.21253115 · Cited by 9 · see citing works

Adenosine deaminase, not immune to a mechanistic rethink in central nervous system disorders?

Hall, B., George, J. G., & Allen, S. P. (2022) · PubMed · doi:10.14670/hh-18-404 · Cited by 6 · see citing works

Exploring the Potential Utility of Psychedelic Therapy for Patients With Amyotrophic Lateral Sclerosis

Gold, N. D., Mallard, A. J., Hermann, J. C., Zeifman, R. J., Pagni, B. A., Bogenschutz, M. P., & Ross, S. (2023) · Journal of Palliative Medicine · doi:10.1089/jpm.2022.0604 · Cited by 6 · see citing works

Neuroimmune characterization of optineurin insufficiency mouse model during ageing

Mohovic, N., Peradinović, J., Markovinović, A., Cimbro, R., Minić, Ž., Dominović, M., Jakovac, H., Nimac, J., Rogelj, B., & Munitić, I. (2023) · Scientific Reports · doi:10.1038/s41598-023-38875-3 · Cited by 6 · see citing works

Association of serum Spp1 levels with disease progression in ALS and SBMA

Ju, W., Ban, J.-J., Im, H.-R., Ko, S.-H., Seo, J., Min, Y., Hong, Y.-H., Choi, S.-J., & Sung, J. (2024) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.52087 · Cited by 8 · see citing works

Reduction of inflammation and mitochondrial degeneration in mutant SOD1 mice through inhibition of voltage-gated potassium channel Kv1.3

Ratano, P., Cocozza, G., Pinchera, C., Busdraghi, L. M., Cantando, I., Martinello, K., Scioli, M., Rosito, M., Bezzi, P., Fucile, S., et al. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1333745 · Cited by 5 · see citing works

A Potential Role of Interleukin-5 in the Pathogenesis and Progression of Amyotrophic Lateral Sclerosis: A New Molecular Perspective

Moțățăianu, A., Andone, S. R., Stoian, A., Bălașa, R., Huţanu, A., & Sărmășan, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073782 · Cited by 5 · see citing works

CHCHD10P80L knock-in zebrafish display a mild ALS-like phenotype

Légaré, V. P., Harji, Z. A., Rampal, C. J., Antonická, H., Gurberg, T. J. N., Persia, O., Rodríguez, E. C., Shoubridge, E. A., & Armstrong, G. A. B. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114945 · Cited by 5 · see citing works

Brain macrophages and pial fibroblasts promote inflammation in a hypomyelination model

Okuno, N., Yamamoto, S., Hamashima, T., Tung, D. S., Okita, N., Fujikawa, M., Kunisawa, T., Takakura, N., Fujimori, T., Mori, H., et al. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02063-3 · Cited by 4 · see citing works

Tofacitinib extends survival in a mouse model of ALS through NK cell-independent mechanisms

Baird, L. A., Teener, S. J., Webber‐Davis, I. F., Carter, A., Huang, F., Jang, D., Famie, J. P., Piecuch, C. E., Guo, K. X., Feldman, E. L., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1662197 · Cited by 4 · see citing works

Mouse Brain Lymphatic Vessels

Tamadon, A., Afshar, A., Mussin, N. M., Zhilisbayeva, K. R., Kurmanalina, M. A., Baspakova, A. M., Aringazina, R. A., Mahdipour, M., Tanideh, N., Khoradmehr, A., et al. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00533 · Cited by 4 · see citing works

Sex-aware causal inference assessment of the immune system in complex neurodegenerative diseases

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Proteomic analysis of brain and spinal cord tissue reveals distinct immune and mitochondrial processes between human and mouse ALS models

Spiteri, A. G., Steele, J. R., Lee, H.-C., Zhang, H., Sun, J., Schittenhelm, R. B., Yu, C., McLean, C. A., Masters, C. L., Goudey, B., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-11466-0 · Cited by 3 · see citing works

Multi-omics-based decoding of circulating biomarkers in amyotrophic lateral sclerosis and risks in environmental toxins

Xu, L., Bin, H., Zhou, Y., Liao, X., Chen, T., & He, H. (2025) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-025-01024-9 · Cited by 3 · see citing works

Dual effects of TGF ‐β inhibitor in ALS ‐ inhibit contracture and neurodegeneration

Lee, D., Kwon, Y. N., Lee, K., Kim, S. J., & Sung, J. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16102 · Cited by 3 · see citing works

Hemizygous Granzyme A Mice Expressing the hSOD1G93A Transgene Show Slightly Extended Lifespan

Moreno‐Martínez, L., Santiago, L., de la Torre, M., Calvo, A. C., Pardo, J., & Osta, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113554 · Cited by 3 · see citing works

Peptide‐based Therapeutics for Inflammatory and Autoimmune Diseases

Chankeshwara, S. V., Czechtizky, W., & Su, W. (2025) · Peptide Science · doi:10.1002/9781119824701.ch10 · Cited by 3 · see citing works

Identification and validation of a tear fluid-derived protein biomarker signature in patients with amyotrophic lateral sclerosis

Scholl, L.-S., Demleitner, A. F., Riedel, J., Adachi, S., Neuenroth, L., Meijs, C., Tzeplaeff, L., Gomes, L. C., Galhoz, A., Cordts, I., et al. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02109-6 · Cited by 2 · see citing works

Regulatory T cell α(1,3)-exofucosylation for treatment of neurodegenerative diseases

Gendelman, H. E., Hu, G., Yeapuri, P., Srivastava, S., Mosley, R. L., Mamilla, S., Intrator, W., Are, M. S., & Sackstein, R. (2025) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiaf154 · Cited by 2 · see citing works

Repurposing immunomodulatory drugs targeting microglia for amyotrophic lateral sclerosis

Maes, K. J. H., & Briedé, J. J. (2025) · Brain Research · doi:10.1016/j.brainres.2025.150032 · Cited by 3 · see citing works

The immunoproteasome as a neuroimmune hub in the central nervous system: from proteostasis stress to inflammatory pathology

Zhao, H., Liu, Y., & Chen, X. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03709-2 · Cited by 2 · see citing works

Inflammatory mediators, lipoproteins and apolipoproteins in early diagnosis of amyotrophic lateral sclerosis

Alarcan, H., Berthet, M., Suire, L., Colas, C., Gonzalez, L., Paget, C., Bretagne, I. B., Piver, É., Vourc’h, P., Andres, C. R., et al. (2022) · SLAS TECHNOLOGY · doi:10.1016/j.slast.2022.07.003 · Cited by 2 · see citing works

Systemic LPS Administration Stimulates the Activation of Non-Neuronal Cells in an Experimental Model of Spinal Muscular Atrophy

Karafoulidou, E., Kesidou, E., Theotokis, P., Konstantinou, C., Nella, M., Michailidou, I., Touloumi, O., Polyzoidou, E., Salamotas, I., Einstein, O., et al. (2024) · Cells · doi:10.3390/cells13090785 · Cited by 2 · see citing works

Herbal medicines for SOD1G93A mice of amyotrophic lateral sclerosis: preclinical evidence and possible immunologic mechanism

Yang, J.-L., Wu, J.-Y., Liu, J., & Zheng, G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1433929 · Cited by 2 · see citing works

A Step in the ALS Direction: Lessons from the Purinome

Volonté, C., Yerbury, J. J., & Sluyter, R. (2023) · Springer eBooks · doi:10.1007/978-3-031-26945-5_10 · Cited by 2 · see citing works

Insulin in Amyotrophic Lateral Sclerosis: Impairment, Tests and TreatmentPreprint

Rappoport, A. (2023) · Preprints.org · doi:10.20944/preprints202212.0297.v3 · Cited by 2 · see citing works

Muscle fatigue and exercise-related biomarkers in amyotrophic lateral sclerosis

Bianchi, F., Becattini, L., Chico, L., Ricci, G., & Siciliano, G. (2023) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2023.00045 · Cited by 1 · see citing works

Peripheral Immune Profiles in Individuals at Genetic Risk of Amyotrophic Lateral Sclerosis and Alzheimer’s Disease

Deecke, L., Ohlei, O., Goldeck, D., Homann, J., Toepfer, S., Demuth, I., Bertram, L., Pawelec, G., & Lill, C. M. (2025) · Cells · doi:10.3390/cells14040250 · Cited by 1 · see citing works

A multi-omics study on monozygotic twins discordant for amyotrophic lateral sclerosis and literature review underline a potential role for innate immunity and epigenetic dysregulation in disease mechanisms

Tosi, M., Favero, F., Zuccalà, M., Visha, E., Caushi, F., Barizzone, N., Pomella, N., Follia, L., Corrado, L., Corà, D., et al. (2026) · Neurological Sciences · doi:10.1007/s10072-026-08813-y · Cited by 1 · see citing works

Calprotectin as an immune-dysregulation biomarker in amyotrophic lateral sclerosis: Insights for diagnosis and therapy

Mendon, A., Jain, S., Mishra, N., & Parab, S. B. (2026) · Revue Neurologique · doi:10.1016/j.neurol.2026.02.148 · Cited by 1 · see citing works

The Gut Microbiome in Amyotrophic Lateral Sclerosis: Emerging Mechanisms and Therapeutic Potential

Oriquat, G. A., Malathi, H., Maharana, L., Dhyani, A., Al-Hasnaawei, S., Singh‐Chauhan, A., Arora, V., Sharma, J., & Sadeghi-Samarjan, R. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05826-8 · Cited by 1 · see citing works

ERVK activity in CD8+ T cell immune cell compartment in patients with ALS

Sharma, S., Cortes-Pérez, C. M., Bird, S., Curzio, D. D., Vandenakker, A., Schellenberg, K. L., & Douville, R. N. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03871-7 · Cited by 1 · see citing works

Lymphatic dysfunction correlates with inflammation in a mouse model of amyotrophic lateral sclerosis

Narayanan, A., Seaberg, B. L., Buxton, A. W., Vernino, A. O., Williams, V. E., Matarazzo, A., Kekre, J., Subramanian, B., Wang, W. J., Rutkowski, J. M., et al. (2025) · Disease Models & Mechanisms · doi:10.1242/dmm.052148 · Cited by 1 · see citing works

Decoding Amyotrophic Lateral Sclerosis: A Systems Biology Approach

Lombard, J., & Hamper, M. (2022) · Journal of Restorative Medicine · doi:10.14200/jrm.2022.0001 · Cited by 1 · see citing works

Behavioral and molecular consequences of a ‘double-hit’ challenge on the pathogenesis of mouse models of depression and amyotrophic lateral sclerosis (ALS)

Трофимов, А. Н. (2024) · doi:10.26481/dis.20240205at · Cited by 1 · see citing works

Identification and Validation of a Tear Fluid-Derived Protein Biomarker Signature in Patients with Amyotrophic Lateral SclerosisPreprint

Scholl, L.-S., Demleitner, A. F., Riedel, J., Adachi, S., Neuenroth, L., Meijs, C., Tzeplaeff, L., Gomes, L. C., Galhoz, A., Cordts, I., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6512597/v1 · Cited by 1 · see citing works

Three ALS genes regulate expression of the MHC class II antigen presentation pathwayPreprint

Chi, B., Öztürk, M. M., Paraggio, C. L., Leonard, C. E., Sanita, M. E., Dastpak, M., O’Connell, J. D., Coady, J. A., Zhang, J., Gygi, S. P., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.11.489680

A função de proteínas associadas à Esclerose Lateral Amiotrófica em diferentes contextos celulares

Assoni, A. F. (2022) · doi:10.11606/t.41.2022.tde-02082022-190632

Insulin-Based Treatment for Amyotrophic Lateral SclerosisPreprint

Rappoport, A. (2022) · Preprints.org · doi:10.20944/preprints202212.0297.v2

Levamisole Derivatives As Immune Modulators for the Treatment of Amyotrophic Lateral Sclerosis (ALS)

Baugh, S. D. P., Morrice, J. R., Reitz, A. B., Shaw, C. A., & Gregory, C. Y. (2023) · Future Medicinal Chemistry · doi:10.4155/fmc-2023-0028

Neuroinflammation in amyotrophic lateral sclerosis: pathogenic insights and therapeutic implications

Calma, A. D., Pavey, N., Menon, P., & Vucic, S. (2024) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001279 · Cited by 47 · see citing works

Inflammation, Immunity, and amyotrophic lateral sclerosis: I. Etiology and pathology

Lyon, M. S., Wosiski‐Kuhn, M., Gillespie, R., Caress, J. B., & Milligan, C. (2018) · Muscle & Nerve · doi:10.1002/mus.26289 · Cited by 88 · see citing works

Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies

Beers, D. R., & Appel, S. H. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30394-6 · Cited by 387 · see citing works

Inflammation, immunity, and amyotrophic lateral sclerosis: II. immune‐modulating therapies

Wosiski‐Kuhn, M., Lyon, M. S., Caress, J. B., & Milligan, C. (2018) · Muscle & Nerve · doi:10.1002/mus.26288 · Cited by 26 · see citing works

Immunological Aspects in Amyotrophic Lateral Sclerosis

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