Is synaptic loss a unique hallmark of Alzheimer’s disease?
Open accessAbstract
Synapses may represent a key nidus for dementia including Alzheimer's disease (AD) pathogenesis. Here we review published studies and present new ideas related to the question of the specificity of synapse loss in AD. Currently, AD is defined by the regional presence of neuritic plaques and neurofibrillary tangles in the brain. The severity of involvement by those pathological hallmarks tends to correlate both with antemortem cognitive status, and also with synapse loss in multiple brain areas. Recent studies from large autopsy series have led to a new standard of excellence with regard to clinical-pathological correlation and to improved comprehension of the numerous brain diseases of the elderly. These studies have provided evidence that it is the rule rather than the exception for brains of aged individuals to demonstrate pathologies (often multiple) other than AD plaques and tangles. For many of these comorbid pathologies, the extent of synapse loss is imperfectly understood but could be substantial. These findings indicate that synapse loss is probably not a hallmark specific to AD but rather a change common to many diseases associated with dementia.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Synaptic dysfunction and synapse loss are key hallmarks of AD, present in the early stages of the disease before clinical symptoms appear.
“Synaptic dysfunction and synapse loss are key hallmarks of AD, present in the early stages of the disease before clinical symptoms appear [79,86,156].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [156]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864 · see citing works
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
Neumann, M., Sampathu, D. M., Kwong, L. K., Truax, A. C., Micsenyi, M. C., Chou, T. T., Bruce, J., Schuck, T., Grossman, M., Clark, C. M., et al. (2006) · Science · doi:10.1126/science.1134108 · Cited by 6,576 · see citing works
The global prevalence of dementia: a systematic review and metaanalysis.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941 · see citing works
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117 · see citing works
McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960 · see citing works
Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811 · see citing works
Neuropathological alterations in Alzheimer disease
Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345 · see citing works
Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092 · see citing works
Self-citationMontine, T. J., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0910-3 · Cited by 2,992 · cited 1× · see citing works
“An important step forward for neuropathologists is the most recent (2012) revision of recommendations for the neuropathologic approach to AD diagnoses [30,31].”
BackgroundSelf-citationLee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480 · see citing works
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376 · see citing works
Self-citationObservations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084 · see citing works
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · cited 13× · see citing works
“However, even in extreme old age, the presence of many neocortical NFTs (Braak neurofibrillary stage VI) correlates with antemortem cognitive decline [48–50].”
BackgroundInfluentialSelf-citationBuée, L., Bussière, T., Buée‐Scherrer, V., Delacourte, A., & Hof, P. R. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00019-9 · Cited by 2,007 · see citing works
Mixed brain pathologies account for most dementia cases in community-dwelling older persons
Schneider, J. A., Arvanitakis, Z., Bang, W., & Bennett, D. A. (2007) · Neurology · doi:10.1212/01.wnl.0000271090.28148.24 · Cited by 1,992 · see citing works
Progressive Supranuclear Palsy
Steele, J. C. (1964) · Archives of Neurology · doi:10.1001/archneur.1964.00460160003001 · Cited by 1,930 · see citing works
(2001) · The Lancet · doi:10.1016/s0140-6736(00)03589-3 · Cited by 1,338 · see citing works
Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups.
(1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.4.416 · Cited by 1,331 · see citing works
Cairns, N. J., Bigio, E. H., Mackenzie, I. R. A., Neumann, M., Lee, V. M.-Y., Hatanpaa, K. J., White, C. L., Schneider, J. A., Grinberg, L. T., Halliday, G., et al. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0237-2 · Cited by 1,110 · see citing works
The Lewy body variant of Alzheimer's disease: A clinical and pathologic entity
Hansen, L., Salmon, D., Galasko, D., Masliah, E., Katzman, R., DeTeresa, R., Thal, L., Pay, M. M., Hofstetter, R., Klauber, M., et al. (1990) · Neurology · doi:10.1212/wnl.40.1.1 · Cited by 1,068 · see citing works
Classification and basic pathology of Alzheimer disease
Duyckaerts, C., Delatour, B., & Potier, M.-C. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0532-1 · Cited by 1,031 · see citing works
Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment
Scheff, S. W., Price, D. A., Schmitt, F. A., & Mufson, E. J. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.012 · Cited by 1,017 · see citing works
Self-citationAge-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease
Bartzokis, G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.03.001 · Cited by 968 · see citing works
Petersen, R. C. (2016) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000313 · Cited by 925 · see citing works
TDP‐43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
Amador‐Ortiz, C., Lin, W., Ahmed, Z., Personett, D., Davies, P., Duara, R., Graff‐Radford, N. R., Hutton, M. L., & Dickson, D. W. (2007) · Annals of Neurology · doi:10.1002/ana.21154 · Cited by 916 · see citing works
Age, Neuropathology, and Dementia
Savva, G. M., Wharton, S. B., Ince, P. G., Forster, G., Matthews, F. E., & Brayne, C. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0806142 · Cited by 900 · see citing works
Hauw, J., Daniel, S. E., Dickson, D. W., Horoupian, D. S., Jellinger, K. A., Lantos, P. L., McKee, A. C., Tabaton, M., & Litvan, I. (1994) · Neurology · doi:10.1212/wnl.44.11.2015 · Cited by 854 · see citing works
Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
Scheff, S. W., Price, D. A., Schmitt, F. A., DeKosky, S. T., & Mufson, E. J. (2007) · Neurology · doi:10.1212/01.wnl.0000260698.46517.8f · Cited by 824 · see citing works
Self-citationDementia and Alzheimer Disease Incidence: A Prospective Cohort Study
Kukull, W. A., Higdon, R., Bowen, J. D., McCormick, W. C., Teri, L., Schellenberg, G. D., van Belle, G., Jolley, L., & Larson, E. B. (2002) · Archives of Neurology · doi:10.1001/archneur.59.11.1737 · Cited by 806 · see citing works
The arterial lesions underlying lacunes
Fisher, C. M. (1969) · Acta Neuropathologica · doi:10.1007/bf00685305 · Cited by 755 · see citing works
The Relationships Between Age, Sex, and the Incidence of Dementia and Alzheimer Disease
Gao, S., Hendrie, H. C., Hall, K. S., & Hui, S. L. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.9.809 · Cited by 751 · see citing works
Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship
Nelson, P. T., Braak, H., & Markesbery, W. R. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181919a48 · Cited by 643 · see citing works
Self-citationThe cholinergic system and Parkinson disease
Bohnen, N. I., & Albin, R. L. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.048 · Cited by 576 · see citing works
Senile dementia of Lewy body type
Perry, R. H., Irving, D., Blessed, G., FAIRBAIRN, A. F., & Perry, E. K. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90236-g · Cited by 573 · see citing works
The epidemiology of dementia associated with Parkinson disease
Aarsland, D., & Kurz, M. W. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.08.034 · Cited by 572 · see citing works
The Neuropsychological Profile of Alzheimer DiseasePreprint
Weıntraub, S., Wicklund, A. H., & Salmon, D. P. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006171 · Cited by 569 · see citing works
Dementia of frontal lobe type.
Neary, D., Snowden, J. S., Northen, B., & Goulding, P. (1988) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.3.353 · Cited by 553 · see citing works
Dementia incidence continues to increase with age in the oldest old: The 90+ study
Corrada, M. M., Brookmeyer, R., Paganini‐Hill, A., Berlau, D., & Kawas, C. H. (2010) · Annals of Neurology · doi:10.1002/ana.21915 · Cited by 523 · see citing works
Rocca, W. A., Petersen, R. C., Knopman, D. S., Hebert, L. E., Evans, D. A., Hall, K. S., Gao, S., Unverzagt, F. W., Langa, K. M., Larson, E. B., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2010.11.002 · Cited by 498 · see citing works
Quantitative assessment of cortical synaptic density in Alzheimer's disease
Scheff, S. W., DeKosky, S. T., & Price, D. A. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90059-9 · Cited by 446 · see citing works
Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology
Schneider, J. A., Wilson, R. S., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2004) · Neurology · doi:10.1212/01.wnl.0000118211.78503.f5 · Cited by 436 · see citing works
Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration
Dickson, D. W. (1999) · Journal of Neurology · doi:10.1007/bf03161076 · Cited by 424 · see citing works
THE FINE STRUCTURE OF NEUROFIBRILLARY TANGLES IN ALZHEIMERʼS DISEASE
Terry, R. D. (1963) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-196310000-00005 · Cited by 403 · cited 1× · see citing works
“Neurofibrillary pathology comprises aberrant, partly-insoluble, protease-resistant, hyperphosphorylated tau aggregates – some with paired helical filament appearance by electron microscopy [13] – inside various cellular compartments or extracellular after death of the parent cell.”
BackgroundKosaka, K., Yoshimura, M., Ikeda, K., & Budka, H. (1984) · PubMed · Cited by 401 · see citing works
Neuropathologic Outcome of Mild Cognitive Impairment Following Progression to Clinical Dementia
Jicha, G. A., Parisi, J. E., Dickson, D. W., Johnson, K., Cha, R., Ivnik, R. J., Tangalos, E. G., Boeve, B. F., Knopman, D. S., Braak, H., et al. (2006) · Archives of Neurology · doi:10.1001/archneur.63.5.674 · Cited by 399 · see citing works
Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies
Scheff, S. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.002 · Cited by 391 · see citing works
Self-citationFrontal lobe degeneration of non-Alzheimer type. II. Clinical picture and differential diagnosis
Gustafson, L. (1987) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(87)90022-7 · Cited by 389 · see citing works
Thal, D. R., Ghebremedhin, E., Orantes, M., & Wiestler, O. D. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.12.1287 · Cited by 384 · see citing works
Differential loss of synaptic proteins in Alzheimer's disease: Implications for synaptic dysfunction
Reddy, P. H., Mani, G., Park, B. S., Jacques, J., MURDOCH, G. H., Whetsell, W. O., Kaye, J. A., & Mańczak, M. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7203 · Cited by 372 · see citing works
Synaptic and neuritic alterations during the progression of Alzheimer's disease
Masliah, E., Mallory, M., Hansen, L., Richard, D., Alford, M., & Terry, R. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90121-x · Cited by 370 · see citing works
Oxidative stress in Alzheimer's disease brain: New insights from redox proteomics
Butterfield, D. A., Perluigi, M., & Sultana, R. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.06.026 · Cited by 363 · see citing works
Parkkinen, L., Pirttilä, T., & Alafuzoff, I. I. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0346-6 · Cited by 357 · see citing works
Cerebrovascular Pathology and Dementia in Autopsied Honolulu‐Asia Aging Study Participants
WHITE, L., PETROVITCH, H., HARDMAN, J., NELSON, J., DAVIS, D. G., ROSS, G. W., MASAKI, K., LAUNER, L., & MARKESBERY, W. R. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04794.x · Cited by 357 · see citing works
Neuropathological assessment of the lesions of significance in vascular dementia
Esiri, M. M., Wilcock, G. K., & Morris, J. H. (1997) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.63.6.749 · Cited by 347 · see citing works
Brain microbleeds and Alzheimer’s disease: innocent observation or key player?
Cordonnier, C., & van der Flier, W. M. (2011) · Brain · doi:10.1093/brain/awq321 · Cited by 310 · see citing works
Okazaki, H., Lipkin, L. E., & Aronson, S. M. (1961) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196104000-00007 · Cited by 303 · see citing works
Synaptic Loss in the Inferior Temporal Gyrus in Mild Cognitive Impairment and Alzheimer's Disease
Scheff, S. W., PRICE, D. A., Schmitt, F. A., Scheff, M. A., & Mufson, E. J. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101782 · Cited by 301 · see citing works
Self-citationROTH, M., TOMLINSON, B. E., & BLESSED, G. (1966) · Nature · doi:10.1038/209109a0 · Cited by 298 · see citing works
Nelson, P. T., Jicha, G. A., Schmitt, F. A., Liu, H., Davis, D. G., Mendiondo, M. S., Abner, E. L., & Markesbery, W. R. (2007) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/nen.0b013e31815c5efb · Cited by 292 · see citing works
Self-citationAlzheimer’s disease-related alterations in synaptic density: neocortex and hippocampus.
Scheff, S. W., & Price, D. A. (2006) · Journal of Alzheimer's Disease · doi:10.3233/jad-2006-9s312 · Cited by 284 · see citing works
Self-citationBouras, C., Hof, P. R., Giannakopoulos, P., Michel, J.-P., & Morrison, J. H. (1994) · Cerebral Cortex · doi:10.1093/cercor/4.2.138 · Cited by 280 · see citing works
Hippocampal sclerosis in advanced age: clinical and pathological features
Nelson, P. T., Schmitt, F. A., Lin, Y., Abner, E. L., Jicha, G. A., Patel, E., Thomason, P. C., Neltner, J. H., Smith, C. D., Santacruz, K. S., et al. (2011) · Brain · doi:10.1093/brain/awr053 · Cited by 279 · see citing works
Self-citationPrevalence of dementia disorders in the oldest-old: an autopsy study
Jellinger, K. A., & Attems, J. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0654-5 · Cited by 276 · see citing works
Neuropathological evaluation of mixed dementia
Jellinger, K. A., & Attems, J. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.045 · Cited by 273 · see citing works
Low sensitivity in clinical diagnoses of dementia with Lewy bodies
Nelson, P. T., Jicha, G. A., Kryscio, R. J., Abner, E. L., Schmitt, F. A., Cooper, G. E., Xu, L., Smith, C. D., & Markesbery, W. R. (2009) · Journal of Neurology · doi:10.1007/s00415-009-5324-y · Cited by 273 · see citing works
Self-citationSynapse loss in the temporal lobe in Alzheimer's disease
Scheff, S. W., & PRICE, D. A. (1993) · Annals of Neurology · doi:10.1002/ana.410330209 · Cited by 263 · see citing works
Self-citationCLINICAL AND PATHOLOGICAL FEATURES OF DIFFUSE CORTICAL LEWY BODY DISEASE (LEWY BODY DEMENTIA)
Gibb, W. R. G., Esiri, M. M., & Lees, A. J. (1987) · Brain · doi:10.1093/brain/110.5.1131 · Cited by 263 · see citing works
Bodner, R. A., Outeiro, T. F., Altmann, S. M., Maxwell, M. M., Cho, S. H., Hyman, B. T., McLean, P. J., Young, A. B., Housman, D. E., & Kazantsev, A. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511256103 · Cited by 255 · see citing works
Synaptic Changes in Alzheimer's Disease
Gylys, K. H., Fein, J. A., Yang, F., Wiley, D. J., Miller, C. A., & Cole, G. M. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63436-0 · Cited by 253 · see citing works
Neuropathologic and clinical features of Parkinson's disease in Alzheimer's disease patients
Ditter, S. M., & Mirra, S. S. (1987) · Neurology · doi:10.1212/wnl.37.5.754 · Cited by 250 · see citing works
Cognitive impact of subcortical vascular and Alzheimer’s disease pathology
Chui, H. C., Zarow, C., Mack, W. J., Ellis, W. G., Zheng, L., Jagust, W. J., Mungas, D., Reed, B. R., Kramer, J. H., DeCarli, C. C., et al. (2006) · Annals of Neurology · doi:10.1002/ana.21009 · Cited by 247 · see citing works
Luis, C. A., Loewenstein, D., Acevedo, A., Barker, W. W., & Duara, R. (2003) · Neurology · doi:10.1212/01.wnl.0000080366.90234.7f · Cited by 245 · see citing works
Clinicopathological analysis of dementia disorders in the elderly
Jellinger, K. A., Danielczyk, W., Fischer, P. A., & Gabriel, E. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90072-u · Cited by 243 · see citing works
Frontal lobe degeneration of non-Alzheimer type.
Gustafson, L., Brun, A., & Passant, U. (1992) · PubMed · Cited by 241 · see citing works
Nelson, P. T., Abner, E. L., Schmitt, F. A., Kryscio, R. J., Jicha, G. A., Smith, C. D., Davis, D. G., Poduska, J. W., Patel, E., Mendiondo, M. S., et al. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00244.x · Cited by 239 · see citing works
Self-citationMirra, S. S. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00058-4 · Cited by 236 · see citing works
Gnanalingham, K. K., Byrne, E. J., Thornton, A., Sambrook, M. A., & Bannister, P. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.3.243 · Cited by 233 · see citing works
Mixed Dementia—the Most Common Cause of Dementia
KORCZYN, A. D. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04807.x · Cited by 219 · see citing works
Counts, S., Nadeem, M., Lad, S. P., Wuu, J., & Mufson, E. J. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-200606000-00007 · Cited by 215 · see citing works
Ishizawa, K., & Dickson, D. W. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.6.647 · Cited by 209 · see citing works
Hatanpaa, K. J., Isaacs, K. R., Shirao, T., Brady, D. R., & Rapoport, S. I. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199906000-00008 · Cited by 200 · see citing works
Disappearance of actin‐binding protein, drebrin, from hippocampal synapses in alzheimer's disease
Harigaya, Y., Shoji, M., Shirao, T., & Hirai, S. (1996) · Journal of Neuroscience Research · doi:10.1002/jnr.490430111 · Cited by 198 · see citing works
Arai, T., Ikeda, K., Akiyama, H., Shikamoto, Y., Tsuchiya, K., Yagishita, S., Beach, T. G., Rogers, J., Schwab, C., & McGeer, P. L. (2001) · Acta Neuropathologica · doi:10.1007/s004010000283 · Cited by 197 · see citing works
Hippocampal sclerosis of aging, a prevalent and high-morbidity brain disease
Nelson, P. T., Smith, C. D., Abner, E. L., Wilfred, B. R., Wang, W., Neltner, J. H., Baker, M., Fardo, D. W., Kryscio, R. J., Scheff, S. W., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1154-1 · Cited by 196 · see citing works
Self-citationThe molecular basis of the frontotemporal lobar degeneration–amyotrophic lateral sclerosis spectrum
Langenhove, T. V., van der Zee, J., & Broeckhoven, C. V. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.665471 · Cited by 192 · see citing works
Mukaetova‐Ladinska, E. B., García‐Sierra, F., Hurt, J., Gertz, H.-J., Xuereb, J. H., Hills, R., Brayne, C., Huppert, F. A., Paykel, E. S., McGee, M. A., et al. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64573-7 · Cited by 187 · see citing works
Shim, K. S., & Lübec, G. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00210-0 · Cited by 186 · see citing works
Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry.
Lennox, G. G., Lowe, J. S., Landon, M., Byrne, E. J., Mayer, R. J., & Godwin-Austen, R. B. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.11.1236 · Cited by 184 · see citing works
Pick's disease versus Alzheimer's disease
Mendez, M. F., Selwood, A., Mastri, A. R., & Frey, W. H. (1993) · Neurology · doi:10.1212/wnl.43.2.289 · Cited by 183 · see citing works
Tau protein and neurodegeneration
Goedert, M. (2004) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2003.12.015 · Cited by 177 · see citing works
Gerhard, A., Trender‐Gerhard, I., Turkheimer, F., Quinn, N. P., Bhatia, K. P., & Brooks, D. J. (2006) · Movement Disorders · doi:10.1002/mds.20668 · Cited by 171 · see citing works
Rukhsana Sultana, A., Banks, W. A., & Butterfield, D. A. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22227 · Cited by 171 · see citing works
Dickson, D. W. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00065-1 · Cited by 168 · see citing works
Dementia with Lewy Bodies Versus Pure Alzheimer Disease
Samuel, W., Alford, M. F., Hofstetter, C. R., & Hansen, L. A. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199705000-00006 · Cited by 167 · see citing works
(1995) · PubMed · Cited by 167 · see citing works
Frontal Lobe Function in Progressive Supranuclear Palsy
Grafman, J. H., Litvan, I., Gomez, C., & Chase, T. N. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530050077015 · Cited by 162 · see citing works
Selective regional loss of exocytotic presynaptic vesicle proteins in Alzheimer’s disease brains
Sze, C., Bi, H., Kleinschmidt-DeMasters, B. K., Filley, C. M., & Martin, L. J. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00285-9 · Cited by 161 · see citing works
Rocca, W. A., Cha, R. H., Waring, S. C., & Kokmen, E. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009560 · Cited by 160 · see citing works
White, L., Small, B. J., Petrovitch, H., Ross, G. W., Masaki, K., Abbott, R. D., Hardman, J., Davis, D., Nelson, J., & Markesbery, W. (2005) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988705281872 · Cited by 155 · see citing works
Role of the neuropathology of Alzheimer disease in dementia in the oldest-old
Haroutunian, V., Schnaider-Beeri, M., Schmeidler, J., Wysocki, M., Purohit, D. P., Perl, D. P., Libow, L. S., Lesser, G. T., Maroukian, M., & Grossman, H. T. (2008) · Archives of Neurology · doi:10.1001/archneur.65.9.1211 · Cited by 154 · see citing works
In vivo imaging of synaptic function in the central nervous system
Nikolaus, S., Antke, C., & Müller, H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.06.008 · Cited by 153 · see citing works
Liu, X., Erikson, C., & Brun, A. E. (1996) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106867 · Cited by 152 · see citing works
Crystal, H. A., Dickson, D., Davies, P., Masur, D., Grober, E., & Lipton, R. B. (2000) · Archives of Neurology · doi:10.1001/archneur.57.5.713 · Cited by 152 · see citing works
Fallacies in the pathological confirmation of the diagnosis of Alzheimer’s disease
Bowler, J., Muñoz, D., Merskey, H., & Hachinski, V. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.1.18 · Cited by 148 · see citing works
Absence of cognitive impairment or decline in preclinical Alzheimer’s disease
Goldman, W. P., Price, J. L., Storandt, M., Grant, E., McKeel, D. W., Rubin, E. H., & Morris, J. C. (2001) · Neurology · doi:10.1212/wnl.56.3.361 · Cited by 143 · see citing works
Biochemistry and Molecular Biology of Amyloid β‐Protein and the Mechanism of Alzheimer's Disease
(2008) · Handbook of Clinical Neurology · doi:10.1016/s0072-9752(07)01223-7 · Cited by 137 · see citing works
Abnormalities in the synaptic vesicle fusion machinery in Huntington’s disease
Morton, A. J., Faull, R. L. M., & Edwardson, J. M. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00611-6 · Cited by 132 · see citing works
Association between male gender and cortical Lewy body pathology in large autopsy series
Nelson, P. T., Schmitt, F. A., Jicha, G. A., Kryscio, R. J., Abner, E. L., Smith, C. D., Van Eldik, L. J., & Markesbery, W. R. (2010) · Journal of Neurology · doi:10.1007/s00415-010-5630-4 · Cited by 131 · see citing works
Self-citationCortical microinfarcts and demyelination affect cognition in cases at high risk for dementia
Kövari, E., Gold, G., Herrmann, F. R., Canuto, A., Hof, P. R., Bouras, C., & Giannakopoulos, P. (2007) · Neurology · doi:10.1212/01.wnl.0000257094.10655.9a · Cited by 128 · see citing works
Neuropathology of Pick’s disease
Dickson, D. W. (2001) · Neurology · doi:10.1212/wnl.56.suppl_4.s16 · Cited by 119 · see citing works
The epidemiology of dementia and Alzheimer disease.
Katzman, R., & Kawas, C. H. (1994) · Cited by 117 · see citing works
Cognitive deficits in the Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy).
Maher, E. R., Smith, E. M., & Lees, A. J. (1985) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.48.12.1234 · Cited by 112 · see citing works
Altered Serotonergic and Cholinergic Synaptic Markers in Pick's Disease
Sparks, D. L., & Markesbery, W. R. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530200032014 · Cited by 112 · see citing works
Zhan, S., Beyreuther, K. T., & Schmitt, H. P. (1993) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000107299 · Cited by 110 · see citing works
Hippocampal Sclerosis Contributes to Dementia in the Elderly
Corey‐Bloom, J., Sabbagh, M. N., Bondi, M. W., Hansen, L., Alford, M. F., Masliah, E., & Thal, L. J. (1997) · Neurology · doi:10.1212/wnl.48.1.154 · Cited by 110 · see citing works
Hippocampal connectivity and Alzheimer's dementia
Samuel, W., Masliah, E., Hill, L., Butters, N., & Terry, R. D. (1994) · Neurology · doi:10.1212/wnl.44.11.2081 · Cited by 108 · see citing works
Morphological substrates of cognitive decline in nonagenarians and centenarians: A new paradigm?
Imhof, A., Kövari, E., von Gunten, A., Gold, G., Rivara, C.-B., Herrmann, F. R., Hof, P. R., Bouras, C., & Giannakopoulos, P. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.025 · Cited by 106 · see citing works
Leuba, G., Savioz, A., Vernay, A., Carnal, B., Kraftsik, R., Tardif, É., Riederer, I. M., & Riederer, B. M. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15112 · Cited by 104 · see citing works
Specificity of the clinical diagnosis of dementia
Todorov, A. B., Go, R. C. P., Constantinidis, J., & Elston, R. C. (1975) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(75)90116-1 · Cited by 104 · see citing works
Premorbid effects of APOE on synaptic proteins in human temporal neocortex
Love, S., Siew, L. K., Dawbarn, D., Wilcock, G. K., Ben‐Shlomo, Y., & Allen, S. J. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.04.008 · Cited by 101 · see citing works
Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies
Nelson, P. T., Kryscio, R. J., Jicha, G. A., Abner, E. L., Schmitt, F. A., Xu, L. O., Cooper, G., Smith, C. D., & Markesbery, W. R. (2009) · Neurology · doi:10.1212/wnl.0b013e3181bacf9e · Cited by 99 · see citing works
Self-citationWakabayashi, K., Honer, W., & Masliah, E. (1994) · Brain Research · doi:10.1016/0006-8993(94)91709-4 · Cited by 98 · see citing works
Seshadri, S., Beiser, A., Au, R., Wolf, P. A., Evans, D. A., Wilson, R. S., Petersen, R. C., Knopman, D. S., Rocca, W. A., Kawas, C. H., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2010.12.002 · Cited by 97 · see citing works
Brun, A. E., Liu, X., & Erikson, C. (1995) · Neurodegeneration · doi:10.1006/neur.1995.0021 · Cited by 96 · see citing works
Role of cerebral cortex in the neuropathology of Huntington's disease
Estrada‐Sánchez, A. M., & Rebec, G. V. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00019 · Cited by 94 · see citing works
Tannenberg, R. K., Scott, H. L., Tannenberg, A. E. G., & Dodd, P. R. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.05.004 · Cited by 89 · see citing works
Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old
Polvikoski, T. M., van Straaten, E. C. W., Barkhof, F., Sulkava, R., Aronen, H. J., Niinistö, L., Oinas, M., Scheltens, P., Erkinjuntti, T., & Kalaria, R. N. (2010) · Neurology · doi:10.1212/wnl.0b013e318200d6f9 · Cited by 88 · see citing works
Hippocampal Drebrin Loss in Mild Cognitive Impairment
Counts, S., He, B., Nadeem, M., Wuu, J., Scheff, S. W., & Mufson, E. J. (2012) · Neurodegenerative Diseases · doi:10.1159/000333122 · Cited by 87 · see citing works
Self-citationSpampanato, J. G., Gu, X., Yang, X. W., & Módy, I. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.09.020 · Cited by 87 · see citing works
Loss of SNAP‐25 and rabphilin 3a in sensory‐motor cortex in Huntington’s disease
Smith, R. A., Klein, P., Koc‐Schmitz, Y., Waldvogel, H. J., Faull, R. L. M., Brundin, P., Plomann, M., & Li, J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04703.x · Cited by 87 · see citing works
Hippocampal Sclerosis: Progress Since Sommer
Thom, M. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00201.x · Cited by 85 · see citing works
The widespread alteration of neurites in Alzheimer's disease may be unrelated to amyloid deposition
Tabaton, M., Mandybur, T. I., Perry, G. L., Onorato, M., AUTILIO‐GAMBETTI, L., & Gambetti, P. L. (1989) · Annals of Neurology · doi:10.1002/ana.410260614 · Cited by 80 · see citing works
Gibson, P. H. (1983) · Acta Neuropathologica · doi:10.1007/bf00684929 · Cited by 79 · see citing works
Synaptic Pathology in Prefrontal Cortex is Present Only with Severe Dementia in Alzheimer Disease
Minger, S. L., Honer, W. G., Esiri, M. M., McDonald, B., Keene, J., Nicoll, J. A. R., Carter, J., Hope, T., & Francis, P. T. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.10.929 · Cited by 76 · see citing works
Wang, X., Dong, C., Zhang, J., Wan, Y.-Z., Li, F., Huang, Y.-X., Han, L., Shan, B., Gao, C., Han, J., et al. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9664-6 · Cited by 75 · see citing works
Lipton, A. M., Cullum, C. M., Satumtira, S., Sontag, E., Hynan, L. S., White, C. L., & Bigio, E. H. (2001) · Archives of Neurology · doi:10.1001/archneur.58.8.1233 · Cited by 73 · see citing works
Frontal cortical synaptophysin in Lewy body diseases: relation to Alzheimer's disease and dementia
Hansen, L. A., Daniel, S. E., Wilcock, G., & Love, S. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.5.653 · Cited by 73 · see citing works
Preclinical AD Workgroup staging: Pathological correlates and potential challenges
Jicha, G. A., Abner, E. L., Schmitt, F. A., Kryscio, R. J., Riley, K. P., Cooper, G. E., Stiles, N., Mendiondo, M. S., Smith, C. D., Van Eldik, L. J., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.02.018 · Cited by 71 · see citing works
Self-citationAge, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing
Dolan, D., Troncoso, J., Resnick, S. M., Crain, B. J., Zonderman, A. B., & O'Brien, R. J. (2010) · Brain · doi:10.1093/brain/awq141 · Cited by 70 · see citing works
Brown, D. F., Risser, R. C., Bigio, E. H., Tripp, P., Stiegler, A., Welch, E., Eagan, K. P., Hladik, C. L., & White, C. L. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199810000-00007 · Cited by 69 · see citing works
A dissociation in the relation between memory tasks and frontal lobe tests in the normal elderly
Parkin, A. J., & Lawrence, A. D. (1994) · Neuropsychologia · doi:10.1016/0028-3932(94)90124-4 · Cited by 68 · see citing works
Dementia incidence may increase more slowly after age 90: Results from the Bronx Aging Study
Hall, C. B., Verghese, J., Sliwinski, M., Chen, Z., Katz, M., Derby, C., & Lipton, R. B. (2005) · Neurology · doi:10.1212/01.wnl.0000176053.98907.3f · Cited by 68 · see citing works
Cortical Synapse Loss in progressive Supranuclear palsy
Bigio, E. H., Vono, M. B., Satumtira, S., Adamson, J. L., Sontag, E., Hynan, L. S., White, C. L., Baker, M. C., & Hutton, M. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.5.403 · Cited by 65 · see citing works
Rosenberg, C. K., Pericak‐Vance, M. A., Saunders, A. M., Gilbert, J. R., Gaskell, P. C., & Hulette, C. M. (2000) · Acta Neuropathologica · doi:10.1007/s004019900155 · Cited by 64 · see citing works
INTRAFAMILIAL DIVERSITY OF PHENOTYPE ASSOCIATED WITH APP DUPLICATION
Guyant-Marechal, I., Berger, É., Laquerrière, A., Rovelet‐Lecrux, A., Viennet, G., Frébourg, T., Rumbach, L., Campion, D., & Hannequin, D. (2008) · Neurology · doi:10.1212/01.wnl.0000339400.64213.56 · Cited by 64 · see citing works
Perdahl, E., Adolfsson, R., Alafuzoff, I. I., Albert, K. A., Nestler, E. J., Greengard, P., & Winblad, B. G. (1984) · Journal of Neural Transmission · doi:10.1007/bf01245030 · Cited by 64 · see citing works
Synapse Stability in the Precuneus Early in the Progression of Alzheimer's Disease
Scheff, S. W., PRICE, D. A., Schmitt, F. A., Roberts, K. N., Ikonomović, M. D., & Mufson, E. J. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122353 · Cited by 59 · see citing works
Self-citationMasliah, E., Mallory, M. E., DeTeresa, R. M., Alford, M. F., & Hansen, L. A. (1993) · Brain Research · doi:10.1016/0006-8993(93)91093-8 · Cited by 58 · see citing works
Elfgren, C., Brun, A. E., Gustafson, L., Johanson, A. M., Minthon, L., Passant, U., & Risberg, J. (1994) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.930090807 · Cited by 58 · see citing works
Linking SIRT2 to Parkinson’s Disease
Garske, A. L., Smith, B. C., & Denu, J. M. (2007) · ACS Chemical Biology · doi:10.1021/cb700160d · Cited by 57 · see citing works
Morphological alterations of the synapses in the locus coeruleus in Parkinson's disease
Balogiannis, S., Costa, V., & Baloyannis, I. S. (2006) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2006.05.006 · Cited by 56 · see citing works
Early cognitive deficits in Swedish gene carriers of Huntington's disease.
Wahlin, T. R., Lundin, A., & Dear, K. B. G. (2007) · Neuropsychology · doi:10.1037/0894-4105.21.1.31 · Cited by 56 · see citing works
Synaptic Proteins in Alzheimer's Disease
Marksteiner, J., Kaufman, W. A., Gurka, P., & Humpel, C. (2002) · Journal of Molecular Neuroscience · doi:10.1385/jmn:18:1-2:53 · Cited by 54 · see citing works
Neary, D. (1990) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1990.tb01601.x · Cited by 50 · see citing works
“End-Stage” Neurofibrillary Tangle Pathology in Preclinical Alzheimer's Disease: Fact or Fiction?
Abner, E. L., Kryscio, R. J., Schmitt, F. A., SantaCruz, K. S., Jicha, G. A., Lin, Y., Neltner, J. M., Smith, C. D., Van Eldik, L. J., & Nelson, P. T. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101980 · Cited by 49 · see citing works
Self-citationNeuropathology and general autopsy findings in nondemented aged subjects
Jellinger, K. A., & Attems, J. (2012) · Clinical Neuropathology · doi:10.5414/np300418 · Cited by 48 · cited 1× · see citing works
“While the morphologic changes resemble atherosclerotic lesions seen systemically, its severity is usually much less than that seen in the systemic circulation, often falling within the mild category [165].”
BackgroundBancher, C., Leitner, H., Jellinger, K. A., Eder, H. T., Setinek, U., Fischer, P. A., Węgiel, J., & Wisniewski, H. M. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00069-3 · Cited by 45 · see citing works
Pathogenesis of Neuritic (Senile) and Amyloid Plaque Formation
Wisniewski, H. M., Vorbrodt, A. W., Moretz, R. C., Lossinsky, A. S., & Grundke-Iqbal, I. (1982) · Experimental Brain Research Supplementum · doi:10.1007/978-3-642-68507-1_1 · Cited by 45 · see citing works
Shin, H., Kim, M. H., Lee, S. J., et al. (2013) · Journal of Clinical Neurology · doi:10.3988/jcn.2013.9.1.21 · Cited by 41 · see citing works
Neuritic Pathology as a Correlate of Synaptic Loss in Dementia With Lewy Bodies
Revuelta, G. J., Rosso, A. L., & Lippa, C. F. (2008) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317507310565 · Cited by 35 · see citing works
Counting dementia: There is no one “best” way
Launer, L. J. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2010.11.003 · Cited by 33 · see citing works
Lippa, C. F. (2004) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/153331750401900606 · Cited by 27 · see citing works
Mixed Dementia: Alzheimer’s Cerebrovascular Disease
Rockwood, K. J. (2003) · International Psychogeriatrics · doi:10.1017/s1041610203008949 · Cited by 26 · see citing works
Carlesimo, G. A., Sabbadini, M., Fadda, L., & Caltagirone, C. (1997) · Cortex · doi:10.1016/s0010-9452(97)80011-1 · Cited by 25 · see citing works
Neuropathology of dementia with Lewy bodies in advanced age: A comparison with Alzheimer disease
Ubhi, K. K., Peng, K. A., Lessig, S. L., Estrella, J., Adame, A., Galasko, D. R., Salmon, D. P., Hansen, L. A., Kawas, C. H., & Masliah, E. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.09.016 · Cited by 21 · see citing works
Characterization of Japanese-American men with a single neocortical AD lesion type
Petrovitch, H., Ross, G. W., He, Q., Uyehara‐Lock, J. H., Markesbery, W. R., Davis, D. G., Nelson, J. R., Masaki, K., Launer, L. J., & White, L. R. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.03.026 · Cited by 19 · see citing works
Frontal Lobe Degeneration of Non-Alzheimer Type
(1993) · KARGER eBooks · doi:10.1159/isbn.978-3-8055-8760-0 · Cited by 17 · see citing works
The Neuropathologic Substrates of Vascular-Ischemic Dementia
Jellinger, K. A. (2005) · Humana Press eBooks · doi:10.1385/1-59259-824-2:023 · Cited by 10 · see citing works
LETTER TO THE EDITOR. Hippocampal Atrophy Measurement in Alzheimer?s Disease
Frisoni, G. B., Trabucchi, M., & Beltramello, A. (1996) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199601)11:1 · Cited by 3 · see citing works
Waldvogel (1999) · doi:10.1002/1531-8249(199907)46:1
Flagged first, then by citations
Research works printed but not linked: 2
- [27]Terry RD Masliah E Hansen L Terry RD Katzman R Bick KL Structural basis of the cognitive alterations in Alzheimer disease Alzheimer disease 1994 179 96 Raven Press New York, NY
- [54]Terry RD Masliah E Hansen L Terry RD Katzman R Bick KL Structural basis of the congnitive alterations in Alzheimer disease Alzheimer disease 1994 179 96 Raven Press New York, NY
Cited by
Sorted by citations
Chen, M.-K., Mecca, A. P., Naganawa, M., Finnema, S. J., Toyonaga, T., Lin, S.-F., Najafzadeh, S., Ropchan, J., Lu, Y., McDonald, J. W., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.1836 · Cited by 431 · see citing works
Dendritic Tau in Alzheimer’s Disease
Ittner, A., & Ittner, L. M. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.003 · Cited by 278 · see citing works
Morris, G. P., Clark, I. A., & Vissel, B. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1918-8 · Cited by 212 · see citing works
Fluid Biomarkers for Synaptic Dysfunction and Loss
Camporesi, E., Nilsson, J., Brinkmalm, A., Becker, B., Ashton, N. J., Blennow, K., & Zetterberg, H. (2020) · Biomarker Insights · doi:10.1177/1177271920950319 · Cited by 165 · see citing works
Buccellato, F. R., D’Anca, M., Fenoglio, C., Scarpini, E., & Galimberti, D. (2021) · Antioxidants · doi:10.3390/antiox10091353 · Cited by 179 · see citing works
“New Old Pathologies”: AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)
Nelson, P. T., Trojanowski, J. Q., Abner, E. L., Al-Janabi, O. M., Jicha, G. A., Schmitt, F. A., Smith, C. D., Fardo, D. W., Wang, W.-X., Kryscio, R. J., et al. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw033 · Cited by 158 · see citing works
Self-citationGender Differences in Alzheimer Disease: Brain Atrophy, Histopathology Burden, and Cognition
Filon, J. R., Intorcia, A. J., Sue, L. I., Vazquez Arreola, E., Wilson, J., Davis, K. J., Sabbagh, M. N., Belden, C. M., Caselli, R. J., Adler, C. H., et al. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw047 · Cited by 143 · see citing works
Scheff, S. W., Ansari, M. A., & Mufson, E. J. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.030 · Cited by 100 · see citing works
Self-citationIn vivo synaptic density loss is related to tau deposition in amnestic mild cognitive impairment
Vanhaute, H., Ceccarini, J., Michiels, L., Koole, M., Sunaert, S., Lemmens, R., Triau, E., Emsell, L., Vandenbulcke, M., & Van Laere, K. (2020) · Neurology · doi:10.1212/wnl.0000000000009818 · Cited by 88 · see citing works
Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy
Chornenkyy, Y., Fardo, D. W., & Nelson, P. T. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0196-y · Cited by 93 · see citing works
Self-citationImaging Synaptic Density: The Next Holy Grail of Neuroscience?
Serrano, M. E., Kim, E., Petrinovic, M. M., Turkheimer, F., & Cash, D. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.796129 · Cited by 67 · see citing works
Olde Rikkert, M. G. M., Verhey, F. R., Blesa, R., von Arnim, C. A. F., Bongers, A., Harrison, J., Sijben, J., Scarpini, E., Vandewoude, M. F. J., Vellas, B., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141305 · Cited by 61 · see citing works
Pettigrew, C., Soldan, A., Moghekar, A., Wang, M.-C., Gross, A. L., O’Brien, R., & Albert, M. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.09.024 · Cited by 38 · see citing works
- Authors
- Scheff, S. W., Neltner, J. H., & Nelson, P. T.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Scheff, Stephen W.
- Nelson, Peter T.
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 88
- Issue
- 4
- Pages
- 517-528
- ISSN
- 0006-2952 (ISSN-L)
- PMC
- PMC4230706
- OpenAlex
- W1970874824
- Cited by
- 118
- References
- 172
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 10 · 2023: 7 · 2022: 15 · 2021: 12 · 2020: 16 · 2019: 10 · 2018: 11 · 2017: 4 · 2016: 11 · 2015: 10 · 2014: 5
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- synaptic loss, Alzheimer's disease, dementia, neuritic plaques, neurofibrillary tangles, clinicopathological correlation, autopsy studies, brain aging, cognitive impairment
- MeSH terms
- Aging, Alzheimer Disease, Animals, Brain, Cognition, Disease Models, Animal, Humans, Synapses
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
