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Cited by 654Sleep and Wakefulness ResearchNeuroscience of respiration and sleepNeural dynamics and brain function

Neuronal excitability modulation over the sleep cycle: a structural and mathematical model

McCarley, RW, Hobson, JA·1975·Science
DOI 10.1126/science.1135627
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Abstract

A model for control of the desynchronized phase of the sleep cycle postulates reciprocal interaction between cells in the pontine gigantocellular tegmental field (FTG cells) and cells in the nucleus locus coeruleus and nucleus subcoeruleus (LC cells). This physiological model leads to equations of the Lotka-Volterra type; the time course of activity predicted by the model is in good agreement with actual long-term recordings of FTG cells and single-cycle data for LC cells.

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Crossref · 10.1126/science.1135627

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  • Cholinergic systems exert significant effects on the initiation of a REM interval, while norepinephrine and serotonin play important roles in terminating a REM period.

    “Cholinergic systems exert significant effects on the initiation of a REM interval, while the monoamine neurotransmitters norepinephrine (NE) and serotonin (5-HT) play important roles in terminating a REM period [McCarley and Hobson, 1975;Velazquez-Moctezuma et al., 1991].”

    From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as McCarley and Hobson, 1975

Cites

No references could be resolved yet.

Research works printed but not linked: 35

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  3. FUXE, K, EVIDENCE FOR EXISTENCE OF MONOAMINE NEURONS IN CENTRAL NERVOUS SYSTEM .3. MONOAMINE NERVE TERMINAL, ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE 65: 573 (1965). · DOI
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  9. HOBSON, J.A., TIME COURSE OF DISCHARGE RATE CHANGES BY CAT PONTINE BRAIN-STEM NEURONS DURING SLEEP CYCLE, JOURNAL OF NEUROPHYSIOLOGY 37: 1297 (1974). · DOI
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Cited by

Sorted by citations

Authors
McCarley, R., & Hobson, J.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1975-07-04
Volume
189
Issue
4196
Pages
58-60
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1135627
OpenAlex
W2018946379
Cited by
654
References
0
Citations by year
2026: 7 · 2025: 8 · 2024: 14 · 2023: 14 · 2022: 11 · 2021: 11 · 2020: 10 · 2019: 18 · 2018: 9 · 2017: 20 · 2016: 20 · 2015: 11 · 2014: 16 · 2013: 26 · 2012: 25
FWCI
5.58
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
neuronal excitability, sleep cycles, desynchronized sleep, locus coeruleus, subcoeruleus, reciprocal interaction, Lotka-Volterra model
MeSH terms
Animals, Brain Stem, Cats, Electroencephalography, Mathematics, Models, Neurological, Neural Pathways, Neurons, Periodicity, Pons, Sleep, Wakefulness

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