Pathogenesis of Neuritic (Senile) and Amyloid Plaque Formation
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Neuritic plaques are more likely to be associated with cognitive impairment than diffuse plaques.
“A particularly important subtype of AβPs are “neuritic plaques” (NPs), as they are more likely to be associated with cognitive impairment than “diffuse plaques” (49-51).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [50]
NPs represent a nidus in which extracellular plaque substance(s) seem to induce intracellular degenerative changes with tau pathology.
“The particular toxic substance(s) within NPs still have not been completely characterized (90, 103, 278), but NPs represent a nidus in which extracellular plaque substance(s) seem to induce intracellular degenerative changes with tau pathology (18, 50, 279-281).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [50]
Cites
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“The particular toxic substance(s) within NPs still have not been completely characterized (90, 103, 278), but NPs represent a nidus in which extracellular plaque substance(s) seem to induce intracellular degenerative changes with tau pathology (18, 50, 279 Y 281).”
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Henry M. Wisniewski M.D. Ph.D.
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Self-citation
- Authors
- Wisniewski, H. M., Vorbrodt, A. W., Moretz, R. C., Lossinsky, A. S., & Grundke-Iqbal, I.
- Venue
- Experimental Brain Research Supplementum
- Publisher
- Springer Berlin Heidelberg
- Published
- 1982
- Volume
- Suppl 5
- Pages
- 3-9
- ISSN
- 0172-9039 (ISSN-L)
- OpenAlex
- W2416805569
- Cited by
- 45
- References
- 7
- Citations by year
- 2025: 1 · 2017: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 2.11
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Experimental brain research. Supplementum (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- neuritic plaques, amyloid plaques, Alzheimer's disease, pathogenesis, amyloid-beta, neurofibrillary tangles
- MeSH terms
- Amyloidosis, Animals, Blood-Brain Barrier, Brain, Brain Diseases, Microscopy, Electron, Scrapie, Sheep, Mice
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