Nitrite and nitrate are formed by endogenous synthesis in the human intestine
Abstract
Studies of nitrate balance in humans and analyses of fecal and ileostomy samples indicate that nitrite and nitrate are formed de novo in the intestine, possibly by heterotrophic nitrification. These findings significantly alter our previous conceptions of human exposure to nitrite and suggest an even wider role for nitrite in the etiology of human cancer.
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Endogenous production of nitrate from NO oxidation is an order of magnitude greater than dietary intake.
“the endogenous production of nitrate from NO oxidation (mainly via reaction with oxy-hemoglobin) has long been recognized to be an order of magnitude greater than dietary intake as shown in the late 1970s [7] and more recently in studies using eNOS-deficient mice [45].”
From Nitrate reduction to nitrite, nitric oxide and ammonia by gut bacteria under physiological conditions (2015) · cites this paper as [7]
Cites
[Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].
Druckrey, H., Preußmann, R., Ivankovic, S., & Schmähl, D. (1967) · PubMed · Cited by 1,407 · see citing works
Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten
Druckrey, H., Preußmann, R., Ivankovic, S., Schm�hl, D., Afkham, J., Blum, G., Mennel, H. D., M�ller, M., Petropoulos, P., & Schneider, H. (1967) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/bf00524152 · Cited by 1,349 · see citing works
A model for gastric cancer epidemiology
CORREA, P. (1975) · The Lancet · doi:10.1016/s0140-6736(75)90498-5 · Cited by 1,158 · see citing works
Formation of N-nitroso compounds: Chemistry, kinetics, and in vivo occurrence
Mirvish, S. S. (1975) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(75)90255-0 · Cited by 779 · see citing works
Nitrosamines as Environmental Carcinogens
Lijinsky, W., & Epstein, S. S. (1970) · Nature · doi:10.1038/225021a0 · Cited by 673 · see citing works
Spiegelhalder, B., Eisenbrand, G., & Preussmann, R. (1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80005-3 · Cited by 596 · see citing works
Mirvish, S. S., Wallcave, L., Eagen, M., & Shubik, P. (1972) · Science · doi:10.1126/science.177.4043.65 · Cited by 496 · see citing works
The effect of nitrate intake on nitrite formation in human saliva
Tannenbaum, S. R., Weisman, M., & Fett, D. (1976) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(76)80006-5 · Cited by 381 · see citing works
Self-citationStudies of Intestinal Microflora
Gorbach, S. L., Plaut, A. G., Nahas, L., Weinstein, L., Spanknebel, G., & Levitan, R. (1967) · Gastroenterology · doi:10.1016/s0016-5085(19)34122-8 · Cited by 343 · see citing works
Studies of Intestinal Microflora
Gorbach, S. L., Nahas, L., Lerner, P. I., & Weinstein, L. (1967) · Gastroenterology · doi:10.1016/s0016-5085(19)34121-6 · Cited by 284 · see citing works
Relative significance of dietary sources of nitrate and nitrite
White, J. W. (1975) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf60201a034 · Cited by 267 · see citing works
Nitrite in Human Saliva. Its Possible Relationship to Nitrosamine Formation23
Tannenbaum, S. R., Sinskey, A. J., Weisman, M., & Bishop, W. (1974) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/53.1.79 · Cited by 237 · see citing works
Self-citationGastric Cancer in Colombia. I. Cancer Risk and Suspect Environmental Agents2
Cuello, C., Correa, P., Haenszel, W. M., Gordillo, G., Brown, C., Archer, M. C., & Tannenbaum, S. R. (1976) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/57.5.1015 · Cited by 228 · see citing works
Self-citationBacteria and the N-Nitrosation of Secondary Amines
HAWKSWORTH, G. M., & Hill, M. J. (1971) · British Journal of Cancer · doi:10.1038/bjc.1971.66 · Cited by 182 · see citing works
Formation in vivo of volatile N-nitrosamines in man after ingestion of cooked bacon and spinach
Fine, D. H., Ross, R. D., Rounbehler, D. P., Silvergleid, A., & Song, L. (1977) · Nature · doi:10.1038/265753a0 · Cited by 130 · see citing works
Protein Requirements of Man: Variations in Obligatory Urinary and Fecal Nitrogen Losses in Young Men
Scrimshaw, N. S., Hussein, M. A., Murray, E. B., Rand, W. M., & Young, V. R. (1972) · Journal of Nutrition · doi:10.1093/jn/102.12.1595 · Cited by 124 · see citing works
Uauy, R. D., Scrimshaw, N. S., & Young, V. R. (1978) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/31.5.779 · Cited by 106 · see citing works
Reaction of Nitrite With Ascorbate and Its Relation to Nitrosamine Formation2
Archer, M. C., Tannenbaum, S. R., Fan, T.-Y., & Weisman, M. (1975) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/54.5.1203 · Cited by 105 · see citing works
Self-citationMirvish, S. S. (1971) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/46.6.1183 · Cited by 105 · see citing works
Heterotrophic nitrification in samples of natural ecosystems
Verstraete, W., & Alexander, M. (1973) · Environmental Science & Technology · doi:10.1021/es60073a007 · Cited by 87 · see citing works
Dietary factors and the etiology of gastric cancer.
Weisburger, J. H., & Raineri, R. R. (1975) · PubMed · Cited by 74 · see citing works
Behavior of the Nitrate Ion in the Dog
Greene, I., & Hiatt, E. P. (1954) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1954.176.3.463 · Cited by 44 · see citing works
Uauy, R. D., Scrimshaw, N. S., Rand, W. M., & Young, V. R. (1978) · Journal of Nutrition · doi:10.1093/jn/108.1.97 · Cited by 32 · see citing works
[Can nitrites in the human diet be the cause of cancerogenesis through formation of nitrosamines?].
Sander, J. (1967) · PubMed · Cited by 24 · see citing works
HETEROTROPHIC NITRIFICATION IN THE SIMULATED OXIDIZED ZONE OF A FLOODED SOIL AMENDED WITH BENOMYL
Gowda, T. K. S., Rao, V. R., & Sethunathan, N. (1977) · Soil Science · doi:10.1097/00010694-197703000-00006 · Cited by 22 · see citing works
[Autotrophic and heterotrophic nitrification in aquatic ecosystems].
Laurent, M. (1971) · PubMed · Cited by 4 · see citing works
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Regulatory Functions of the Vascular Endothelium
Epstein, F. H., Vane, J. R., Änggård, E., & Botting, R. M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230106 · Cited by 1,870 · see citing works
Stuehr, D. J., & Marletta, M. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7738 · Cited by 1,126 · see citing works
Determination of Inorganic Nitrate in Serum and Urine by a Kinetic Cadmium-Reduction Method
Cortas, N. K., & Wakid, N. W. (1990) · Clinical Chemistry · doi:10.1093/clinchem/36.8.1440 · Cited by 894 · see citing works
Inflammation, immunoregulation, and inducible nitric oxide synthase
Nussler, A. K., & Billiar, T. R. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.54.2.171 · Cited by 859 · see citing works
Isoforms of nitric oxide synthase Characterization and purification from different cell types
Förstermann, U., Schmidt, H. H. H. W., Pollock, J. S., Sheng, H., Mitchell, J. A., Warner, T. D., Nakane, M., & Murad, F. (1991) · Biochemical Pharmacology · doi:10.1016/0006-2952(91)90581-o · Cited by 817 · see citing works
Green, L. C., Ruiz de Luzuriaga, K., Wagner, D. A., Rand, W., Istfan, N., Young, V. R., & Tannenbaum, S. R. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.12.7764 · Cited by 665 · see citing works
Self-citationRole of nitric oxide in the biology, physiology and pathophysiology of reproduction
Rosselli, M. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.1.3 · Cited by 597 · see citing works
Nitrate Synthesis in the Germfree and Conventional Rat
Green, L. C., Tannenbaum, S. R., & Goldman, P. (1981) · Science · doi:10.1126/science.6451927 · Cited by 557 · see citing works
Self-citationN-Nitroso compounds in the diet
Lijinsky, W. (1999) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5742(99)00015-0 · Cited by 481 · see citing works
Nutritional and toxicological aspects of the Maillard browning reaction in foods
O'Brien, J., Morrissey, P. A., & Ames, J. M. (1989) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398909527499 · Cited by 477 · see citing works
Nitric oxide: A radical neurotransmitter in the central nervous system
Vincent, S. R. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90023-x · Cited by 464 · see citing works
Espey, M. G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.554 · Cited by 396 · see citing works
Walker, R. (1990) · Food Additives and Contaminants · doi:10.1080/02652039009373938 · Cited by 391 · see citing works
Potential genotoxicity of chronically elevated nitric oxide: A review
Liu, R. H., & Hotchkiss, J. H. (1995) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(95)90004-7 · Cited by 381 · see citing works
Nitrate, nitrite and N-nitroso compounds
Gangolli, S. D., van den Brandt, P. A., Feron, V. J., Janzowsky, C., Koeman, J. H., Speijers, G. J. A., Spiegelhalder, B., Walker, R., & Wishnok, J. S. (1994) · European Journal of Pharmacology: Environmental Toxicology and Pharmacology · doi:10.1016/0926-6917(94)90022-1 · Cited by 380 · see citing works
Ingested nitrate and nitrite and stomach cancer risk: An updated review
Bryan, N. S., Alexander, D. D., Coughlin, J. R., Milkowski, A. L., & Boffetta, P. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.07.062 · Cited by 335 · see citing works
Synthesis of nitrite and nitrate in murine macrophage cell lines.
Stuehr, D. J., & Marletta, M. A. (1987) · PubMed · Cited by 335 · see citing works
Law, A. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00051-5 · Cited by 312 · see citing works
Tiso, M., & Schechter, A. N. (2015) · PLOS ONE · doi:10.1371/journal.pone.0119712 · Cited by 311 · see citing works
Nitrate and Nitrite in Health and Disease
Ma, L., Hu, L., Feng, X., & Wang, S. (2018) · Aging and disease · doi:10.14336/ad.2017.1207 · Cited by 294 · see citing works
Scharfstein, J., Keaney, J. F., Slivka, A., Welch, G. N., Vita, J. A., Stamler, J. S., & Loscalzo, J. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117480 · Cited by 288 · see citing works
Nitrite in nitric oxide biology: Cause or consequence?
Bryan, N. S. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.019 · Cited by 260 · see citing works
Discovery of the nitric oxide signaling pathway and targets for drug development
Nathan, S. B. (2009) · Frontiers in bioscience · doi:10.2741/3228 · Cited by 256 · see citing works
Recent Trends in Research on Intestinal Flora
MITSUOKA, T. (1982) · Bifidobacteria and Microflora · doi:10.12938/bifidus1982.1.1_3 · Cited by 249 · see citing works
Nutrition and its Relationship to Cancer
Reddy, B. S., Cohen, L. A., McCoy, G. D., Hill, P., Weisburger, J. H., & Wynder, E. L. (1980) · Advances in cancer research · doi:10.1016/s0065-230x(08)60363-2 · Cited by 248 · see citing works
Nitrate and nitrite in the diet: How to assess their benefit and risk for human health
Habermeyer, M., Roth, A., Guth, S., Diel, P. R., Engel, K., Epe, B., Fürst, P., Heinz, V., Humpf, H., Joost, H., et al. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400286 · Cited by 244 · see citing works
Fermentation in the Rumen and Human Large Intestine
Wolin, M. J. (1981) · Science · doi:10.1126/science.7280665 · Cited by 231 · see citing works
A prospective study of stomach cancer and its relation to diet, cigarettes, and alcohol consumption.
Nomura, A. M. Y., Grove, J., Stemmermann, G. N., & Severson, R. K. (1990) · PubMed · Cited by 212 · see citing works
Wagner, D. A., Young, V. R., & Tannenbaum, S. R. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.14.4518 · Cited by 205 · see citing works
Self-citation(1983) · PubMed · Cited by 202 · see citing works
Self-citationClinical biology of nitric oxide
Davies, M. G., Fulton, G. J., & Hagen, P.-O. (1995) · British journal of surgery · doi:10.1002/bjs.1800821206 · Cited by 183 · see citing works
The pharmacology of dietary nitrate and the origin of urinary nitrate
Bartholomew, B., & Hill, M. J. (1984) · Food and Chemical Toxicology · doi:10.1016/0278-6915(84)90116-9 · Cited by 175 · see citing works
Gut Microbiota, Nitric Oxide, and Microglia as Prerequisites for Neurodegenerative Disorders
Tse, J. K. Y. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00176 · Cited by 172 · see citing works
Blood nitrates and infantile methemoglobinemia
Hegesh, E., & Shiloah, J. (1982) · Clinica Chimica Acta · doi:10.1016/0009-8981(82)90187-5 · Cited by 170 · see citing works
Dietary vitamin E and selenium and toxicity of nitrite and nitrate
Chow, C. K., & Hong, C. B. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00391-8 · Cited by 168 · see citing works
Intrinsically difficult problems: The kinetics of body proteins and amino acids in man
Bier, D. M. (1989) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610050203 · Cited by 163 · see citing works
Rodeberg, D. A., Chaet, M. S., Bass, R. C., Arkovitz, M. S., & Garcia, V. F. (1995) · The American Journal of Surgery · doi:10.1016/s0002-9610(05)80017-0 · Cited by 154 · see citing works
Nitric Oxide and Parasitic Disease
Clark, I. A., & Rockett, K. A. (1996) · Advances in Parasitology/Advances in parasitology · doi:10.1016/s0065-308x(08)60218-3 · Cited by 151 · see citing works
Duncan, C., Li, H., Dykhuizen, R., Frazer, R., Johnston, P., MacKnight, G., Smith, L., Lamza, K., McKenzie, H., Batt, L., et al. (1997) · Comparative Biochemistry and Physiology Part A: Physiology · doi:10.1016/s0300-9629(97)00023-6 · Cited by 147 · see citing works
L-Arginine is a precursor for nitrate biosynthesis in humans
Leaf, C. D., Wishnok, J. S., & Tannenbaum, S. R. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92325-5 · Cited by 129 · see citing works
Self-citationInorganic nitrite and nitrate: evidence to support consideration as dietary nutrients
Bryan, N. S., & Ivy, J. L. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.06.001 · Cited by 131 · see citing works
Glomeruli synthesize nitrite in experimental nephrotoxic nephritis
Cattell, V., Cook, T. H., & Moncada, S. (1990) · Kidney International · doi:10.1038/ki.1990.312 · Cited by 131 · see citing works
Genotoxic and carcinogenic risk to humans of drug–nitrite interaction products
Brambilla, G., & Martelli, A. (2006) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2006.09.003 · Cited by 127 · see citing works
Nitrite, nitrite alternatives, and the control of clostridium botulinum in cured meats
Pierson, M. D., Smoot, L. A., & Robach, M. C. (1983) · C R C Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398209527346 · Cited by 125 · see citing works
Nitric Oxide and Salmonella Pathogenesis
Henard, C. A., & Vázquez‐Torres, A. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00084 · Cited by 123 · see citing works
Elder, J. B., Ganguli, P. C., & Gillespie, I. E. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92757-0 · Cited by 116 · see citing works
Naturally Occurring Anticarcinogenic Substances in Foodstuffs
Fiala, E. S., Reddy, B. S., & Weisburger, J. H. (1985) · Annual Review of Nutrition · doi:10.1146/annurev.nu.05.070185.001455 · Cited by 116 · see citing works
Biotransformation of Nitric Oxide
Yoshida, K., & Kasama, K. (1987) · Environmental Health Perspectives · doi:10.1289/ehp.8773201 · Cited by 114 · see citing works
Hobbs, D. A., George, T. W., & Lovegrove, J. A. (2013) · Nutrition Research Reviews · doi:10.1017/s0954422413000188 · Cited by 114 · see citing works
Adaptation in Bacillus cereus: From Stress to Disease
Duport, C., Jobin, M.-P., & Schmitt, P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01550 · Cited by 104 · see citing works
Nitrate-reducing bacteria on rat tongues
Li, H., Duncan, C., Townend, J., Killham, K., Smith, L. M., Johnston, P., Dykhuizen, R., Kelly, D., Golden, M., Benjamin, N., et al. (1997) · Applied and Environmental Microbiology · doi:10.1128/aem.63.3.924-930.1997 · Cited by 103 · see citing works
Silvester, K. R., Bingham, S. A., Pollock, J. R. A., Cummings, J. H., & O'Neill, I. K. (1997) · Nutrition and Cancer · doi:10.1080/01635589709514596 · Cited by 97 · see citing works
Wakabayashi, K., Ochiai, M., Saitô, H., Tsuda, M., Suwa, Y., Nagao, M., & Sügimura, T. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.10.2912 · Cited by 91 · see citing works
Nitrates and Nitrites: Ingestion, Pharmacodynamics, and Toxicology
Hartman, P. E. (1982) · Springer eBooks · doi:10.1007/978-1-4615-6625-0_6 · Cited by 86 · see citing works
Decomposition of Nitrite Under Various pH and Aeration Conditions
Braida, W., & Ong, S. K. (2000) · Water Air & Soil Pollution · doi:10.1023/a:1005193313166 · Cited by 80 · see citing works
Nitrite Promotes Lymphoma Incidence in Rats
Newberne, P. M. (1979) · Science · doi:10.1126/science.451551 · Cited by 78 · see citing works
Brüne, B., Mohr, S., & Meßmer, U. K. (1995) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0048263 · Cited by 76 · see citing works
Parks, N. J., Krohn, K. A., Mathis, C. A., Chasko, J. H., Geiger, K. R., Gregor, M. E., & Peek, N. F. (1981) · Science · doi:10.1126/science.7209517 · Cited by 75 · see citing works
Volatile nitrosamines in normal human faeces
WANG, T., Kakizoe, T., Dion, P. W., Furrer, R., Varghese, A. J., & Bruce, W. R. (1978) · Nature · doi:10.1038/276280a0 · Cited by 74 · see citing works
Bueno, E., Sit, B., Waldor, M. K., & Cava, F. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0253-0 · Cited by 66 · see citing works
Bueno, M., Wang, J., Mora, A. L., & Gladwin, M. T. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4833 · Cited by 68 · see citing works
Redox Regulation of Inflammatory Processes Is Enzymatically Controlled
Lorenzen, I., Mullen, L., Bekeschus, S., & Hanschmann, E.-M. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8459402 · Cited by 68 · see citing works
Environmental factors and cultural measures affecting the nitrate content in spinach
Breimer, T. (1982) · Nutrient Cycling in Agroecosystems · doi:10.1007/bf01063766 · Cited by 62 · see citing works
Plasma nitrate concentration in infective gastroenteritis and inflammatory bowel disease
Dykhuizen, R. S., Masson, J., McKnight, G., Mowat, A. N., Smith, C. C., Smith, L. M., & Benjamin, N. (1996) · Gut · doi:10.1136/gut.39.3.393 · Cited by 59 · see citing works
Rietjens, I. M. C. M., Michael, A., Bolt, H. M., Bourdoux, S., Andrea, H., Nils, H., Kalisch, C., Angela, M., Pellegrino, G. M., Ribera, D., et al. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03242-0 · Cited by 57 · see citing works
On the mechanism by which dietary nitrate improves human skeletal muscle function
Affourtit, C., Bailey, S. J., Jones, A. M., Smallwood, M. J., & Winyard, P. G. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00211 · Cited by 58 · see citing works
Distribution of Nitrogen-13 from Labeled Nitrate ( 13 NO 3 - ) in Humans and Rats
Witter, J. P., Gatley, S. J., & Balish, E. (1979) · Science · doi:10.1126/science.441728 · Cited by 56 · see citing works
Chemistry meets biology in colitis-associated carcinogenesis
Mangerich, A., Dedon, P. C., Fox, J. G., Tannenbaum, S. R., & Wogan, G. N. (2013) · Free Radical Research · doi:10.3109/10715762.2013.832239 · Cited by 51 · see citing works
Self-citationUnderbakke, E. S., Sürmeli, N. B., Smith, B. C., Wynia‐Smith, S. L., & Marletta, M. A. (2013) · Elsevier eBooks · doi:10.1016/b978-0-08-097774-4.00320-x · Cited by 51 · see citing works
Nitrates and Nitrites in Vegetables
Tamme, T., Reinik, M., & Roasto, M. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374628-3.00021-9 · Cited by 51 · see citing works
Volatile N-nitrosamines in the urine of normal donors and of bladder cancer patients.
Kakizoe, T., Wang, T.-T., Eng, V., Furrer, R., Dion, P. W., & Bruce, W. R. (1979) · PubMed · Cited by 50 · see citing works
Distribution and metabolism of ingested NO3- and NO2- in germfree and conventional-flora rats
Witter, J. P., & Balish, E. (1979) · Applied and Environmental Microbiology · doi:10.1128/aem.38.5.861-869.1979 · Cited by 48 · see citing works
Nitrate, nitrite balance, and de novo synthesis of nitrate in humans consuming cured meats
Lee, K., Greger, J., Consaul, J. R., Graham, K., & Chinn, B. L. (1986) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/44.2.188 · Cited by 48 · see citing works
The effect of dietary nitrate on nitrate and nitrite excretion in man
Florin, T. H. J., Neale, G., & Cummings, J. H. (1990) · British Journal of Nutrition · doi:10.1079/bjn19900040 · Cited by 47 · see citing works
A nested case-control study of methemoglobinemia risk factors in children of Transylvania, Romania.
Zeman, C. L., Kross, B. C., & Vlad, M. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110817 · Cited by 46 · see citing works
Biotransfornation of nitric oxide, nitrite and nitrate
Yoshida, K., Kasama, K., Kitabatake, M., & Imai, M. (1983) · International Archives of Occupational and Environmental Health · doi:10.1007/bf00405415 · Cited by 46 · see citing works
Postulated Mechanisms whereby Fiber May Protect against Large Bowel Cancer
Cummings, J. H., & Branch, W. J. (1982) · Springer eBooks · doi:10.1007/978-1-4615-6850-6_26 · Cited by 46 · see citing works
Distribution of nitrogen-13 from labeled nitrate and nitrite in germfree and conventional-flora rats
Witter, J. P., Balish, E., & Gatley, S. J. (1979) · Applied and Environmental Microbiology · doi:10.1128/aem.38.5.870-878.1979 · Cited by 45 · see citing works
Inhibition of Nitrosamine Formation by Ascorbic Acida
Tannenbaum, S. R., & Wishnok, J. S. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb23774.x · Cited by 45 · see citing works
Self-citationRole of Nitrogen Dioxide in the Biosynthesis of Nitrosamines in Mice
Iqbal, Z. M., Dahl, K. D., & Epstein, S. S. (1980) · Science · doi:10.1126/science.7361099 · Cited by 45 · see citing works
Scragg, R. K. R., McMichael, A. J., Baghurst, P., & Dorsch, M. M. (1982) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1982.tb132578.x · Cited by 44 · see citing works
Herbert, V. D. (1979) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/32.7.1534 · Cited by 42 · see citing works
Ramsay, B., Johnson, M. R., Leone, A., & Steer, P. J. (1995) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1995.tb11296.x · Cited by 41 · see citing works
The prevention of colon cancer
Sherlock, P., Lipkin, M., & Winawer, S. J. (1980) · The American Journal of Medicine · doi:10.1016/0002-9343(80)90226-0 · Cited by 40 · see citing works
Excretion of nitrates and nitrites in saliva and bile in the dog
Fritsch, P., Blanquat, G. D. S., & Klein, D. (1985) · Food and Chemical Toxicology · doi:10.1016/0278-6915(85)90153-x · Cited by 37 · see citing works
Termine, E., Lairon, D., Taupier‐Letage, B., Gautier, S., Lafont, R., & Lafont, H. (1987) · Plant Foods for Human Nutrition · doi:10.1007/bf01092208 · Cited by 39 · see citing works
Nitrate and nitrogen balances in men
Kurzer, M. S., & Calloway, D. H. (1981) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.7.1305 · Cited by 38 · see citing works
The paracrine control of vascular motion. A historical perspective
Nava, E., & Llorens, S. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.08.003 · Cited by 36 · see citing works
Intestinal Formation of N-Nitroso Compounds in the Pig Cecum Model
Engemann, A., Focke, C., & Humpf, H. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf305040e · Cited by 37 · see citing works
Lairon, D., Spitz, N., Termine, E., Ribaud, P., Lafont, H., & Hauton, J. C. (1984) · Plant Foods for Human Nutrition · doi:10.1007/bf01094837 · Cited by 35 · see citing works
Pharmacokinetic Aspects of Inorganic Nitrate Ingestion in Man
Cortas, N. K., & Wakid, N. W. (1991) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1991.tb01221.x · Cited by 36 · see citing works
Nitric oxide synthesis in patients with infective gastroenteritis
Forte, P., Dykhuizen, R. S., Milne, E., McKenzie, A., Smith, C. C., & Benjamin, N. (1999) · Gut · doi:10.1136/gut.45.3.355 · Cited by 35 · see citing works
Tsuda, M., Takahashi, Y., Nagao, M., Hirayama, T. T., & Sügimura, T. (1980) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(80)90038-5 · Cited by 35 · see citing works
Cardioprotective actions of nitrite therapy and dietary considerations
Nathan, S. B. (2009) · Frontiers in bioscience · doi:10.2741/3568 · Cited by 34 · see citing works
Amino acids in human nutrition and health
D’Mello, J. P. F. (2011) · CABI eBooks · doi:10.1079/9781845937980.0000 · Cited by 35 · see citing works
α-Tocopherol (Vitamin E) and Its Relationship to Tumor Induction and Development
Newmark, H. L., & Mergens, W. J. (1981) · Springer eBooks · doi:10.1007/978-1-4615-9218-1_5 · Cited by 34 · see citing works
Diabetogenic effect of N-nitrosomethylurea and N-nitrosomethylurethane in the adult rat.
Portha, B., Giroix, M.-H., Cros, J. C., & Picon, L. (1980) · PubMed · Cited by 33 · see citing works
Inhibition by coffee of nitrosourea-mediated DNA damage in mice
Aeschbacher, H. U., & Jaccaud, E. (1990) · Food and Chemical Toxicology · doi:10.1016/0278-6915(90)90171-i · Cited by 33 · see citing works
The effect of water-borne nitrate on salivary nitrite
Walters, C. L., & Smith, P. (1981) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(81)90388-6 · Cited by 33 · see citing works
The significance of N‐Nitroso compounds as environmental carcinogens∗
Lijinsky, W. (1986) · Environmental Carcinogenesis Reviews · doi:10.1080/10590508609373336 · Cited by 32 · see citing works
- Authors
- Tannenbaum, S. R., Fett, D., Young, V. R., Land, P. D., & Bruce, W. R.
- Affiliations
- Massachusetts Institute of Technology (US)
- Ontario Cancer Institute, Toronto, Ontario M4X 1K9, Canada
- ORCID
- Tannenbaum, S. R.
- Venue
- Science
- Published
- 1978-06-30
- Volume
- 200
- Issue
- 4349
- Pages
- 1487-1489
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044183185
- Cited by
- 284
- References
- 26
- Citations by year
- 2025: 3 · 2024: 2 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 1 · 2013: 6 · 2012: 6
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- nitrite, nitrate, human intestine, heterotrophic nitrification, cancer etiology, ileostomy
- MeSH terms
- Adult, Aged, Dietary Proteins, Feces, Humans, Ileostomy, Intestinal Mucosa, Male, Nitrates, Nitrites
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