Effects of fornix transection and cingulate cortical ablation on spatial memory in rhesus monkeys
Abstract
This study, together with a parallel study in rats (Markowska et al. 1988), attempted to relate the effects of hippocampal-system damage on similar tasks in both rats and monkeys. Not only were monkeys given a task (Experiment 1) which was of the sort usually used with rats, but in the companion study rats were given tasks (Experiment 2) like those usually used with monkeys. Experiment 1 examined the performance of rhesus monkeys with hippocampal-system damage on a spatial working memory task. Monkeys were trained preoperatively on delayed nonmatching-to-sample in a T-maze, placed into groups matched for their preoperative learning scores, and then received one of three treatments: 1) transection of the fornix; 2) ablation of the cingulate cortex; or 3) a sham operation. Monkeys with fornix transection were severely and significantly impaired, but monkeys with cingulate cortical ablations were not significantly impaired, relative to the controls. The results demonstrate that monkeys with fornix transection are severely impaired on a spatial working memory task requiring locomotion and, taken together with earlier work, suggest that the effect of fornix transection in both rodents and nonhuman primates is at least qualitatively similar (see Markowska et al. 1988). Experiment 2 assessed the role of the fornix and cingulate cortex in three conditional tasks in which the monkeys were provided with various spatial cues to indicate which one of two objects was rewarded. Both experi…
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Extensive cingulate resections above the corpus callosum, involving the cingulum bundle, had no apparent effect on T-maze alternation.
“Regarding other functions, extensive cingulate resections above corpus callosum, which again involved the cingulum bundle, had no apparent effect on T-maze alternation (Murray et al., 1989)”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Murray et al., 1989
T-maze alternation and scene discrimination tasks are hippocampal sensitive.
“yet both tasks are hippocampal sensitive (Gaffan, 1994; Murray et al., 1989).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Murray et al., 1989
Working memory per se is preserved following dorsal cingulum bundle damage.
“Taken together, these findings indicate a preservation of working memory per se following dorsal cingulum bundle damage (Meunier et al., 1997; Murray et al., 1989; Pribram and Fulton., 1954).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Murray et al., 1989
Extensive lesions of the monkey anterior and posterior cingulate cortices spare both spatial alternation and scene discrimination learning.
“extensive lesions of the monkey anterior and posterior cingulate cortices, which involve the bundle, spare both spatial alternation and scene discrimination learning (Murray et al., 1989; Parker and Gaffan, 1997; but see Buckley and Mitchell, 2016)”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Murray et al., 1989
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“Taken together, these findings indicate a preservation of working memory per se following dorsal cingulum bundle damage (Meunier et al., 1997; Murray et al., 1989; Pribram and Fulton., 1954).”
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- Authors
- Murray, E. A., Davidson, M., Gaffan, D., Olton, D. S., & Suomi, S.
- Affiliations
- National Institutes of Health (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- University of Oxford (GB)
- Johns Hopkins University (US)
- Venue
- Experimental Brain Research
- Published
- 1989
- Volume
- 74
- Issue
- 1
- Pages
- 173-86
- ISSN
- 0014-4819 (ISSN-L)
- 1432-1106
- OpenAlex
- W1970165071
- Cited by
- 200
- References
- 0
- Citations by year
- 2025: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 4 · 2013: 2 · 2012: 4
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Experimental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH24213)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Keywords
- fornix transection, spatial working memory, rhesus monkeys, delayed nonmatching-to-sample, T-maze, place learning, conditional learning, spatial cues
- MeSH terms
- Animals, Female, Gyrus Cinguli, Hippocampus, Macaca mulatta, Male, Memory, Spatial Behavior, Visual Pathways
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