A quantitative study of the human cerebellum with unbiased stereological techniques

Andersen, Birgitte Bo; Korbo, Lise; Pakkenberg, Bente

doi:10.1002/cne.903260405

Cited by 276Point processes and geometric inequalitiesMedical and Biological SciencesCell Image Analysis Techniques

A quantitative study of the human cerebellum with unbiased stereological techniques

Andersen, Birgitte Bo, Korbo, Lise, Pakkenberg, Bente·1992·Journal of Comparative Neurology

DOI 10.1002/cne.903260405

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Abstract

Estimates of total number of different neuron and glial cell types in the dentate nuclei and the four major regions of the human cerebellum were obtained by new stereological methods. With the optical disector and Cavalieri methods, the total number of neurons and glial cells in the human cerebellum of five elderly men was estimated to be 105,000 x 10(6) (coefficient of variation, CV = 0.13). Of this total, the granule cells comprised 101,000 x 10(6) (CV = 0.13) and the Purkinje cells comprised 30.5 x 10(6) (CV = 0.13) of the neurons. The mean of the total number of neurons in the dentate nucleus was 5.01 x 10(6) (CV = 0.28). The average surface area of the human cerebellum was estimated to be 1160 cm2 (CV = 0.29). The rationale for the different sampling schemes used to quantify the various cell types is described.

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Using more recent estimates of 21-26 billion cortical neurons and 101 billion cerebellar neurons, the total number of human brain neurons would exceed 120 billion.
“With more recent estimates of 21–26 billion neurons in the cerebral cortex (Pelvig et al., 2008) and 101 billion neurons in the cerebellum (Andersen et al., 1992), however, the total number of neurons in the human brain would increase to over 120 billion neurons.”
From The human brain in numbers: a linearly scaled-up primate brain (2009) · cites this paper as Andersen et al., 1992
Because cerebellar glial cells are outnumbered by neurons at least 25:1, the ubiquitous claim of 10 times more glial than neuronal cells in the whole human brain would require nearly one trillion glial cells in the remaining structures, which is unlikely since those structures are <10% of brain mass.
“the only possible explanation for the ubiquitous quote of 10 times more glial than neuronal cells in the entire human brain would be the presence of nearly one trillion glial cells in the remaining structures alone – an unlikely scenario, since these structures represent <10% of total brain mass.”
From The human brain in numbers: a linearly scaled-up primate brain (2009) · cites this paper as Andersen et al., 1992

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Authors: Andersen, B. B., Korbo, L., & Pakkenberg, B.
Affiliations: Aarhus University (DK)
Copenhagen Municipal Hospital (DK)
ORCID: Pakkenberg, Bente
Venue: Journal of Comparative Neurology
Publisher: Wiley
Published: 1992-12-22
Volume: 326
Issue: 4
Pages: 549-560
ISSN: 0021-9967 (ISSN-L)
1096-9861
DOI: 10.1002/cne.903260405
OpenAlex: W2087923797
Cited by: 276
References: 37
Citations by year: 2026: 11 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 7 · 2021: 10 · 2020: 16 · 2019: 12 · 2018: 9 · 2017: 18 · 2016: 13 · 2015: 9 · 2014: 8 · 2013: 11 · 2012: 6
FWCI: 4.39
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4309 d)
Locations: The Journal of Comparative Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Mathematics › Applied Mathematics › Point processes and geometric inequalities
Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
Keywords: human cerebellum, neuron number estimation, glial cells, dentate nucleus, granule cells, Purkinje cells, optical disector, Cavalieri method, stereology, cell number
MeSH terms: Cell Count, Cerebellum, Cytological Techniques, Granulocytes, Humans, Male, Neuroglia, Neurons, Purkinje Cells

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A quantitative study of the human cerebellum with unbiased stereological techniques

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