Circadian rhythm of gastric inhibitory polypeptide (GIP) in man
Abstract
The diurnal variations of serum gastric inhibitory polypeptide (GIP), serum insulin, plasma glucagon, plasma glucose and serum triglycerides were studied for 24 hr in 6 healthy young men, consuming three meals and performing their usual physical activities. Serum GIP levels peaked after each meal and stayed significantly elevated from the peak after lunch till late night. Glucose and insulin showed early and short-lasting postprandial peaks, declining thereafter to basal values within a short time. Plasma glucagon was inhibited by the meal ingestion and fluctuated around the basal levels in the interdigestive periods. On the other hand, serum triglycerides tended to parallel GIP changes for most of the day, being significantly elevated starting from lunch consumption to late night. The present results suggest that GIP may have effects other than the insulinogenic one, being probably involved in the control of lipid metabolism.
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Besides ghrelin, other appetite-related hormones (leptin, pancreatic peptide, gastric inhibitory peptide) show both ultradian and circadian rhythms.
“Besides ghrelin, other appetite-related hormones show both ultradian and circadian rhythms, e.g., leptin [20], pancreatic peptide (PP) [25], gastric inhibitory peptide [26].”
From Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption (2013) · cites this paper as [26]
Cites
THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY
Greenwood, F., Hunter, W., & GLOVER, J. S. (1963) · Biochemical Journal · doi:10.1042/bj0890114 · Cited by 10,178 · see citing works
STIMULATION OF INSULIN SECRETION BY GASTRIC INHIBITORY POLYPEPTIDE IN MAN. <sup>1</sup>
Dupre, J., Ross, S. A., Watson, D., & Brown, J. C. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-37-5-826 · Cited by 860 · see citing works
Creutzfeldt, W. (1979) · Diabetologia · doi:10.1007/bf01225454 · Cited by 731 · see citing works
Identification and Actions of Gastric Inhibitory Polypeptide
Brown, J. C., Dryburgh, J. R., ROSS, S. A., & DUPRÉ, J. (1975) · Elsevier eBooks · doi:10.1016/b978-0-12-571131-9.50017-7 · Cited by 333 · see citing works
Radioimmunoassay for Gastric Inhibitory Polypeptide
Kuzio, M. D., Dryburgh, J. R., Malloy, K. M., & Brown, J. C. (1974) · Gastroenterology · doi:10.1016/s0016-5085(74)80134-4 · Cited by 241 · see citing works
Oral Glucose Augmentation of Insulin Secretion
Andersen, D. K., Elahi, D., Brown, J. C., Tobin, J. D., & Andres, R. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109100 · Cited by 239 · see citing works
Gastric Inhibitory Polypeptide (GIP) Stimulation by Oral Glucose in Man
Cataland, S., Crockett, S. E., Brown, J. C., & Mazzaferri, E. L. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-2-223 · Cited by 227 · see citing works
Gastric Inhibitory Polypeptide Enhanced Lipoprotein Lipase Activity in Cultured Preadipocytes
Eckel, R. H., Fujimoto, W. Y., & Brunzell, J. D. (1979) · Diabetes · doi:10.2337/diab.28.12.1141 · Cited by 219 · see citing works
The Insulinotropic Action of Gastric Inhibitory Polypeptide in the Perfused Isolated Rat Pancreas
Pederson, R. A., & Brown, J. C. (1976) · Endocrinology · doi:10.1210/endo-99-3-780 · Cited by 210 · see citing works
Gastric Inhibitory Polypeptide (GIP) Stimulated by Fat Ingestion in Man
Falko, J. M., Crockett, S. E., Cataland, S., & Mazzaferri, E. L. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-41-2-260 · Cited by 192 · see citing works
Pederson, R. A., & Brown, J. C. (1972) · Gastroenterology · doi:10.1016/s0016-5085(72)80144-6 · Cited by 164 · see citing works
Effect of gastric inhibitory polypeptide on plasma levels of chylomicron triglycerides in dogs.
Wasada, T., McCorkle, K., Harris, V., Kawai, K., Howard, B. V., & Unger, R. H. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110335 · Cited by 153 · see citing works
Thomas, F. B., Mazzaferri, E. L., Crockett, S. E., Mekhjian, H. S., Grümer, H.-D., & Cataland, S. (1976) · Gastroenterology · doi:10.1016/s0016-5085(76)80489-1 · Cited by 117 · see citing works
Ebert, R., Illmer, K., & Creutzfeldt, W. (1979) · Gastroenterology · doi:10.1016/s0016-5085(79)80219-x · Cited by 107 · see citing works
Effect of gastric inhibitory polypeptide on pentagastrin-stimulated acid secretion in man
Maxwell, V., Shulkes, A., Brown, J. C., Solomon, T. E., Walsh, J. H., & Grossman, M. I. (1980) · Digestive Diseases and Sciences · doi:10.1007/bf01308308 · Cited by 84 · see citing works
The Insulinotropic Effect of Endogenous Gastric Inhibitory Polypeptide in Normal Subjects
Crockett, S. E., Cataland, S., Falko, J. M., & Mazzaferri, E. L. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-6-1098 · Cited by 70 · see citing works
Taminato, T., Seino, Y., Goto, Y., Inoue, Y., Kadowaki, S., Mori, K., Nozawa, M., Yajima, H., & Imura, H. (1977) · Diabetes · doi:10.2337/diab.26.5.480 · Cited by 68 · see citing works
Schauder, P., Brown, J. C., Frerichs, H., & Creutzfeldt, W. (1975) · Diabetologia · doi:10.1007/bf00429919 · Cited by 65 · see citing works
Rabinovitch, A., & Dupré, J. (1974) · Endocrinology · doi:10.1210/endo-94-4-1139 · Cited by 64 · see citing works
Gastric inhibitory polypeptide enhanced lipoprotein lipase activity in cultured preadipocytes
Eckel, R. H., Fujimoto, W. Y., & Brunzell, J. D. (1979) · Diabetes · doi:10.2337/diabetes.28.12.1141 · Cited by 63 · see citing works
Inhibition of actions of glucagon in adipocytes by gastric inhibitory polypeptide
Dupre, J., Greenidge, N., McDonald, T. J., Ross, S. A., & Rubinstein, D. (1976) · Metabolism · doi:10.1016/s0026-0495(76)80002-9 · Cited by 53 · see citing works
Arnold, R., Creutzfeldt, W., Ebert, R., Becker, H. D., Börger, H. W., & Schafmayer, A. (1978) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365527809179804 · Cited by 42 · see citing works
Simultaneous recording of the gastro-entero-pancreatic hormonal peptide response to food in man
HORNNES, P. J., Kühl, C., Holst, J. J., Lauritsen, K. B., Rehfeld, J. F., & Schwartz, T. W. (1980) · Metabolism · doi:10.1016/0026-0495(80)90203-6 · Cited by 34 · see citing works
Diurnal Variation of Plasma Gastric Inhibitory Polypeptide in Man
Jorde, R., BURHOL, P. G., Waldum, H. L., Schulz, T. B., Lygren, I., & Florholmen, J. R. (1980) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528009182224 · Cited by 17 · see citing works
Taminato, T., Seino, Y., Goto, Y., et al. (1977) · Diabetes · doi:10.2337/diabetes.26.5.480 · Cited by 10 · see citing works
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Ørskov, C., Wettergren, A., & Holst, J. J. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609009147 · Cited by 271 · see citing works
Tseng, C., Kieffer, T. J., Jarboe, L. A., Usdin, T. B., & Wolfe, M. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119060 · Cited by 149 · see citing works
Krarup, T., Saurbrey, N., Moody, A. J., Kühl, C., & Madsbad, S. (1987) · Metabolism · doi:10.1016/0026-0495(87)90153-3 · Cited by 128 · see citing works
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Oosterman, J. E., Wopereis, S., & Kalsbeek, A. (2020) · Endocrinology · doi:10.1210/endocr/bqaa180 · Cited by 105 · see citing works
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Quellec, A. L., Kervran, A., Blache, P., Ciurana, A., & BATAILLE, D. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.6.1592887 · Cited by 99 · see citing works
Diurnal Profiles of Gastrointestinal Regulatory Peptides
Jorde, R., & BURHOL, P. G. (1985) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528509089624 · Cited by 88 · see citing works
Lewis, J. T., Dayanandan, B., Habener, J. F., & Kieffer, T. J. (2000) · Endocrinology · doi:10.1210/endo.141.10.7750 · Cited by 85 · see citing works
Effects of meal timing on postprandial glucose metabolism and blood metabolites in healthy adults
Takahashi, M., Ozaki, M., Kang, M.-I., Sasaki, H., Fukazawa, M., Iwakami, T., Lim, P. J., Kim, H.-K., Aoyama, S., & Shibata, S. (2018) · Nutrients · doi:10.3390/nu10111763 · Cited by 81 · see citing works
Thondam, S. K., Cuthbertson, D. J., & Wilding, J. P. H. (2020) · Peptides · doi:10.1016/j.peptides.2019.170208 · Cited by 77 · see citing works
Circadian rhythm of blood glucose values in critically ill patients
Egi, M., Bellomo, R., Stachowski, E., French, C., Hart, G. K., & Stow, P. J. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000253814.78836.43 · Cited by 56 · see citing works
Takahashi, M., Ozaki, M., Miyashita, M., Fukazawa, M., Nakaoka, T., Wakisaka, T., Matsui, Y., Hibi, M., Osaki, N., & Shibata, S. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108221 · Cited by 39 · see citing works
Circadian rhythms of insulin needs and actions
Waldhäusl, W. (1989) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(89)90074-0 · Cited by 29 · see citing works
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Holst, J. J., Fahrenkrug, J., STADIL, F., & Rehfeld, J. F. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609094558 · Cited by 28 · see citing works
Krarup, T., Madsbad, S., & MOODY, A. J. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-1-120 · Cited by 17 · see citing works
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Ebert, R. (1990) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1990.tb01773.x · Cited by 16 · see citing works
Rubin, N. H., Alinder, G., Rietveld, W. J., Rayford, P. L., & Thompson, J. C. (1988) · Regulatory Peptides · doi:10.1016/0167-0115(88)90228-5 · Cited by 14 · see citing works
Gama, R. M., Norris, F., Morgan, L., Hampton, S. M., Wright, J., & Marks, V. (1997) · Clinical Science · doi:10.1042/cs0930343 · Cited by 13 · see citing works
Homeostatic and Circadian Control of Food Intake: Clinical Strategies to Prevent Overconsumption
Drapeau, V., & Gallant, A. R. (2013) · Current Obesity Reports · doi:10.1007/s13679-012-0038-3 · Cited by 10 · see citing works
Intra‐pancreatic fat is associated with continuous glucose monitoring metrics
Liu, Y., Kimita, W., Shamaitijiang, X., Skudder‐Hill, L., Sequeira, I. R., & Petrov, M. S. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15550 · Cited by 9 · see citing works
Senesi, P., Ferrulli, A., Luzi, L., & Terruzzi, I. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.975509 · Cited by 6 · see citing works
McIver, V. J. (2026) · e-space (Manchester Metropolitan University) · doi:10.83056/mmu.32477979
Andrews, K. E., Sibthorpe, P. E. M., Fitzgerald, D. M., & de Laat, M. A. (2026) · The Veterinary Journal · doi:10.1016/j.tvjl.2026.106644
- Authors
- Salera, M., Giacomoni, P., Pironi, L., Ustra, C., Capelli, M., Giorgi, A., Miglioli, M., & Barbara, L.
- Affiliations
- IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola (IT)
- Corresponding author
- Salera, Marcello
- ORCID
- Pironi, Loris
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 1983-01
- Volume
- 32
- Issue
- 1
- Pages
- 21-24
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W1988044902
- Cited by
- 23
- References
- 25
- Citations by year
- 2026: 2 · 2024: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2012: 1
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- glucose-dependent insulinotropic polypeptide, circadian rhythm, diurnal variation, insulin, glucagon, plasma glucose, serum triglycerides, postprandial response, lipid metabolism, meal ingestion
- MeSH terms
- Adult, Blood Glucose, Circadian Rhythm, Eating, Gastric Inhibitory Polypeptide, Gastrointestinal Hormones, Glucagon, Humans, Insulin, Male, Triglycerides
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