Glycated haemoglobin predicts progression to diabetes mellitus in Pima Indians with impaired glucose tolerance
Open accessAbstract
Glycated haemoglobin could offer several practical advantages over the OGTT for assessing glucose metabolism. Initial cross-sectional studies (1983-1985) on 381 subjects (mostly Pima Indians) described the relationship between HbA1c (a specific glycated Hb) and the OGTT. We performed follow-up OGTTs and HbA1c measurements on 257 of these same subjects 1.6-6.1 years later. Subjects were again grouped according to both the result of the OGTT (normal, IGT or diabetes, by WHO criteria) and HbA1c result (normal or elevated based on mean +/- 1.96 SD of normal). Of 66 subjects with IGT at baseline, 47 (71%) had normal HbA1c and 19 (29%) had elevated HbA1c. Twenty-six (39%) of these subjects had diabetes at follow-up. Of these subjects with IGT, a significantly greater percentage of subjects with elevated HbA1c at baseline (68%) showed worsening to diabetes than those with a normal HbA1c (28%); (chi-square = 7.8, df = 1, p < 0.01). Thus, in subjects with IGT, glycated Hb may be a useful predictor of progression to diabetes.
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- Authors
- Little, R. R., England, J. D., Wiedmeyer, H. M., Madsen, R. W., Pettitt, D. J., Knowler, W. C., & Goldstein, D. E.
- Affiliations
- University of Missouri (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Venue
- Diabetologia
- Published
- 1994-03
- Volume
- 37
- Issue
- 3
- Pages
- 252-256
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2026726084
- Cited by
- 43
- References
- 24
- Citations by year
- 2026: 2 · 2023: 2 · 2021: 1 · 2017: 2 · 2016: 3 · 2014: 1 · 2012: 2
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- HbA1c, impaired glucose tolerance, Pima Indians, oral glucose tolerance test, diabetes prediction, glucose metabolism
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Arizona, Diabetes Mellitus, Female, Follow-Up Studies, Glucose Tolerance Test, Glycated Hemoglobin, Humans, Indians, North American, Male, Middle Aged, Predictive Value of Tests, Risk Factors, Glucose Intolerance
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