The influence of levodopa on gastric emptying in healthy elderly volunteers
Abstract
Paracetamol absorption and 99Tc-DTPA measurements have been used to determine the influence of levodopa on gastric emptying in 8 healthy elderly volunteers. In the absence of levodopa 7 subjects showed a rapid gastric emptying pattern by gamma-camera and a single major peak in the plasma concentration-time curve of paracetamol. One subject showed two rapid phases of gastric emptying separated by a period of negligible emptying and had 2 separate peaks in the paracetamol plasma concentration-time curve. In the presence of levodopa, the gamma-camera data for 6 subjects showed a pattern of gastric emptying consisting of 2 rapid phases separated by a plateau. In each case secondary peaks in the plasma concentration-time curve of paracetamol occurred about 30 min after the end of the plateau. The time to 90% emptying on the gamma scan was increased significantly from 40 min to 65 min in the presence of levodopa. Comparison of the present data with those reported previously indicates that levodopa affects gastric emptying in the both elderly and young volunteers to a similar extent.
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Single or multiple dosages of levodopa induced delayed gastric emptying in healthy volunteers.
“Several clinical studies revealed that single or multiple dosages of levodopa induced delayed gastric emptying in healthy volunteers (Epprecht et al., 2015;Robertson et al., 1992Robertson et al., , 1990;;Waller et al., 1991)”
From The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies (2017) · cites this paper as Robertson et al., 1992
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- Authors
- Robertson, D. R. C., Renwick, A. G., Macklin, B., Jones, S., Waller, D. G., George, C. F., & Fleming, J. S.
- Affiliations
- Southampton General Hospital (GB)
- ORCID
- Fleming, J. S.
- Venue
- European Journal of Clinical Pharmacology
- Published
- 1992-04
- Volume
- 42
- Issue
- 4
- Pages
- 409-412
- ISSN
- 0031-6970 (ISSN-L)
- 1432-1041
- OpenAlex
- W85278196
- Cited by
- 45
- References
- 16
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 4 · 2018: 5 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 3 · 2013: 2 · 2012: 4
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- levodopa, gastric emptying, paracetamol absorption, plasma concentration-time curve, elderly volunteers
- MeSH terms
- Acetaminophen, Age Factors, Aged, Gastric Emptying, Humans, Levodopa, Male, Technetium Tc 99m Pentetate
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