GPCR and Voltage-Gated Calcium Channels (VGCC) Signaling Complexes
Abstract
Voltage-gated ion channels are transmembrane proteins that control nerve impulses and cell homeostasis. Signaling molecules that regulate ion channel activity and density at the plasma membrane must be specifically and efficiently coupled to these channels in order to control critical physiological functions such as action potential propagation. Although their regulation by G-protein receptor activation has been extensively explored, the assembly of ion channels into signaling complexes of GPCRs plays a fundamental role, engaging specific downstream -signaling pathways that trigger precise downstream effectors. Recent work has confirmed that GPCRs can intimately interact with ion channels and serve as -chaperone proteins that finely control their gating and trafficking in subcellular microdomains. This chapter aims to describe examples of GPCR-ion channel co-assembly, focusing mainly on signaling complexes between GPCRs and voltage-gated calcium channels.
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GPCRs serve as chaperones and interact with voltage-gated calcium channels to form complexes.
“GPCRs serve as chaperones and interact with voltage-gated calcium channels to form complexes [41].”
From G-protein-coupled receptor participates in 20-hydroxyecdysone signaling on the plasma membrane (2014) · cites this paper as [41]
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Self-citation
Flagged first, then by citations
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Short-chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling
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G-protein-coupled receptor participates in 20-hydroxyecdysone signaling on the plasma membrane
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- Authors
- Altier, C.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Altier, Christophe
- ORCID
- Altier, Christophe
- Venue
- Subcellular Biochemistry
- Publisher
- Springer Netherlands
- Published
- 2012
- Volume
- 63
- Pages
- 241-262
- ISSN
- 0306-0225 (ISSN-L)
- OpenAlex
- W145264147
- Cited by
- 22
- References
- 138
- Citations by year
- 2025: 3 · 2021: 3 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 2 · 2014: 3
- FWCI
- 1.64
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Sub-cellular biochemistry/Subcellular biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- G protein-coupled receptors, voltage-gated calcium channels, molecular chaperones, channel gating, ion channel trafficking, action potential propagation
- MeSH terms
- Animals, Humans, Calcium Channels, Signal Transduction, Ion Channel Gating, Receptors, G-Protein-Coupled, Protein Multimerization
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