Pharmacology of Ecdysones in Vertebrates
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The results confirmed BIO101 good safety profiles observed in rats and dogs as well as low toxicity previously observed with 20E in male mice.
“The results confirmed BIO101 good safety profiles observed in rats and dogs (data not shown) as well as low toxicity previously observed with 20E in male mice. 19”
From A Phase 1 study for safety and pharmacokinetics of BIO101 (20‐hydroxyecdysone) in healthy young and older adults (2023) · cites this paper as [19]
20E has a good safety profile with low oral toxicity ascertained by no LD50 reached at 9 g/kg on mice and no change in organ weight reported after chronic administration for up to 35 days at 2 g/kg in rabbits.
“20E has a good safety profile with low oral toxicity ascertained by no LD50 (lethal dose 50%) reached at 9 g/kg on mice 18 and no change in organ weight reported after a chronic administration for up to 35 days at 2 g/kg in rabbits. 19”
From A Phase 1 study for safety and pharmacokinetics of BIO101 (20‐hydroxyecdysone) in healthy young and older adults (2023) · cites this paper as [19]
Cites
Pharmacological studies of insect metamorphosing steroids from Achyranthis radix
Matsuda (1970) · Folia Pharmacologica Japonica · doi:10.1254/fpj.66.551 · Cited by 19 · see citing works
THE SIGNIFICANCE OF INVERTEBRATE HORMONES IN RELATION TO DIFFERENTIATION.
Burdette, W. J. (1964) · PubMed · Cited by 16 · see citing works
On the Remarks of Dr. W. R. Duryee
Rafferty, K. A. (1964) · Cancer Research · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Phytoecdysteroids: Biological aspects
Dinan, L. (2001) · Phytochemistry · doi:10.1016/s0031-9422(01)00078-4 · Cited by 392 · see citing works
Practical uses for ecdysteroids in mammals including humans: and update
Lafont, R., & Dinan, L. (2003) · Journal of Insect Science · doi:10.1093/jis/3.1.7 · Cited by 196 · see citing works
Identification of ligands and coligands for the ecdysone-regulated gene switch
Sáez, E., Nelson, M. C., Eshelman, B., Banayo, E., Koder, A., Cho, G. J., & Evans, R. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.260499497 · Cited by 114 · see citing works
20-Hydroxyecdysone Increases Fiber Size in a Muscle-Specific Fashion in Rat
Tóth, N., Szabó, A., Kacsala, P., Héger, J., & Zádor, E. (2008) · Phytomedicine · doi:10.1016/j.phymed.2008.04.015 · Cited by 85 · see citing works
Jones, C. G. (1983) · Elsevier eBooks · doi:10.1016/b978-0-12-209160-5.50024-6 · Cited by 46 · see citing works
Dioh, W., Tourette, C., Del Signore, S., Daudigny, L., Dupont, P., Balducci, C., Dilda, P. J., Lafont, R., & Veillet, S. (2023) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.13195 · Cited by 40 · see citing works
“The results confirmed BIO101 good safety profiles observed in rats and dogs (data not shown) as well as low toxicity previously observed with 20E in male mice.(19) No SAE occurred during the treatment of healthy human volunteers with BIO101 in the SAD or in the MAD.”
BackgroundResultShuvalov, O., Fedorova, O., Tananykina, E., Gnennaya, Y., Daks, A., Petukhov, A., & Barlev, N. A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.561537 · Cited by 30 · see citing works
Solomon, K. R., Mango, C. K. A., & Obenchain, F. D. (1982) · Elsevier eBooks · doi:10.1016/b978-0-08-024937-7.50016-0 · Cited by 29 · see citing works
Ecdysteroid metabolism in mammals: The fate of ingested 20-hydroxyecdysone in mice and rats
Dinan, L., Balducci, C., Guibout, L., Foucault, A.-S., Bakrim, A., Kumpun, S., Girault, J.-P., Tourette, C., Dioh, W., Dilda, P. J., et al. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105896 · Cited by 23 · see citing works
Innovative and Future Applications for Ecdysteroids
Lafont, R., & Dinan, L. N. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9112-4_23 · Cited by 17 · see citing works
Tang, W., & Eisenbrand, G. (1992) · Springer eBooks · doi:10.1007/978-3-642-73739-8_2 · Cited by 15 · see citing works
Effect of 20-hydroxyecdysone on proteolytic regulation in skeletal muscle atrophy
HIRUNSAI, M., YIMLAMAI, T., & SUKSAMRARN, A. (2016) · In Vivo · doi:10.21873/invivo.11007 · Cited by 13 · see citing works
Dinan, L. N., Mamadalieva, N. Z., & Lafont, R. (2019) · Springer eBooks · doi:10.1007/978-981-13-1745-3_35-1 · Cited by 15 · see citing works
Shuvalov, O., Kirdeeva, Y., Fefilova, E., Daks, A., Fedorova, O., Parfenyev, S., Nazarov, A., Vlasova, Y., Krasnov, G. S., & Barlev, N. A. (2024) · Antioxidants · doi:10.3390/antiox13111349 · Cited by 9 · see citing works
Ecdysteroids are present in the blood of wild passerine birds
Hornok, S., Csorba, A., Kováts, D., Csörgő, T., & Hunyadi, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-53090-9 · Cited by 7 · see citing works
Analysis of ecdysteroids by micellar electrokinetic chromatography with on-line preconcentration
Santagati, N. A., Tropea, S., & Ronsisvalle, G. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.05.004 · Cited by 9 · see citing works
20-Hydroxyecdysone Release from Biodegradable Devices: the Effect of Size and Shape
Dittrich, M., Solich, P., Opletal, L., Hunt, A., & Smart, J. D. (2000) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-100102310 · Cited by 8 · see citing works
In Vitro. Antibacterial Activity of FourLeuzea. Species
Kokoška, L., Janovská, D., Rada, V., Nepovím, A., & Vanek, T. (2005) · Pharmaceutical Biology · doi:10.1080/13880200590903237 · Cited by 9 · see citing works
β-Ecdysterone accumulation and regulation in Ajuga multiflora Bunge suspension culture
Wang, Y.-C., Zhao, J., & Chi, D. (2018) · 3 Biotech · doi:10.1007/s13205-018-1117-2 · Cited by 8 · see citing works
Dinan, L. N., Mamadalieva, N. Z., & Lafont, R. (2021) · Springer eBooks · doi:10.1007/978-981-15-4148-3_35 · Cited by 5 · see citing works
Franco, R. R., Franco, R. M., Justino, A. B., Borges, A. L. S., Bittar, V. P., Saito, N., Saraiva, A. L., Nicolau-Júnior, N., Otoni, W. C., & Espíndola, F. S. (2024) · PROTOPLASMA · doi:10.1007/s00709-023-01916-9 · Cited by 5 · see citing works
Investigation of plants containing unusual ecdysteroids with ring in their side-chain
Ványolós, A. (2012) · doi:10.14232/phd.1514 · Cited by 3 · see citing works
Rice, T. T. (2018) · Figshare · doi:10.71889/5fylantbak.29862167 · Cited by 1 · see citing works
Acute toxicity of nanoscale form of 20-hydroxyecdysone in intragastric administration
Erimbetov, K. T., Федорова, А. В., Goncharova, A. Y., & Obvintseva, O. V. (2021) · Toxicological Review · doi:10.36946/0869-7922-2021-2-59-63
Suhatcho, K., Yingyongnarongkul, B., Kumpun, S., & Srikuea, R. (2023) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v22i10.11
Pharmacokinetic and Safety Profiles of Phytoecdysteroids in Mammals
Dinan, L. N., & Lafont, R. (2026) · Springer eBooks · doi:10.1007/978-981-95-8423-9_7
- Authors
- Ogawa, S., Nishimoto, N., & Matsuda, H.
- ORCID
- Matsuda, Hiroyuki
- Venue
- Invertebrate Endocrinology and Hormonal Heterophylly
- Publisher
- Springer Berlin Heidelberg
- Published
- 1974
- Pages
- 341-344
- OpenAlex
- W638991397
- Cited by
- 29
- References
- 3
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.00
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Springer eBooks (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- ecdysteroids, 20-hydroxyecdysone, inokosterone, pharmacology, toxicity, LD50, oral administration, intraperitoneal administration, vertebrates, mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
