Cited by 284Gut microbiota and healthNitric Oxide and Endothelin EffectsNutritional Studies and Diet

Nitrite and nitrate are formed by endogenous synthesis in the human intestine

Tannenbaum, S. R., Fett, D., Young, V. R., Land, P. D., Bruce, W. R.·1978·Science

Abstract

Studies of nitrate balance in humans and analyses of fecal and ileostomy samples indicate that nitrite and nitrate are formed de novo in the intestine, possibly by heterotrophic nitrification. These findings significantly alter our previous conceptions of human exposure to nitrite and suggest an even wider role for nitrite in the etiology of human cancer.

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Crossref · 10.1126/science.663630

Cites

26 of 26 references verified0 citation errors · 0 not checkable

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  • Endogenous production of nitrate from NO oxidation is an order of magnitude greater than dietary intake.

    “the endogenous production of nitrate from NO oxidation (mainly via reaction with oxy-hemoglobin) has long been recognized to be an order of magnitude greater than dietary intake as shown in the late 1970s [7] and more recently in studies using eNOS-deficient mice [45].”

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Authors
Tannenbaum, S. R., Fett, D., Young, V. R., Land, P. D., & Bruce, W. R.
Affiliations
  • Massachusetts Institute of Technology (US)
  • Ontario Cancer Institute, Toronto, Ontario M4X 1K9, Canada
Venue
Science
Published
1978-06-30
Volume
200
Issue
4349
Pages
1487-1489
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2044183185
Cited by
284
References
26
Citations by year
2025: 3 · 2024: 2 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 1 · 2013: 6 · 2012: 6
FWCI
12.02
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
nitrite, nitrate, human intestine, heterotrophic nitrification, cancer etiology, ileostomy
MeSH terms
Adult, Aged, Dietary Proteins, Feces, Humans, Ileostomy, Intestinal Mucosa, Male, Nitrates, Nitrites

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