Cited by 247Lipid Membrane Structure and BehaviorIon channel regulation and functionCaveolin-1 and cellular processes

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Cholesterol and Ion Channels

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Levitan, Irena, Fang, Yun, Rosenhouse-Dantsker, Avia, Romanenko, Victor·2010·Subcellular Biochemistry

DOI 10.1007/978-90-481-8622-8_19PMC PMC2895485

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Abstract

A variety of ion channels, including members of all major ion channel families, have been shown to be regulated by changes in the level of membrane cholesterol and partition into cholesterol-rich membrane domains. In general, several types of cholesterol effects have been described. The most common effect is suppression of channel activity by an increase in membrane cholesterol, an effect that was described for several types of inwardly-rectifying K(+) channels, voltage-gated K(+) channels, Ca(+2) sensitive K(+) channels, voltage-gated Na(+) channels, N-type voltage-gated Ca(+2) channels and volume-regulated anion channels. In contrast, several types of ion channels, such as epithelial amiloride-sensitive Na(+) channels and Transient Receptor Potential channels, as well as some of the types of inwardly-rectifying and voltage-gated K(+) channels were shown to be inhibited by cholesterol depletion. Cholesterol was also shown to alter the kinetic properties and current-voltage dependence of several voltage-gated channels. Finally, maintaining membrane cholesterol level is required for coupling ion channels to signalling cascades. In terms of the mechanisms, three general mechanisms have been proposed: (i) specific interactions between cholesterol and the channel protein, (ii) changes in the physical properties of the membrane bilayer and (iii) maintaining the scaffolds for protein-protein interactions. The goal of this review is to describe systematically the role of cholesterol in regulation of the major types of ion channels and to discuss these effects in the context of the models proposed.

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Lipid Raft Segregation Modulates TRPM8 Channel Activity
Morenilla‐Palao, C., Pertusa, M., Meseguer, V., Cabedo, H., & Viana, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807228200 · Cited by 136
Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells
Panyi, G., Vámosi, G., Bacsó, Z., Bagdány, M., Bodnár, A., Varga, Z., Gáspár, R., Mátyus, L., & Damjanovich, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307421100 · Cited by 134
TRPV1, but not P2X3, requires cholesterol for its function and membrane expression in rat nociceptors
Liu, M., Huang, W., Wu, D., & Priestley, J. V. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04889.x · Cited by 132
Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes
Lucken‐Ardjomande, S., Montessuit, S., & Martinou, J. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402280 · Cited by 132
Enhanced role of potassium channels in relaxations to acetylcholine in hypercholesterolemic rabbit carotid artery
Najibi, S., Cowan, C. L., Palacino, J. J., & Cohen, R. A. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.5.h2061 · Cited by 126
Activation of TRPM7 Channels by Phospholipase C-coupled Receptor Agonists
Langeslag, M., Clark, K., Moolenaar, W. H., van Leeuwen, F. N., & Jalink, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605300200 · Cited by 124
Targeting of voltage-gated potassium channel isoforms to distinct cell surface microdomains
O’Connell, K. M. S., & Tamkun, M. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02348 · Cited by 122
Trafficking and Cell Surface Stability of the Epithelial Na+ Channel Expressed in Epithelial Madin-Darby Canine Kidney Cells
Hanwell, D., Ishikawa, T., Saleki, R., & Rotin, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110904200 · Cited by 121
ATP-sensitive potassium channels: metabolic sensing and cardioprotection
Zingman, L. V., Алексеев, А. Э., Hodgson‐Zingman, D., & Terzic, A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00747.2007 · Cited by 120
Lipid microdomains contribute to apoptosis-associated modifications of mitochondria in T cells
Garofalo, T., Giammarioli, A. M., Misasi, R., Tinari, A., Manganelli, V., Gambardella, L., Pavan, A., Malorni, W., & Sorice, M. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401672 · Cited by 119
Caveolae Localize Protein Kinase A Signaling to Arterial ATP-Sensitive Potassium Channels
Sampson, L. J., Hayabuchi, Y., Standen, N. B., & Dart, C. (2004) · Circulation Research · doi:10.1161/01.res.0000148634.47095.ab · Cited by 119
Effects of methyl β‐cyclodextrin on EDHF responses in pig and rat arteries; association between SKCa channels and caveolin‐rich domains
Absi, M., Burnham, M. P., Weston, A. H., Harno, E., Rogers, M., & Edwards, G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707222 · Cited by 116
Maxi-K channels localize to caveolae in human myometrium: a role for an actin-channel-caveolin complex in the regulation of myometrial smooth muscle K+ current
Brainard, A. M., Miller, A. J., Martens, J. R., & England, S. K. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00399.2004 · Cited by 114
Cholesterol Antagonizes Ethanol Potentiation of Human Brain BKCa Channels Reconstituted into Phospholipid Bilayers
Crowley, J. J., Treistman, S. N., & Dopico, A. M. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.2.365 · Cited by 113
Phosphoinositide-mediated gating of inwardly rectifying K+ channels
Logothetis, D. E., Jin, T., Lupyan, D., & Rosenhouse‐Dantsker, A. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0276-5 · Cited by 112
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Diversity of Cl− Channels
Suzuki, M., Morita, T., & Iwamoto, T. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5336-4 · Cited by 111
Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol
Epshtein, Y., Chopra, A., Rosenhouse-Dantsker, A., Kowalsky, G., Logothetis, D., & Levitan, I. (2009) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0809847106 · Cited by 111
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Apical sorting of a voltage- and Ca 2+ -activated K + channel α-subunit in Madin-Darby canine kidney cells is independent of N-glycosylation
Bravo‐Zehnder, M., Orio, P., Norambuena, A., Wallner, M., Meera, P., Toro, L., Latorre, R., & González, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240455697 · Cited by 109
Regulation of transient receptor potential canonical channel 1 (TRPC1) by sphingosine 1-phosphate in C2C12 myoblasts and its relevance for a role of mechanotransduction in skeletal muscle differentiation
Formigli, L., Sassoli, C., Squecco, R., Bini, F., Martinesi, M., Chellini, F., Luciani, G., Sbrana, F., Zecchi‐Orlandini, S., Francini, F., et al. (2009) · Journal of Cell Science · doi:10.1242/jcs.035402 · Cited by 108
Differential Recruitment of Kv1.4 and Kv4.2 to Lipid Rafts by PSD-95
Wong, W., & Schlichter, L. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304675200 · Cited by 107
Hypercholesterolemia Suppresses Inwardly Rectifying K + Channels in Aortic Endothelium In Vitro and In Vivo
Fang, Y. H., Mohler, E. R., Hsieh, E., Osman, H. E., Hashemi, S., Davies, P. F., Rothblat, G. H., Wilensky, R. L., & Levitan, I. (2006) · Circulation Research · doi:10.1161/01.res.0000218776.87842.43 · Cited by 107
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Swelling‐activated ion channels: functional regulation in cell‐swelling, proliferation and apoptosis
Stutzin, A., & Hoffmann, E. K. (2006) · Acta Physiologica · doi:10.1111/j.1748-1716.2006.01537.x · Cited by 107
Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms
Bock, J., Szabó, I., Gamper, N. L., Adams, C., & Gulbins, E. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00763-0 · Cited by 107
Transient receptor potential protein subunit assembly and membrane distribution in human platelets
Brownlow, S., & Sage, S. O. (2005) · Thrombosis and Haemostasis · doi:10.1160/th05-06-0391 · Cited by 106
Potassium Channels in the Human Myometrium
Khan, R. N., Matharoo‐Ball, B., Arulkumaran, S., & Ashford, M. L. J. (2001) · Experimental Physiology · doi:10.1113/eph8602181 · Cited by 106
Assembly and Trafficking of a Multiprotein ROMK (Kir 1.1) Channel Complex by PDZ Interactions
Yoo, D. S., Flagg, T. P., Olsen, O., Raghuram, V., Foskett, J. K., & Welling, P. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311599200 · Cited by 101
Depletion of membrane cholesterol eliminates the Ca2+‐activated component of outward potassium current and decreases membrane capacitance in rat uterine myocytes
Shmygol, A., Noble, K., & Wray, S. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.129452 · Cited by 101
Localization of Ion Channels to Lipid Raft Domains within the Cardiovascular System
O’Connell, K. M. S. (2004) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2003.10.002 · Cited by 100
Membrane cholesterol modulates Kv1.5 potassium channel distribution and function in rat cardiomyocytes
Abi-Char, J., Maguy, A., Coulombe, A., Balse, E., Ratajczak, P., Samuel, J., Nattel, S., & Hatem, S. N. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.134809 · Cited by 100
BK Channels Are Linked to Inositol 1,4,5-Triphosphate Receptors via Lipid Rafts
Weaver, A. K., Olsen, M. L., McFerrin, M. B., & Sontheimer, H. W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702866200 · Cited by 97
Caveolin-1 Regulates Store-Operated Ca2+ Influx by Binding of Its Scaffolding Domain to Transient Receptor Potential Channel-1 in Endothelial Cells
Kwiatek, A. M., Minshall, R. D., Cool, D. R., Skidgel, R. A., Malik, A. B., & Tiruppathì, C. (2006) · Molecular Pharmacology · doi:10.1124/mol.105.021741 · Cited by 96
Endogenously Expressed Epithelial Sodium Channel Is Present in Lipid Rafts in A6 Cells
Hill, W. G., An, B., & Johnson, J. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200309200 · Cited by 95
The Neural Cell Adhesion Molecule Regulates Cell-Surface Delivery of G-Protein-Activated Inwardly Rectifying Potassium Channels Via Lipid Rafts
Delling, M., Wischmeyer, E., Dityatev, A. E., Sytnyk, V., Veh, R. W., Karschin, A., & Schachner, M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07154.2002 · Cited by 94
Caveolin‐1 modulates the activity of the volume‐regulated chloride channel
Trouet, D., Nilius, B., Jacobs, A., Remacle, C., Droogmans, G., & Eggermont, J. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.t01-1-00113.x · Cited by 91
Regulation of caveolar cardiac sodium current by a single Gsα histidine residue
Palygin, O., Pettus, J. M., & Shibata, E. F. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01337.2007 · Cited by 90
Cholesterol modifies the gating of Kv1.3 in human T lymphocytes
Hajdú, P., Varga, Z., Pieri, C., Panyi, G., & Gáspár, R. (2003) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-002-0974-y · Cited by 89
Partial restoration of cAMP-stimulated CFTR chloride channel activity in ΔF508 cells by deoxyspergualin
Jiang, C., Fang, S. L., Xiao, Y., O’Connor, S. P., Nadler, S. G., Lee, D. W., Jefferson, D. M., Kaplan, J. M., Smith, A. E., & Cheng, S. H. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.275.1.c171 · Cited by 88
Hypercholesterolemia inhibits L-type calcium current in coronary macro-, not microcirculation
Bowles, D. K., Heaps, C. L., Turk, J. R., Maddali, K. K., & Price, E. M. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01229.2003 · Cited by 87
Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes
Panyi, G., Bagdány, M., Bodnár, A., Vámosi, G., Szentesi, G., Jenei, A., Mátyus, L., Varga, S., Waldmann, T. A., Gáspár, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438057100 · Cited by 86
Reactive oxygen species are important mediators of taurine release from skeletal muscle cells
Ørtenblad, N., Young, J. F., Oksbjerg, N., Nielsen, J. H., & Lambert, I. H. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00287.2002 · Cited by 85
β2 and β4 Subunits of BK Channels Confer Differential Sensitivity to Acute Modulation by Steroid Hormones
King, J. T., Lovell, P. V., Rishniw, M., Kotlikoff, M. I., Zeeman, M. L., & McCobb, D. P. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01352.2005 · Cited by 83
Regulation of membrane potential and fluid secretion by Ca2+‐activated K+ channels in mouse submandibular glands
Romanenko, V. G., Nakamoto, T., Srivastava, A., Begenisich, T. B., & Melvin, J. E. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.127498 · Cited by 82
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Cholesterol modulates the volume-regulated anion current in Ehrlich-Lettre ascites cells via effects on Rho and F-actin
Klausen, T. K., Hougaard, C. Ø., Hoffmann, E. K., & Pedersen, S. F. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00029.2006 · Cited by 79
Caveolin-1 Expression and Membrane Cholesterol Content Modulate N-Type Calcium Channel Activity in NG108-15 Cells
Toselli, M., Biella, G. R., Taglietti, V., Cazzaniga, E., & Parenti, M. D. (2005) · Biophysical Journal · doi:10.1529/biophysj.105.065623 · Cited by 78
Sensitivity of Volume-regulated Anion Current to Cholesterol Structural Analogues
Romanenko, V. G., Rothblat, G. H., & Levitan, I. (2003) · The Journal of General Physiology · doi:10.1085/jgp.200308882 · Cited by 78
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Hypercholesterolemia abolishes voltage-dependent K+ channel contribution to adenosine-mediated relaxation in porcine coronary arterioles
Heaps, C. L., Tharp, D. L., & Bowles, D. K. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00157.2004 · Cited by 74
CFTR in a lipid raft-TNFR1 complex modulates gap junctional intercellular communication and IL-8 secretion
Dudez, T. S., Borot, F., Huang, S. L., Kwak, B. R., Bacchetta, M., Ollero, M., Stanton, B. A., & Chanson, M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.007 · Cited by 71
Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels
Sampson, L. J., Davies, L. M., Barrett‐Jolley, R., Standen, N. B., & Dart, C. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.05.020 · Cited by 70
Kv1.5 Association Modifies Kv1.3 Traffic and Membrane Localization
Vicente, R., Villalonga, N., Calvo, M., Escalada, A., Solsona, C., Soler, C., Tamkun, M. M., & Felipe, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708223200 · Cited by 69
Free Cholesterol Alters Lipid Raft Structure and Function Regulating Neutrophil Ca2+ Entry and Respiratory Burst: Correlations with Calcium Channel Raft Trafficking
Kannan, K. B., Barlos, D., & Hauser, C. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5253 · Cited by 69
Cholesterol inhibits spontaneous action potentials and calcium currents in guinea pig gallbladder smooth muscle
Jennings, L. J., Xu, Q.-W., Firth, T. A., Nelson, M. T., & Mawe, G. M. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.5.g1017 · Cited by 69
Membrane cholesterol content modulates activation of BK channels in colonic epithelia
Lam, R. S., Shaw, A. R., & Duszyk, M. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.11.004 · Cited by 69
Cutting Edge: Optical Microspectrophotometry Supports the Existence of Gel Phase Lipid Rafts at the Lamellipodium of Neutrophils: Apparent Role in Calcium Signaling
Kindzelskii, A. L., Sitrin, R. G., & Petty, H. R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4681 · Cited by 68
Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2
Fang, Y. H., Schram, G., Romanenko, V. G., Shi, C., Conti, L. R., Vandenberg, C. A., Davies, P. F., Nattel, S., & Levitan, I. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00077.2005 · Cited by 68
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The Epithelial Sodium Channel (ENaC) Traffics to Apical Membrane in Lipid Rafts in Mouse Cortical Collecting Duct Cells
Hill, W. G., Butterworth, M. B., Wang, H., Edinger, R. S., Lebowitz, J., Peters, K. W., Frizzell, R. A., & Johnson, J. P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704084200 · Cited by 68
Neuronal fusion pore assembly requires membrane cholesterol
Cho, W. J., Jeremic, A. M., Jin, H., Ren, G., & Jena, B. P. (2007) · Cell Biology International · doi:10.1016/j.cellbi.2007.06.011 · Cited by 66
Swelling-Induced Taurine Transport: Relationship with Chloride Channels, Anion-Exchangers and Other Swelling-Activated Transport Pathways
SHENNAN, D. B. (2008) · Cellular Physiology and Biochemistry · doi:10.1159/000113743 · Cited by 65
Membrane Cholesterol Regulates Smooth Muscle Phasic Contraction
Babiychuk, E. B., Smith, R. D., Burdyga, T. V., Vs, B., Wray, S., & Draeger, A. (2004) · The Journal of Membrane Biology · doi:10.1007/s00232-004-0663-1 · Cited by 65
Inhibition of Volume-Regulated Anion Channels by Dominant-Negative Caveolin-1
Trouet, D., Hermans, D., Droogmans, G., Nilius, B., & Eggermont, J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4995 · Cited by 63
Cellular cholesterol controls TRPC3 function: evidence from a novel dominant-negative knockdown strategy
Graziani, A., Rosker, C., Kohlwein, S. D., Zhu, M. X., Romanin, C., Sattler, W., Groschner, K., & Poteser, M. (2006) · Biochemical Journal · doi:10.1042/bj20051246 · Cited by 63
A role for hTRPC1 and lipid raft domains in store-mediated calcium entry in human platelets
Brownlow, S., Harper, A. G. S., Harper, M. T., & Sage, S. O. (2003) · Cell Calcium · doi:10.1016/j.ceca.2003.08.002 · Cited by 61
TRPC channel lipid specificity and mechanisms of lipid regulation
Beech, D. J., Naguib, Y. M., Dedman, A., & ALSHAWAF, E. M. M. (2009) · Cell Calcium · doi:10.1016/j.ceca.2009.02.006 · Cited by 61
Bilayer Thickness Modulates the Conductance of the BK Channel in Model Membranes
Yuan, C., O’Connell, R. J., Feinberg‐Zadek, P. L., Johnston, L. J., & Treistman, S. N. (2004) · Biophysical Journal · doi:10.1529/biophysj.103.029678 · Cited by 59
Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells
Yogi, Á., Callera, G. E., Tostes, R. C., & Touyz, R. M. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90602.2008 · Cited by 59
The Activity of the Epithelial Sodium Channels Is Regulated by Caveolin-1 via a Nedd4-2-dependent Mechanism
Lee, I., Campbell, C. R., Song, S., Day, M. L., Kumar, S., Cook, D. I., & Dinudom, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809737200 · Cited by 58
Lipid Rafts in Membrane–Cytoskeleton Interactions and Control of Cellular Biomechanics: Actions of oxLDL
Levitan, I., & Gooch, K. J. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1686 · Cited by 58
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Relationship between Kir2.1/Kir2.3 activity and their distributions between cholesterol-rich and cholesterol-poor membrane domains
Tikku, S., Epshtein, Y., Collins, H., Travis, A. J., Rothblat, G. H., & Levitan, I. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00492.2006 · Cited by 58
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cAMP-induced Cytoskeleton Rearrangement Increases Calcium Transients through the Enhancement of Capacitative Calcium Entry
GRIMALDI, M., Favit, A., & Alkon, D. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.47.33557 · Cited by 57
Membrane cholesterol modulates dihydropyridine receptor function in mice fetal skeletal muscle cells
Pouvreau, S., Berthier, C., Blaineau, S., Amsellem, J., Coronado, R., & Strube, C. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.055285 · Cited by 57
Targeting of Voltage-Gated K + and Ca 2+ Channels and Soluble N -Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Proteins to Cholesterol-Rich Lipid Rafts in Pancreatic α-Cells: Effects on Glucagon Stimulus-Secretion Coupling
Xia, F., Leung, Y., Gaisano, G., Gao, X., Chen, Y., Fox, J. E. M., Bhattacharjee, A., Wheeler, M. B., Gaisano, H. Y., & Tsushima, R. G. (2007) · Endocrinology · doi:10.1210/en.2006-1296 · Cited by 56
Enhanced role of K+ channels in relaxations of hypercholesterolemic rabbit carotid artery to NO
Najibi, S., & Cohen, R. A. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.269.3.h805 · Cited by 56
TRPC1 is regulated by caveolin‐1 and is involved in oxidized LDL‐induced apoptosis of vascular smooth muscle cells
Ingueneau, C., Huynh‐Do, U., Marcheix, B., Athias, A., Gambert, P., Nègre‐Salvayre, A., Salvayre, R., & Vindis, C. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00593.x · Cited by 53
Identification of yeast proteins necessary for cell-surface function of a potassium channel
Haass, F. A., Jonikas, M. C., Walter, P., Weissman, J. S., Jan, Y. N., Jan, L. Y., & Schuldiner, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708765104 · Cited by 52
Effect of subunit composition and Liddle’s syndrome mutations on biosynthesis of ENaC
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Caveolin Regulates Kv1.5 Trafficking to Cholesterol-Rich Membrane Microdomains
McEwen, D. P., Li, Q., Jackson, S., Jenkins, P. M., & Martens, J. R. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.042093 · Cited by 51
Estrogen Inhibition of Cystic Fibrosis Transmembrane Conductance Regulator-Mediated Chloride Secretion
Singh, A. K., Schultz, B. D., Katzenellenbogen, J. A., Price, E. M., Bridges, R. J., & Bradbury, N. A. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38887-1 · Cited by 49
Localization of Kv1.5 channels in rat and canine myocyte sarcolemma
Eldstrom, J., Wagoner, D. R. V., Moore, E. D. W., & Fedida, D. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.09.069 · Cited by 49
Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder
Sprossmann, F., Pankert, P., Sausbier, U., Wirth, A., Zhou, X., Madlung, J., Zhao, H. L., Bucurenciu, I., Jakob, A., Lamkemeyer, T., et al. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.06900.x · Cited by 48
Distinct detergent‐resistant membrane microdomains (lipid rafts) respectively harvest K+ and water transport systems in brain astroglia
Hibino, H., & Kurachi, Y. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05876.x · Cited by 47
Characterization of the mitochondrial porin from Drosophila melanogaster
Pinto, V. D., Benz, R., Caggese, C., & Palmieri, F. (1989) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(89)90447-1 · Cited by 47
Membrane cholesterol extraction decreases Na+ transport in A6 renal epithelia
Balut, C., Steels, P., Radu, M., Ameloot, M. M., Driessche, W. V., & Jans, D. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00184.2005 · Cited by 45
Cholesterol Effects on BAX Pore Activation
Christenson, E. T., Merlin, S., Saito, M., & Schlesinger, P. H. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.06.037 · Cited by 43
Lipid Raft Proteomics: More than Just Detergent-Resistant Membranes
Foster, L. J., & Chan, Q. W. T. (2007) · Springer eBooks · doi:10.1007/978-1-4020-5943-8_4 · Cited by 43
Mechanosensitive channel activity and F‐actin organization in cholesterol‐depleted human leukaemia cells
Morachevskaya, E. A., Sudarikova, A. V., & Negulyaev, Y. A. (2007) · Cell Biology International · doi:10.1016/j.cellbi.2007.01.024 · Cited by 43
Localization and mobility of the delayed-rectifer K+channel Kv2.1 in adult cardiomyocytes
O’Connell, K. M. S., Whitesell, J. D., & Tamkun, M. M. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01038.2007 · Cited by 43
Membrane Cholesterol Content Modulates ClC-2 Gating and Sensitivity to Oxidative Stress
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The effect of hypercholesterolemia on the sodium inward currents in cardiac myocyte
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See all 247

Authors: Levitan, I., Fang, Y., Rosenhouse-Dantsker, A., & Romanenko, V.
Affiliations: University of Illinois Chicago (US)
University of Pennsylvania (US)
University of Rochester Medicine (US)
Corresponding author: Levitan, Irena
ORCID: Levitan, Irena
Fang, Yun
Venue: Subcellular Biochemistry
Publisher: Springer Netherlands
Published: 2010
Volume: 51
Pages: 509-549
ISSN: 0306-0225 (ISSN-L)
DOI: 10.1007/978-90-481-8622-8_19
PMC: PMC2895485
OpenAlex: W1497754562
Cited by: 247
References: 213
Citations by year: 2026: 17 · 2025: 17 · 2024: 14 · 2023: 16 · 2022: 26 · 2021: 19 · 2020: 11 · 2019: 14 · 2018: 9 · 2017: 12 · 2016: 7 · 2015: 10 · 2014: 21 · 2013: 15 · 2012: 17
FWCI: 20.98
Type: book chapter
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Sub-cellular biochemistry/Subcellular biochemistry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL073965, HL073965, R01HL083298, HL-083298)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Keywords: membrane cholesterol, ion channel modulation, cholesterol-rich membrane domains, inwardly rectifying potassium channels, voltage-gated potassium channels, voltage-gated sodium channels, N-type calcium channels, volume-regulated anion channel, amiloride-sensitive sodium channel, TRP channels, cholesterol depletion, channel kinetics
MeSH terms: Animals, Cholesterol, Humans, Hypercholesterolemia, Ion Channels, Membrane Lipids, Molecular Conformation, Calcium Channels, Sodium Channels, Signal Transduction, Ion Channel Gating, Chloride Channels, Membrane Microdomains, Potassium Channels, Voltage-Gated, Potassium Channels, Inwardly Rectifying, Potassium Channels, Calcium-Activated, TRPC Cation Channels

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