β-arrestins: regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126 · see citing works

Goodman and Gilman's the Pharmacological Basis of Therapeutics

Stigelman, W. H., & Pharm, D. (1986) · Military Medicine · doi:10.1093/milmed/151.1.386 · Cited by 6,796 · see citing works

International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors

Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., et al. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.161 · Cited by 2,819 · see citing works

Goodman and Gilman's the Pharmacological Basis of Therapeutics

Coon, J. T. (2002) · Focus on Alternative and Complementary Therapies · doi:10.1111/j.2042-7166.2002.tb05480.x · Cited by 1,750 · see citing works

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioid-receptor gene

Matthes, H. W. D., Maldonado, R., Simonin, F., Valverde, O., Slowe, S., Kitchen, I., Befort, K., Dierich, A., Le Meur, M., Dollé, P., et al. (1996) · Nature · doi:10.1038/383819a0 · Cited by 1,722 · see citing works

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

Lohse, M. J., Benovic, J., Codina, J., Caron, M. G., & Lefkowitz, R. J. (1990) · Science · doi:10.1126/science.2163110 · Cited by 1,222 · see citing works

Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2

Bohn, L., Lefkowitz, R. J., Gainetdinov, R. R., Peppel, K., Caron, M. G., & Lin, F. (1999) · Science · doi:10.1126/science.286.5449.2495 · Cited by 1,079 · see citing works

Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice

Zimmer, A., Zimmer, A. M., Hohmann, A. G., Herkenham, M. A., & Bonner, T. I. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5780 · Cited by 1,065 · see citing works

Pain Management: A Fundamental Human Right

Brennan, F. P., Carr, D. B., & Cousins, M. J. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000268145.52345.55 · Cited by 999 · see citing works

State-dependent opioid control of pain

Fields, H. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1431 · Cited by 946 · cited 2× · see citing works

μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

Bohn, L., Gainetdinov, R. R., Lin, F., Lefkowitz, R. J., & Caron, M. G. (2000) · Nature · doi:10.1038/35047086 · Cited by 930 · see citing works

DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS

Gainetdinov, R. R., Premont, R. T., Bohn, L., Lefkowitz, R. J., & Caron, M. G. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144206 · Cited by 864 · see citing works

Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance

Williams, J. T., Ingram, S. L., Henderson, G., Chavkin, C., von Zastrow, M., Schulz, S., Koch, T., Evans, C. J., & Christie, M. J. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.005942 · Cited by 802 · see citing works

An endocannabinoid mechanism for stress-induced analgesia

Hohmann, A. G., Suplita, R. L., Bolton, N. M., Neely, M. H., Fegley, D., Mangieri, R., Krey, J. F., Michael Walker, J., Holmes, P. V., Crystal, J. D., et al. (2005) · Nature · doi:10.1038/nature03658 · Cited by 778 · see citing works

Molecular Mechanisms and Regulation of Opioid Receptor Signaling

Law, P., Wong, Y. H., & Loh, H. H. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.389 · Cited by 661 · see citing works

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine

DeWire, S. M., Yamashita, D. S., Rominger, D. H., Liu, G., Cowan, C. L., Graczyk, T. M., Chen, X.-T., Pitis, P. M., Gotchev, D., Yuan, C., et al. (2013) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.201616 · Cited by 647 · see citing works

Morphine Side Effects in β-Arrestin 2 Knockout Mice

Raehal, K. M., Walker, J. K. L., & Bohn, L. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.087254 · Cited by 626 · see citing works

Exploring the opioid system by gene knockout

Kieffer, B. L., & Gavériaux-Ruff, C. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00008-4 · Cited by 620 · see citing works

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

Attramadal, H., Arriza, J. L., Aoki, C. J., Dawson, T. M., Codina, J., Kwatra, M. M., Snyder, S. H., Caron, M. G., & Lefkowitz, R. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37125-x · Cited by 548 · see citing works

Opiate receptor knockout mice define μ receptor roles in endogenous nociceptive responses and morphine-induced analgesia

Sora, I., Takahashi, N., Funada, M., Ujike, H., Revay, R. S., Donovan, D. M., Miner, L. L., & Uhl, G. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1544 · Cited by 525 · see citing works

Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness

Zhang, J., Ferguson, S. S. G., Barak, L. S., Bodduluri, S. R., Laporte, S. A., Law, P., & Caron, M. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.7157 · Cited by 505 · see citing works

Opioids: first lessons from knockout mice

Kieffer, B. L. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(98)01279-6 · Cited by 489 · see citing works

Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures — A short review

Svíženská, I. H., Dubový, P., & Šulcová, A. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.05.010 · Cited by 459 · see citing works

Functional Dissociation of μ Opioid Receptor Signaling and Endocytosis

Whistler, J. L., Chuang, H.-H., Chu, P., Jan, L. Y., & von Zastrow, M. (1999) · Neuron · doi:10.1016/s0896-6273(01)80032-5 · Cited by 413 · see citing works

CB2 cannabinoid receptor-mediated peripheral antinociception

Malan, P. T., Ibrahim, M. M., Deng, H., Liu, Q., Mata, H. P., Vanderah, T., Porreca, F., & Makriyannis, A. (2001) · Pain · doi:10.1016/s0304-3959(01)00321-9 · Cited by 391 · see citing works

Morphine-activated opioid receptors elude desensitization by β-arrestin

Whistler, J. L., & von Zastrow, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9914 · Cited by 370 · see citing works

The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain

Jaggar, S., Hasnie, F. S., Sellaturay, S., & Rice, A. S. C. (1998) · Pain · doi:10.1016/s0304-3959(98)00041-4 · Cited by 351 · see citing works

Effects of Chronic Treatment with Δ 9 -Tetrahydrocannabinol on Cannabinoid-Stimulated [ 35 S]GTPγS Autoradiography in Rat Brain

Sim, L. J., Hampson, R. E., Deadwyler, S. A., & Childers, S. R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-08057.1996 · Cited by 311 · see citing works

μ-Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization

McPherson, J., Rivero, G., Baptist, M., Llorente, J., Al‐Sabah, S., Krasel, C., Dewey, W. L., Bailey, C. P., Rosethorne, E. M., Charlton, S. J., et al. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.066613 · Cited by 263 · see citing works

Distinct Domains of the CB1 Cannabinoid Receptor Mediate Desensitization and Internalization

Jin, W., Brown, S. M., Roche, J. P., Hsieh, C., Celver, J. P., Kovoor, A., Chavkin, C., & Mackie, K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-03773.1999 · Cited by 262 · see citing works

Functional Selectivity at the μ-Opioid Receptor: Implications for Understanding Opioid Analgesia and Tolerance

Raehal, K. M., Schmid, C. L., Groer, C. E., & Bohn, L. (2011) · Pharmacological Reviews · doi:10.1124/pr.111.004598 · Cited by 258 · see citing works

Differential Mechanisms of Morphine Antinociceptive Tolerance Revealed in βArrestin-2 Knock-Out Mice

Bohn, L., Lefkowitz, R. J., & Caron, M. G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10494.2002 · Cited by 242 · see citing works

An Opioid Agonist that Does Not Induce μ-Opioid Receptor—Arrestin Interactions or Receptor Internalization

Groer, C. E., Tidgewell, K. J., Moyer, R. A., Harding, W. W., Rothman, R. B., Prisinzano, T. E., & Bohn, L. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.028258 · Cited by 225 · see citing works

Primary and secondary structure of bovine retinal S antigen (48-kDa protein).

Shinohara, T., Dietzschold, B., Craft, C. M., Wistow, G. J., Early, J. J., Donoso, L. A., Horwitz, J., & Tao, R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.20.6975 · Cited by 205 · see citing works

The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids

Pertwee, R. G. (2005) · The AAPS Journal · doi:10.1208/aapsj070364 · Cited by 204 · see citing works

The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics

Raehal, K. M., & Bohn, L. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.08.003 · Cited by 190 · see citing works

Cone arrestin identified by targeting expression of a functional family.

Craft, C., Whitmore, D., & Wiechmann, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41820-5 · Cited by 179 · see citing works

CB2 cannabinoid receptor mediation of antinociception

Ibrahim, M. M., Rude, M. L., Stagg, N. J., Mata, H. P., Lai, J. Y., Vanderah, T. W., Porreca, F., Buckley, N. E., Makriyannis, A., & Malan, P. T. (2006) · Pain · doi:10.1016/j.pain.2005.12.018 · Cited by 172 · see citing works

Cannabinoid CB₂ receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain

Elmes, S. J. R., Jhaveri, M. D., Smart, D., Kendall, D. A., & Chapman, V. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03690.x · Cited by 160 · see citing works

Morphine Promotes Rapid, Arrestin-Dependent Endocytosis of μ-Opioid Receptors in Striatal Neurons

Haberstock-Debic, H., Kim, K., Yu, Y., & von Zastrow, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5045-04.2005 · Cited by 148 · see citing works

Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling

Daigle, T. L., Kearn, C. S., & Mackie, K. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.06.005 · Cited by 147 · see citing works

Molecular Biology of Opioid Analgesia

Pasternak, G. W. (2005) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2005.01.011 · Cited by 140 · see citing works

μ and δ Opioid Receptors Are Differentially Desensitized by the Coexpression of β-Adrenergic Receptor Kinase 2 and β-Arrestin 2 in Xenopus Oocytes

Kovoor, A., Nappey, V., Kieffer, B. L., & Chavkin, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.27605 · Cited by 136 · see citing works

Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)

Ahn, K. H., Mahmoud, M. M., Shim, J., & Kendall, D. A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.438804 · Cited by 136 · see citing works

Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy.

Kovoor, A., Celver, J. P., Wu, A., & Chavkin, C. (1998) · PubMed · Cited by 135 · see citing works

X‐Arrestin: a new retinal arrestin mapping to the X chromosome

Murakami, A., Yajima, T., Sakuma, H., McLaren, M. J., & Inana, G. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81712-9 · Cited by 127 · see citing works

Selective Activation of Cannabinoid CB2 Receptors Suppresses Hyperalgesia Evoked by Intradermal Capsaicin

Hohmann, A. G., Farthing, J. N., Zvonok, A. M., & Makriyannis, A. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.060079 · Cited by 123 · see citing works

Agonist-directed Interactions with Specific β-Arrestins Determine μ-Opioid Receptor Trafficking, Ubiquitination, and Dephosphorylation

Groer, C. E., Schmid, C. L., Jaeger, A. M., & Bohn, L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.248310 · Cited by 122 · see citing works

Cannabinoid CB1receptor‐interacting proteins: novel targets for central nervous system drug discovery?

Smith, T. H., Sim‐Selley, L. J., & Selley, D. E. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00777.x · Cited by 117 · see citing works

β-Arrestin2 Regulates Cannabinoid CB1 Receptor Signaling and Adaptation in a Central Nervous System Region–Dependent Manner

Nguyen, P., Schmid, C. L., Raehal, K. M., Selley, D. E., Bohn, L., & Sim‐Selley, L. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.027 · Cited by 113 · see citing works

Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development

Gurevich, E. V., Benovic, J., & Gurevich, V. V. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00511-5 · Cited by 110 · see citing works

Morphine-like Opiates Selectively Antagonize Receptor-Arrestin Interactions

Molinari, P., Vezzi, V., Sbraccia, M., Grò, M. C., Riitano, D., Ambrosio, C., Casella, I., & Costa, T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.059410 · Cited by 104 · see citing works

The New Face of Active Receptor Bound Arrestin Attracts New Partners

Gurevich, V. V., & Gurevich, E. V. (2003) · Structure · doi:10.1016/s0969-2126(03)00184-9 · Cited by 104 · see citing works

Involvement of PKCα and G‐protein‐coupled receptor kinase 2 in agonist‐selective desensitization of µ‐opioid receptors in mature brain neurons

Bailey, C. P., Oldfield, S., Llorente, J., Caunt, C. J., Teschemacher, A., Roberts, L. D., McArdle, C. A., Smith, F., Dewey, W. L., Kelly, E., et al. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00140.x · Cited by 103 · see citing works

μ-Opioid receptor-knockout mice: the role of μ-opioid receptor in gastrointestinal transit

Roy, S., Liu, H.-C., & Loh, H. H. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00051-5 · Cited by 103 · see citing works

Regulation of endocytic clathrin dynamics by cargo ubiquitination

Henry, A. G., Hislop, J. N., Grove, J., Thorn, K., Marsh, M., & von Zastrow, M. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.08.003 · Cited by 100 · see citing works

β-Arrestin2 and c-Src Regulate the Constitutive Activity and Recycling of μ Opioid Receptors in Dorsal Root Ganglion Neurons

Walwyn, W. M., Evans, C. J., & Hales, T. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1157-07.2007 · Cited by 99 · see citing works

Distinct Domains of the μ-Opioid Receptor Control Uncoupling and Internalization

Celver, J. P., Xu, M., Jin, W., Lowe, J., & Chavkin, C. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.3.528 · Cited by 98 · see citing works

Protein Kinase C Activation Enhances Morphine-Induced Rapid Desensitization of μ-Opioid Receptors in Mature Rat Locus Ceruleus Neurons

Bailey, C. P., Kelly, E., & Henderson, G. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.004747 · Cited by 96 · see citing works

Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: A Potent, Orally Bioavailable Human CB1/CB2Dual Agonist with Antihyperalgesic Properties and Restricted Central Nervous System Penetration

Dziadulewicz, E. K., Bevan, S., Brain, C. T., Coote, P. R., Culshaw, A. J., Aj, D., Edwards, L. J., Fisher, A. J., Fox, A. J., Gentry, C., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070317a · Cited by 95 · see citing works

Molecular cloning of the S-antigen cDNA from bovine retina

Yamaki, K., Takahashi, Y., Sakuragi, S., & Matsubara, K. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)91499-9 · Cited by 92 · see citing works

Recovery from μ-Opioid Receptor Desensitization after Chronic Treatment with Morphine and Methadone

Quillinan, N., Lau, E. K., Virk, M., von Zastrow, M., & Williams, J. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4874-10.2011 · Cited by 92 · see citing works

Threonine 180 Is Required for G-protein-coupled Receptor Kinase 3- and β-Arrestin 2-mediated Desensitization of the μ-Opioid Receptor in Xenopus Oocytes

Celver, J. P., Lowe, J., Kovoor, A., Gurevich, V. V., & Chavkin, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007437200 · Cited by 91 · see citing works

Selective Cannabinoid CB1Receptor Activation Inhibits Spinal Nociceptive Transmission In Vivo

Kelly, S., & Chapman, V. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.6.3061 · Cited by 84 · see citing works

Mu Opioid Receptor Activation of ERK1/2 Is GRK3 and Arrestin Dependent in Striatal Neurons

Macey, T. A., Lowe, J., & Chavkin, C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604278200 · Cited by 84 · see citing works

μ-Opioid Receptor Desensitization

Qiu, Y. L., Law, P., & Loh, H. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305857200 · Cited by 84 · see citing works

Agonist Induced Homologous Desensitization of μ-Opioid Receptors Mediated by G Protein-Coupled Receptor Kinases Is Dependent on Agonist Efficacy

Kovoor, A., Celver, J. P., Wu, A. Y., & Chavkin, C. (1998) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)13072-6 · Cited by 80 · see citing works

Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate

Rea, K., Roche, M., & Finn, D. P. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707440 · Cited by 79 · see citing works

The Role of Cannabinoid Receptors in the Descending Modulation of Pain

Palazzo, E., Luongo, L., de Novellis, V., Rossi, F., & Maione, S. (2010) · Pharmaceuticals · doi:10.3390/ph3082661 · Cited by 78 · see citing works

Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia

Suplita, R. L., Gutierrez, T., Fegley, D., Piomelli, D., & Hohmann, A. G. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.10.007 · Cited by 78 · see citing works

Cannabinoid CB2 receptor agonist activity in the hindpaw incision

LaBuda, C. J., Koblish, M., & Little, P. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.10.020 · Cited by 76 · see citing works

[29] Arrestin: Mutagenesis, expression, purification, and functional characterization

Gurevich, V. V., & Benovic, J. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)15859-8 · Cited by 75 · see citing works

Antinociceptive potentiation and attenuation of tolerance by intrathecal β-arrestin 2 small interfering RNA in rats

Yang, C.-H., Huang, H.-W., Chen, K., Chen, Y.-S., Sheen‐Chen, S., & Lin, C. (2011) · British Journal of Anaesthesia · doi:10.1093/bja/aer291 · Cited by 75 · see citing works

Chronic Morphine Treatment Inhibits Opioid Receptor Desensitization and Internalization

Eisinger, D. A., Ammer, H., & Schulz, R. W. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10192.2002 · Cited by 72 · see citing works

Cellular Morphine Tolerance Produced by βArrestin-2-Dependent Impairment of μ-Opioid Receptor Resensitization

Dang, V. C., Chieng, B. C. H., Azriel, Y., & Christie, M. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5999-10.2011 · Cited by 70 · see citing works

Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurones via activation of CB2 receptors in anaesthetised rats

Sokal, D. M., Elmes, S. J. R., Kendall, D. A., & Chapman, V. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00195-3 · Cited by 67 · see citing works

Phospholipase D2 modulates agonist‐induced µ‐opioid receptor desensitization and resensitization

Koch, T., Brandenburg, L., Liang, Y.-J., Schulz, S., Beyer, A., Schröder, H., & Höllt, V. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02189.x · Cited by 65 · see citing works

Recent Developments in the Study of Opioid Receptors

Cox, B. M. (2012) · Molecular Pharmacology · doi:10.1124/mol.112.083279 · Cited by 64 · see citing works

Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: New concepts in mu opioid receptor pharmacology: From a symposium on new concepts in mu-opioid pharmacology

Lamb, K. R., Tidgewell, K. J., Simpson, D. S., Bohn, L., & Prisinzano, T. E. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.10.026 · Cited by 63 · see citing works

Sensitivity to Δ9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2−/− mice

Breivogel, C. S., Lambert, J. M., Gerfin, S., Huffman, J. W., & Razdan, R. K. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328308f1e6 · Cited by 62 · see citing works

Src Phosphorylation of μ-Receptor Is Responsible for the Receptor Switching from an Inhibitory to a Stimulatory Signal

Zhang, L., Zhao, H., Qiu, Y. L., Loh, H. H., & Law, P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807971200 · Cited by 58 · see citing works

The Role of β-Arrestin2 in the Mechanism of Morphine Tolerance in the Mouse and Guinea Pig Gastrointestinal Tract

Kang, M., Maguma, H. T., Smith, T. H., Ross, G. R., Dewey, W. L., & Akbarali, H. I. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.186320 · Cited by 57 · see citing works

Improvement of Morphine-Mediated Analgesia by Inhibition of β-Arrestin 2 Expression in Mice Periaqueductal Gray Matter

Li, Y., Liu, X., Liu, C., Kang, J., Yang, J., Pei, G., & Wu, C. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10030954 · Cited by 55 · see citing works

β-Arrestin-2 Desensitizes the Transient Receptor Potential Vanilloid 1 (TRPV1) Channel

Por, E. D., Bierbower, S. M., Berg, K. A., Gómez, R. S., Akopian, A. N., Wetsel, W. C., & Jeske, N. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.391847 · Cited by 55 · see citing works

μ-Opioid Receptors Desensitize Less Rapidly than δ-Opioid Receptors Due to Less Efficient Activation of Arrestin

Lowe, J., Celver, J. P., Gurevich, V. V., & Chavkin, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200612200 · Cited by 52 · see citing works

Two Distinct Mechanisms Mediate Acute μ-Opioid Receptor Desensitization in Native Neurons

Dang, V. C., Napier, I. A., & Christie, M. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4749-08.2009 · Cited by 51 · see citing works

Opioid receptor signaling: relevance for gastrointestinal therapy

Bohn, L., & Raehal, K. M. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.06.007 · Cited by 47 · see citing works

The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with β-arrestins

Schmidlin, F., Roosterman, D., & Bunnett, N. W. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00541.2002 · Cited by 47 · see citing works

Novel Roles for the E3 Ubiquitin Ligase Atrophin-interacting Protein 4 and Signal Transduction Adaptor Molecule 1 in G Protein-coupled Receptor Signaling

Malik, R., Soh, U. J. K., Trejo, J., & Marchese, A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.336792 · Cited by 45 · see citing works

G Protein-Coupled Receptor Kinase/β-Arrestin Systems and Drugs of Abuse: Psychostimulant and Opiate Studies in Knockout Mice

Bohn, L., Gainetdinov, R. R., & Caron, M. G. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:1:041 · Cited by 43 · see citing works

Knockdown of spinal opioid receptors by antisense targeting β-arrestin reduces morphine tolerance and allodynia in rat

Przewłocka, B., Sieja, A., Starowicz, K., Maj, M., Bilecki, W., & Przewłocki, R. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00246-x · Cited by 42 · see citing works

Morphine Induces μ Opioid Receptor Endocytosis in Guinea Pig Enteric Neurons Following Prolonged Receptor Activation

Patierno, S., Anselmi, L., Jaramillo, I., Scott, D., Garcia, R., & Sternini, C. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.11.005 · Cited by 35 · see citing works

Phosphorylation regulates TRPV1 association with β-arrestin-2

Por, E. D., Gómez, R. S., Akopian, A. N., & Jeske, N. A. (2013) · Biochemical Journal · doi:10.1042/bj20121637 · Cited by 34 · see citing works

Analgesic Tone Conferred by Constitutively Active Mu Opioid Receptors in Mice Lacking β-Arrestin 2

Lam, H. A., Maga, M., Pradhan, A. A. A., Evans, C. J., Maidment, N. T., Hales, T. G., & Walwyn, W. M. (2011) · Molecular Pain · doi:10.1186/1744-8069-7-24 · Cited by 34 · see citing works

Distinct Cellular and Subcellular Distributions of G Protein-Coupled Receptor Kinase and Arrestin Isoforms in the Striatum

Бычков, Э. Р., Zurkovsky, L., Garret, M. B., Ahmed, M. R., & Gurevich, E. V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048912 · Cited by 34 · see citing works

Evidence that Behavioral Phenotypes of Morphine in β-arr2−/− Mice Are Due to the Unmasking of JNK Signaling

Mittal, N., Tan, M., Egbuta, O., Desai, N., Crawford, C. A., Xie, C.-W., Evans, C. J., & Walwyn, W. M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.42 · Cited by 32 · see citing works

Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons

Walwyn, W. M., Wei, W., Xie, C. W., Chiu, K., Kieffer, B. L., Evans, C. J., & Maidment, N. T. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.06.021 · Cited by 29 · see citing works

Decreased morphine analgesia in rat overexpressing β-arrestin 2 at periaqueductal gray

Jiang, B., Shi, Y., Li, H., Kang, L., & Ma, L. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.02.071 · Cited by 28 · see citing works

Opioid use disorder

Strang, J., Volkow, N. D., Degenhardt, L., Hickman, M., Johnson, K., Koob, G. F., Marshall, B. D. L., Tyndall, M., & Walsh, S. L. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0137-5 · Cited by 639 · see citing works

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

Gillis, A., Gondin, A. B., Kliewer, A., Sanchez, J., Lim, H. D., Alamein, C., Manandhar, P., Santiago, M., Fritzwanker, S., Schmiedel, F., et al. (2020) · Science Signaling · doi:10.1126/scisignal.aaz3140 · Cited by 365 · see citing works

Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development

Koob, G. F. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000083 · Cited by 337 · see citing works

CB1 Receptor Signaling in the Brain: Extracting Specificity from Ubiquity

Busquets-García, A., Bains, J. S., & Marsicano, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.206 · Cited by 341 · see citing works

Chapter 1. Neurocircuitry of Addiction

Koob, G. F., & Volkow, N. D. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb01 · Cited by 236 · see citing works

The Mechanisms Involved in Morphine Addiction: An Overview

Listos, J., Łupina, M., Talarek, S., Mazur, A., Orzelska‐Górka, J., & Kotlinska, J. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174302 · Cited by 190 · see citing works

Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents

Altarifi, A. A., David, B., Muchhala, K. H., Blough, B. E., Akbarali, H., & Negus, S. S. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881116689257 · Cited by 166 · see citing works

Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression

Imam, M. Z., Kuo, A., Ghassabian, S., & Smith, M. T. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.12.032 · Cited by 144 · see citing works

New Insights in Cannabinoid Receptor Structure and Signaling

Ye, L., Cao, Z., Wang, W., & Zhou, N. (2019) · Current Molecular Pharmacology · doi:10.2174/1874467212666190215112036 · Cited by 137 · see citing works

Minireview: More Than Just a Hammer: Ligand “Bias” and Pharmaceutical Discovery

Luttrell, L. M. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1314 · Cited by 131 · see citing works

In vivo brain GPCR signaling elucidated by phosphoproteomics

Liu, J. J., Sharma, K., Zangrandi, L., Chen, C., Humphrey, S. J., Chiu, Y.-T., Spetea, M., Liu‐Chen, L., Schwarzer, C., & Mann, M. (2018) · Science · doi:10.1126/science.aao4927 · Cited by 118 · see citing works

Kratom policy: The challenge of balancing therapeutic potential with public safety

Prozialeck, W. C., Avery, B. A., Boyer, E. W., Grundmann, O., Henningfield, J. E., Kruegel, A. C., McMahon, L. R., McCurdy, C. R., Swogger, M. T., Veltri, C. A., et al. (2019) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2019.05.003 · Cited by 112 · see citing works

Opioid receptors: Structural and mechanistic insights into pharmacology and signaling

Shang, Y., & Filizola, M. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.05.012 · Cited by 97 · see citing works

Sex-dependent effects of cannabis-induced analgesia

Cooper, Z. D., & Haney, M. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.08.001 · Cited by 92 · see citing works

How Oliceridine (TRV-130) Binds and Stabilizes a μ-Opioid Receptor Conformational State That Selectively Triggers G Protein Signaling Pathways

Schneider, S., Provasi, D., & Filizola, M. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00948 · Cited by 91 · see citing works

The CB1 Receptor as the Cornerstone of Exostasis

Piazza, P. V., Cota, D., & Marsicano, G. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.002 · Cited by 89 · see citing works

CGRP receptor antagonist activity of olcegepant depends on the signalling pathway measured

Walker, C. S., Raddant, A. C., Woolley, M. J., Russo, A. F., & Hay, D. L. (2017) · Cephalalgia · doi:10.1177/0333102417691762 · Cited by 79 · see citing works

Current and Future Issues in the Development of Spinal Agents for the Management of Pain

Yaksh, T. L., Fisher, C. J., Hockman, T. M., & Wiese, A. J. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160307145542 · Cited by 73 · see citing works

Assessment of Biased Agonism among Distinct Synthetic Cannabinoid Receptor Agonist Scaffolds

Wouters, E., Walraed, J., Robertson, M. J., Meyrath, M., Szpakowska, M., Chevigné, A., Skiniotis, G., & Stove, C. P. (2019) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00069 · Cited by 69 · see citing works

Mu Opioid Receptor Heterodimers Emerge as Novel Therapeutic Targets: Recent Progress and Future Perspective

Zhang, L., Zhang, J., Hang, L., & Liu, T. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01078 · Cited by 69 · see citing works

Site and mechanism of morphine tolerance in the gastrointestinal tract

Akbarali, H. I., Inkisar, A., & Dewey, W. L. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12443 · Cited by 67 · see citing works

Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties

Brust, T. F., Alongkronrusmee, D., Soto-Velasquez, M., Baldwin, T. A., Ye, Z., Dai, M., Dessauer, C. W., van Rijn, R. M., & Watts, V. J. (2017) · Science Signaling · doi:10.1126/scisignal.aah5381 · Cited by 64 · see citing works

Clinical Pharmacology, Toxicity, and Abuse Potential of Opioids

Vearrier, D., & Grundmann, O. (2021) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.1923 · Cited by 64 · see citing works

Update on the Pharmacology and Legal Status of Kratom

Prozialeck, W. C. (2016) · Journal of Osteopathic Medicine · doi:10.7556/jaoa.2016.156 · Cited by 55 · see citing works

Redefining Ketamine Pharmacology for Antidepressant Action: Synergistic NMDA and Opioid Receptor Interactions?

Levinstein, M. R., Budinich, R. C., Bonaventura, J., Schatzberg, A. F., Zarate, C. A., & Michaelides, M. (2025) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20240378 · Cited by 56 · see citing works

A cryptic pocket in CB1 drives peripheral and functional selectivity

Rangari, V. A., O’Brien, E. S., Powers, A. S., Slivicki, R. A., Bertels, Z., Appourchaux, K., Aydın, D., Ramos‐Gonzalez, N., Mwirigi, J. M., Lin, L., et al. (2025) · Nature · doi:10.1038/s41586-025-08618-7 · Cited by 49 · see citing works

A bifunctional-biased mu-opioid agonist–neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects

la Rochelle, A. D., Guillemyn, K., Dumitrascuta, M., Martin, C., Utard, V., Quillet, R., Schneider, S., Daubeuf, F., Willemse, T., Mampuys, P., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001262 · Cited by 49 · see citing works

Pharmacologic and clinical assessment of kratom: An update

White, C. M. (2019) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/zxz221 · Cited by 49 · see citing works

Arresting the Development of Addiction: The Role of β-Arrestin 2 in Drug Abuse

Porter‐Stransky, K. A., & Weinshenker, D. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.240622 · Cited by 43 · see citing works

The American Psychiatric Association Publishing Textbook of Substance Use Disorder Treatment

Brady, K. T., LEVIN, F. R., Galanter, M. S., & Kleber, H. D. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970 · Cited by 41 · see citing works

Characterization of structurally novel G protein biased CB 1 agonists: Implications for drug development

Ford, B. M., Franks, L. N., Tai, S., Fantegrossi, W. E., Stahl, E. L., Berquist, M. D., Cabanlong, C. V., Wilson, C. D., Penthala, N. R., Crooks, P. A., et al. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.08.008 · Cited by 40 · see citing works

Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat

Araldi, D., Ferrari, L. F., & Levine, J. D. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.10.015 · Cited by 38 · see citing works

Analysis of natural product regulation of opioid receptors in the treatment of human disease

Badal, S. A. M., Turfus, S. C., Rajnarayanan, R. V., Wilson-Clarke, C. F., & Sandiford, S. L. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.10.021 · Cited by 36 · see citing works

Selexipag Active Metabolite ACT-333679 Displays Strong Anticontractile and Antiremodeling Effects but Low β-Arrestin Recruitment and Desensitization Potential

Gatfield, J., Menyhart, K., Wanner, D., Gnerre, C., Monnier, L., Morrison, K., Hess, P., Iglarz, M., Clozel, M., & Nayler, O. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.239665 · Cited by 35 · see citing works

Members of the same pharmacological family are not alike: Different opioids, different consequences, hope for the opioid crisis?

Emery, M. A., & Eitan, S. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.02.010 · Cited by 35 · see citing works

Emerging Insights into Mu Opioid Pharmacology

Pasternak, G. W., Childers, S. R., & Pan, Y. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_270 · Cited by 35 · see citing works

The Basic Science of Cannabinoids

Sideris, A., Lauzadis, J., & Kaczocha, M. (2023) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006472 · Cited by 36 · see citing works

Structure-based identification of a G protein–biased allosteric modulator of cannabinoid receptor CB1

Shen, S., Wu, C., Lin, G., Yang, X., Zhou, Y., Zhao, C. S., Miao, Z., Tian, X., Wang, K., Yang, Z., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2321532121 · Cited by 34 · see citing works

TRV0109101, a G Protein-Biased Agonist of the µ-Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration

Koblish, M., Carr, R. W., Siuda, E. R., Rominger, D. H., Gowen-MacDonald, W., Cowan, C. L., Crombie, A. L., Violin, J. D., & Lark, M. W. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.241117 · Cited by 33 · see citing works

CB2 agonism controls pain and subchondral bone degeneration induced by mono-iodoacetate: Implications GPCR functional bias and tolerance development

Mlost, J., Kostrzewa, M., Borczyk, M., Bryk, M., Chwastek, J., Korostyński, M., & Starowicz, K. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111283 · Cited by 32 · see citing works

G Protein–Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands

Tsvetanova, N. G., Trester-Zedlitz, M., Newton, B. W., Riordan, D. P., Sundaram, A. B., Johnson, J. R., Krogan, N. J., & von Zastrow, M. (2016) · Molecular Pharmacology · doi:10.1124/mol.116.106369 · Cited by 31 · see citing works

Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway

Gaspari, S., Purushothaman, I., Cogliani, V., Sakloth, F., Neve, R. L., Howland, D., Ring, R. H., Ross, E. M., Shen, L., & Zachariou, V. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707887115 · Cited by 29 · see citing works

Chapter 13. Methadone and Buprenorphine Maintenance Treatment of Opioid-Related Disorders

Strain, E. C., & Stoller, K. B. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb13 · Cited by 27 · see citing works

Optimizing Perioperative Use of Opioids: a Multimodal Approach

Ramirez, M. F., Kamdar, B. B., & Cata, J. P. (2020) · Current anesthesiology reports · doi:10.1007/s40140-020-00413-6 · Cited by 28 · see citing works

Synthesis, biological, and structural explorations of a series of μ-opioid receptor (MOR) agonists with high G protein signaling bias

Yang, Y., Wang, Y., Zuo, A., Li, C., Wang, W., Jiang, W., Zhang, X., Che, X., Zhang, Y., Wu, W., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113986 · Cited by 27 · see citing works

Chapter 2. Genetics and Epigenetics of Addiction

Gelernter, J. E., & Polimanti, R. A. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb02 · Cited by 26 · see citing works

Chapter 37. Substance-Related Disorders in Adolescents

Roten, A. T., & Gray, K. M. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb37 · Cited by 26 · see citing works

Chapter 3. Epidemiology of Addiction

Smith, N., & Cottler, L. B. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb03 · Cited by 26 · see citing works

Type‐1 cannabinoid receptors and their ever‐expanding roles in brain energy processes

Fernández‐Moncada, I., Rodrigues, R. S., Fundazuri, U. B., Bellocchio, L., & Marsicano, G. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15922 · Cited by 26 · see citing works

Analysis of natural product regulation of cannabinoid receptors in the treatment of human disease

Badal, S. A. M., Smith, K. N., & Rajnarayanan, R. V. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.06.003 · Cited by 26 · see citing works

Chapter 48. Trauma- and Stressor-Related Disorders

Fitzpatrick, S., Jarnecke, A. M., Back, S. E., Straus, E., Norman, S., & Hien, D. A. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb48 · Cited by 25 · see citing works

Epigenetic Regulation of Cannabinoid-Mediated Attenuation of Inflammation and Its Impact on the Use of Cannabinoids to Treat Autoimmune Diseases

Holloman, B. L., Nagarkatti, M., & Nagarkatti, P. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147302 · Cited by 27 · see citing works

Sequence-Specific Regulation of Endocytic Lifetimes Modulates Arrestin-Mediated Signaling at the µ Opioid Receptor

Weinberg, Z. Y., Zajac, A. S., Phan, T., Shiwarski, D., & Puthenveedu, M. (2017) · Molecular Pharmacology · doi:10.1124/mol.116.106633 · Cited by 27 · see citing works

Chapter 35. Prevention of Substance Use Disorders

Champion, K. E., Newton, N. C., & Teesson, M. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb35 · Cited by 24 · see citing works

Chapter 23. Cognitive-Behavioral Therapy

Carroll, K. M., & Kiluk, B. D. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb23 · Cited by 23 · see citing works

Chapter 27. Family Therapy

Steinglass, P. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb27 · Cited by 23 · see citing works

Chapter 25. Motivational Enhancement

Shulman, M., Pruzan, K., & Carpenter, K. M. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb25 · Cited by 23 · see citing works

Chapter 44. Mood Disorders

Wai, J. M., Shulman, M., & Nunes, E. V. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb44 · Cited by 23 · see citing works

Selective modulation of the cannabinoid type 1 (CB 1 ) receptor as an emerging platform for the treatment of neuropathic pain

Banister, S. D., Kumar, K. K., Kumar, V., Kobilka, B. K., & Malhotra, S. V. (2019) · MedChemComm · doi:10.1039/c8md00595h · Cited by 22 · see citing works

Oliceridine- Opioid of the 21st Century

Goudra, B. (2022) · Saudi Journal of Anaesthesia · doi:10.4103/sja.sja_510_21 · Cited by 23 · see citing works

Kratom Dependence and Treatment Options: A Comprehensive Review of the Literature

Abdullah, M. F. I. L. B. (2020) · Current Drug Targets · doi:10.2174/1389450121666200719011653 · Cited by 22 · see citing works

Molecular and cellular basis of mu-opioid receptor signaling: mechanisms underlying tolerance and dependence development

Swingler, M., Donadoni, M., Unterwald, E. M., Maggirwar, S. B., & Sariyer, I. K. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1597922 · Cited by 21 · see citing works

Class A and C GPCR Dimers in Neurodegenerative Diseases

Moreira, I. S., Caniceiro, A. B., Bueschbell, B., & Schiedel, A. C. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220327221830 · Cited by 18 · see citing works

Respiratory effects of low and high doses of fentanyl in control and β-arrestin 2-deficient mice

Haouzi, P. A., McCann, M. L., & Tubbs, N. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00711.2020 · Cited by 20 · see citing works

Oliceridine and its potential to revolutionize GI endoscopy sedation

Goudra, B., & Singh, P. M. (2020) · Saudi Journal of Anaesthesia · doi:10.4103/sja.sja_813_19 · Cited by 19 · see citing works

Evidence for the emergence of an opioid‐resistant respiratory rhythm following fentanyl overdose

Haouzi, P. A., Mellen, N. M., McCann, M. L., Sternick, M. E., Guck, D., & Tubbs, N. (2020) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2020.103428 · Cited by 19 · see citing works

The endocannabinoidomes: Pharmacological redundancy and promiscuity, and multi-kingdom variety of sources and molecular targets

Iannotti, F. A., & Marzo, V. D. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100070 · Cited by 21 · see citing works

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4′-pyridylcarboxamido)morphinan (NAP) Modulating the Mu Opioid Receptor in a Biased Fashion

Zhang, Y., Williams, D. A., Zaidi, S. A., Yuan, Y., Braithwaite, A., Bilsky, E. J., Dewey, W. L., Akbarali, H. I., Streicher, J. M., & Selley, D. E. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00245 · Cited by 18 · see citing works

Medical, Political, and Economic Considerations for the Use of MAC for Endoscopic Sedation: Big Price, Little Justification?

Goudra, B., Singh, P., & Lichtenstein, G. (2020) · Digestive Diseases and Sciences · doi:10.1007/s10620-020-06464-3 · Cited by 16 · see citing works

Opioid Maintenance Therapy: A Review of Methadone, Buprenorphine, and Naltrexone Treatments for Opioid Use Disorder

Fipps, D. C., Oesterle, T., & Kolla, B. P. (2024) · Seminars in Neurology · doi:10.1055/s-0044-1787571 · Cited by 16 · see citing works

Contribution of G-Protein α-Subunits to Analgesia, Hyperalgesia, and Hyperalgesic Priming Induced by Subanalgesic and Analgesic Doses of Fentanyl and Morphine

Araldi, D., Bonet, I. J. M., Green, P. G., & Levine, J. D. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1982-21.2021 · Cited by 15 · see citing works

New Insights Into Peptide Cannabinoids: Structure, Biosynthesis and Signaling

Riquelme-Sandoval, A., de Sá-Ferreira, C. O., Miyakoshi, L. M., & Hedin‐Pereira, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.596572 · Cited by 13 · see citing works

Exploring Pharmacological Activities and Signaling of Morphinans Substituted in Position 6 as Potent Agonists Interacting with the μ Opioid Receptor

Haddou, T. B., Malfacini, D., Calò, G., Aceto, M. D. G., Harris, L. S., Traynor, J. R., Coop, A., Schmidhammer, H., & Spetea, M. (2014) · Molecular Pain · doi:10.1186/1744-8069-10-48 · Cited by 13 · see citing works

Opioids and Vitamin C: Known Interactions and Potential for Redox-Signaling Crosstalk

Newman, M. S., Connery, H., & Boyd, J. (2022) · Antioxidants · doi:10.3390/antiox11071267 · Cited by 12 · see citing works

Quantitative Systems Pharmacology and Biased Agonism at Opioid Receptors: A Potential Avenue for Improved Analgesics

Bedini, A., Cuna, E., Baiula, M., & Spampinato, S. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095114 · Cited by 10 · see citing works

Kratom use disorder: a primer for primary care physicians

Groff, D., Stuckey, H. L., Philpott, C. D., Dyke, E. V., Silvis, M. L., Leong, S. L., & Bone, C. (2021) · Journal of Addictive Diseases · doi:10.1080/10550887.2021.1950263 · Cited by 10 · see citing works

The Development of Cannabinoids as Therapeutic Agents in the United States

Murray, C. H., Gannon, B. M., Winsauer, P. J., Cooper, Z. D., & Delatte, M. S. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.123.001121 · Cited by 9 · see citing works

Opioid Modulation of Neuronal Iron and Potential Contributions to NeuroHIV

Nash, B., Irollo, E., Brandimarti, R., & Meucci, O. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0884-5_13 · Cited by 8 · see citing works

Low concentrations of tricyclic antidepressants stimulate TRPC4 channel activity by acting as an opioid receptor ligand

Jeong, B., Song, Y. P., Chung, J. Y., Park, K. C., Kim, J., So, I., & Hong, C. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00535.2022 · Cited by 7 · see citing works

A pilot study to identify pharmacogenomic and clinical risk factors associated with opioid related falls and adverse effects in older adults

Sheikh, S., Fernandez, R., Smotherman, C. R., Brailsford, J., Langaee, T. Y., Velasquez, E., Henson, M., Munson, T., Bertrand, A. H., Hendry, P. L., et al. (2023) · Clinical and Translational Science · doi:10.1111/cts.13634 · Cited by 7 · see citing works

Anti-allodynic and medullary modulatory effects of a single dose of delta-9-tetrahydrocannabinol (THC) in neuropathic rats tolerant to morphine

Pearl‐Dowler, L., Posa, L., López-Canul, M., Teggin, A., & Gobbi, G. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110805 · Cited by 7 · see citing works

Examining the Severity and Progression of Illicitly Manufactured Fentanyl Withdrawal: A Quasi-experimental Comparison

Sharma, A., Dunn, K. E., Schmid-Doyle, K., Dowell, S., Kim, N., Strain, E. C., & Bergeria, C. L. (2024) · Journal of Addiction Medicine · doi:10.1097/adm.0000000000001395 · Cited by 6 · see citing works

Reduced Tolerance and Asymmetrical Crosstolerance to Effects of the Indole Quinuclidinone Analog PNR-4-20, a G Protein–Biased Cannabinoid 1 Receptor Agonist in Mice: Comparisons with Δ9-Tetrahydrocannabinol and JWH-018

Ford, B. M., Cabanlong, C. V., Tai, S., Franks, L. N., Penthala, N. R., Crooks, P. A., Prather, P. L., & Fantegrossi, W. E. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.252965 · Cited by 6 · see citing works

Morphine induces HADHA succinylation, while HADHA desuccinylation alleviates morphine tolerance by influencing autophagy

Huang, Y., Lu, S., Chen, Y., Feng, Y., & Lu, W. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02697-x · Cited by 5 · see citing works

Chapter 47. Attention-Deficit/Hyperactivity Disorder

Wilens, T. E., & Kaminski, T. A. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb47 · Cited by 5 · see citing works

Peripheral CRF-R1/CRF-R2 antagonist, astressin C, induces a long-lasting blockade of acute stress-related visceral pain in male and female rats

Larauche, M. H., Érchegyi, J., Miller, C. L., Sim, M., Rivier, J., Behan, D. P., & Taché, Y. (2022) · Peptides · doi:10.1016/j.peptides.2022.170881 · Cited by 4 · see citing works

Rational design of Gi-biased CB1 agonist with reduced side effects

Liao, Y.-Y., Che, J., Yun-tao, G., Xue, J., Li, L., Wu, L.-L., Hu, J.-X., Hu, M.-T., Xie, L., Zhang, H., et al. (2026) · Cell · doi:10.1016/j.cell.2026.03.020 · Cited by 3 · see citing works

Exercise-Induced Hypoalgesia: Cellular and Molecular Mechanisms Linking Pain Modulation and Stress Regulation—A Narrative Review

Gajic, P., Kovac, I., Lubinsky, G. T., & Knežević, N. N. (2026) · Cells · doi:10.3390/cells15100858 · Cited by 3 · see citing works

Chapter 20. Neurobiology and Treatment of Sedative-, Hypnotic-, and Anxiolytic-Related Disorders

Jones, J. L., VandenBerg, A., & Malcolm, R. J. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb20 · Cited by 3 · see citing works

Chapter 10. Neurobiology of Stimulants

Sofuoglu, M., DeVito, E. E., & Kosten, T. R. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb10 · Cited by 3 · see citing works

Chapter 14. Opioid Antagonist Treatment of Opioid-Related Disorders

Capata, M., & Hartwell, K. J. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb14 · Cited by 3 · see citing works

Perioperative Pain, Analgesics and Cancer-Related Outcomes: where do we Stand?

Ramirez, M. F., Rangel, F. P., & Cata, J. P. (2021) · Pain Management · doi:10.2217/pmt-2021-0070 · Cited by 3 · see citing works

Chapter 34. Nicotine and Public Health

Cummings, K. M., Borland, R., & Braak, D. C. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb34 · Cited by 3 · see citing works

Dezocine and Addiction: Friend or Foe?

Childers, W. E., Elokely, K. M., & Abou-Gharbia, M. A. (2025) · Pharmaceuticals · doi:10.3390/ph18030386 · Cited by 2 · see citing works

Chapter 4. Substance Use Disorder Diagnoses in DSM-5

Hasin, D. S., & Larson, F. R. R. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb04 · Cited by 2 · see citing works

Structure–function relationship of dynorphin B variants using naturally occurring amino acid substitutions

Zangrandi, L., Fogli, B., Mutti, A., Staritzbichler, R., Most, V., Hildebrand, P. W., Heilbronn, R., & Schwarzer, C. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1484730 · Cited by 2 · see citing works

Peripheral inflammatory injury alters the relative abundance of Gα subunits in the dorsal horn of the spinal cord and in the rostral ventromedial medulla of male rats

Wattiez, A., Walder, R. Y., Sande, C. M., White, S. R., & Hammond, D. L. (2017) · Molecular Pain · doi:10.1177/1744806917715210 · Cited by 2 · see citing works

Opioids

Koob, G. F., Arends, M. A., McCracken, M. L., & Moal, M. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-816988-9.00001-1 · Cited by 2 · see citing works

Chapter 49. Schizophrenia Spectrum and Other Psychotic Disorders

Schwartz, E., Brunette, M. F., & Green, A. I. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb49 · Cited by 2 · see citing works

Chapter 18. Neurobiology of Nicotine and Tobacco

Gubner, N. R., & Benowitz, N. L. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb18 · Cited by 2 · see citing works

Modulation of Mu-Opioid Receptor Signaling by Cannabinoid CB1 Receptor through Heteromerization, a Novel Analgesic Target

Xiang, G., Baki, L., Kawano, T., & Logothetis, D. E. (2019) · Biophysical Journal · doi:10.1016/j.bpj.2018.11.1287

Opioid-Induced Side Effects in Beta-arrestin2 adn G Protein-Coupled Receptor Kinase Knockout Mice

Raehal, K. M. (2009) · OhioLink ETD Center (Ohio Library and Information Network)

Toward Directing Opioid Receptor Signaling to Refine Opioid Therapeutics

Grim, T. W., Acevedo‐Canabal, A., & Bohn, L. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.10.020 · Cited by 87 · see citing works

Role of β-arrestin in μ-opioid and TRPV1 receptor signalling

Nagy-Marková, V. (2023) · Digital Repository (National Repository of Grey Literature)

I3. Oliceridine (TRV130) Has a Differentiated Profile of G Protein and β-arrestin Signaling Versus Select Opioids

Cowan, C. L., Gowen-MacDonald, W., Graczyk, T. M., & Lark, M. (2017) · Pain Management Nursing · doi:10.1016/j.pmn.2017.02.193