The DOI matches its Crossref record; 333 of the 334 references it cites were found in a registry or an index, and 1 are not checked yet.
Digital Interventions for Mental Disorders: Key Features, Efficacy, and Potential for Artificial Intelligence Applications
Open accessAbstract
Mental disorders are highly prevalent and often remain untreated. Many limitations of conventional face-to-face psychological interventions could potentially be overcome through Internet-based and mobile-based interventions (IMIs). This chapter introduces core features of IMIs, describes areas of application, presents evidence on the efficacy of IMIs as well as potential effect mechanisms, and delineates how Artificial Intelligence combined with IMIs may improve current practices in the prevention and treatment of mental disorders in adults. Meta-analyses of randomized controlled trials clearly show that therapist-guided IMIs can be highly effective for a broad range of mental health problems. Whether the effects of unguided IMIs are also clinically relevant, particularly under routine care conditions, is less clear. First studies on IMIs for the prevention of mental disorders have shown promising results. Despite limitations and challenges, IMIs are increasingly implemented into routine care worldwide. IMIs are also well suited for applications of Artificial Intelligence and Machine Learning, which provides ample opportunities to improve the identification and treatment of mental disorders. Together with methodological innovations, these approaches may also deepen our understanding of how psychological interventions work, and why. Ethical and professional restraints as well as potential contraindications of IMIs, however, should also be considered. In sum, IMIs have a high potential for improving the prevention and treatment of mental health disorders across various indications, settings, and populations. Therefore, implementing IMIs into routine care as both adjunct and alternative to face-to-face treatment is highly desirable. Technological advancements may further enhance the variability and flexibility of IMIs, and thus even further increase their impact in people's lives in the future.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Methods for the Economic Evaluation of Health Care Programmes
Drummond, M. E., Sculpher, M. J., Torrance, G. W., O’Brien, B. J., & Stoddart, G. L. (2005) · doi:10.1093/oso/9780198529446.001.0001 · Cited by 13,648
Whiteford, H. A., Degenhardt, L., Rehm, J., Baxter, A. J., Ferrari, A. J., Erskine, H. E., Charlson, F. J., Norman, R. E., Flaxman, A. D., Johns, N., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61611-6 · Cited by 6,006
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643
Moons, K. G. M., Altman, D. G., Reitsma, J. B., Ioannidis, J. P. A., Macaskill, P., Steyerberg, E. W., Vickers, A. J., Ransohoff, D. F., & Collins, G. S. (2015) · Annals of Internal Medicine · doi:10.7326/m14-0698 · Cited by 5,147
Statistical Modeling: The Two Cultures (with comments and a rejoinder by the author)
Breiman, L. (2001) · Statistical Science · doi:10.1214/ss/1009213726 · Cited by 4,340
The Efficacy of Cognitive Behavioral Therapy: A Review of Meta-analyses
Hofmann, S. G., Asnaani, A., Vonk, I. J. J., Sawyer, A. T., & Fang, A. (2012) · Cognitive Therapy and Research · doi:10.1007/s10608-012-9476-1 · Cited by 3,445
Clement, S., Schauman, O., Graham, T., Maggioni, F., Evans-Lacko, S., Bezborodovs, N., Morgan, C., Rüsch, N., Brown, J. S. L., & Thornicroft, G. (2015) · Psychological Medicine · doi:10.1017/s0033291714000129 · Cited by 3,152
The global prevalence of common mental disorders: a systematic review and meta-analysis 1980–2013
Steel, Z., Marnane, C., Iranpour, C., Chey, T., Jackson, J. W., Patel, V., & Silove, D. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu038 · Cited by 2,846
Fitzpatrick, K. K., Darcy, A., & Vierhile, M. (2017) · JMIR Mental Health · doi:10.2196/mental.7785 · Cited by 2,730
Research works printed but not linked: 10
- World Health Organization. The Global Burden of Disease: 2004 update. 2008 PMID:15572474.
- Buntrock C, Ebert DD, Lehr D, Smit F, Riper H, Berking M, Cuijpers P. Effect of a web-based guided self-help intervention for prevention of major depression in adults with subthreshold depression. JAMA. 2016;315(17):1854. https://doi.org/10.1001/jama.2016.4326 American Medical Association. · DOI · Paper page
- Riper H, Blankers M, Hadiwijaya H, Cunningham J, Clarke S, Wiers R, Ebert DD, Cuijpers P. Effectiveness of guided and unguided low-intensity internet interventions for adult alcohol misuse: a meta-analysis. PLoS One. 2014;9(6):e99912 PMID:24937483, Stewart R, editor, Public Library of Science. · DOI · Paper page
- Ebert DD, Berking M, Cuijpers P, Lehr D, Pörtner M, Baumeister H. Increasing the acceptance of internet-based mental health interventions in primary care patients with depressive symptoms. A randomized controlled trial. J Affect Disord. 2015; https://doi.org/10.1016/j.jad.2015.01.056 . · DOI · Paper page
- Ebert DD, Berking M, Thiart H, Riper H, Laferton JAC, Cuijpers P, Sieland B, Lehr D. Restoring depleted resources: efficacy and mechanisms of change of an internet-based unguided recovery training for better sleep and psychological detachment from work. Heal Psychol. 2015;34(Suppl):1240–51 PMID:26651465. · DOI · Paper page
- Ebert DD, Lehr D, Heber E, Riper H, Cuijpers P, Berking M. Internet-and mobile-based stress management for employees with adherence-focused guidance: efficacy and mechanism of change. Scand J Environ Heal. 2016;42(5):382–94. · DOI · Paper page
- Terhorst Y, Rathner EM, Baumeister H, Sander L. Help from the App-Store? a systematic review of apps for depression (in press). Verhaltenstherapie 2017.
- Wampold BE, Imel ZE. The great psychotherapy debate: the evidence for what makes psychotherapy work. Routledge; 2015. ISBN:1136672605. · DOI · Paper page
- Cadwalladr C, Graham-Harrison E. Revealed: 50 million Facebook profiles harvested for Cambridge Analytica in major data breach. Guard 2018;17.
- Nahum-Shani I, Smith SN, Spring BJ, Collins LM, Witkiewitz K, Tewari A, Murphy SA. Just-in-time adaptive interventions (JITAIs) in mobile health: key components and design principles for ongoing health behavior support. Ann Behav Med. 2017;52(6):446–62 Oxford University Press US. · DOI · Paper page
Cited by
Sorted by citations
Exploring the Ethical Challenges of Conversational AI in Mental Health Care: Scoping Review
Rahsepar Meadi, M., Sillekens, T., Metselaar, S., van Balkom, A., Bernstein, J., & Batelaan, N. (2025) · JMIR Mental Health · doi:10.2196/60432 · Cited by 211
“In 2019, Ebert et al [45] reported that only 4% of commercial apps for depression and anxiety symptoms (not only CAI apps) had been subjected to rigorous clinical studies.”
InfluentialEngagement in digital interventions.
Nahum-Shani, I., Shaw, S. D., Carpenter, S. M., Murphy, S. A., & Yoon, C. (2022) · American Psychologist · doi:10.1037/amp0000983 · Cited by 177
Saheb, T., Saheb, T., & Carpenter, D. O. (2021) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2021.104660 · Cited by 148
Alhuwaydi, A. M. (2024) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s461562 · Cited by 159
“It provides an overview of the current state of digital mental health interventions and an introduction to their potential to improve the efficacy of treatment and intervention strategies through AI.”
BackgroundChatGPT is not ready yet for use in providing mental health assessment and interventions
Dergaa, I., Fekih-Romdhane, F., Hallit, S., Loch, A. A., Glenn, J. M., Fessi, M. S., Ben Aissa, M., Souissi, N., Guelmami, N., Swed, S., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1277756 · Cited by 125
“AI chatbots, as these tools are commonly referred to, may be useful in the delivery of evidence-based mental health interventions (10).”
Background
Metadata
- Authors
- Ebert, D. D., Harrer, M., Apolinário-Hagen, J., & Baumeister, H.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- FernUniversität in Hagen (DE)
- Universität Ulm (DE)
- Corresponding author
- Ebert, David Daniel
- Venue
- Advances in Experimental Medicine and Biology
- Publisher
- Springer Singapore
- Published
- 2019
- Volume
- 1192
- Pages
- 583-627
- ISSN
- 0065-2598 (ISSN-L)
- 2214-8019
- OpenAlex
- W2985217336
- Semantic Scholar
- 5a72a586e0eb3ea08d584944e4fb08ff2fb960f0
- Cited by
- 76
- References
- 333
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 21 · 2023: 10 · 2022: 9 · 2021: 12 · 2020: 2
- FWCI
- 35.41
- Type
- book chapter
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- online intervention, mobile-based interventions, digital mental health, mental illness, artificial intelligence, machine learning, therapist-guided intervention, mental disorder prevention, treatment efficacy, effect mechanism, adults
- MeSH terms
- Adult, Artificial Intelligence, Mental Disorders, Humans, Psychotherapy, Telemedicine, Internet, Mobile Applications
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review