Cited by 22Ion channel regulation and functionReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

GPCR and Voltage-Gated Calcium Channels (VGCC) Signaling Complexes

Altier, Christophe·2012·Subcellular Biochemistry

Abstract

Voltage-gated ion channels are transmembrane proteins that control nerve impulses and cell homeostasis. Signaling molecules that regulate ion channel activity and density at the plasma membrane must be specifically and efficiently coupled to these channels in order to control critical physiological functions such as action potential propagation. Although their regulation by G-protein receptor activation has been extensively explored, the assembly of ion channels into signaling complexes of GPCRs plays a fundamental role, engaging specific downstream -signaling pathways that trigger precise downstream effectors. Recent work has confirmed that GPCRs can intimately interact with ion channels and serve as -chaperone proteins that finely control their gating and trafficking in subcellular microdomains. This chapter aims to describe examples of GPCR-ion channel co-assembly, focusing mainly on signaling complexes between GPCRs and voltage-gated calcium channels.

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Crossref · 10.1007/978-94-007-4765-4_13

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Authors
Altier, C.
Affiliations
University of Calgary (CA)
Corresponding author
Altier, Christophe
Venue
Subcellular Biochemistry
Published
2012
Volume
63
Pages
241-262
ISSN
0306-0225 (ISSN-L)
OpenAlex
W145264147
Cited by
22
References
138
Citations by year
2025: 3 · 2021: 3 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 2 · 2014: 3
FWCI
1.64
Type
book chapter
Language
en
Open access
closed
Locations
  • Sub-cellular biochemistry/Subcellular biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
G protein-coupled receptors, voltage-gated calcium channels, molecular chaperones, channel gating, ion channel trafficking, action potential propagation
MeSH terms
Animals, Humans, Calcium Channels, Signal Transduction, Ion Channel Gating, Receptors, G-Protein-Coupled, Protein Multimerization

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