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Effect of the antidepressant Org 3770 on human sleep
Abstract
The effect of a single dose (30 mg) of Org 3770 (metirzapine) on human sleep was assessed in a double blind, placebo controlled, cross over study in 6 young, healthy male volunteers. The sleep stage classification was based on visual scoring of 24 h electroencephalographic recordings according to the criteria of Rechtschaffen and Kales. Org 3770 30 mg p.o. given 2 h before bedtime had a sleep promoting action in all subjects, resulting in a shortened time to the onset of sleep. Bedtime waking and dozing (Stage 1) were reduced in favour of deep, slow wave sleep (Stages 3 and 4). Org 3770 increased the latency of REM sleep with respect to Stage 2 sleep in all subjects. It also caused a minor reduction in waking periods during REM sleep and a lower frequency of awakenings after periods of movement. No effect of Org 3770 was observed in reaction and vigilance tests on the post treatment day. The observed effects of Org 3770 on normal human sleep suggest that it might ameliorate the sleep disturbances encountered in endogenous depression, which are characterized by a reduction in slow wave sleep, an increase in nighttime awakenings and shortening of REM sleep latency.
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In a double-blind, placebo-controlled, crossover study of six healthy volunteers, a single 30 mg dose of mirtazapine decreased sleep latency, wake time, awakenings, and Stage I sleep, and increased slow wave sleep and the latency between sleep onset and the first REM episode.
“Mirtazapine ad-ministration decreased sleep latency, wake time, and awakenings and Stage I sleep, and increased slow wave sleep and the latency between sleep onset and the first REM episode.”
From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Ruigt et al., 1990
No overall REM suppression was observed with a single 30 mg dose of mirtazapine in healthy volunteers.
“No overall REM suppression was observed with this single dose of mirtazapine.”
From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Ruigt et al., 1990
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Research works printed but not linked: 20
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Metadata
- Authors
- Ruigt, G. S. F., Kemp, B., Groenhout, C. M., & Kamphuisen, H. A. C.
- Affiliations
- Organon (Netherlands) (NL)
- Venue
- European Journal of Clinical Pharmacology
- Published
- 1990-06
- Volume
- 38
- Issue
- 6
- Pages
- 551-554
- ISSN
- 0031-6970 (ISSN-L)
- 1432-1041
- OpenAlex
- W2084240932
- Cited by
- 110
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 8
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- antidepressants, sleep, sleep latency, slow-wave sleep, REM latency, sleep stages, REM sleep, nocturnal awakenings, endogenous depression, sleep disorders
- MeSH terms
- Mirtazapine, Adult, Antidepressive Agents, Double-Blind Method, Electroencephalography, Humans, Male, Mianserin, Psychomotor Performance, Sleep, Sleep Stages
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