Cell number and cell density in the cerebellar cortex of man and some other mammals

Lange, W.

doi:10.1007/bf00223234

Cited by 171Neurogenesis and neuroplasticity mechanismsPrimate Behavior and EcologyMotor Control and Adaptation

Cell number and cell density in the cerebellar cortex of man and some other mammals

Lange, W.·1975·Cell and Tissue Research

DOI 10.1007/bf00223234

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Abstract

The number of cells per unit volume was determined in the cerebellar cortex of man and 19 other mammals. The cell density (i.e. the number of cells per unit volume) decreases from mammals with a low brain weight to those with a higher brain weight. This decrease in the number of cells is found to be proportional for all three layers of the cerebellar cortex. In addition, the ratio of Purkinje cells to granule cells was determined. In contrast to the decrease of all cell types with increasing brain weight, this ratio varies remarkably among the mammals and is not correlated with brain weight. In man, this ratio is 1:2991, while it is lower in all other mammals investigated. These differences in the ratio of Purkinje cells to granule cells and the decrease in cell density with increasing brain weight are discussed in relation to brain evolution.

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Williams and Herrup estimated the human brain has about 85 billion neurons: 12-15 billion in the telencephalon, 70 billion cerebellar granule cells, and fewer than 1 billion in the brainstem.
“These authors estimated the number of neurons in the human brain at about 85 billion: 12–15 billion in the telencephalon (Shariff, 1953), 70 billion in the cerebellum, as granule cells (based on Lange, 1975), and fewer than 1 billion in the brainstem.”
From The human brain in numbers: a linearly scaled-up primate brain (2009) · cites this paper as Lange, 1975

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Self-citation
Quantitative study of granule and Purkinje cells in the cerebellar cortex of the rat
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Authors: Lange, W.
Corresponding author: Lange, W.
Venue: Cell and Tissue Research
Publisher: Springer Science and Business Media LLC
Published: 1975-03
Volume: 157
Issue: 1
Pages: 115-24
ISSN: 0302-766X (ISSN-L)
1432-0878
DOI: 10.1007/bf00223234
OpenAlex: W2094276452
Cited by: 171
References: 25
Citations by year: 2026: 5 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 14 · 2020: 5 · 2019: 8 · 2018: 11 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 10 · 2012: 6
FWCI: 1.51
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cell and Tissue Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
Keywords: cerebellar cortex, cell density, cell number, Purkinje cells, granule cells, brain weight, brain evolution, comparative neuroanatomy, human cerebellum, mammals
MeSH terms: Animals, Haplorhini, Artiodactyla, Carnivora, Cell Count, Cerebellar Cortex, Cetacea, Elephants, Biological Evolution, Humans, Eulipotyphla, Mammals, Opossums, Organ Size, Purkinje Cells, Rabbits, Rodentia, Species Specificity

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Cell number and cell density in the cerebellar cortex of man and some other mammals

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