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Non-invasive opening of BBB by focused ultrasound
Abstract
Blood brain barrier (BBB) is a major barrier for delivering therapeutic agents in the brain. In this study we investigated the feasibility of open the BBB by using focused ultrasound. Rabbit brains were exposed to pulsed focused ultrasound while injecting ultrasound contrast agent containg microbubbles intravenously. The BBB opening was measured after the sonications by injecting MRI contrast agent i.v. and evaluating the local enhancement in the brain. Low ultrasound powers and pressure amplitudes were found to cause focal enhancement. Before sacrificing the animals trypan blue was also injected i.v.. After the sacrifice of the animals blue spots were found in the brain in the sonicated locations. This method may have potential for targeted delivery of macromolecules in the brain.
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“Animal studies have demonstrated safe and reversible BBB opening (4, 6, 7) as well as reduction of amyloid-beta plaque, neurogenesis, and improvement of memory.”
From Noninvasive hippocampal blood-brain barrier opening in Alzheimer's disease with focused ultrasound. (2020) · cites this paper as [7]
In the citing paper
“Animal studies have demonstrated safe and reversible BBB opening (4, 6, 7) as well as reduction of amyloid-beta plaque, neurogenesis, and improvement of memory.”
From Noninvasive hippocampal blood-brain barrier opening in Alzheimer's disease with focused ultrasound. (2020) · cites this paper as [7]
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Research works printed but not linked: 12
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Metadata
- Authors
- Hynynen, K., McDannold, N., Vykhodtseva, N., & Jolesz, F. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Brain Edema XII
- Publisher
- Springer Vienna
- Published
- 2003
- Volume
- 86
- Pages
- 555-558
- OpenAlex
- W1801991441
- Cited by
- 156
- References
- 12
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 9 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 15 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 9 · 2012: 10
- FWCI
- 15.03
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Springer eBooks (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (46627)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
- Keywords
- blood-brain barrier opening, focused ultrasound, ultrasound contrast agents, microbubbles, brain drug delivery, MRI contrast enhancement, rabbit brain
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Coloring Agents, Feasibility Studies, Injections, Intravenous, Rabbits, Sonication, Trypan Blue, Drug Delivery Systems, Microbubbles
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