Cholesterol metabolism, apolipoprotein E, adenosine triphosphate-binding cassette transporters, and Alzheimer's disease

Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786 · see citing works

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920 · see citing works

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

Brooks-Wilson, A., Marcil, M., Clee, S. M., Zhang, L.-H., Roomp, K., van Dam, M., Yu, L., Brewer, C., Collins, J. A., Molhuizen, H. O. F., et al. (1999) · Nature Genetics · doi:10.1038/11905 · Cited by 1,687 · see citing works

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525 · see citing works

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

Bodzioch, M., Orsó, E., Klucken, J., Langmann, T., Böttcher, A., Diederich, W., Drobnik, W., Barlage, S., Büchler, C., Porsch-Özcürümez, M., et al. (1999) · Nature Genetics · doi:10.1038/11914 · Cited by 1,512 · see citing works

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

Rust, S., Rosier, M., Funke, H., Real, J., Amoura, Z., Piette, J.-C., Deleuze, J.-F., Brewer, H. B., Duverger, N., Denèfle, P., et al. (1999) · Nature Genetics · doi:10.1038/11921 · Cited by 1,433 · see citing works

Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

Shibata, M., Yamada, S., Kumar, S. R., Calero, M., Bading, J., Frangione, B., Holtzman, D. M., Miller, C. A., Strickland, D. K., Ghiso, J., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10498 · Cited by 1,413 · see citing works

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

Simons, M., Keller, P., Strooper, B. D., Beyreuther, K. T., Dotti, C. G., & Simons, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6460 · Cited by 1,167 · see citing works

LXR, a nuclear receptor that defines a distinct retinoid response pathway.Preprint

Willy, P. J., Umesono, K., Ong, E. S., Evans, R. M., Heyman, R. A., & Mangelsdorf, D. J. (1995) · Genes & Development · doi:10.1101/gad.9.9.1033 · Cited by 1,124 · see citing works

Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

Ehehalt, R., Keller, P., Haass, C., Thiele, C., & Simons, K. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207113 · Cited by 1,107 · see citing works

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

William Rebeck, G., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90070-8 · Cited by 1,107 · see citing works

Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

Fassbender, K. C., Simons, M., Bergmann, C., Stroick, M., Lütjohann, D., Keller, P., Runz, H., Kühl, S., Bertsch, T., von Bergmann, K., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081620098 · Cited by 1,078 · see citing works

ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins

Wang, N., Lan, D., Chen, W., Matsuura, F., & Tall, A. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403506101 · Cited by 1,059 · see citing works

Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model

Refolo, L. M., Pappolla, M. A., Malester, B., LaFrancois, J. J., Bryant‐Thomas, T., Wang, R., Tint, G. S., Sambamurti, K., & Duff, K. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0304 · Cited by 1,003 · see citing works

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., Mackey, B., Olney, J., McKeel, D., Wozniak, D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050004797 · Cited by 937 · see citing works

Cholesterol metabolism in the brain

Dietschy, J. M., & Turley, S. D. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00003 · Cited by 906 · see citing works

Alzheimer's disease: the cholesterol connection

Puglielli, L., Tanzi, R. E., & Kovacs, D. M. (2003) · Nature Neuroscience · doi:10.1038/nn0403-345 · Cited by 864 · see citing works

Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β

Repa, J. J., Berge, K. E., Pomajzl, C., Richardson, J. A., Hobbs, H. H., & Mangelsdorf, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109927200 · Cited by 852 · see citing works

Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

Bales, K. R., Verina, T., Dodel, R. C., Du, Y., Altstiel, L., Bender, M., Hyslop, P., Johnstone, E. M., Little, S. P., Cummins, D. J., et al. (1997) · Nature Genetics · doi:10.1038/ng1197-263 · Cited by 830 · see citing works

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10

Kojro, E., Gimpl, G., Lammich, S., März, W., & Fahrenholz, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081612998 · Cited by 804 · see citing works

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms.

Weisgraber, K. H., Rall, S. C., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52510-8 · Cited by 777 · see citing works

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

Pitas, R. E., Boyles, J. K., Lee, S. H., Hui, D., & Weisgraber, K. H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47945-8 · Cited by 714 · see citing works

Apolipoprotein E and Alzheimer disease.

Strittmatter, W. J., & Roses, A. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4725 · Cited by 699 · see citing works

Clinicopathologic Studies in Cognitively Healthy Aging and Alzheimer Disease: Relation of Histologic Markers to Dementia Severity, Age, Sex, and Apolipoprotein E Genotype

Berg, L., McKeel, D. W., Miller, J. P., Storandt, M., Rubin, E. H., Morris, J. C., Baty, J., Coats, M., Norton, J., Goate, A. M., et al. (1998) · Archives of Neurology · doi:10.1001/archneur.55.3.326 · Cited by 657 · see citing works

LXRS AND FXR: The Yin and Yang of Cholesterol and Fat Metabolism

Kalaany, N. Y., & Mangelsdorf, D. J. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.033104.152158 · Cited by 619 · see citing works

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

Koistinaho, M., Lin, S., Wu, X., Esterman, M., Koger, D., Hanson, J., Higgs, R., Liu, F., Malkani, S., Bales, K. R., et al. (2004) · Nature Medicine · doi:10.1038/nm1058 · Cited by 571 · see citing works

Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification

Zannis, V. I., & Breslow, J. L. (1981) · Biochemistry · doi:10.1021/bi00507a059 · Cited by 563 · see citing works

ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport

Klucken, J., Büchler, C., Orsó, E., Kaminski, W. E., Özcürümez, M. K., Liebisch, G., Kapinsky, M., Diederich, W., Drobnik, W., Dean, M. C., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.817 · Cited by 543 · see citing works

Isoform-specific binding of apolipoprotein E to beta-amyloid.

LaDu, M. J., Falduto, M. T., Manelli, A. M., Reardon, C. A., Getz, G. S., & Frail, D. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31529-6 · Cited by 540 · see citing works

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

Björkhem, I., Lütjohann, D., Diczfalusy, U., Ståhle, L., Ahlborg, G., & Wahren, J. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32188-x · Cited by 538 · see citing works

ATP-Binding Cassette Transporter A1: A Cell Cholesterol Exporter That Protects Against Cardiovascular Disease

Oram, J. F., & Heinecke, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00005.2005 · Cited by 521 · see citing works

Apolipoprotein E is essential for amyloid deposition in the <i>APP</i> ^V717F transgenic mouse model of Alzheimer's disease

Bales, K. R., Verina, T., Cummins, D. J., Du, Y., Dodel, R. C., Saura, J., Fishman, C. E., DeLong, C. A., Piccardo, P., Petegnief, V., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15233 · Cited by 486 · see citing works

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE

Wahrle, S. E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J. D., Kowalewski, T., & Holtzman, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407963200 · Cited by 474 · see citing works

Cholesterol Modulates α-Secretase Cleavage of Amyloid Precursor Protein

Bodovitz, S., & Klein, W. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4436 · Cited by 447 · see citing works

ABCA1 and ABCG1 Synergize to Mediate Cholesterol Export to ApoA-I

Gelissen, I. C., Harris, M., Rye, K., Quinn, C. M., Brown, A. J., Kockx, M., Cartland, S. P., Packianathan, M., Kritharides, L., & Jessup, W. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000200082.58536.e1 · Cited by 430 · see citing works

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.

Zlokovic, B. V., Martel, C. L., Matsubara, E., McComb, J. G., Zheng, G., McCluskey, R. T., Frangione, B., & Ghiso, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4229 · Cited by 430 · see citing works

Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains

Schindler, S. E., Das, P., Nyborg, A. C., McLendon, C., Shoji, M., Kawarabayashi, T., Younkin, L. H., Younkin, S. G., & Golde, T. E. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0470 · Cited by 426 · see citing works

Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease.

Francis, G. A., Knopp, R. H., & Oram, J. F. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118082 · Cited by 424 · see citing works

ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models

Price, D. L., Tanzi, R. E., Borchelt, D. R., & Sisodia, S. S. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.461 · Cited by 406 · see citing works

Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain

Hirsch-Reinshagen, V., Zhou, S., Burgess, B. L., Bernier, L., McIsaac, S. A., Chan, J. Y., Tansley, G. H., Cohn, J. S., Hayden, M. R., & Wellington, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407962200 · Cited by 385 · see citing works

Lack of ABCA1 Considerably Decreases Brain ApoE Level and Increases Amyloid Deposition in APP23 Mice

Koldamova, R., Staufenbiel, M., & Lefterov, I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504513200 · Cited by 350 · see citing works

Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease

Holtzman, D. M., Bales, K. R., Wu, S., Bhat, P., Parsadanian, M., Fagan, A. M., Chang, L. K., Sun, Y., & Paul, S. M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6179 · Cited by 349 · see citing works

Apolipoprotein Specificity for Lipid Efflux by the Human ABCAI Transporter

Remaley, A. T., Stonik, J. A., Demosky, S. J., Neufeld, E. B., Bocharov, A. V., Vishnyakova, T. G., Eggerman, T. L., Patterson, A. P., Duverger, N., Santamarina-Fojo, S., et al. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4219 · Cited by 327 · see citing works

Deletion of Abca1 Increases Aβ Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease

Wahrle, S. E., Jiang, H., Parsadanian, M., Hartman, R. E., Bales, K. R., Paul, S. M., & Holtzman, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508780200 · Cited by 325 · see citing works

ABCA1 mRNA and Protein Distribution Patterns Predict Multiple Different Roles and Levels of Regulation

Wellington, C. L., Walker, E. K.-Y., Suarez, A., Kwok, A. Y. C., Bissada, N., Singaraja, R. R., Yang, Y., Zhang, L., James, E. R., Wilson, J. E., et al. (2002) · Laboratory Investigation · doi:10.1038/labinvest.3780421 · Cited by 296 · see citing works

Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α2‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein

Rebeck, G. W., Harr, S. D., Hyman, B. T., & Strickland, D. K. (1995) · Annals of Neurology · doi:10.1002/ana.410370212 · Cited by 294 · see citing works

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor

Claudel, T., Leibowitz, M. D., Fiévet, C., Tailleux, A., Wagner, B. L., Repa, J. J., Torpier, G., Lobaccaro, J. A., Paterniti, J. R., Mangelsdorf, D. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041609298 · Cited by 292 · see citing works

Complete Characterization of the Human ABC Gene Family

Dean, M. C., & Allikmets, R. L. (2001) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1012823120935 · Cited by 290 · see citing works

ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL

Vaughan, A. M., & Oram, J. F. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600218-jlr200 · Cited by 283 · see citing works

Importance of a Novel Oxidative Mechanism for Elimination of Brain Cholesterol

Björkhem, I., Lütjohann, D., Breuer, O., Sakinis, A., & Wennmalm, Å. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30178 · Cited by 281 · see citing works

The Liver X Receptor Ligand T0901317 Decreases Amyloid β Production in Vitro and in a Mouse Model of Alzheimer's Disease

Koldamova, R. P., Lefterov, I. M., Staufenbiel, M., Wolfe, D., Huang, S., Glorioso, J. C., Walter, M., Roth, M. G., & Lazo, J. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411420200 · Cited by 279 · see citing works

Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid β peptides

TOKUDA, T., CALERO, M., MATSUBARA, E., VIDAL, R., KUMAR, A., PERMANNE, B., ZLOKOVIC, B., SMITH, J. D., LADU, M. J., ROSTAGNO, A., et al. (2000) · Biochemical Journal · doi:10.1042/bj3480359 · Cited by 272 · see citing works

ABCG1 Redistributes Cell Cholesterol to Domains Removable by High Density Lipoprotein but Not by Lipid-depleted Apolipoproteins

Vaughan, A. M., & Oram, J. F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505368200 · Cited by 266 · see citing works

Role of ABCG1 and other ABCG family members in lipid metabolism

Schmitz, G., Langmann, T., & Heimerl, S. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32205-7 · Cited by 265 · see citing works

Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease

Nagy, Z. S., Esiri, M. M., Jobst, K. A., Johnston, C., Litchfield, S., Sim, E., & Smith, A. D. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00331-c · Cited by 250 · see citing works

22R-Hydroxycholesterol and 9-cis-Retinoic Acid Induce ATP-binding Cassette Transporter A1 Expression and Cholesterol Efflux in Brain Cells and Decrease Amyloid β Secretion

Koldamova, R. P., Lefterov, I. M., Ikonomovic, M. D., Skoko, J., Lefterov, P. I., Isanski, B. A., DeKosky, S. T., & Lazo, J. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300044200 · Cited by 237 · see citing works

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease

Hirsch-Reinshagen, V., Maia, L. F., Burgess, B. L., Blain, J.-F., Naus, K. E., McIsaac, S. A., Parkinson, P. F., Chan, J. Y., Tansley, G. H., Hayden, M. R., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508781200 · Cited by 233 · see citing works

Impact of <i>APOE</i> genotype on neuropathologic and neurochemical markers of Alzheimer disease

Tiraboschi, P., Hansen, L. A., Masliah, E., Alford, M., Thal, L. J., & Corey-Bloom, J. (2004) · Neurology · doi:10.1212/01.wnl.0000128091.92139.0f · Cited by 226 · see citing works

Diet-induced hypercholesterolemia enhances brain Aβ accumulation in transgenic mice

Shie, F., Jin, L., Cook, D. G., Leverenz, J. B., & LeBoeuf, R. C. (2002) · Neuroreport · doi:10.1097/00001756-200203250-00019 · Cited by 225 · see citing works

Nuclear Receptors in Lipid Metabolism: Targeting the Heart of Dyslipidemia

Beaven, S. W., & Tontonoz, P. (2006) · Annual Review of Medicine · doi:10.1146/annurev.med.57.121304.131428 · Cited by 225 · see citing works

Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons

Bu, G., Maksymovitch, E. A., Nerbonne, J. M., & Schwartz, A. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32340-2 · Cited by 216 · see citing works

Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer's disease

Dodart, J.-C., Marr, R. A., Koistinaho, M., Gregersen, B. M., Malkani, S., Verma, I. M., & Paul, S. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409072102 · Cited by 207 · see citing works

Lipoproteins in the Central Nervous System

LaDu, M. J., Reardon, C. A., Eldik, L. J. V., Fagan, A. M., Bu, G., HOLTZMAN, D., & Getz, G. S. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06365.x · Cited by 206 · see citing works

Role of ABCG1 and ABCA1 in Regulation of Neuronal Cholesterol Efflux to Apolipoprotein E Discs and Suppression of Amyloid-β Peptide Generation

Kim, W. S., Rahmanto, A. S., Kamili, A., Rye, K.-A., Guillemin, G. J., Gelissen, I. C., Jessup, W., Hill, A. F., & Garner, B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607831200 · Cited by 191 · see citing works

Purification of Apolipoprotein E Attenuates Isoform-specific Binding to β-Amyloid

LaDu, M. J., Pederson, T. M., Frail, D. E., Reardon, C. A., Getz, G. S., & Falduto, M. T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.16.9039 · Cited by 189 · see citing works

Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid β peptides but not on plaque formation

Buttini, M., Yu, G.-Q., Shockley, K., Huang, Y., Jones, B., Masliah, E., Mallory, M., Yeo, T., Longo, F. M., & Mucke, L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10539.2002 · Cited by 183 · see citing works

Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

Sun, Y., Yao, J., Kim, T.-W., & Tall, A. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300760200 · Cited by 179 · see citing works

Presenilin Redistribution Associated with Aberrant Cholesterol Transport Enhances β-Amyloid ProductionIn Vivo

Burns, M. P., Gaynor, K., Olm, V., Mercken, M. H., LaFrancois, J. J., Wang, L., Mathews, P. M., Noble, W. J., Matsuoka, Y., & Duff, K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05645.2003 · Cited by 172 · see citing works

Induction of the Cholesterol Transporter ABCA1 in Central Nervous System Cells by Liver X Receptor Agonists Increases Secreted Aβ Levels

Fukumoto, H., Deng, A., Irizarry, M. C., Fitzgerald, M. L., & Rebeck, G. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209085200 · Cited by 160 · see citing works

Distinct spatio‐temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain

Tachikawa, M., Watanabe, M., Hori, S., Fukaya, M., Ohtsuki, S., Asashima, T., & Terasaki, T. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03369.x · Cited by 139 · see citing works

The Low Density Lipoprotein Receptor Regulates the Level of CentralNervous System Human and Murine Apolipoprotein E but Does Not Modify AmyloidPlaque Pathology in PDAPPMice

Fryer, J. D., DeMattos, R. B., McCormick, L. M., O'Dell, M. A., Spinner, M. L., Bales, K. R., Paul, S. M., Sullivan, P. M., Parsadanian, M., Bu, G., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502143200 · Cited by 139 · see citing works

Interaction of Nascent ApoE2, ApoE3, and ApoE4 Isoforms Expressed in Mammalian Cells with Amyloid Peptide β (1−40). Relevance to Alzheimer's Disease

Aleshkov, S., Abraham, C. R., & Zannis, V. I. (1997) · Biochemistry · doi:10.1021/bi9626362 · Cited by 138 · see citing works

Expression of ABCG1, but Not ABCA1, Correlates with Cholesterol Release by Cerebellar Astroglia

Karten, B., Campenot, R. B., Vance, D. E., & Vance, J. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508915200 · Cited by 136 · see citing works

Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

Zerbinatti, C. V., Wozniak, D. F., Cirrito, J., Cam, J. A., Osaka, H., Bales, K. R., Zhuo, M., Paul, S. M., Holtzman, D. M., & Bu, G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305803101 · Cited by 133 · see citing works

Apolipoprotein E and Low Density Lipoprotein Receptor-related Protein Facilitate Intraneuronal Aβ42 Accumulation in Amyloid Model Mice

Zerbinatti, C. V., Wahrle, S. E., Kim, H., Cam, J. A., Bales, K., Paul, S. M., Holtzman, D. M., & Bu, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604436200 · Cited by 129 · see citing works

Cholesterol efflux regulatory protein, Tangier disease and familial high-density lipoprotein deficiency

Hayden, M. R., Clee, S. M., Brooks-Wilson, A. R., Genest, J. J., Attie, A., & Kastelein, J. J. P. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200004000-00003 · Cited by 123 · see citing works

The effects of ABCA1 on cholesterol efflux and Aβ levels <i>in vitro</i> and <i>in vivo</i>

Burns, M. P., Vardanian, L., Pajoohesh‐Ganji, A., Wang, L., Cooper, M., Harris, D. C., Duff, K., & Rebeck, G. W. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03925.x · Cited by 106 · see citing works

Alzheimer amyloid-beta peptide forms denaturant-resistant complex with type epsilon 3 but not type epsilon 4 isoform of native apolipoprotein E.

Zhou, Z., Smith, J. D., Greengard, P., & Gandy, S. (1996) · PubMed Central · Cited by 71 · see citing works

Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Aβ peptide

Buxbaum, J. D., Geoghagen, N. S. M., & Friedhoff, L. T. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3207 · Cited by 69 · see citing works

Human apolipoprotein E4 accelerates β‐amyloid deposition in APPsw transgenic mouse brain

Carter, D. B., Dunn, E., McKinley, D. D., Stratman, N. C., Boyle, T. P., Kuiper, S. L., Oostveen, J. A., Weaver, R. J., Boller, J. A., & Gurney, M. E. (2001) · Annals of Neurology · doi:10.1002/ana.1134 · Cited by 68 · see citing works

Modulation of Aβ Deposition in APP Transgenic Mice by an Apolipoprotein E Null Background

IRIZARRY, M. C., REBECK, G. W., CHEUNG, B., BALES, K., PAUL, S. M., HOLZMAN, D., & HYMAN, B. T. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06919.x · Cited by 66 · see citing works

Alzheimer Amyloid-β Peptide Forms Denaturant-Resistant Complex with Type ε3 but Not Type ε4 Isoform of Native Apolipoprotein E

Zhou, Z., Smith, J. D., Greengard, P., & Gandy, S. (1996) · Molecular Medicine · doi:10.1007/bf03401614 · Cited by 46 · see citing works

Solvation Effects on the Conformational Behaviour of Gellan and Calcium Ion Binding to Gellan Double Helices

Larwood, V., Webb, G. A., & Howlin, B. J. (1996) · Journal of Molecular Modeling · doi:10.1007/s0089460020175 · Cited by 41 · see citing works

Clinical assessment of Alzheimer's disease

Morris, J. C. (1997) · Neurology · doi:10.1212/wnl.49.3_suppl_3.s7 · Cited by 41 · see citing works

Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Aβ deposition, in an AβPP/PS double transgenic mouse model of Alzheimer's disease

Costa, D. A., Nilsson, L. N. G., Bales, K. R., Paul, S. M., & Potter, H. (2004) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6508 · Cited by 14 · see citing works

Diagnostic criteria for primary progressive mutiple sclerosis: a position paper.

(2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200006)47:6 · Cited by 2 · see citing works

Untitled work

Cole (2000) · doi:10.1002/1097-0029(20000815)50:4

Cholesterol metabolism in neurons and astrocytes

Pfrieger, F. W., & Ungerer, N. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.06.002 · Cited by 500 · see citing works

Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies

Chew, H., Solomon, V. A., & Fonteh, A. N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00598 · Cited by 353 · see citing works

Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

Vance, J. E. (2012) · Disease Models &amp; Mechanisms · doi:10.1242/dmm.010124 · Cited by 342 · see citing works

High Density Lipoprotein Structure–Function and Role in Reverse Cholesterol Transport

Lund-Katz, S., & Phillips, M. C. (2010) · Subcellular Biochemistry · doi:10.1007/978-90-481-8622-8_7 · Cited by 262 · see citing works

Role of ATP‐binding cassette transporters in brain lipid transport and neurological disease

Kim, W. S., Weickert, C. S., & Garner, B. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05099.x · Cited by 237 · see citing works

Apolipoproteins in the brain: implications for neurological and psychiatric disorders

Elliott, D. A., Weickert, C. S., & Garner, B. (2010) · Clinical Lipidology · doi:10.2217/clp.10.37 · Cited by 196 · see citing works

Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis

Wood, W. G., Li, L., Müller, W. E., & Eckert, G. P. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12637 · Cited by 194 · see citing works

Formation and function of apolipoprotein E-containing lipoproteins in the nervous system

Vance, J. E., & Hayashi, H. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.02.007 · Cited by 178 · see citing works

miR-106b impairs cholesterol efflux and increases Aβ levels by repressing ABCA1 expression

Kim, J., Yoon, H., Ramírez, C. M., Lee, S.-M., Hoe, H.-S., Fernández-Hernando, C., & Kim, J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.010 · Cited by 173 · see citing works

Apolipoprotein E and cholesterol in aging and disease in the brain

de Chaves, E. P., Narayanaswami, V., Christoffersen, C., & Nielsen, L. B. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.505 · Cited by 164 · see citing works

ATP‐binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro

Chan, S. L., Kim, W. S., Kwok, J. B., Hill, A. F., Cappai, R., Rye, K., & Garner, B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05433.x · Cited by 133 · see citing works

Apolipoprotein E: Implications for AD neurobiology, epidemiology and risk assessment

Schipper, H. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.04.021 · Cited by 105 · see citing works

The effects of cholesterol on learning and memory

Schreurs, B. G. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.04.010 · Cited by 105 · see citing works

Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood–brain barrier: Use of an in vitro model

Gosselet, F., Candela, P., Sevin, E., Bérézowski, V., Cecchelli, R., & Fénart, L. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.036 · Cited by 97 · see citing works

Expression profiling in APP23 mouse brain: inhibition of Aβ amyloidosis and inflammation in response to LXR agonist treatment

Lefterov, I., Bookout, A., Wang, Z., Staufenbiel, M., Mangelsdorf, D., & Koldamova, R. (2007) · Molecular Neurodegeneration · doi:10.1186/1750-1326-2-20 · Cited by 89 · see citing works

Recent advances in biosensors for neurodegenerative disease detection

Ganesh, H. V. S., Chow, A. M., & Kerman, K. (2016) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2016.02.012 · Cited by 68 · see citing works

Amyloid β-protein stimulates trafficking of cholesterol and caveolin-1 from the plasma membrane to the Golgi complex in mouse primary astrocytes

Igbavboa, U., Sun, G. Y., Weisman, G. A., He, Y., & Wood, W. G. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.04.049 · Cited by 59 · see citing works

Inhibition of acyl‐coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway

Huttunen, H. J., Peach, C., Bhattacharyya, R., Barren, C., Pettingell, W. H., Hutter‐Paier, B., Windisch, M., Berezovska, O., & Kovacs, D. M. (2009) · The FASEB Journal · doi:10.1096/fj.09-134999 · Cited by 56 · see citing works

Bexarotene Promotes Cholesterol Efflux and Restricts Apical-to-Basolateral Transport of Amyloid-β Peptides in an In Vitro Model of the Human Blood-Brain Barrier

Kuntz, M., Candela, P., Saint‐Pol, J., Lamartinière, Y., Boucau, M., Sevin, E., Fénart, L., & Gosselet, F. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150469 · Cited by 54 · see citing works

Brain lipid metabolism, apolipoprotein E and the pathophysiology of Alzheimer's disease

Bales, K. R. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.01.005 · Cited by 53 · see citing works

Plasma lipoprotein β-amyloid in subjects with Alzheimer's disease or mild cognitive impairment

Mamo, J. C. L., Jian, L., James, A. P., Flicker, L. A., Esselmann, H., & Wiltfang, J. (2008) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2008.007214 · Cited by 53 · see citing works

A differential association of Apolipoprotein E isoforms with the amyloid‐β oligomer in solution

Petrlová, J., Hong, H., Bricarello, D. A., Ghimire, H., Lorigan, G. A., Jin, L., & Voss, J. C. (2010) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.22891 · Cited by 51 · see citing works

Haptoglobin binds the antiatherogenic protein apolipoprotein E – impairment of apolipoprotein E stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytes

Cigliano, L., Pugliese, C. R., Spagnuolo, M. S., Palumbo, R., & Abrescia, P. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07319.x · Cited by 46 · see citing works

Cholesterol in Alzheimer’s Disease and other Amyloidogenic Disorders

Harris, J. R., & Milton, N. G. N. (2010) · Subcellular Biochemistry · doi:10.1007/978-90-481-8622-8_2 · Cited by 44 · see citing works

miRNA and cholesterol homeostasis

Jeon, T.-I., & Osborne, T. F. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.01.005 · Cited by 42 · see citing works

HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer’s Disease Pathogenesis

Borràs, C., Mercer, A., Sirisi, S., Alcolea, D. A., Escolá‐Gil, J. C., Blanco‐Vaca, F., & Tondo, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169356 · Cited by 41 · see citing works

Metabolite transport across the mammalian and insect brain diffusion barriers

Weiler, A., Volkenhoff, A., Hertenstein, H., & Schirmeier, S. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.02.008 · Cited by 42 · see citing works

Lipids in health and disease

Finkelstein, J. M., Heemels, M.-T., Shadan, S., & Weiss, U. K. (2014) · Nature · doi:10.1038/510047a · Cited by 40 · see citing works

Sterols in the central nervous system

Mulder, M. T. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32832182da · Cited by 37 · see citing works

Apolipoprotein E isoform-dependent effects on the processing of Alzheimer's amyloid-β

Chai, A. B., Lam, H. H. J., Kockx, M., & Gelissen, I. C. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158980 · Cited by 39 · see citing works

Retinoic Acid Isomers Up-Regulate ATP Binding Cassette A1 and G1 and Cholesterol Efflux in Rat Astrocytes: Implications for Their Therapeutic and Teratogenic Effects

Chen, J., Costa, L. G., & Guizzetti, M. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.182196 · Cited by 36 · see citing works

β-Cyclodextrins Decrease Cholesterol Release and ABC-Associated Transporter Expression in Smooth Muscle Cells and Aortic Endothelial Cells

Coisne, C., Hallier-Vanuxeem, D., Boucau, M., Hachani, J., Tilloy, S., Bricout, H., Monflier, É., Wils, D., Serpelloni, M., Parissaux, X., et al. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00185 · Cited by 35 · see citing works

Association of Cardiovascular Factors and Alzheimer's Disease Plasma Amyloid-β Protein in Subjective Memory Complainers

Bates, K. A., Sohrabi, H. R., Rodrigues, M. A., Beilby, J. P., Dhaliwal, S. S., Taddei, K., Criddle, A., Wraith, M. J., Howard, M., Martins, G., et al. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1050 · Cited by 34 · see citing works

Oxysterols and the NeuroVascular Unit (NVU): A far true love with bright and dark sides

Saint‐Pol, J., & Gosselet, F. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.04.017 · Cited by 33 · see citing works

Cholesterol and Dementia: A Long and Complicated Relationship

McFarlane, O., & Kędziora–Kornatowska, K. (2019) · Current Aging Science · doi:10.2174/1874609812666190917155400 · Cited by 31 · see citing works

A network pharmacology-based study on key pharmacological pathways and targets of Qi Fu Yin acting on Alzheimer's disease

Xiao, Q., Ye, T., Wang, X., Han, L., Wang, T.-X., Qi, D., Cheng, X., & Wang, S. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111336 · Cited by 28 · see citing works

Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

Basak, J. M., Kim, J., Pyatkivskyy, Y., Wildsmith, K. R., Jiang, H., Parsadanian, M., Patterson, B. W., Bateman, R. J., & Holtzman, D. M. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-14 · Cited by 27 · see citing works

An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia

Fan, J., Stukas, S. K., Wong, C. A., Chan, J., May, S., DeValle, N., Hirsch‐Reinshagen, V., Wilkinson, A., Oda, M. N., & Wellington, C. L. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m014365 · Cited by 23 · see citing works

Heavy marijuana users show increased serum apolipoprotein C-III levels: evidence from proteomic analyses

Jayanthi, S., Buie, S., Moore, S., Herning, R. I., BETTER, W. E., Wilson, N. M., Contoreggi, C. S., & Cadet, J. L. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.50 · Cited by 22 · see citing works

Proteomic 2-D DIGE Profiling of APP23 Transgenic Mice Brain from Pre-plaque and Plaque Phenotypes

Guerreiro, N., Staufenbiel, M., & Gomez‐Mancilla, B. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13102 · Cited by 19 · see citing works

Differential regulation of ABCA1 and ABCG1 gene expressions in the remodeling mouse hippocampus after entorhinal cortex lesion and liver-X receptor agonist treatment

Jasmin, S. B., Pearson, V., Lalonde, D., Domenger, D., Théroux, L., & Poirier, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.03.016 · Cited by 17 · see citing works

Apolipoprotein E Highly Correlates with AβPP- and Tau-Related Markers in Human Cerebrospinal Fluid

Vuletic, S., Li, G., Peskind, E. R., Kennedy, H., Marcovina, S. M., Leverenz, J. B., Petrie, E. C., Lee, V. M. ‐., Galasko, D. R., Schellenberg, G. D., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15307 · Cited by 12 · see citing works

Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1

Parkinson, P. F., Kannangara, T. S., Eadie, B. D., Burgess, B. L., Wellington, C. L., & Christie, B. R. (2009) · Lipids in Health and Disease · doi:10.1186/1476-511x-8-5 · Cited by 12 · see citing works

Dietary High Cholesterol and Trace Metals in the Drinking Water Increase Levels of ABCA1 in the Rabbit Hippocampus and Temporal Cortex

Schreurs, B. G., & Sparks, D. L. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150601 · Cited by 10 · see citing works

Lipid metabolism and Alzheimer's disease: pathways and possibilities

Saxena, U. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220902738720 · Cited by 8 · see citing works

Disruption of cholesterol homeostasis in developmental neurotoxicity

Guizzetti, M., Chen, J., & Costa, L. G. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-382032-7.10065-7 · Cited by 7 · see citing works

Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies

Tripathi, S., Sharma, Y., & Kumar, D. (2024) · Current Protein and Peptide Science · doi:10.2174/0113892037326839241014054430 · Cited by 4 · see citing works

The LXR/RXR Approaches in Alzheimer’s Disease: Is the Blood-Bra in Barrier the Forgotten Partner?

Fenart, P. C. L. (2013) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000e131 · Cited by 4 · see citing works

No association of genetic variants of liver X receptor‐β with alzheimer's disease risk

Rodríguez‐Rodríguez, E., Llorca, J., Mateo, I., Infante, J., Sánchez‐Quintana, C., García‐Gorostiaga, I., Fernández‐Viadero, C., Peña, N., Berciano, J., & Combarros, O. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30652 · Cited by 4 · see citing works

Cholesterol Lowering and Beyond: Role of Statins in Alzheimer’s Disease

Rebollo, A., Pou, J., & Alegret, M. (2008) · Aging Health · doi:10.2217/1745509x.4.2.171 · Cited by 3 · see citing works

A putative role for PCSK9 in synaptic remodelling and plasticity in response to brain injury: implications for Alzheimer's disease

Jasmin, S. B. (2011) · eScholarship@McGill (McGill) · doi:10.82308/52384 · Cited by 3 · see citing works

La maladie d’Alzheimer et les pharmaciens en contact avec le public

DREUX, C. (2009) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2008.11.003 · Cited by 2 · see citing works

Proton Pump Inhibitor Use and Risk of Dementia in Older Adults: A Systematic Review

Gao, X., Shao, Z. Y., Grysman, N., & Grossberg, G. T. (2023) · touchREVIEWS in Neurology · doi:10.17925/usn.2023.19.1.21 · Cited by 2 · see citing works

Identification and characterisation of potential neuroprotective proteins induced by erythropoietin (EPO) preconditioning of cortical neuronal cultures

Boulos, S. (2007) · UWA Profiles and Research Repository (UWA)

Modulating Amyloid Beta Clearance by Altering Cellular and Whole Brain Apolipoprotein E Metabolism

Basak, J. M. (2014) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/k7dz06bk

Épidémiologie des pathologies nutritionnelles

Czernichow, S., Féray, J.-C., Longuet, M., & Herçberg, S. (2008) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(08)48981-3

The Search for Biomarkers in Alzheimer's Disease

Meiliana, A., & Wijaya, A. (2010) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v2i1.107

Disruption of Cholesterol Homeostasis in Developmental Neurotoxicity

Guizzetti, M., & Costa, L. G. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804239-7.00057-3

GENETIC VARIANTS RELATED TO LIPID METABOLISM AS A RISK FACTOR TO LATE-ONSET ALZHEIMER’S DISEASE

Pinhel, M. A. S., Crestani, A. M., Sousa-Amorim, G. F., Gregório, M. L., Cação, J. D. C., Tognola, W. A., & Souza, D. R. S. (2017) · Journal of Aging Research and Lifestyle · doi:10.14283/jarcp.2017.3

Current World Literature

(2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328303e27e

Rôle du transporteur ABCA7 dans les mécanismes de transport du cholestérol et des peptides β-amyloïdes au niveau de la barrière hémato-encéphalique et implications dans la maladie d'Alzheimer

Lamartinière, Y. (2018) · theses.fr (ABES) · doi:10.70675/b0a8ed96zf1a9z474fzbc32z3fac7c6a413f

Why lipids are important for Alzheimer disease?

Hirsch-Reinshagen, V., Burgess, B. L., & Wellington, C. L. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-0012-2 · Cited by 86 · see citing works

Cholesterol metabolism and Alzheimer's disease

Li, C. (2005) · Chinese New Drugs Journal

Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease

Martins, I. J., Berger, T. R., Sharman, M. J., Verdile, G., Fuller, S. J., & Martins, R. N. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06408.x · Cited by 233 · see citing works

Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease

Poirier, J. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00007-8 · Cited by 162 · see citing works

The Role of Cholesterol in Pathogenesis of Alzheimer's Disease: Dual Metabolic Interaction between Amyloid β-Protein and Cholesterol

Michikawa, M. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:1:1 · Cited by 88 · see citing works