Cholesterol in Alzheimer’s Disease and other Amyloidogenic Disorders
Abstract
The complex association of cholesterol metabolism and Alzheimer's disease is presented in depth, including the possible benefits to be gained from cholesterol-lowering statin therapy. Then follows a survey of the role of neuronal membrane cholesterol in Abeta pore formation and Abeta fibrillogenesis, together with the link with membrane raft domains and gangliosides. The contribution of structural studies to Abeta fibrillogenesis, using TEM and AFM, is given some emphasis. The role of apolipoprotein E and its isoforms, in particular ApoE4, in cholesterol and Abeta binding is presented, in relation to genetic risk factors for Alzheimer's disease. Increasing evidence suggests that cholesterol oxidation products are of importance in generation of Alzheimer's disease, possibly induced by Abeta-produced hydrogen peroxide. The body of evidence for a link between cholesterol in atherosclerosis and Alzheimer's disease is increasing, along with an associated inflammatory response. The possible role of cholesterol in tau fibrillization, tauopathies and in some other non-Abeta amyloidogenic disorders is surveyed.
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Diets with increased cholesterol increase tau phosphorylation in wild-type and human tau transgenic mammals.
“Reports in both wild-type and in human tau transgenic mammals indicate that diets with increased cholesterol do indeed increase tau phosphorylation (265–267).”
From Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation (2011) · cites this paper as [266]
Cites
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Cholesterol metabolism in neurons and astrocytes
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- Authors
- Harris, J. R., & Milton, N. G. N.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- University of Westminster (GB)
- Corresponding author
- Harris, J. Robin
- Venue
- Subcellular Biochemistry
- Publisher
- Springer Netherlands
- Published
- 2010
- Volume
- 51
- Pages
- 47-75
- ISSN
- 0306-0225 (ISSN-L)
- OpenAlex
- W80882466
- Cited by
- 44
- References
- 7
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 9
- FWCI
- 25.74
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Sub-cellular biochemistry/Subcellular biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- cholesterol, Alzheimer's disease, amyloid-beta, cholesterol metabolism, statin therapy, lipid rafts, gangliosides, apolipoprotein E, APOE ε4, genetic risk factors, cholesterol oxidation, hydrogen peroxide, atherosclerosis, neuroinflammation, tau fibrillization, tauopathy
- MeSH terms
- Alzheimer Disease, Amyloid, Apolipoproteins E, Brain, Cholesterol, G(M1) Ganglioside, Humans, Male, Neurons, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, tau Proteins, Oxidative Stress, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Tauopathies, Atherosclerosis, Amyloid Precursor Protein Secretases
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