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Non-invasive opening of BBB by focused ultrasound
Abstract
Blood brain barrier (BBB) is a major barrier for delivering therapeutic agents in the brain. In this study we investigated the feasibility of open the BBB by using focused ultrasound. Rabbit brains were exposed to pulsed focused ultrasound while injecting ultrasound contrast agent containg microbubbles intravenously. The BBB opening was measured after the sonications by injecting MRI contrast agent i.v. and evaluating the local enhancement in the brain. Low ultrasound powers and pressure amplitudes were found to cause focal enhancement. Before sacrificing the animals trypan blue was also injected i.v.. After the sacrifice of the animals blue spots were found in the brain in the sonicated locations. This method may have potential for targeted delivery of macromolecules in the brain.
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“Animal studies have demonstrated safe and reversible BBB opening (4, 6, 7) as well as reduction of amyloid-beta plaque, neurogenesis, and improvement of memory.”
From Noninvasive hippocampal blood-brain barrier opening in Alzheimer's disease with focused ultrasound. (2020) · cites this paper as [7]
In the citing paper
“Animal studies have demonstrated safe and reversible BBB opening (4, 6, 7) as well as reduction of amyloid-beta plaque, neurogenesis, and improvement of memory.”
From Noninvasive hippocampal blood-brain barrier opening in Alzheimer's disease with focused ultrasound. (2020) · cites this paper as [7]
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Research works printed but not linked: 12
- Abbott NJ, Romero IA (1996) Transporting therapeutics across the blood brain barrier. Mol Med Today 2: 106–113 · DOI
- Dalecki D, Raeman CH, Child SZ, Cox C, Francis CW, Meltzer RS et al (1997) Hemolysis in vivo from exposure to pulsed ultrasound. Ultrasound Med Biol 23: 307– · DOI
- Dalecki D, Raeman CH, Child SZ, Penney DP, Mayer R, Carstensen EL (1997) The influence of contrast agents on hemorrhage produced by lithotripter fields. Ultrasound Med Biol 23: 1435–1439 · DOI
- Doolittle ND, Miner ME, Hall WA, Siegal T, Jerome E, Osztie E et al (2000) Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood brain barrier for the treatment of patients with malignant brain tumors. Cancer Feb 1, 88(3): 637–647
- Hynynen K, Freund W, Cline HE, Chung A, Watkins R, Vetro J et al (1996) A clinical noninvasive MRI monitored ultrasound surgery method. RadioGraphies 16: 185–195 · DOI
- Hynynen K, McDannold N, Vykhodtseva N, Jolesz FA (2001) Noninvasive MR imaging guided focal opening of the blood brain barrier in rabbits. Radiology 220: 640–646 · DOI
- Kroll RA, Neuwelt EA (1998) Outwitting the blood brain barrier for therapeutic purposes: osmotic opening and other means. Neurosurgery 42: 1083–1099 · DOI
- Kuroda K, Chung A, Hynynen K, Jolesz FA (1998) Calibration of water proton chemical shift with temperature for noninvasive temperature imaging during focused ultrasound surgery. JMRI 8: 175–181 · DOI
- Miller DL, Thomas RM (1996) Contrast agent gas bodies enhance hemolysis induced by lithotripter shock waves and high intensity focused ultrasound in whole blood. Ultrasound Med Biol 22: 1089–1095 · DOI
- Qureshi NH, Chiocca EA (1999) A review of gene therapy for the treatment of central nervous system tumors. Crit Rev Oncog 10: 261–274
- Vykhodtseva N, Sorrentino V, Jolesz FA, Bronson RT, Hynynen K (2000) MRI detection of the thermal effects of focused ultrasound on the brain. Ultrasound Med Biol Jun 1, 26(5): 871–880 · DOI
- Vykhodtseva NI, Hynynen K, Damianou C (1995) Histologic effects of high intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in vivo. Ultrasound Med Biol 21: 969–979 · DOI
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BackgroundUltrasound-Induced Blood-Brain Barrier Opening
Konofagou, E., Tung, Y.-S., Choi, J. J., Deffieux, T., Baseri, B., & Vlachos, F. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112800624364 · Cited by 183
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Jolesz, F., Hynynen, K., McDannold, N., & Tempany, C. (2005) · Magnetic Resonance Imaging Clinics of North America · doi:10.1016/j.mric.2005.04.008 · Cited by 174
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BackgroundSheikov, N. A., McDannold, N. J., Jolesz, F. A., Zhang, Y., Tam, K., & Hynynen, K. (2006) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2006.05.015 · Cited by 163
Self-citationChen, K., Wei, K., & Liu, H.-L. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00086 · Cited by 173
“The permeability of the BBB can be transiently increased using low-energy burst-tone focused ultrasound following an administration of intravenous microbubbles (Hynynen et al., 2001, 2003; Park et al., 2012; Chai et al., 2014).”
Wintermark, M., Druzgal, T. J., Huss, D., Khaled, M., Monteith, S. J., Raghavan, P., Huerta, T. E., Schweickert, L. C., Burkholder, B., Loomba, J. J., et al. (2013) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3808 · Cited by 162
“Very mild enhancement was seen at 24 hours, likely resulting from the reversible alteration of the blood-brain barrier caused by the focused sonography treatment.(30) This alteration of the blood-brain barrier typically happens within the first 24 hours and then resolves,(31) explaining that enhancement was captured a…”
BackgroundChen, P.-Y., Hsieh, H.-Y., Huang, C.-Y., Lin, C.-Y., Wei, K.-C., & Liu, H.-L. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0451-y · Cited by 143
“This BBB disruptive effect was found to be temporary and reversible without damaging surrounding central nervous system (CNS) tissues or neural cells [29].”
BackgroundChoi, J. J., Pernot, M., Brown, T. R., Small, S. A., & Konofagou, E. E. (2007) · Physics in Medicine and Biology · doi:10.1088/0031-9155/52/18/004 · Cited by 141
“…allow for the reduction of the ultrasound intensity so that most of the disruption is contained within the vasculature with reduced likelihood of irreversible neuronal damage (Hynynen et al 2003, 2005, 2006, McDannold et al 2004, 2005, 2006, Sheikov et al 2004, 2006, Choi et al 2005, 2006, 2007).”
BackgroundMeng, Y., Pople, C. B., Lea‐Banks, H., Abrahão, A., Davidson, B., Suppiah, S., Vecchio, L. M., Samuel, N., Mahmud, F., Hynynen, K., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.07.023 · Cited by 160
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“[85] showed that local and reversible BBB disruption by non-invasive FUS results in focal disruption of the BBB, necessitating future research on the brain and diagnostic and therapeutic effects.”
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“At the lowest power levels used, the sonications did not cause neuronal damage to the brain, and the BBB opening is completely reversible within 24 hours [35].”
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“Trypan blue injected before animals were sacrificed indicated blue spots in the areas of the sonicated locations [61].”
BackgroundLiu, H., Hsu, P., Chu, P., Wai, Y., Chen, J., Shen, C., Yen, T., & Wang, J. (2009) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21599 · Cited by 54
“First, opening of the BBB following sonication is a transient phenomenon and recovers after several hours (2).”
BackgroundPRODUCTION OF UNIFORMLY SIZED SERUM ALBUMIN AND DEXTROSE MICROBUBBLES
Borrelli, M., O'Brien, W., Bernock, L. J., Williams, H., Hamilton, E., Wu, J., Oelze, M., & Culp, W. (2011) · Ultrasonics sonochemistry · doi:10.1016/j.ultsonch.2011.05.010 · Cited by 52
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“In addition, it presents a potential limitation if and when there will be a need for a repeated tcMRgFUS in the cases of BBB opening [25-27] that should be synced to chemotherapy administration or when ‘time to treat’ may be limited, as could be the case in stroke clot lysis [28,29].”
BackgroundWang, C.-H., Kang, S.-T., & Yeh, C. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2012.11.037 · Cited by 45
Liu, H.-L., Jan, C.-K., Chu, P.-C., Hong, J.-C., Lee, P.-Y., Hsu, J.-D., Lin, C.-C., Huang, C.-Y., Chen, P.-Y., & Wei, K.-C. (2014) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2014.2305723 · Cited by 43
“parenchyma after FUS-BBB opening procedure was considered to be a hazardous complication [3], [4], [37].”
BackgroundQuantification of blood-brain barrier permeability by dynamic contrast-enhanced NIRS
Milej, D., Abdalmalak, A., Desjardins, L., Ahmed, H., Lee, T.-Y., Diop, M., & Lawrence, K. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-01922-x · Cited by 40
Long, L., Cai, X.-D., Guo, R.-M., Wang, P., Wu, L., Yin, T.-H., Liao, S.-Y., & Lu, Z.-Q. (2017) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2016.10.141 · Cited by 39
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“discovered that ultrasound combined with microbubbles (USCM) can safely and effectively open the BBB, thereby establishing a new field of transcranial ultrasound treatment for brain diseases [15].”
BackgroundLiao, A.-H., Liu, H.-L., Su, C.-H., Hua, M., Yang, H.-W., Weng, Y.-T., Hsu, P.-H., Huang, S.-M., Wu, S.-Y., Wang, H.-E., et al. (2012) · Physics in Medicine and Biology · doi:10.1088/0031-9155/57/9/2787 · Cited by 37
“To confirm BBB opening, Gdperfluorocarbon-filled albumin–gadolinium-diethylene-triamine penta-acetic acid (Gd-DTPA) contrast-enhanced T1-weighted MR imaging has been regarded as a gold standard to detect the positive contrast change at the BBB-opening locations (Hynynen et al 2001, 2003, 2005).”
BackgroundFoley, J. L., Vaezy, S., & Crum, L. (2007) · Applied Acoustics · doi:10.1016/j.apacoust.2005.09.009 · Cited by 37
“applied either through a cranial window or completely transcranially, to reversibly open the blood–brain barrier in rats [33,46–51].”
BackgroundMethodRecent Trend of Ultrasound-Mediated Nanoparticle Delivery for Brain Imaging and Treatment
Jo, S., Sun, I., Ahn, C., Lee, S., & Kim, K. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c22803 · Cited by 34
Liu, H.-L., Pan, C.-H., Ting, C.-Y., & Hsiao, M.-J. (2009) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2009.10.004 · Cited by 32
Current status of clinical high-intensity focused ultrasound
Hwang, J., & Crum, L. (2009) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society · doi:10.1109/iembs.2009.5335244 · Cited by 34
“Neurologic applications Neurologic applications of HIFU include disrupting the blood-brain barrier to permit delivery of therapeutic molecules into the brain [24-27], focal ablation of brain lesions for the treatment of hyperkinetic disorders or epilepsy [28], and ablation of brain tumors [29].”
BackgroundLiu, H.-L., Chen, P.-Y., Yang, H.-W., Wu, J.-S., Tseng, I.-C., Ma, Y.-J., Huang, C.-Y., Tsai, H.-C., Chen, S.-M., Lu, Y.-J., et al. (2011) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22697 · Cited by 32
Odéen, H., DeBever, J., Almquist, S., Farrer, A. I., Todd, N., Payne, A., Snell, J., Christensen, D., & Parker, D. (2014) · Journal of Therapeutic Ultrasound · doi:10.1186/2050-5736-2-19 · Cited by 30
“Irreversible surgical procedures utilizing high US intensities for tissue ablation [24,29,30] as well as reversible neuro-modulation and blood-brain barrier disruption procedures utilizing lower US intensities [31-35] have been investigated.”
BackgroundRecent advances in gene delivery with ultrasound and microbubbles
Pichon, C., Kaddur, K., Midoux, P., Tranquart, F., & Bouakaz, A. (2008) · doi:10.1080/17458080801993422 · Cited by 30
“There are several reports concerning in vitro gene delivery into neural cells and the use of US to breach the blood brain barrier [10,38,39].”
BackgroundCharacterization of bioeffects on endothelial cells under acoustic droplet vaporization
Seda, R., Li, D. S., Fowlkes, J., & Bull, J. L. (2015) · Ultrasound in Medicine and Biology · doi:10.1016/j.ultrasmedbio.2015.07.019 · Cited by 29
“where the endothelial wall is highly impermeable, such as the blood brain barrier [32, 33, 34, 35].”
BackgroundZhang, Y.-R., Wang, J., Ghobadi, S. N., Zhou, H.-Y., Huang, A.-W., Gerosa, M., Hou, Q., Keunen, O., Gołȩbiewska, A., Habte, F., et al. (2023) · Ultrasound in Medicine and Biology · doi:10.1016/j.ultrasmedbio.2022.12.006 · Cited by 28
In vivo targeted delivery of large payloads with an ultrasound clinical scanner.
Couture, O., Urban, A., Bretagne, A., Martinez, L., Tanter, M., & Tabeling, P. (2012) · Medical Physics (Lancaster) · doi:10.1118/1.4736822 · Cited by 28
Applications of Ultrasound to Stimulate Therapeutic Revascularization
Gorick, C. M., Chappell, J. C., & Price, R. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123081 · Cited by 23
Sorace, A., Korb, M., Warram, J., Umphrey, H., Zinn, K., Rosenthal, E., & Hoyt, K. (2014) · Ultrasound in Medicine and Biology · doi:10.1016/j.ultrasmedbio.2013.11.002 · Cited by 26
“This strategy was first introduced to augment delivery of molecules through the blood-brain barrier (Hynynen et al. 2003; Marty et al. 2012; McDannold et al. 2012; Schlachetzki et al. 2002), and has since been investigated for multiple other purposes.”
BackgroundFan, L., Liu, Y., Ying, H., Xue, Y., Zhang, Z., Wang, P., Liu, L., & Zhang, H. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9479-x · Cited by 29
“Smart” liposomal nanocontainers in biology and medicine
Tarahovsky, Y. S. (2010) · Biochemistry (Moscow) · doi:10.1134/s0006297910070023 · Cited by 25
Suzuki, R., & Klibanov, A. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-22536-4_12 · Cited by 25
Hartman, R. K., Hallam, K. A., Donnelly, E., & Emelianov, S. (2019) · Laser Physics Letters · doi:10.1088/1612-202x/aaf89e · Cited by 24
Laser-activated perfluorocarbon nanodroplets: a new tool for blood brain barrier opening
Hallam, K. A., Donnelly, E. M., Karpiouk, A. B., Hartman, R. K., & Emelianov, S. (2018) · Biomedical Optics Express · doi:10.1364/boe.9.004527 · Cited by 28
Drug-Loaded Microbubbles Combined with Ultrasound for Thrombolysis and Malignant Tumor Therapy
Gong, Q., Gao, X.-X., Liu, W.-F., Hong, T., & Chen, C. (2019) · BioMed Research International · doi:10.1155/2019/6792465 · Cited by 23
“Ultrasound can instantly open BBB without damage to nerve cells [83, 84].”
BackgroundDelivery of hydroxycamptothecin via sonoporation: An effective therapy for liver fibrosis
Chen, Q., Huang, J., Ye, Y., Hu, A., Xu, B., Hu, D., Wang, L., Xing, L., Chen, S., Gui, X., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.05.002 · Cited by 24
Valdez, M. A., Fernandez, E., Matsunaga, T. O., Erickson, R. P., & Trouard, T. P. (2019) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2019.08.024 · Cited by 25
“This method is often carried out in conjunction with magnetic resonance imaging (MRI) to guide and assess BBB opening and has been referred to as MRI guided FUS (MRgFUS) (Chen et al. 2013; Choi et al. 2007; Hynynen et al. 2001; Hynynen et al. 2003; Hynynen et al. 2005; Kinoshita et al. 2006a).”
MethodCarradori, D., Chen, H., Werner, B., Shah, A., Leonardi, C., Usuelli, M., Mezzenga, R., Platt, F., & Leroux, J. (2020) · Small · doi:10.1002/smll.202004735 · Cited by 19
Magnetic Resonance Methods for Focused Ultrasound-Induced Blood-Brain Barrier Opening
Conti, A., Kamimura, H. A. S., Novell, A., Duggento, A., & Toschi, N. (2020) · Frontiers in Physics · doi:10.3389/fphy.2020.547674 · Cited by 22
“This includes the potential use of magnetic resonance (MR) contrast agents (CA) [11, 14, 21, 22] to control the safety of the permeabilization protocol [23, 24], as well as putative changes induced in brain function [25–27].”
BackgroundIntracranial Applications of MR Imaging–Guided Focused Ultrasound
Khanna, N., Gandhi, D., Steven, A. J., Frenkel, V., & Melhem, E. R. (2016) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4902 · Cited by 19
“Rather, mechanical effects will predominate, which may be used to enhance drug and gene delivery(9) via reversible localized enhanced permeability of the BBB (Fig 3).(15) Early investigations into FUS-induced BBB permeability enhancement were inconsistent and required acoustic energy levels that resulted in localized…”
BackgroundLiu, J., Li, M., Huang, Y., Zhang, L., Li, W., Cao, P., Min, W., Li, J., & Jing, W. (2021) · Journal of Nanomaterials · doi:10.1155/2021/6623031 · Cited by 25
Liu, H.-L., Chen, H.-W., Kuo, Z.-H., & Huang, W.-C. (2008) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2008.925697 · Cited by 18
Jungehulsing, G. J., Brunecker, P., Nolte, C. H., Fiebach, J. B., Kunze, C., Doepp, F., Villringer, A., & Schreiber, S. J. (2007) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2007.07.006 · Cited by 21
Kong, C., Park, S. H., Shin, J., Baek, H. G., Park, J., Na, Y. C., Chang, W., & Chang, J. W. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.783048 · Cited by 17
“Meanwhile, research on non-thermal FUS for blood brain barrier (BBB) opening and neuromodulation has also been widely expanded (Hynynen et al., 2003; Treat et al., 2007; Vykhodtseva et al., 2008) (Tufail et al., 2010).”
BackgroundMaimbourg, G., Houdouin, A., Santin, M., Lehéricy, S., Tanter, M., & Aubry, J. (2018) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aaca21 · Cited by 17
“For these reasons, an alternative method, combining the injection of encapsulated microbubbles with transcranial focused ultrasound, has been developed to open the BBB [19, 20].”
MethodLiu, H.-L., Wai, Y., Hsu, P.-H., Lyu, L.-A., Wu, J.-S., Shen, C.-R., Chen, J.-C., Yen, T., & Wang, J.-J. (2010) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.2009.179 · Cited by 17
“If microbubbles are combined with ultrasound exposure, the effects of ultrasound can be focused to reduce the acoustic intensity required to produce BBB opening (Hynynen et al, 2003, 2005, 2006; Kinoshita et al, 2006; McDannold et al, 2005).”
Background
Metadata
- Authors
- Hynynen, K., McDannold, N., Vykhodtseva, N., & Jolesz, F. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Brain Edema XII
- Publisher
- Springer Vienna
- Published
- 2003
- Volume
- 86
- Pages
- 555-558
- OpenAlex
- W1801991441
- Cited by
- 156
- References
- 12
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 9 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 15 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 9 · 2012: 10
- FWCI
- 15.03
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Springer eBooks (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (46627)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
- Keywords
- blood-brain barrier opening, focused ultrasound, ultrasound contrast agents, microbubbles, brain drug delivery, MRI contrast enhancement, rabbit brain
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Coloring Agents, Feasibility Studies, Injections, Intravenous, Rabbits, Sonication, Trypan Blue, Drug Delivery Systems, Microbubbles
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