Neurofilament Light Chain as a Biomarker, and Correlation with Magnetic Resonance Imaging in Diagnosis of CNS-Related Disorders
Open accessAbstract
The search for diagnostic and prognostic biomarkers for neurodegenerative conditions is of high importance, since these disorders may present difficulties in differential diagnosis. Biomarkers with high sensitivity and specificity are required. Neurofilament light chain (NfL) is a unique biomarker related to axonal damage and neural cell death, which is elevated in a number of neurological disorders, and can be detected in cerebrospinal fluid (CSF), as well as blood, serum, or plasma samples. Although the NfL concentration in CSF is higher than that in blood, blood measurement may be easier in practice due to its lesser invasiveness, reproducibility, and convenience. Many studies have investigated NfL in both CSF and serum/plasma as a potential biomarker of neurodegenerative disorders. Neuroimaging biomarkers can also potentially improve detection of CNS-related disorders at an early stage. Magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) are sensitive techniques to visualize neuroaxonal loss. Therefore, investigating the combination of NfL levels with indices extracted from MRI and DTI scans could potentially improve diagnosis of CNS-related disorders. This review summarizes the evidence for NfL being a reliable biomarker in the early detection and disease management in several CNS-related disorders. Moreover, we highlight the correlation between MRI and NfL and ask whether they can be combined.
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Systematic reviews and meta-analyses encountered limitations when combining results from studies using serum and plasma NfL concentrations.
“Studies using serum as well as plasma NfL concentrations are abundant in the literature, but systematic reviews and meta-analyses encountered limitations when combining results from these studies (7–9).”
From A Method to Combine Neurofilament Light Measurements From Blood Serum and Plasma in Clinical and Population-Based Studies (2022) · cites this paper as [7]
The Abstract says many studies have measured NfL in serum or plasma. The “Assays to detect soluble neurofilaments” section says validation studies and meta-analyses emphasized a need to standardize assays, but it does not say that reviews had difficulty combining serum-based and plasma-based results specifically. (LLM, conf=0.79)
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- Authors
- Alirezaei, Z., Pourhanifeh, M. H., Borran, S., Nejati, M., Mirzaei, H., & Hamblin, M. R.
- Affiliations
- Isfahan University of Medical Sciences (IR)
- Kashan University of Medical Sciences (IR)
- Shahid Beheshti University (IR)
- Harvard University (US)
- Corresponding author
- Mirzaei, Hamed
- Hamblin, Michael R.
- Venue
- Molecular Neurobiology
- Published
- 2019-08-05
- Volume
- 57
- Issue
- 1
- Pages
- 469-491
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- PMC
- PMC6980520
- OpenAlex
- W2966118960
- Cited by
- 142
- References
- 186
- Citations by year
- 2026: 33 · 2025: 34 · 2024: 16 · 2023: 18 · 2022: 21 · 2021: 9 · 2020: 10 · 2019: 1
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI050875, R21AI121700)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- neurofilament light chain, biomarkers, neurodegenerative diseases, cerebrospinal fluid, serum biomarkers, magnetic resonance imaging, diffusion tensor imaging, axonal injury, neuroimaging biomarkers, early diagnosis, central nervous system disorders
- MeSH terms
- Animals, Central Nervous System Diseases, Humans, Magnetic Resonance Imaging, Models, Biological, Solubility, Biomarkers, Neurofilament Proteins
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