The incretin concept today
Open accessAbstract
1. The insulinogenic factor of the gastrointestinal mucosa named "incretin" is only one part of the complex enteroinsular axis. --2. Of the chemically defined gastrointestinal hormones GIP is the strongest incretin candidate. --3. Because of the dual function of GIP as gastrone and insulinotropic substance several safeguards against GIP-mediated insulin hypoglycaemia exist. --4. No pathological condition has yet been found which is causally related to hyper- or hyposecretion of GIP. However, an exaggerated GIP response (usually secondary to the disease) may participate in the pathogenesis of hyperinsulinaemia of patients with obesity and duodenal ulcer. --5. The injection of GIP antibodies only partially abolishes the incretin effect. Therefore, GIP, although important, is not the only incretin.
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- Authors
- Creutzfeldt, W.
- Affiliations
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Creutzfeldt, W.
- Venue
- Diabetologia
- Published
- 1979-02
- Volume
- 16
- Issue
- 2
- Pages
- 75-85
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2075404533
- Cited by
- 731
- References
- 68
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 19 · 2023: 13 · 2022: 16 · 2021: 14 · 2020: 6 · 2019: 21 · 2018: 11 · 2017: 10 · 2016: 14 · 2015: 24 · 2014: 17 · 2013: 22 · 2012: 14
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- incretins, glucagon-like peptide-1, enteroinsular axis, gastrointestinal hormones, insulin secretion, insulin-induced hypoglycemia, hyperinsulinemia, obesity, duodenal ulcer, gastric acid secretion
- MeSH terms
- Absorption, Insulin Secretion, Diabetes Mellitus, Feedback, Gastrins, Gastrointestinal Hormones, Humans, Insulin, Obesity, Peptides, Vagus Nerve, Neurotransmitter Agents
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