Tfm Lac: A second isolation of testicular feminization in mice
Abstract
TfmLac, a new occurrence of the X-linked mutation testicular feminization, has been isolated in a stock of mice and mapped to the same region as the original TfmH mutation. We compared these two mutants to determine if there are differences in their putative residual androgen receptors or androgen responsiveness. Such differences have been reported for Tfm mutations in humans. We found no evidence for induction of ornithine decarboxylase (ODC) activity in TfmLac despite androgen treatment for up to 3 weeks. This is in agreement with findings for TfmH. Both of these mutants expressed small amounts of androgen binding activity which shared some properties with the normal androgen receptors in mouse kidney. The binding was distinguishable between the two mutants, however, as determined by hormone saturation experiments utilizing DNA-cellulose chromatography. These findings confirm the independence of the two mutations and are consistent with their being allelic: both result in severe deficits of androgen binding and response.
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The Tfm mouse model has limitations, including potential residual AR activity due to the production of a truncated AR protein.
“the Tfm mouse model has a number of limitations, including potential residual AR activity due to the production of a truncated AR protein.”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [135]
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- Authors
- Politch, J. A., Fox, T. O., Houben, P., Bullock, L., & Lovell, D.
- Affiliations
- Harvard University (US)
- Tufts University (US)
- Medical Research Council (GB)
- ORCID
- Politch, J. A.
- Venue
- Biochemical Genetics
- Published
- 1988-04
- Volume
- 26
- Issue
- 3-4
- Pages
- 213-221
- ISSN
- 0006-2928 (ISSN-L)
- 1573-4927
- OpenAlex
- W2066189995
- Cited by
- 8
- References
- 31
- Citations by year
- 2022: 1 · 2014: 2
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biochemical Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5t32am007337-08)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD20327, HD 17666)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- androgen insensitivity syndrome, X-linked mutations, androgen receptor, androgen binding, androgen response, ornithine decarboxylase, allelic mutations, gene mapping
- MeSH terms
- Animals, Enzyme Induction, Female, Kidney, Genetic Linkage, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Ornithine Decarboxylase, Androgen-Insensitivity Syndrome, Testosterone, X Chromosome, Mice
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