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Cited by 745Medical and Biological SciencesNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

Human cingulate cortex: Surface features, flat maps, and cytoarchitecture

Vogt, Brent A., Nimchinsky, Esther A., Vogt, Leslie J., Hof, Patrick R.·1995·Journal of Comparative Neurology
DOI 10.1002/cne.903590310
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Abstract

The surface morphology land cytoarchitecture of human cingulate cortex was evaluated in the brains of 27 neurologically intact individuals. Variations in surface features included a single cingulate sulcus (CS) with or without segmentation or double parallel sulci with or without segmentation. The single CS was deeper (9.7 ± 0.81 mm) than in cases with double parallel sulci (7.5 ± 0.48 mm). There were dimples parallel to the CS in anterior cingulate cortex (ACC) and anastomoses between the CS and the superior CS. Flat maps of the medial cortical surface were made in a two‐stage reconstruction process and used to plot areas. The ACC is agranular and has a prominent layer V. Areas 33 and 25 have poor laminar differentiation, and there are three parts of area 24: area 24a adjacent to area 33 and partially within the callosal sulcus has homogeneous layers II and III, area 24b on the gyral surface has the most prominent layer Va of any cingulate area and distinct layers IIIa‐b and IIIc, and area 24c in the ventral bank of the CS has thin layers II–III and no differentiation of layer V. There are four caudal divisions of area 24. Areas 24a′ and 24b′ have a thinner layer Va and layer III is thicker and less dense than in areas 24a and 24b. Area 24c′ is caudal to area 24c and has densely packed, large pyramids throughout layer V. Area 24c'g is caudal to area 24c′ and has the largest layer Vb pyramidal neurons in cingulate cortex. Area 32 is a cingulofrontal transition cortex with large layer IIIc pyramidal neurons and a dysgranular layer IV. Area 32′ is caudal to area 32 and has an indistinct layer IV, larger layer IIIc pyramids, and fewer neurons in layer Va. Posterior cingulate cortex has medial and lateral parts of area 29, a dysgranular area 30, and three divisions of area 23: area 23a has a thin layer IIIc and moderate‐sized pyramids in layer Va, area 23b has large and prominent pyramids in layers IIIc and Va, and area 23c has the thinnest layers V and VI in cingulate cortex. Area 31 is the cinguloparietal transition area in the parasplenial lobules and has very large layer IIIc pyramids. Finally, variations in architecture between cases were assessed in neuron perikarya counts in area 23a. There was an age‐related decrease in neuron density in layer IV (r = −0.63; ages 45–102), but not in other layers. These observations provide structural underpinnings for interpreting functional imaging studies of the human medial surface. © 1995 Wiley‐Liss, Inc.

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  • Similar projections exist between each of these locations and the other domain-independent regions within this putative network.

    “Similar projections exist between each of these locations and the other domain-independent regions within this putative network [42, 66–69].”

    From Neurocomputational mechanisms underlying subjective valuation of effort costs (2017) · cites this paper as [69]

  • The boundary defined based on anatomical connectivity was located slightly anterior but adjacent to the borders between area 25 and several more anterior areas, including 32, 24, and 10, identified on the basis of cytoarchitectonics.

    “The boundary that we defined based on anatomical connectivity was located slightly anterior but adjacent to the borders between area 25 and several more anterior areas, including 32, 24, and 10, that have been identified on the basis of cytoarchitectonics (Vogt et al. 1995; Ongur et al. 2003).”

    From Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression (2008) · cites this paper as Vogt et al. 1995

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Authors
Vogt, B. A., Nimchinsky, E. A., Vogt, L. J., & Hof, P. R.
Affiliations
  • Atrium Health Wake Forest Baptist (US)
  • Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Vogt, Brent A.
ORCID
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1995-08-28
Volume
359
Issue
3
Pages
490-506
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.903590310
OpenAlex
W2082646619
Cited by
745
References
49
Citations by year
2026: 16 · 2025: 12 · 2024: 36 · 2023: 28 · 2022: 25 · 2021: 24 · 2020: 22 · 2019: 17 · 2018: 22 · 2017: 14 · 2016: 19 · 2015: 15 · 2014: 27 · 2013: 31 · 2012: 36
FWCI
38.93
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3331 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
cingulate cortex, anterior cingulate cortex, posterior cingulate cortex, cingulate sulcus, cytoarchitecture, Brodmann areas, layer 5 pyramidal neurons, human brain atlas
MeSH terms
Brain Mapping, Cerebral Cortex, Gyrus Cinguli, Humans, Surface Properties

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