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Cited by 380Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cell Densities in the Mouse Brain: A Systematic Review

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Keller, Daniel, Erö, Csaba, Markram, Henry·2018·Frontiers in Neuroanatomy
DOI 10.3389/fnana.2018.00083PMC PMC6205984
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Abstract

The mouse brain is the most extensively studied brain of all species. We performed an exhaustive review of the literature to establish our current state of knowledge on cell numbers in mouse brain regions, arguably the most fundamental property to measure when attempting to understand a brain. The synthesized information, collected in one place, can be used by both theorists and experimentalists. Although for commonly-studied regions cell densities could be obtained for principal cell types, overall we know very little about how many cells are present in most brain regions and even less about cell-type specific densities. There is also substantial variation in cell density values obtained from different sources. This suggests that we need a new approach to obtain cell density datasets for the mouse brain.

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  • Microglia originate from the embryonic yolk sac, migrate and colonize the brain during early development, around E9.5 in mice.

    “Originating from the embryonic yolk sac, microglia migrate and colonize the brain during early development, around embryonic day (E)9.5 in mice.”

    From Sex chromosomes and sex hormones differently shape microglial properties during normal physiological conditions in the adult mouse hippocampus (2025) · cites this paper as [33]

    The Introduction describes microglia as a type of glial cell, and the Discussion reports their densities across adult mouse brain regions. Neither those passages nor searches for “yolk sac,” “E9.5,” and embryonic brain colonization yielded a passage addressing microglial origin or when they enter the brain. (LLM, conf=0.77)

    Experimental — accuracy not yet measured

  • Microglial colonization precedes a hormonal surge in the brain, with androgens and estrogens peaking at around E17.5-18.

    “This precedes a hormonal surge in the brain, with androgens and estrogens peaking at around E17.5–18 [29–34].”

    From Sex chromosomes and sex hormones differently shape microglial properties during normal physiological conditions in the adult mouse hippocampus (2025) · cites this paper as [33]

    The Results section’s subcortical cell-density table reports microglial counts, not when microglia colonize the brain. Searches for E17.5, E18, and an embryonic androgen or estrogen surge found no passage in our copy establishing the claimed timing or sequence; the References mention adult androgen responsiveness but do not address it. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

  • The dentate gyrus is one of the two principal neurogenic niches, where stem cells can differentiate into neuroblasts that have the potential to migrate to sites of injury in a potential compensatory neural repair role.

    “The dentate gyrus is also one of the two principal neurogenic niches, where stem cells can differentiate into neuroblasts that have the potential to migrate to sites of injury in a potential compensatory neural repair role [42, 43].”

    From Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease (2023) · cites this paper as [42]

    The Results section, “Hippocampus and associated areas” (page unavailable), identifies the dentate gyrus and reports cell densities, but does not describe it as a neurogenic niche. Searches for stem-cell differentiation, neuroblast migration, injury, and neural repair found no passage in our copy addressing those claims. (LLM, conf=0.73)

    Experimental — accuracy not yet measured

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References 180 · Cited by 380

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Authors
Keller, D., Erö, C., & Markram, H.
Affiliations
École Polytechnique Fédérale de Lausanne (CH)
Corresponding author
Keller, Daniel
ORCID
Venue
Frontiers in Neuroanatomy
Publisher
Frontiers Media SA
Published
2018-10-23
Volume
12
Pages
83-83
ISSN
1662-5129 (ISSN-L)
DOI
10.3389/fnana.2018.00083
PMC
PMC6205984
OpenAlex
W2897977514
Cited by
380
References
180
Citations by year
2026: 30 · 2025: 64 · 2024: 51 · 2023: 56 · 2022: 71 · 2021: 50 · 2020: 44 · 2019: 13 · 2018: 1
FWCI
3.41
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Neuroanatomy (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Horizon 2020 Framework Programme (604102, 720270)
  • École Polytechnique Fédérale de Lausanne
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
cell density, mouse brain, brain regions, inter-laboratory variability, neuroanatomy

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