Cited by 94Genomics and Phylogenetic StudiesEvolution and Paleontology StudiesPleistocene-Era Hominins and Archaeology

Improved dating of the human/chimpanzee separation in the mitochondrial DNA tree: Heterogeneity among amino acid sites

Adachi, Jun, Hasegawa, Masami·1995·Journal of Molecular Evolution

Abstract

The internal branch lengths estimated by distance methods such as neighbor-joining are shown to be biased to be short when the evolutionary rate differs among sites. The variable-invariable model for site heterogeneity fits the amino acid sequence data encoded by the mitochondrial DNA from Hominoidea remarkably well. By assuming the orangutan separation to be 13 or 16 Myr old, a maximum-likelihood analysis estimates a young date of 3.6 +/- 0.6 or 4.4 +/- 0.7 Myr (+/- 1 SE) for the human/chimpanzee separation, and these estimates turn out to be robust against differences in the assumed model for amino acid substitutions. Although some uncertainties still exist in our estimates, this analysis suggests that humans separated from chimpanzees some 4-5 Myr ago.

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Crossref · 10.1007/bf00160510

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  • Underestimating the degree of rate heterogeneity between sites will tend to underestimate the dates of divergence caused by a nonlinear effect of heterogeneity on branch length.

    “Underestimating the degree of rate heterogeneity between sites will tend to underestimate the dates of divergence (16, 25) caused by a nonlinear effect of heterogeneity on branch length.”

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Authors
Adachi, J., & Hasegawa, M.
Affiliations
The Graduate University for Advanced Studies, SOKENDAI (JP)
Venue
Journal of Molecular Evolution
Published
1995-06
Volume
40
Issue
6
Pages
622-628
ISSN
  • 0022-2844 (ISSN-L)
  • 1432-1432
OpenAlex
W2040287264
Cited by
94
References
61
Citations by year
2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 4
FWCI
2.35
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Molecular Evolution (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Physical Sciences › Earth and Planetary Sciences › Paleontology › Evolution and Paleontology Studies
  • Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
Keywords
human-chimpanzee divergence, divergence time estimation, mitochondrial DNA, apes, site rate heterogeneity, maximum likelihood estimation, amino acid substitution models
MeSH terms
Amino Acid Sequence, Animals, Pan troglodytes, DNA, Mitochondrial, Humans, Phylogeny, Pongo pygmaeus, Hominidae

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