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Cited by 46Nitric Oxide and Endothelin EffectsPharmacogenetics and Drug MetabolismEicosanoids and Hypertension Pharmacology

Biotransfornation of nitric oxide, nitrite and nitrate

Yoshida, K., Kasama, K., Kitabatake, M., Imai, M.·1983·International Archives of Occupational and Environmental Health
DOI 10.1007/bf00405415
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Abstract

Biotransformation of NO, nitrite and nitrate was investigated in rats and mice in a 15NO inhalation experiment and intraperitoneal injection experiments of 15N-nitrite and 15N-nitrate, and the following results were obtained: (1) Rats were forced to inhale 15NO (145 ppm, 123 minutes) or were given an intraperitoneal injection of 15N-nitrite (2 mg animal-1 as 15N) or 15N-nitrate (2mg animal-1 as 15N), and determination of 15N recovery in urine was made up to 48 h later. The results were 55, 53 and 78% of the inhaled or injected 15N, respectively. (2) 15N-nitrate in the urine was converted into a 6-nitro derivative of 3,4-xylenol and its identification and quantitative determination were made by the GC-MS method. As to 15N-urea in the urine, identification and quantitative determination were made by the urease method. 15N was present in the urine of rats after 15NO inhalation in the form of NO3- and urea. 75 and 24% respectively. In the urine of rats injected with 15N-nitrite, about 20% of unidentified 15N-compounds not discovered in the inhalation experiment was found. The content of 15N-urea in the urine after injection with 15N-nitrate was lower than that after injection with 15N-nitrite. (3) When 15N-nitrite (0.617 mg animal-1 as 15N) was injected intraperitoneally in mice, 60.7, 7.8 and 0.3% of the injected 15N were found in the urine, feces and exhaled gas (NO, NO2 and NH3 in the gas were caught) up to 48 h after injection respectively, and 1.6% was found in the body 48 h after injection, but the remaining 30% of 15N could not be recovered.

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Crossref · 10.1007/bf00405415

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  • NO readily reacts with molecular oxygen through a single electron oxidation to HNO; further oxidation results in formation of nitrite, with the major pathway for NO metabolism being oxidation to nitrite and nitrate under normal physiological conditions.

    “NO readily reacts with molecular oxygen through a single electron oxidation to HNO. Further oxidation of this species results in the formation of nitrite (NO2−) with the major pathway for NO metabolism being oxidation to nitrite and nitrate under normal physiological conditions [67].”

    From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [67]

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Authors
Yoshida, K., Kasama, K., Kitabatake, M., & Imai, M.
Affiliations
Mie University (JP)
ORCID
Yoshida, K.
Venue
International Archives of Occupational and Environmental Health
Publisher
Springer Science and Business Media LLC
Published
1983-07
Volume
52
Issue
2
Pages
103-115
ISSN
  • 0340-0131 (ISSN-L)
  • 1432-1246
DOI
10.1007/bf00405415
OpenAlex
W2345946497
Cited by
46
References
17
Citations by year
2022: 2 · 2021: 1 · 2019: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 3 · 2012: 2
FWCI
0.41
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • International Archives of Occupational and Environmental Health (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords
nitric oxide, nitrite, nitrate, biotransformation, urinary excretion, 15N-urea, inhaled nitric oxide, rats, mice, nitrogen metabolism
MeSH terms
Animals, Biotransformation, Injections, Intraperitoneal, Male, Nitrates, Nitric Oxide, Nitrites, Nitrogen Isotopes, Rats, Inbred Strains, Species Specificity, Urea, Mice, Rats

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